92
Views
31
CrossRef citations to date
0
Altmetric
Research Article

Determination of Sphericity of Pellets Prepared by Extrusion/Spheronization and the Impact of Some Process Parameters

&
Pages 2375-2392 | Published online: 20 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Shivanand P. Puthli & Pradeep R. Vavia. (2009) Fabrication, characterization and in vivo studies of biodegradable gamma sterilized injectable microparticles for contraception. Pharmaceutical Development and Technology 14:3, pages 278-289.
Read now
Markus Thommes & Peter Kleinebudde. (2008) The Behavior of Different Carrageenans in Pelletization by Extrusion/Spheronization. Pharmaceutical Development and Technology 13:1, pages 27-35.
Read now
Yuh-Tyng Huang, Tong-Rong Tsai, Chun-Jen Cheng, Thau-Ming Cham, Tsun-Fwu Lai & Wen-Ho Chuo. (2007) Formulation Design of a Highly Hygroscopic Drug (Pyridostigmine Bromide) for its Hygroscopic Character Improvement and Investigation of In Vitro/In Vivo Dissolution Properties. Drug Development and Industrial Pharmacy 33:4, pages 403-416.
Read now
Ranjana Chopra, J. Michael Newton, Göran Alderborn & Fridrun Podczeck. (2001) Preparation of Pellets of Different Shape and Their Characterization. Pharmaceutical Development and Technology 6:4, pages 495-503.
Read now
Kaisri Umprayn, Padungkwan Chitropas & Sukavat Amarekajorn. (1999) Influence of Process Variables on Physical Properties of the Pellets Using Extruder and Spheronizer. Drug Development and Industrial Pharmacy 25:1, pages 46-61.
Read now
Gregory A. Hileman, Sathyanarayana M. Upadrashta & Steven H. Neau. (1997) Drug Solubility Effects on Predicting Optimum Conditions for Extrusion and Spheronization of Pellets. Pharmaceutical Development and Technology 2:1, pages 43-52.
Read now
Cathy C. Ku, Yatindra M. Joshi, James S. Bergum & Nemi B. Jain. (1993) Bead Manufacture by Extrusion/spheronization – a Statistical Design for Process Optimization. Drug Development and Industrial Pharmacy 19:13, pages 1505-1519.
Read now
Gregory A. Hileman, Sanjay R. Goskonda, Anthony J. Spalitto & Sathyanarayana M. Upadrashta. (1993) A Factorial Approach to High Dose Product Development by an Extrusion/Spheronization Process. Drug Development and Industrial Pharmacy 19:4, pages 483-491.
Read now

Articles from other publishers (22)

