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Research Article

Alternative Granulation Technique: Melt Granulation

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Pages 917-924 | Published online: 20 Oct 2008

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Cai-Xia He, Zhong-Gui He & Jian-Qing Gao. (2010) Microemulsions as drug delivery systems to improve the solubility and the bioavailability of poorly water-soluble drugs. Expert Opinion on Drug Delivery 7:4, pages 445-460.
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Yucun Zhu, Navnit H. Shah, A. Waseem Malick, Martin H. Infeld & James W. McGinity. (2002) Influence of Thermal Processing on the Properties of Chlorpheniramine Maleate Tablets Containing an Acrylic Polymer. Pharmaceutical Development and Technology 7:4, pages 481-489.
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Yu-E Zhang, Ruy Tchao & Joseph B. Schwartz. (2001) Effect of Processing Methods and Heat Treatment on the Formation of Wax Matrix Tablets for Sustained Drug Release. Pharmaceutical Development and Technology 6:2, pages 131-144.
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Articles from other publishers (29)

Adwait Pradhan, Mark Costello, Fengyuan Yang, Vivian Bi, Thomas Durig & Feng Zhang. (2022) Using twin-screw melt granulation to co-process mannitol and hydroxypropylcellulose. Journal of Drug Delivery Science and Technology 77, pages 103880.
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Petra Záhonyi, Edina Szabó, András Domokos, Anna Haraszti, Martin Gyürkés, Erzsébet Moharos & Zsombor K. Nagy. (2022) Continuous integrated production of glucose granules with enhanced flowability and tabletability. International Journal of Pharmaceutics 626, pages 122197.
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Seth P. Forster, Erin Dippold & Tiffany Chiang. (2021) Twin-Screw Melt Granulation for Oral Solid Pharmaceutical Products. Pharmaceutics 13:5, pages 665.
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Kamla Pathak. 2021. Advances and Challenges in Pharmaceutical Technology. Advances and Challenges in Pharmaceutical Technology 181 228 .
Kristina E. Steffens, Marvin B. Brenner, Michael U. Hartig, Marius Monschke & Karl G. Wagner. (2020) Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation. International Journal of Pharmaceutics 591, pages 119941.
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Harshita, Md. Abul Barkat, Sabya S. Das, Faheem H. Pottoo, Sarwar Beg & Ziyaur Rahman. (2020) Lipid-Based Nanosystem As Intelligent Carriers for Versatile Drug Delivery Applications. Current Pharmaceutical Design 26:11, pages 1167-1180.
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Nada Kittikunakorn, Changquan Calvin Sun & Feng Zhang. (2019) Effect of screw profile and processing conditions on physical transformation and chemical degradation of gabapentin during twin-screw melt granulation. European Journal of Pharmaceutical Sciences 131, pages 243-253.
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Rajan Verma, Maneesha Patil & Carlos O. Paz. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 203 259 .
Michael M. Farag, Nevine S. Abd El Malak & Soad A. Yehia. (2018) Controlled buccal patches of Zaleplon using melt granulation technique: An approach to overcome early morning awakening. Journal of Drug Delivery Science and Technology 43, pages 439-445.
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Sabna Kotta, Navneet Sharma, Prateek Raturi, Mohd Aleem & Rakesh Kumar Sharma. (2018) Exploring Novel Strategies for Lipid-Based Drug Delivery. Journal of Nanotoxicology and Nanomedicine 3:1, pages 1-22.
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Navneet Sharma, Sabna Kotta, Mohd Aleem, Shubham Singh & Rakesh Kumar Sharma. 2018. Multifunctional Nanocarriers for Contemporary Healthcare Applications. Multifunctional Nanocarriers for Contemporary Healthcare Applications 60 84 .
C. Eckert, M. Pein & J. Breitkreutz. (2014) Lean production of taste improved lipidic sodium benzoate formulations. European Journal of Pharmaceutics and Biopharmaceutics 88:2, pages 455-461.
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Hina Shrestha, Rajni Bala & Sandeep Arora. (2014) Lipid-Based Drug Delivery Systems. Journal of Pharmaceutics 2014, pages 1-10.
