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Cancer Investigation Volume 29, 2011 - Issue 1
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ORIGINAL ARTICLE: CELLULAR AND MOLECULAR BIOLOGY

Claudin-6, 7, or 9 Overexpression in the Human Gastric Adenocarcinoma Cell Line AGS Increases Its Invasiveness, Migration, and Proliferation Rate

Veronica Elizabeth Zavala-ZendejasDepto. Bioquímica y Depto. Biologia Celular y Tisular, Facultad de Medicina, UNAM, México
,
Ana Cristina Torres-MartinezDepto. Bioquímica y Depto. Biologia Celular y Tisular, Facultad de Medicina, UNAM, México
,
Berenice Salas-MoralesDepto. Bioquímica y Depto. Biologia Celular y Tisular, Facultad de Medicina, UNAM, México
,
Teresa Imelda FortoulDepto. Bioquímica y Depto. Biologia Celular y Tisular, Facultad de Medicina, UNAM, México
,
Luis Felipe MontañoDepto. Bioquímica y Depto. Biologia Celular y Tisular, Facultad de Medicina, UNAM, México
&
Erika Patricia Rendon-HuertaDepto. Bioquímica y Depto. Biologia Celular y Tisular, Facultad de Medicina, UNAM, MéxicoCorrespondence[email protected]
Pages 1-11 | Published online: 27 Sep 2010

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Sara Cherradi, Pierre Martineau, Céline Gongora & Maguy Del Rio. (2019) Claudin gene expression profiles and clinical value in colorectal tumors classified according to their molecular subtype. Cancer Management and Research 11, pages 1337-1348.
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Xia Cao & Guo-Zhao He. (2018) Knockdown of CLDN6 inhibits cell proliferation and migration via PI3K/AKT/mTOR signaling pathway in endometrial carcinoma cell line HEC-1-B. OncoTargets and Therapy 11, pages 6351-6360.
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Lei Ding, Zhe Lu, Qun Lu & Yan-Hua Chen. (2013) The claudin family of proteins in human malignancy: a clinical perspective. Cancer Management and Research 5, pages 367-375.
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Articles from other publishers (66)

Rin Inamoto, Naoki Takahashi & Yasuhide Yamada. (2023) Claudin18.2 in Advanced Gastric Cancer. Cancers 15:24, pages 5742.
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Xinguo Zhuang, Tracey A. Martin, Fiona Ruge, Jianyuan (Jimmy) Zeng, Xinyu (Amber) Li, Elyas Khan, Qingping Dou, Eleri Davies & Wen G. Jiang. (2023) Expression of Claudin-9 (CLDN9) in Breast Cancer, the Clinical Significance in Connection with Its Subcoat Anchorage Proteins ZO-1 and ZO-3 and Impact on Drug Resistance. Biomedicines 11:12, pages 3136.
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Xiangqian Zhang, Yun Li & Yongheng Chen. (2023) Development of a Comprehensive Gene Signature Linking Hypoxia, Glycolysis, Lactylation, and Metabolomic Insights in Gastric Cancer through the Integration of Bulk and Single-Cell RNA-Seq Data. Biomedicines 11:11, pages 2948.
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Daoyu Tao, Bingxin Guan, Hui Li & Chengjun Zhou. (2023) Expression patterns of claudins in cancer. Heliyon 9:11, pages e21338.
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Julia Castillo-González, José Luis Ruiz, Ignacio Serrano-Martínez, Irene Forte-Lago, Ana Ubago-Rodriguez, Marta Caro, Jesús Miguel Pérez-Gómez, Alejandro Benítez-Troncoso, Eduardo Andrés-León, Macarena Sánchez-Navarro, Raúl M. Luque & Elena González-Rey. (2023) Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity. Journal of Neuroinflammation 20:1.
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Jorge H. Romero-Estrada, Luis F. Montaño & Erika P. Rendón-Huerta. (2023) Binding of YY1/CREB to an Enhancer Region Triggers Claudin 6 Expression in H. pylori LPS-Stimulated AGS Cells. International Journal of Molecular Sciences 24:18, pages 13974.
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Jiaqi Zhu & Qi Jiang. (2023) Twist1‑mediated transcriptional activation of Claudin‑4 promotes cervical cancer cell migration and invasion. Oncology Letters 26:2.
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De-Wen Wang, Wei-Han Zhang, Galiullin Danil, Kun Yang & Jian-Kun Hu. (2022) The role and mechanism of claudins in cancer. Frontiers in Oncology 12.
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Brad Screnci, Lewis J. Stafford, Trevor Barnes, Kristen Shema, Samantha Gilman, Rebecca Wright, Suzie Al Absi, Tim Phillips, Charles Azuelos, Katherine Slovik, Paige Murphy, Daniel B. Harmon, Tom Charpentier, Benjamin J. Doranz, Joseph B. Rucker & Ross Chambers. (2022) Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point. iScience 25:12, pages 105665.
