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Research Article

Effect of Amount of Added Water During Extrusion-Spheronization Process on Pharmaceutical Properties of Granules

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Pages 2977-2992 | Published online: 20 Oct 2008

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Payal Sharma, Sameer R. Modi & Arvind K. Bansal. (2015) Co-processing as a tool to improve aqueous dispersibility of cellulose ethers. Drug Development and Industrial Pharmacy 41:11, pages 1745-1758.
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Zhouhua Wang, Bao Chen, Guilan Quan, Feng Li, Qiaoli Wu, Linghui Dian, Yixuan Dong, Ge Li & Chuanbin Wu. (2012) Increasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica. International Journal of Nanomedicine 7, pages 5807-5818.
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Elnazeer I. Hamedelniel, János Bajdik, Péter Kása$suffix/text()$suffix/text() & Klára Pintye-Hódi. (2012) Study of the influence of alkalizing components on matrix pellets prepared by extrusion/spheronization. Pharmaceutical Development and Technology 17:2, pages 204-211.
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Jakob Kristensen, Torben Schæfer & Peter Kleinebudde. (2002) Development of Fast-Disintegrating Pellets in a Rotary Processor. Drug Development and Industrial Pharmacy 28:10, pages 1201-1212.
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Kaisri Umprayn, Padungkwan Chitropas & Sukavat Amarekajorn. (1999) Influence of Process Variables on Physical Properties of the Pellets Using Extruder and Spheronizer. Drug Development and Industrial Pharmacy 25:1, pages 46-61.
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G. Sienkiewicz, R. Pereira, E. M. Rudnic, J. M. Lausier & C. T. Rhodes. (1997) Spheronization of Theophylline-Avicel Combinations Using a Fluidized-Bed Rotogranulation Technique. Drug Development and Industrial Pharmacy 23:2, pages 173-182.
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Articles from other publishers (14)

R. Chandrasekar, Prudhvi Raj V & Sameer Shaik. (2023) Formulation Development and Invitro Evaluation of Gliclazide Pellets using Superdisintegrants by Extrusion Spheronization Technique. International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16:1, pages 6266-6280.
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Matthew Lam, Daniel Commandeur, Mohammed Maniruzzaman, Deck Khong Tan & Ali Nokhodchi. (2020) The crucial effect of water and co-solvent on Liqui-Pellet pharmaceutical performance. Advanced Powder Technology 31:5, pages 1903-1914.
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F.J. Otero-Espinar, A. Luzardo-Alvarez & J. Blanco-Méndez. (2010) Non-MCC materials as extrusion-spheronization aids in pellets production. Journal of Drug Delivery Science and Technology 20:4, pages 303-318.
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David Megias-Alguacil & Erich J. Windhab. (2006) Experimental Study of Drop Deformation and Breakup in a Model Multitoothed Rotor-Stator. Journal of Fluids Engineering 128:6, pages 1289-1294.
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Markus Thommes & Peter Kleinebudde. (2006) Use of κ-carrageenan as alternative pelletisation aid to microcrystalline cellulose in extrusion/spheronisation. I. Influence of type and fraction of filler. European Journal of Pharmaceutics and Biopharmaceutics 63:1, pages 59-67.
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Makoto Otsuka. (2006) Chemoinformetrical evaluation of granule and tablet properties of pharmaceutical preparations by near-infrared spectroscopy. Chemometrics and Intelligent Laboratory Systems 82:1-2, pages 109-114.
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Sibeum Lee, Min-Soo Kim, Seoung Wook Jun, Jeong-Sook Park & Sung-Joo Hwang. (2005) Preparation of controlled release spheronized beads by a simple extrusion and modified spheronization process. Archives of Pharmacal Research 28:5, pages 619-625.
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Makoto Otsuka, Yoshifumi Mouri & Yoshihisa Matsuda. (2003) Chemometric evaluation of pharmaceutical properties of antipyrine granules by near-infrared spectroscopy. AAPS PharmSciTech 4:3, pages 142-148.
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Herbert StickerHerbert Sticker. 2003. Arzneiformen-Entwicklung. Arzneiformen-Entwicklung 73 96 .
Y.S Habib, L.L Augsburger & R.F Shangraw. (2002) Production of inert cushioning beads: effect of excipients on the physicomechanical properties of freeze-dried beads containing microcrystalline cellulose produced by extrusion–spheronization. International Journal of Pharmaceutics 233:1-2, pages 67-83.
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J.J. Sousa, A. Sousa, F. Podczeck & J.M. Newton. (2002) Factors influencing the physical characteristics of pellets obtained by extrusion-spheronization. International Journal of Pharmaceutics 232:1-2, pages 91-106.
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Makoto Otsuka, Tomoko Ohfusa & Yoshihisa Matsuda. (2000) Effect of binders on polymorphic transformation kinetics of carbamazepine in aqueous solution. Colloids and Surfaces B: Biointerfaces 17:3, pages 145-152.
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Rajesh Gandhi, Chaman Lal Kaul & Ramesh Panchagnula. (1999) Extrusion and spheronization in the development of oral controlled-release dosage forms. Pharmaceutical Science & Technology Today 2:4, pages 160-170.
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Ramarao Chatlapalli & Bhagwan D Rohera. (1998) Physical characterization of HPMC and HEC and investigation of their use as pelletization aids. International Journal of Pharmaceutics 161:2, pages 179-193.
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