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Sandeep Kalepu, Mohanvarma Manthina & Veerabhadhraswamy Padavala. (2013) Oral lipid-based drug delivery systems – an overview. Acta Pharmaceutica Sinica B 3:6, pages 361-372.
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Sanni Matero, Frans van Den Berg, Sami Poutiainen, Jukka Rantanen & Jari Pajander. (2013) Towards Better Process Understanding: Chemometrics and Multivariate Measurements in Manufacturing of Solid Dosage Forms. Journal of Pharmaceutical Sciences 102:5, pages 1385-1403.
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U.S Desai, P.D Chaudhari, D.B. Bhavsar & R.P. Chavan. (2013) MELT GRANULATION: AN ALTERNATIVE TO TRADITIONAL GRANULATION TECHNIQUES. INDIAN DRUGS 50:03, pages 5-13.
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Jay P. Lakshman. 2013. Melt Extrusion. Melt Extrusion 329 362 .
Madhav Vasanthavada, Yanfeng Wang, Thomas Haefele, Jay P. Lakshman, Manisha Mone, Weiqin Tong, Yatindra M. Joshi & Abu T.M. Serajuddin. (2011) Application of Melt Granulation Technology Using Twin-screw Extruder in Development of High-dose Modified-Release Tablet Formulation. Journal of Pharmaceutical Sciences 100:5, pages 1923-1934.
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Jay P. Lakshman, James Kowalski, Madhav Vasanthavada, Wei-Qin Tong, Yatindra M. Joshi & Abu T.M. Serajuddin. (2011) Application of Melt Granulation Technology to Enhance Tabletting Properties of Poorly Compactible High-Dose Drugs. Journal of Pharmaceutical Sciences 100:4, pages 1553-1565.
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L. Ochoa, M. Igartua, R.M. Hernández, A.R. Gascón, M.A. Solinis & J.L. Pedraz. (2011) Novel extended-release formulation of lovastatin by one-step melt granulation: In vitro and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics 77:2, pages 306-312.
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Shailesh T. Prajapati, Amit N. Patel & Chhagan N. Patel. (2011) Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique. ISRN Pharmaceutics 2011, pages 1-8.
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Lourdes Ochoa, Manoli Igartua, Rosa M. Hernández, Maria Ángeles Solinís, Alicia R. Gascón & Jose Luis Pedraz. (2010) In vivo evaluation of two new sustained release formulations elaborated by one-step melt granulation: Level A in vitro–in vivo correlation. European Journal of Pharmaceutics and Biopharmaceutics 75:2, pages 232-237.
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James Kowalski, Oskar Kalb, Yatindra M. Joshi & Abu T.M. Serajuddin. (2009) Application of melt granulation technology to enhance stability of a moisture sensitive immediate-release drug product. International Journal of Pharmaceutics 381:1, pages 56-61.
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V. Jannin, J. Musakhanian & D. Marchaud. (2008) Approaches for the development of solid and semi-solid lipid-based formulations. Advanced Drug Delivery Reviews 60:6, pages 734-746.
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B.H. Ng, C.C. Kwan, Y.L. Ding, M. Ghadiri & X.F. Fan. (2007) Solids motion of calcium carbonate particles in a high shear mixer granulator: A comparison between dry and wet conditions. Powder Technology 177:1, pages 1-11.
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B.H. Ng, C.C. Kwan, Y.L. Ding, M. Ghadiri & X.F. Fan. (2007) Solids motion in a conical frustum-shaped high shear mixer granulator. Chemical Engineering Science 62:3, pages 756-765.
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Thomas Vilhelmsen, Jakob Kristensen & Torben Schæfer. (2004) Melt pelletization with polyethylene glycol in a rotary processor. International Journal of Pharmaceutics 275:1-2, pages 141-153.
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Torben Schæfer. (2001) Growth mechanisms in melt agglomeration in high shear mixers. Powder Technology 117:1-2, pages 68-82.
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B Campisi, D Vojnovic, D Chicco & R Phan-Tan-Luu. (1999) Melt granulation in a high shear mixer: optimization of mixture and process variables using a combined experimental design. Chemometrics and Intelligent Laboratory Systems 48:1, pages 59-70.
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