Yousif H-E.Y. Ibrahim, Patience Wobuoma, Katalin Kristó, Ferenc Lajkó, Gábor Klivényi, Béla Jancsik, Géza Regdon jr, Klára Pintye-Hódi & Tamás Sovány. (2021) Effect of processing conditions and material attributes on the design space of lysozyme pellets prepared by extrusion/spheronization. Journal of Drug Delivery Science and Technology 66, pages 102714.
Crossref
Sarah Moherdaui Martins, Vinicius Müller, Vanderson Galan, Fabio Pinheiro de Souza, Itamar Francisco Andreazza & Maurício Ferreira da Rosa. (2018) Development and evaluation of multiparticulate biphasic system for the treatment of circadian diseases. Brazilian Journal of Pharmaceutical Sciences 54:4.
Crossref
Daniel Treffer, Patrick R. Wahl, Theresa R. Hörmann, Daniel Markl, Simone Schrank, Ian Jones, Paul Cruise, Reinhardt-Karsten Mürb, Gerold Koscher, Eva Roblegg & Johannes G. Khinast. (2014) In-line implementation of an image-based particle size measurement tool to monitor hot-melt extruded pellets. International Journal of Pharmaceutics 466:1-2, pages 181-189.
Crossref
Raveendra Pai, Kanchan Kohli & Birendra Shrivastava. (2012) Compression and evaluation of extended release matrix pellets prepared by the extrusion/spheronization process into disintegrating tablets. Brazilian Journal of Pharmaceutical Sciences 48:1, pages 117-129.
Crossref
Raveendra Pai, Kanchan Kohli, Gaurav Jain & Birendra Srivastava. (2011) In vitro and in vivo evaluations of ketoprofen extended release pellets prepared using powder layering technique in a rotary centrifugal granulator. Archives of Pharmacal Research 34:7, pages 1135-1142.
Crossref
P Kleinebudde, A J Sølvberg & H Lindner. (1994) The Power-consumption-controlled Extruder: A Tool for Pellet Production. Journal of Pharmacy and Pharmacology 46:7, pages 542-546.
Crossref
Shivanand Puthli & Pradeep Vavia. (2009) Formulation and Performance Characterization of Radio-Sterilized “Progestin-Only” Microparticles Intended for Contraception. AAPS PharmSciTech 10:2, pages 443-452.
Crossref
S. Puthli & P. Vavia. (2008) Gamma irradiated micro system for long-term parenteral contraception: An alternative to synthetic polymers. European Journal of Pharmaceutical Sciences 35:4, pages 307-317.
Crossref
Sergio Almeida-Prieto, José Blanco-Méndez & Francisco J. Otero-Espinar. (2007) Microscopic image analysis techniques for the morphological characterization of pharmaceutical particles: Influence of the software, and the factor algorithms used in the shape factor estimation. European Journal of Pharmaceutics and Biopharmaceutics 67:3, pages 766-776.
Crossref
Sergio Almeida-Prieto, José Blanco-Méndez & Francisco J. Otero-Espinar. (2006) Microscopic image analysis techniques for the morphological characterization of pharmaceutical particles: Influence of process variables. Journal of Pharmaceutical Sciences 95:2, pages 348-357.
Crossref
Atmaram Pawar, Anant Paradkar, Shivajirao Kadam & Kakasaheb Mahadik. (2004) Agglomeration of ibuprofen with talc by novel crystallo-co-agglomeration technique. AAPS PharmSciTech 5:4, pages 30-35.
Crossref
Sergio Almeida-Prieto, José Blanco-Méndez & Francisco J. Otero-Espinar. (2004) Image Analysis of the Shape of Granulated Powder Grains. Journal of Pharmaceutical Sciences 93:3, pages 621-634.
Crossref
Herbert StickerHerbert Sticker. 2003. Arzneiformen-Entwicklung. Arzneiformen-Entwicklung 73 96 .
P.A Elchidana & S.G Deshpande. (1999) Microporous membrane drug delivery system for indomethacin. Journal of Controlled Release 59:3, pages 279-285.
Crossref
Christian Schmidt & Peter Kleinebudde. (1998) Comparison between a twin-screw extruder and a rotary ring die press. Part II: influence of process variables. European Journal of Pharmaceutics and Biopharmaceutics 45:2, pages 173-179.
Crossref
M. Eriksson, G. Alderborn, C. Nystr?m, F. Podczeck & J.M. Newton. (1997) Comparison between and evaluation of some methods for the assessment of the sphericity of pellets. International Journal of Pharmaceutics 148:2, pages 149-154.
Crossref
J. Vertommen, P. Rombaut & R. Kinget. (1997) Shape and surface smoothness of pellets made in a rotary processor. International Journal of Pharmaceutics 146:1, pages 21-29.
Crossref
P.B. Deasy & M.P. Gouldson. (1996) In vitro evaluation of pellets containing enteric coprecipitates of nifedipine formed by non-aqueous spheronization. International Journal of Pharmaceutics 132:1-2, pages 131-141.
Crossref
Gregory A. Hileman, Sanjay R. Goskonda, Anthony J. Spalitto & Sathyanarayana M. Upadrashta. (1993) Response surface optimization of high dose pellets by extrusion and spheronization. International Journal of Pharmaceutics 100:1-3, pages 71-79.
Crossref
Leena Hell?n & Jouko Yliruusi. (1993) Process variables of instant granulator and spheroniser: III. Shape and shape distributions of pellets. International Journal of Pharmaceutics 96:1-3, pages 217-223.
Crossref
P. Kleinebudde. (1993) Application of low substituted hydroxypropylcellulose (L-HPC) in the production of pellets using extrusion/spheronization. International Journal of Pharmaceutics 96:1-3, pages 119-128.
Crossref
Peter Kleinebudde & Hans Lindner. (1993) Experiments with an instrumented twin-screw extruder using a single-step granulation/extrusion process. International Journal of Pharmaceutics 94:1-3, pages 49-58.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.