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Research Article

Mucoadhesive Drug Delivery Systems

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Pages 489-515 | Published online: 20 Oct 2008

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Radha Kulkarni, Suraj Fanse & Diane J. Burgess. (2023) Mucoadhesive drug delivery systems: a promising non-invasive approach to bioavailability enhancement. Part I: biophysical considerations. Expert Opinion on Drug Delivery 20:3, pages 395-412.
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Mahmoud H. Teaima, Moaz A. Eltabeeb, Mohamed A. El-Nabarawi & Menna M. Abdellatif. (2022) Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation. Drug Delivery 29:1, pages 2549-2560.
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Aseel Abu-Rumman, Rana Abu-Huwaij & Rania Hamed. (2022) Development and in vitro appraisal of Soluplus® and/or Carbopol® 971 buccoadhesive patches releasing atorvastatin. The Journal of Adhesion 98:7, pages 915-933.
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Anja Hoffmann, Joerg T. Fischer & Rolf Daniels. (2020) Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion. Drug Development and Industrial Pharmacy 46:11, pages 1753-1762.
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Muhammad Zaman, Muhammad Hanif & Mahtab Ahmad Khan. (2018) Arabinoxylan-Based Mucoadhesive Oral Films of Tizanidine HCL Designed and Optimized Using Central Composite Rotatable Design. Polymer-Plastics Technology and Engineering 57:5, pages 471-483.
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Arshad Mahmood, Sonja Bonengel, Flavia Laffleur, Muhammad Ijaz, Muneeb Ahmad Idrees, Shah Hussain, Christian W. Huck, Barbara Matuszczak & Andreas Bernkop-Schnürch. (2016) Can thiolation render a low molecular weight polymer of just 20-kDa mucoadhesive?. Drug Development and Industrial Pharmacy 42:5, pages 686-693.
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Shaikh Ershadul Haque & Angappan Sheela. (2015) Development of polymer-bound fast-dissolving metformin buccal film with disintegrants. International Journal of Nanomedicine 10:sup2, pages 199-205.
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András Kelemen, Mihály Gottnek, Géza Regdon$suffix/text()$suffix/text() & Klára Pintye-Hódi. (2015) New equipment for measurement of the force of adhesion of mucoadhesive films. Journal of Adhesion Science and Technology 29:13, pages 1360-1367.
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Joe M. Viljoen, Jan H. Steenekamp, Andries F. Marais & Awie F. Kotzé. (2014) Effect of moisture content, temperature and exposure time on the physical stability of chitosan powder and tablets. Drug Development and Industrial Pharmacy 40:6, pages 730-742.
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Emil Meng-Lund, Jette Jacobsen, Morten B. Andersen, Mads L. Jespersen, Jens-Jacob Karlsson, Mats Garmer, Erling B. Jørgensen & René Holm. (2014) Conscious and anaesthetised Göttingen mini-pigs as an in-vivo model for buccal absorption – pH-dependent absorption of metoprolol from bioadhesive tablets. Drug Development and Industrial Pharmacy 40:5, pages 604-610.
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Sumeet Sood, Kunal Jain & K. Gowthamarajan. (2014) Intranasal therapeutic strategies for management of Alzheimer’s disease. Journal of Drug Targeting 22:4, pages 279-294.
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Kwame G. Yeboah, Janet Akande, Richard T. Addo, Rodney C. Siwale, Kwesi Aninkorah-Yeboah & Aladin Siddig. (2014) In vitro and ex vivo characterization of lectin-labeled Mycobacterium tuberculosis antigen-containing microspheres for enhanced oral delivery. Journal of Drug Targeting 22:1, pages 34-47.
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F. Maestrelli, M. Cirri, N. Mennini, M. Bragagni, N. Zerrouk & P. Mura. (2012) Influence of cross-linking agent type and chitosan content on the performance of pectinate-chitosan beads aimed for colon-specific drug delivery. Drug Development and Industrial Pharmacy 38:9, pages 1142-1151.
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Raphaela Regina de Araújo Pereira & Marcos Luciano Bruschi. (2012) Vaginal mucoadhesive drug delivery systems. Drug Development and Industrial Pharmacy 38:6, pages 643-652.
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Asim Sattwa Mandal, Sugata Chatterjee, Kazi Masud Karim, Nikhil Biswas, Arijit Guha, Mamata Behera & Ketousetuo Kuotsu. (2012) Fabrication and in vitro evaluation of bidirectional release and stability studies of mucoadhesive donut-shaped captopril tablets. Drug Development and Industrial Pharmacy 38:6, pages 706-717.
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Subhash S. Vaghani, Sneha G. Patel, Rishad Ramjan Jivani, N. P. Jivani, Madhabhai M. Patel & Rohit Borda. (2012) Design and optimization of a stomach-specific drug delivery system of repaglinide: Application of simplex lattice design. Pharmaceutical Development and Technology 17:1, pages 55-65.
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D.P. Maurya, Yasmin Sultana, M. Aqil, D. Kumar, K. Chuttani, A. Ali & A.K. Mishra. (2011) Formulation and optimization of alkaline extracted ispaghula husk microparticles of isoniazid – in vitro and in vivo assessment. Journal of Microencapsulation 28:6, pages 472-482.
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Brahmeshwar Mishra, C. Sankar & Madhusmita Mishra. (2011) Polymer based solutions of bupranolol hydrochloride for intranasal systemic delivery. Journal of Drug Targeting 19:3, pages 204-211.
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Shagufta Khan, Kundan Patil, Nishan Bobade, Pramod Yeole & Rajiv Gaikwad. (2010) Formulation of intranasal mucoadhesive temperature-mediated in situ gel containing ropinirole and evaluation of brain targeting efficiency in rats. Journal of Drug Targeting 18:3, pages 223-234.
