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Drug Development and Industrial Pharmacy Volume 12, 1986 - Issue 11-13
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Research Article

Effect of Compressibility and Powder Flow Properties on Tablet Weight Variation

A. R. Fassihi School of Pharmaceutical Sciences, Rhodes University, Grahamstown, South Africa
&
I. Kanfer School of Pharmaceutical Sciences, Rhodes University, Grahamstown, South Africa
Pages 1947-1966 | Published online: 20 Oct 2008

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Sadaf Farooqi, Rabia Ismail Yousuf, Muhammad Harris Shoaib, Kamran Ahmed, Sabah Ansar & Tazeen Husain. (2020) Quality by Design (QbD)-Based Numerical and Graphical Optimization Technique for the Development of Osmotic Pump Controlled-Release Metoclopramide HCl Tablets. Drug Design, Development and Therapy 14, pages 5217-5234.
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Slavomír Kurhajec, Aleš Franc, Petr Doležel & Dana Sabadková. (2017) Quality by design approach: antioxidant activity of the tablets containing cornelian cherry fruits in relation to their composition and physical properties. Pharmaceutical Development and Technology 22:7, pages 881-888.
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Martin Kuentz & Peter Schirg. (2013) Powder flow in an automated uniaxial tester and an annular shear cell: a study of pharmaceutical excipients and analytical data comparison. Drug Development and Industrial Pharmacy 39:9, pages 1476-1483.
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Linda A. Felton, Daniel I. Garcia & Ryan Farmer. (2002) Weight and Weight Uniformity of Hard Gelatin Capsules Filled with Microcrystalline Cellulose and Silicified Microcrystalline Cellulose. Drug Development and Industrial Pharmacy 28:4, pages 467-472.
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M. C. Monedero Perales, A. Muñoz-Ruiz, M. V. Velasco Antequera, N. Muñoz Muñoz & M. R. Jiménez-Castellanos Ballesteros. (1996) Comparative Tableting and Microstructural Properties of a New Starch for Direct Compression. Drug Development and Industrial Pharmacy 22:7, pages 689-695.
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Makoto Otsuka, Fumiya Funakubo, Takumi Suzuki, Yusuke Hattori, Kunihiko Tsutsui, Naoki Adachi & Tetsuo Sasaki. (2022) Real-time monitoring of tablet surface temperature during high-speed tableting by infrared thermal imaging. Journal of Drug Delivery Science and Technology 68, pages 102736.
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Jayendrasingh P. Bayas & M. Sumithra. (2022) QbD method to the formulation and development of a spironolactone immediate-release tablet with enhanced dissolving research. Materials Today: Proceedings 51, pages 2539-2549.
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Johnson Ajeh Isaac, Kokonne Elizabeth Ekere, Ekeh Ezekiel, Isa Hayatu Galadima, Rashida Abdulahi & Ayuba Samali. (2021) Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves. Borneo Journal of Pharmacy 4:4, pages 333-344.
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Mitja Pohlen, Luka Pirker & Rok Dreu. (2021) The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study. Pharmaceutics 13:8, pages 1177.
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Lamia Diang Mahalia, Stefanus Supriyanto & Yandi Syukri. (2022) Development of Sweet Potato (Ipomoea Batatas Lamk.) as Excipient in Tablet Formulation. Journal of Public Health Research 9:2, pages jphr.2020.1831.
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Alexander Kalies, Hüseyin Özcoban & Claudia S. Leopold. (2019) Application of Externally Applied Lower Punch Vibration and its Effects on Tablet Manufacturing. Pharmaceutical Research 36:12.
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Petra Svačinová, Barbora Vraníková, Martin Dominik, Jan Elbl, Sylvie Pavloková, Roman Kubalák, Pavlína Kopecká & Aleš Franc. (2019) Comprehensive study of co-processed excipients F- Melts®: Flow, viscoelastic and compacts properties. Powder Technology 355, pages 675-687.
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Justin Yong Soon Tay, Berlinda Wen Ting Kok, Celine Valeria Liew & Paul Wan Sia Heng. (2019) Effects of Particle Surface Roughness on In-Die Flow and Tableting Behavior of Lactose. Journal of Pharmaceutical Sciences 108:9, pages 3011-3019.
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Emmanuel Reginald Jacques & Paschalis Alexandridis. (2019) Tablet Scoring: Current Practice, Fundamentals, and Knowledge Gaps. Applied Sciences 9:15, pages 3066.
