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ORIGINAL ARTICLEClinical Translational Therapeutics

Circulating Soluble CTLA4 (sCTLA4) Is Elevated in Patients With Breast Cancer

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Pages 828-832 | Published online: 18 May 2010

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Mariela A. Moreno Ayala, Maria Florencia Gottardo, Antonela S. Asad, Camila Zuccato, Alejandro Nicola, Adriana Seilicovich & Marianela Candolfi. (2017) Immunotherapy for the treatment of breast cancer. Expert Opinion on Biological Therapy 17:7, pages 797-812.
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Nasrollah Erfani, Behzad Khademi, Mohammad Reza Haghshenas, Zahra Mojtahedi, Bijan Khademi & Abbas Ghaderi. (2013) Intracellular CTLA4 and Regulatory T Cells in Patients with Laryngeal Squamous Cell Carcinoma. Immunological Investigations 42:2, pages 81-90.
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Articles from other publishers (21)

Shaho Ghahremani Dehbokri, Nazila Alizadeh, Alireza Isazadeh, Amir Baghbanzadeh, Soheil Abbaspour-Ravasjani, Khalil Hajiasgharzadeh & Behzad Baradaran. (2023) CTLA-4: As an Immunosuppressive Immune Checkpoint in Breast Cancer. Current Molecular Medicine 23:6, pages 521-526.
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Rodrigo Kern, Janaina Carla da Silva, Fábio Negretti, Mariane Okamoto Ferreira, Matheus Iago Oliveira Coletto, Stefania Tagliari de Oliveira, Fernanda Mara Alves, Thalita Basso Scandolara, Daniel Rech & Carolina Panis. (2023) The Expression of CTLA-4 in Breast Tumors and Tumor-Infiltrating Leukocytes Affects Patients’ Systemic Inflammatory Status and Varies According to Their Molecular Subtypes. Inflammation.
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Hossein Javid, Fatemeh Attarian, Toktam Saadatmand, Nastaran Rezagholinejad, Ali Mehri, Hamed Amiri & Mehdi Karimi‐Shahri. (2023) The therapeutic potential of immunotherapy in the treatment of breast cancer: Rational strategies and recent progress. Journal of Cellular Biochemistry 124:4, pages 477-494.
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Yoel Genaro Montoyo-Pujol, Marta García-Escolano, José J. Ponce, Silvia Delgado-García, Tina Aurora Martín, Hortensia Ballester, Elena Castellón-Molla, Pascual Martínez-Peinado, Sandra Pascual-García, José Miguel Sempere-Ortells & Gloria Peiró. (2023) Variable Intrinsic Expression of Immunoregulatory Biomarkers in Breast Cancer Cell Lines, Mammospheres, and Co-Cultures. International Journal of Molecular Sciences 24:5, pages 4478.
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Jiajia Liu, Xiaoyi Tian, Yan Wang, Xixiong Kang & Wenqi Song. (2021) Soluble cytotoxic T-lymphocyte–associated antigen 4 (sCTLA-4) as a potential biomarker for diagnosis and evaluation of the prognosis in Glioma. BMC Immunology 22:1.
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Amany M. Kamal, Eman F. Wasfey, Wesam R. Elghamry, Omar M. Sabry, Hany A. Elghobary & Sara M. Radwan. (2021) Genetic signature of CTLA-4, BTLA, TIM-3 and LAG-3 molecular expression in colorectal cancer patients: Implications in diagnosis and survival outcomes. Clinical Biochemistry 96, pages 13-18.
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Jil M. Jubel, Thomas M. Randau, Janine Becker-Gotot, Sebastian Scheidt, Matthias D. Wimmer, Hendrik Kohlhof, Christof Burger, Dieter C. Wirtz & Frank A. Schildberg. (2021) sCD28, sCD80, sCTLA-4, and sBTLA Are Promising Markers in Diagnostic and Therapeutic Approaches for Aseptic Loosening and Periprosthetic Joint Infection. Frontiers in Immunology 12.
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Andreia Gameiro, Catarina Nascimento, Ana Catarina Urbano, Jorge Correia & Fernando Ferreira. (2021) Serum and Tissue Expression Levels of Leptin and Leptin Receptor Are Putative Markers of Specific Feline Mammary Carcinoma Subtypes. Frontiers in Veterinary Science 8.
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Hwee Won Ji, Heejoo Kim, Hyeon Woo Kim, Sung Hwan Yun, Jae Eun Park, Eun Ha Choi & Sun Jung Kim. (2020) Genome-Wide Comparison of the Target Genes of the Reactive Oxygen Species and Non-Reactive Oxygen Species Constituents of Cold Atmospheric Plasma in Cancer Cells. Cancers 12:9, pages 2640.