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Lingmin Jiang, Lei Gao, Xiaoqing Wang, Liang Tang & Jianli Ma. (2010) The application of mucoadhesive polymers in nasal drug delivery. Drug Development and Industrial Pharmacy 36:3, pages 323-336.
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Janet Akande, Kwame G. Yeboah, Richard T. Addo, Aladin Siddig, Carl W. Oettinger & Martin J. D'Souza. (2010) Targeted delivery of antigens to the gut-associated lymphoid tissues: 2. Ex vivo evaluation of lectin-labelled albumin microspheres for targeted delivery of antigens to the M-cells of the Peyer's patches. Journal of Microencapsulation 27:4, pages 325-336.
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Joshua S. Boateng, Howard N.E. Stevens, Gillian M. Eccleston, Anthony D. Auffret, Michael J. Humphrey & Kerr H. Matthews. (2009) Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces. Drug Development and Industrial Pharmacy 35:8, pages 986-996.
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İ. Tuncer Değim, Fatmanur Tuğcu-Demiröz, Sibel Tamer-İlbasmış & Füsun Acartürk. (2008) Development of Controlled Release Sildenafil Formulations for Vaginal Administration. Drug Delivery 15:4, pages 259-265.
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G. S. Asane, S. A. Nirmal, K. B. Rasal, A. A. Naik, M. S. Mahadik & Y. Madhusudan Rao. (2008) Polymers for Mucoadhesive Drug Delivery System: A Current Status. Drug Development and Industrial Pharmacy 34:11, pages 1246-1266.
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Munish Kumar Dhiman, Pramod D. Yedurkar & Krutika K. Sawant. (2008) Buccal Bioadhesive Delivery System of 5-Fluorouracil: Optimization and Characterization. Drug Development and Industrial Pharmacy 34:7, pages 761-770.
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Ashmitha P. Munasur, Thirumala Govender & Irene Mackraj. (2007) Using an Experimental Design to Identify and Quantify the Effects of Environment Related Test Parameters on the In Vitro Mucoadhesivity Testing of a Propanolol Buccal Tablet. Drug Development and Industrial Pharmacy 33:7, pages 709-716.
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Jaleh Varshosaz, N. Tavakoli & F. Roozbahani. (2006) Formulation and In Vitro Characterization of Ciprofloxacin Floating and Bioadhesive Extended-Release Tablets. Drug Delivery 13:4, pages 277-285.
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Madhu S. Surapaneni, Sudip K. Das & Nandita G. Das. (2006) Effect of Excipient and Processing Variables on Adhesive Properties and Release Profile of Pentoxifylline From Mucoadhesive Tablets. Drug Development and Industrial Pharmacy 32:3, pages 377-387.
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John D Smart. (2005) Buccal drug delivery. Expert Opinion on Drug Delivery 2:3, pages 507-517.
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Marcos Luciano Bruschi & Osvaldo de Freitas. (2005) Oral Bioadhesive Drug Delivery Systems. Drug Development and Industrial Pharmacy 31:3, pages 293-310.
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T. K. De, E. J. Bergey, S. J. Chung, D. J. Rodman, D. J. Bharali & P. N. Prasad. (2004) Polycarboxylic acid nanoparticles for ophthalmic drug delivery: an ex vivo evaluation with human cornea. Journal of Microencapsulation 21:8, pages 841-855.
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Calum R. Park & Dale L. Munday. (2004) Evaluation of Selected Polysaccharide Excipients in Buccoadhesive Tablets for Sustained Release of Nicotine. Drug Development and Industrial Pharmacy 30:6, pages 609-617.
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N. Mezreb, Christine Charrueau, P. Boy, P. Allain & J. C. Chaumeil. (2004) Production of Carbopol® 974P and Carbopol® 971P Pellets by Extrusion‐Spheronization: Optimization of the Processing Parameters and Water Content. Drug Development and Industrial Pharmacy 30:5, pages 481-490.
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T. K. De, D. J. Rodman, B. A. Holm, P. N. Prasad & E. J. Bergey. (2003) Brimonidine formulation in polyacrylic acid nanoparticles for ophthalmic delivery. Journal of Microencapsulation 20:3, pages 361-374.
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Kavita Vermani, Sanjay Garg & Lourens J. D. Zaneveld. (2002) Assemblies for In Vitro Measurement of Bioadhesive Strength and Retention Characteristics in Simulated Vaginal Environment. Drug Development and Industrial Pharmacy 28:9, pages 1133-1146.
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D. Solomonidou, K. Cremer, M. Krumme & J. Kreuter. (2001) Effect of carbomer concentration and degree of neutralization on the mucoadhesive properties of polymer films . Journal of Biomaterials Science, Polymer Edition 12:11, pages 1191-1205.
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B. S. Lele & A. S. Hoffman. (2000) Insoluble ionic complexes of polyacrylic acid with a cationic drug for use as a mucoadhesive, ophthalmic drug delivery system . Journal of Biomaterials Science, Polymer Edition 11:12, pages 1319-1331.
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Hemant H. Alur, S. Indiran Pather, Ashim K. Mitra & Thomas P. Johnston. (1999) Evaluation of the Gum from Hakea gibbosa as a Sustained-Release and Mucoadhesive Component in Buccal Tablets. Pharmaceutical Development and Technology 4:3, pages 347-358.
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Varsha Agarwal & B. Mishra. (1999) Design, Development, and Biopharmaceutical Properties of Buccoadhesive Compacts of Pentazocine. Drug Development and Industrial Pharmacy 25:6, pages 701-709.
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