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João C. Campos, Domingos C. Ferreira, Sofia Lima, Salette Reis & Paulo J. Costa. (2019) Swellable polymeric particles for the local delivery of budesonide in oral mucositis. International Journal of Pharmaceutics 566, pages 126-140.
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Hui Ping Goh, Paul Wan Sia Heng & Celine Valeria Liew. (2019) The Effects of Feed Frame Parameters and Turret Speed on Mini-Tablet Compression. Journal of Pharmaceutical Sciences 108:3, pages 1161-1171.
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Hui Ping Goh, Paul Wan Sia Heng & Celine Valeria Liew. (2018) Investigation on the impact of powder arching in small die filling. International Journal of Pharmaceutics 551:1-2, pages 42-51.
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Hui Ping Goh, Paul Wan Sia Heng & Celine Valeria Liew. (2017) Understanding die fill variation during mini-tablet production. International Journal of Pharmaceutics 534:1-2, pages 279-286.
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Yifan Wang, Tianyi Li, Fernando J. Muzzio & Benjamin J. Glasser. (2017) Predicting feeder performance based on material flow properties. Powder Technology 308, pages 135-148.
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A. Crouter & L. Briens. (2016) Monitoring lubricant addition using passive acoustic emissions in a V-blender. Powder Technology 301, pages 1119-1129.
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Juan G. Osorio, Koushik Sowrirajan & Fernando J. Muzzio. (2016) Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets. Advanced Powder Technology 27:4, pages 1141-1148.
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Tina Lien Vestland, Øyvind Jacobsen, Sverre Arne Sande, Astrid Hilde Myrset & Jo Klaveness. (2015) Compactible powders of omega-3 and β-cyclodextrin. Food Chemistry 185, pages 151-158.
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Abid Mehmood Yousaf, Dong Wuk Kim, Jin Ki Kim, Jong Oh Kim, Chul Soon Yong & Han-Gon Choi. (2015) Novel fenofibrate-loaded gelatin microcapsules with enhanced solubility and excellent flowability: Preparation and physicochemical characterization. Powder Technology 275, pages 257-262.
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Allison Crouter & Lauren Briens. (2013) The Effect of Moisture on the Flowability of Pharmaceutical Excipients. AAPS PharmSciTech 15:1, pages 65-74.
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Garett Morin & Lauren Briens. (2013) The Effect of Lubricants on Powder Flowability for Pharmaceutical Application. AAPS PharmSciTech 14:3, pages 1158-1168.
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Venkateshwar Rao Nalluri, Maxim Puchkov & Martin Kuentz. (2013) Toward better understanding of powder avalanching and shear cell parameters of drug?excipient blends to design minimal weight variability into pharmaceutical capsules. International Journal of Pharmaceutics 442:1-2, pages 49-56.
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Ian J Hardy & Walter G Cook. (2003) Predictive and correlative techniques for the design, optimisation and manufacture of solid dosage forms. Journal of Pharmacy and Pharmacology 55:1, pages 3-18.
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Niklas Sandler & David Wilson. (2010) Prediction of granule packing and flow behavior based on particle size and shape analysis. Journal of Pharmaceutical Sciences 99:2, pages 958-968.
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Y. Yaginuma, Y. Ozeki, M. Kakizawa, S.-I. Gomi & Y. Watanabe. (2007) Effects of powder flowability on die-fill properties in rotary compression. Journal of Drug Delivery Science and Technology 17:3, pages 205-210.
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Herbert StickerHerbert Sticker. 2003. Arzneiformen-Entwicklung. Arzneiformen-Entwicklung 97 127 .
Hyunjo Kim, Gopi Venkatesh & Reza Fassihi. (1998) Compactibility characterization of granular pectin for tableting operation using a compaction simulator1This work is dedicated to Professor Dr W.A. Ritschel, one of the pioneers in the area of Industrial Pharmacy, Biopharmaceutics and Pharmacokinetics, on the occasion of his retirement.1. International Journal of Pharmaceutics 161:2, pages 149-159.
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Alex C. Hoffmann, Hendrikus J. Finkers & Jacobus A. Seegers. (2006) Relationships Between Particle Properties and Bulk Behaviour for some industrial powders. Particle & Particle Systems Characterization 13:6, pages 354-361.
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