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Ana Catarina Urbano, Catarina Nascimento, Maria Soares, Jorge Correia & Fernando Ferreira. (2020) Clinical Relevance of the serum CTLA-4 in Cats with Mammary Carcinoma. Scientific Reports 10:1.
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Rituparna Chakrabarti, Bhavya Kapse & Gayatri Mukherjee. (2019) Soluble immune checkpoint molecules: Serum markers for cancer diagnosis and prognosis. CANCER REPORTS, pages e1160.
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Maria Pia Pistillo, Vincenzo Fontana, Anna Morabito, Beatrice Dozin, Stefania Laurent, Roberta Carosio, Barbara Banelli, Francesca Ferrero, Laura Spano, Enrica Tanda, Pier Francesco Ferrucci, Chiara Martinoli, Emilia Cocorocchio, Michele Guida, Stefania Tommasi, Federica De Galitiis, Elena Pagani, Gian Carlo Antonini Cappellini, Paolo Marchetti, Pietro Quaglino, Paolo Fava, Simona Osella-Abate, Paolo Antonio Ascierto, Mariaelena Capone, Ester Simeone, Massimo Romani, Francesco Spagnolo & Paola Queirolo. (2018) Soluble CTLA-4 as a favorable predictive biomarker in metastatic melanoma patients treated with ipilimumab: an Italian melanoma intergroup study. Cancer Immunology, Immunotherapy 68:1, pages 97-107.
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Priyanka Wagh, Priyanka Kulkarni, Shilpa Kerkar, Himangi Warke, Hemangi Chaudhari, Kedar Deodhar, Bharat Rekhi, Hemant Tongaonkar & Jayanti Mania-Pramanik. (2018) Polymorphisms in Cytotoxic T-lymphocyte Associated Antigen 4 Gene Does Not Affect sCytotoxic T-lymphocyte Associated Antigen 4 Levels in Human Papillomavirus-Infected Women with or without Cervical Cancer. Indian Journal of Medical Microbiology 36:2, pages 207-210.
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Soykan Arikan, Alper Gümüş, Özlem Küçükhüseyin, Cihan Coşkun, Saime Turan, Canan Cacina, Canan Kelten Talu, Filiz Akyüz, Ammad Ahmad Farooqi, Bayram Kıran & İlhan Yaylım. (2017) The effect of CTLA-4 and CD28 gene variants and circulating protein levels in patients with gastric cancer. Turkish Journal of Biochemistry 42:5, pages 551-558.
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San Jiun Chai, Yoke Yeow Yap, Yoke Ching Foo, Lee Fah Yap, Sathibalan Ponniah, Soo Hwang Teo, Sok Ching Cheong, Vyomesh Patel & Kue Peng Lim. (2015) Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma. PLOS ONE 10:11, pages e0130464.
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Haiming Yu, Junlan Yang, Shunchang Jiao, Ying Li, Wei Zhang & Jiandong Wang. (2015) Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis. Cancer Immunology, Immunotherapy 64:7, pages 853-860.
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Ling-Yuan Kong, Jun Wei, Ali S. Haider, Brandon D. Liebelt, Xiaoyang Ling, Charles A. Conrad, Gregory N. Fuller, Nicholas B. Levine, Waldemar Priebe, Raymond Sawaya & Amy B. Heimberger. (2014) Therapeutic targets in subependymoma. Journal of Neuroimmunology 277:1-2, pages 168-175.
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Anna M. Leung, Agnes Fermin Lee, Junko Ozao-Choy, Romela Irene Ramos, Omid Hamid, Steven J. O’Day, Myung Shin-Sim, Donald L. Morton, Mark B. Faries, Peter A. Sieling & Delphine J. Lee. (2014) Clinical Benefit from Ipilimumab Therapy in Melanoma Patients may be Associated with Serum CTLA4 Levels. Frontiers in Oncology 4.
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Ghada I. Mossallam & Mohamed A. Samra. (2013) CTLA-4 polymorphism and clinical outcome post allogeneic hematopoietic stem cell transplantation. Human Immunology 74:12, pages 1643-1648.
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Nasrollah Erfani, Shayesteh Mofakhami Mehrabadi, Mohammad Ali Ghayumi, Mohammad Reza Haghshenas, Zahra Mojtahedi, Abbas Ghaderi & Davar Amani. (2012) Increase of regulatory T cells in metastatic stage and CTLA-4 over expression in lymphocytes of patients with non-small cell lung cancer (NSCLC). Lung Cancer 77:2, pages 306-311.
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Ju Cao, Liping Zhang, Shifeng Huang, Pu Chen, Lin Zou, Hui Chen, Yu Xiang, Xiaofei Lai & Guosheng Ren. (2011) Aberrant production of soluble co-stimulatory molecules CTLA-4 and CD28 in patients with chronic hepatitis B. Microbial Pathogenesis 51:4, pages 262-267.
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