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Drug Development and Industrial Pharmacy Volume 20, 1994 - Issue 1
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Research Article

Process Considerations in Reducing Tablet Friability and Their Effect on in vitro Dissolution

Marc S. Gordon Institute of Pharmaceutical Sciences Syntex (USA) Inc., 3401 Hillview Avenue, Palo Alto, California, 94304
Pages 11-29 | Published online: 20 Oct 2008

Citations (13)

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Read on this site (3)

Tusharmouli Mukherjee & Fotios M. Plakogiannis. (2012) Effects of process parameters on solid self-microemulsifying particles in a laboratory scale fluid bed. Pharmaceutical Development and Technology 17:4, pages 511-520.
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M. Perrault, F. Bertrand & J. Chaouki. (2011) An experimental investigation of the effect of the amount of lubricant on tablet properties. Drug Development and Industrial Pharmacy 37:2, pages 234-242.
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N. V. Mulye & S. J. Turco. (1995) A Simple Model Based on First Order Kinetics to Explain Release of Highly Water Soluble Drugs from Porous Dicalcium Phosphate Dihydrate Matrices. Drug Development and Industrial Pharmacy 21:8, pages 943-953.
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Articles from other publishers (10)

Emmanuel Reginald Jacques & Paschalis Alexandridis. (2019) Tablet Scoring: Current Practice, Fundamentals, and Knowledge Gaps. Applied Sciences 9:15, pages 3066.
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Fabio Salvatori, Pietro Binel & Marco Mazzotti. (2019) Efficient assessment of combined crystallization, milling, and dissolution cycles for crystal size and shape manipulation. Chemical Engineering Science: X 1, pages 100004.
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Frederick Osei-Yeboah & Changquan Calvin Sun. (2015) Validation and applications of an expedited tablet friability method. International Journal of Pharmaceutics 484:1-2, pages 146-155.
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Saadia A. Tayel, Iman I. Soliman & Dina Louis. (2010) Formulation of Ketotifen Fumarate Fast-Melt Granulation Sublingual Tablet. AAPS PharmSciTech 11:2, pages 679-685.
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Shein-Chung ChowIain J. McGilveray. 2010. Encyclopedia of Biopharmaceutical Statistics. Encyclopedia of Biopharmaceutical Statistics 170 185 .
Tero Närvänen, Osmo Antikainen & Jouko Yliruusi. (2009) Predicting Particle Size During Fluid Bed Granulation Using Process Measurement Data. AAPS PharmSciTech 10:4.
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Xinhui Hu, John C. Cunningham & Denita Winstead. (2008) Study growth kinetics in fluidized bed granulation with at-line FBRM. International Journal of Pharmaceutics 347:1-2, pages 54-61.
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B Rambali, L Baert & D.L Massart. (2001) Using experimental design to optimize the process parameters in fluidized bed granulation on a semi-full scale. International Journal of Pharmaceutics 220:1-2, pages 149-160.
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George Lukas. (2016) Critical Manufacturing Parameters Influencing Dissolution. Drug Information Journal 30:4, pages 1091-1104.
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Soma Chakrabarti & Marylee Z. Southard. (1996) Control of Poorly Soluble Drug Dissolution in Conditions Simulating the Gastrointestinal Tract Flow. 1. Effect of Tablet Geometry in Buffered Medium. Journal of Pharmaceutical Sciences 85:3, pages 313-319.
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