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Priscila Anhel Medrano-Gonzálezl, Franklin Cruz-Villegas, Alejandro Alarcón del Carmen, Luis Felipe Montaño & Erika Patricia Rendón-Huerta. (2022) Claudin-6 increases SNAI1, NANOG and SOX2 gene expression in human gastric adenocarcinoma AGS cells. Molecular Biology Reports 49:12, pages 11663-11674.
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Sanyog Dwivedi, Georgina Hernández-Montes, Luis Felipe Montaño & Erika Patricia Rendón-Huerta. (2022) Chromosomally Unstable Gastric Cancers Overexpressing Claudin-6 Disclose Cross-Talk between HNF1A and HNF4A, and Upregulated Cholesterol Metabolism. International Journal of Molecular Sciences 23:22, pages 13977.
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Hyunjhung Jhun, Won-Young Lee, Jin-Ki Park, Sun-Goo Hwang & Hyun-Jung Park. (2022) Transcriptomic Analysis of Testicular Gene Expression in a Dog Model of Experimentally Induced Cryptorchidism. Cells 11:16, pages 2476.
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Elif Eroglu, Christopher Y. T. Yen, Yat-Long Tsoi, Nevin Witman, Ahmed Elewa, Alberto Joven Araus, Heng Wang, Tamara Szattler, Chimezie H. Umeano, Jesper Sohlmér, Alexander Goedel, András Simon & Kenneth R. Chien. (2022) Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders. Nature Cell Biology 24:5, pages 645-658.
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Carlos E. Torres, Javier Cifuentes, Saúl C. Gómez, Valentina Quezada, Kevin A. Giraldo, Paola Ruiz Puentes, Laura Rueda-Gensini, Julian A. Serna, Carolina Muñoz-Camargo, Luis H. Reyes, Johann F. Osma & Juan C. Cruz. (2022) Microfluidic Synthesis and Purification of Magnetoliposomes for Potential Applications in the Gastrointestinal Delivery of Difficult-to-Transport Drugs. Pharmaceutics 14:2, pages 315.
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Claudia Ivette Rivas-Ortiz, Stephanie Euridice Morales-Guerrero, Sergio Ponce-de-León-Rosales, Armando Gamboa-Domínguez, Claudia Rangel-Escareño, Luis Federico Uscanga-Domínguez, Germán Rubén Aguilar-Gutiérrez, David Kershenobich-Stalnikowitz, Yolanda López-Vidal & Gonzalo Castillo-Rojas. (2022) Overview of Gene Expression Analysis in Gastric Disease Infected with Helicobacter pylori: CLDN1 and MMP9 Could Be Biomarkers for Early Diagnosis of Gastric Cancer. Processes 10:2, pages 196.
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Elizabeth Hernández-Nava, Luis F. Montaño & Erika P. Rendón-Huerta. (2021) Transcriptional and Epigenetic Bioinformatic Analysis of Claudin-9 Regulation in Gastric Cancer. Journal of Oncology 2021, pages 1-16.
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Marta Justyna Kozieł, Maksymilian Ziaja & Agnieszka Wanda Piastowska-Ciesielska. (2021) Intestinal Barrier, Claudins and Mycotoxins. Toxins 13:11, pages 758.
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Huan Du, Xiyue Yang, Jinjia Fan & Xiaobo Du. (2021) Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation (Review). Molecular Medicine Reports 24:3.
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Pablo Astudillo. (2021) A Non-canonical Wnt Signature Correlates With Lower Survival in Gastric Cancer. Frontiers in Cell and Developmental Biology 9.
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Yichao Hou, Lidan Hou, Yu Liang, Qingwei Zhang, Xialu Hong, Yu Wang, Xin Huang, Ting Zhong, Wenjing Pang, Ci Xu, Liming Zhu, Lei Li, Jingyuan Fang & Xiangjun Meng. (2020) The p53-inducible CLDN7 regulates colorectal tumorigenesis and has prognostic significance. Neoplasia 22:11, pages 590-603.
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You-Zhu Lu, Yang Li, Ting Zhang & Shu-tang Han. (2020) Claudin-6 is down-regulated in gastric cancer and its potential pathway. Cancer Biomarkers 28:3, pages 329-340.
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Lingyuan Huang, Chanjuan Zhao, Kai Sun, Dandan Yang, Linxia Yan, Dan Luo, Jinli He, Xuemei Hu, Rong Wang, Xiaofei Shen, Ning Xiao & Zhendong Zhong. (2020) Downregulation of CLDN6 inhibits cell proliferation, migration, and invasion via regulating EGFR/AKT/mTOR signalling pathway in hepatocellular carcinoma. Cell Biochemistry and Function 38:5, pages 541-548.
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Tomohiro Kohmoto, Kiyoshi Masuda, Katsutoshi Shoda, Rizu Takahashi, Sae Ujiro, Shoichiro Tange, Daisuke Ichikawa, Eigo Otsuji & Issei Imoto. (2019) Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer. Gastric Cancer 23:3, pages 403-417.
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Neetu Dahiya. (2020) Amyloid precursor-like protein 2 interacts with claudin-7 and affects ovarian cancer cell survival. Future Science OA, pages FSO457.
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Hongwei Wu, Lijing Fan, Haiping Liu, Baozhang Guan, Bo Hu, Fanna Liu, Berthold Hocher & Lianghong Yin. (2020) Identification of Key Genes and Prognostic Analysis between Chromophobe Renal Cell Carcinoma and Renal Oncocytoma by Bioinformatic Analysis. BioMed Research International 2020, pages 1-11.
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Mónica Díaz-Coránguez, Xuwen Liu & David A. Antonetti. (2019) Tight Junctions in Cell Proliferation. International Journal of Molecular Sciences 20:23, pages 5972.
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Murat Seker, Cármen Fernández-Rodríguez, Luis Martínez-Cruz & Dominik Müller. (2019) Mouse Models of Human Claudin-Associated Disorders: Benefits and Limitations. International Journal of Molecular Sciences 20:21, pages 5504.
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Kayle Dickson & Christian Lehmann. (2019) Inflammatory Response to Different Toxins in Experimental Sepsis Models. International Journal of Molecular Sciences 20:18, pages 4341.
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Xiaowei Zhang, Xianbin Wang, Aiyu Wang, Qian Li, Ming Zhou & Tao Li. (2019) CLDN10 promotes a malignant phenotype of osteosarcoma cells via JAK1/Stat1 signaling. Journal of Cell Communication and Signaling 13:3, pages 395-405.
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Lemeng Sun, Liangshu Feng & Jiuwei Cui. (2018) Increased expression of claudin-17 promotes a malignant phenotype in hepatocyte via Tyk2/Stat3 signaling and is associated with poor prognosis in patients with hepatocellular carcinoma. Diagnostic Pathology 13:1.
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Xiaowei Zhang, Haiming Wang, Qian Li & Tao Li. (2018) CLDN2 inhibits the metastasis of osteosarcoma cells via down-regulating the afadin/ERK signaling pathway. Cancer Cell International 18:1.
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Lemeng Sun, Liangshu Feng & Jiuwei Cui. (2018) Increased expression of claudin‑12 promotes the metastatic phenotype of human bronchial epithelial cells and is associated with poor prognosis in lung squamous cell carcinoma. Experimental and Therapeutic Medicine.
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L.M. Crosby, Calin A. Tatu, Matthew Varonka, Kaylene M. Charles & William H. Orem. (2018) Toxicological and chemical studies of wastewater from hydraulic fracture and conventional shale gas wells. Environmental Toxicology and Chemistry 37:8, pages 2098-2111.
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Minlan Yang, Yanru Li, Yang Ruan, Yan Lu, Dongjing Lin, Yinping Xie, Bing Dong, Qihua Dang & Chengshi Quan. (2017) CLDN6 enhances chemoresistance to ADM via AF-6/ERKs pathway in TNBC cell line MDAMB231. Molecular and Cellular Biochemistry 443:1-2, pages 169-180.
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Christian O. Chavarría-Velázquez, Ana C. Torres-Martínez, Luis F. Montaño & Erika P. Rendón-Huerta. (2018) TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells. Immunobiology 223:1, pages 38-48.
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Alejandra Sandoval-Bórquez, Iva Polakovicova, Nicolás Carrasco-Véliz, Lorena Lobos-González, Ismael Riquelme, Gonzalo Carrasco-Avino, Carolina Bizama, Enrique Norero, Gareth I. Owen, Juan C. Roa & Alejandro H. Corvalán. (2017) MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer. Clinical Epigenetics 9:1.
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Hong Liu, Feifei Jiang, Xinshan Jia, Jing Lan, Hao Guo, Erran Li, Aihui Yan & Yan Wang. (2016) Cycling hypoxia affects cell invasion and proliferation through direct regulation of claudin1 / claudin7 expression, and indirect regulation of P18 through claudin7. Oncotarget 8:6, pages 10298-10311.
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Dongjing Lin, Yaxiong Guo, Yanru Li, Yang Ruan, Mingzi Zhang, Xiangshu Jin, Minlan Yang, Yan Lu, Peiye Song, Shuai Zhao, Bing Dong, Yinping Xie, Qihua Dang & Chengshi Quan. (2017) Bioinformatic analysis reveals potential properties of human Claudin-6 regulation and functions. Oncology Reports 38:2, pages 875-885.
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A.C. Torres-Martínez, J.F. Gallardo-Vera, A.N. Lara-Holguin, L.F. Montaño & E.P. Rendón-Huerta. (2017) Claudin-6 enhances cell invasiveness through claudin-1 in AGS human adenocarcinoma gastric cancer cells. Experimental Cell Research 350:1, pages 226-235.
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Rahel Philip, Sarah Heiler, Wei Mu, Markus W. Büchler, Margot Zöller & Florian Thuma. (2014) Claudin-7 promotes the epithelial - mesenchymal transition in human colorectal cancer. Oncotarget 6:4, pages 2046-2063.
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