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ORIGINAL ARTICLE: CLINICAL TRANSLATIONAL THERAPEUTICS

Clinical Significance of GPR56, Transglutaminase 2, and NF-κB in Esophageal Squamous Cell Carcinoma

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Pages 42-48 | Published online: 27 Sep 2010

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Andrey D. Bondarev, Misty M. Attwood, Jörgen Jonsson, Vladimir N. Chubarev, Vadim V. Tarasov & Helgi B. Schiöth. (2020) Opportunities and challenges for drug discovery in modulating Adhesion G protein-coupled receptor (GPCR) functions. Expert Opinion on Drug Discovery 15:11, pages 1291-1307.
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Chen Liu, Tianci Liu, Yuzhe Hu, Xingyue Zeng, Xiayidan Alimu, Shi Song, Songsong Lu, Ying Song & Pingzhang Wang. (2023) G Protein–Coupled Receptor 56 Characterizes CTLs and Reflects the Progression of Lung Cancer Patients. The Journal of Immunology 211:4, pages 683-692.
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Mengshu You, Zhuolin Xie, Nan Zhang, Yixuan Zhang, Desheng Xiao, Shuang Liu, Wei Zhuang, Lili Li & Yongguang Tao. (2023) Signaling pathways in cancer metabolism: mechanisms and therapeutic targets. Signal Transduction and Targeted Therapy 8:1.
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Tiantian Su, Qiuyun Guan, Huijuan Cheng, Zhenduo Zhu, Chunru Jiang, Paipai Guo, Yu Tai, Hanfei Sun, Manman Wang, Wei Wei & Qingtong Wang. (2022) Functions of G protein‐coupled receptor 56 in health and disease. Acta Physiologica 236:2.
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Jeanette M. Einspahr & Douglas G. Tilley. (2022) Pathophysiological impact of the adhesion G protein-coupled receptor family. American Journal of Physiology-Cell Physiology 323:2, pages C640-C647.
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Lixiazi He, Christian Arnold, Judith Thoma, Christian Rohde, Maksim Kholmatov, Swati Garg, Cheng‐Chih Hsiao, Linda Viol, Kaiqing Zhang, Rui Sun, Christina Schmidt, Maike Janssen, Tara MacRae, Karin Huber, Christian Thiede, Josée Hébert, Guy Sauvageau, Julia Spratte, Herbert Fluhr, Gabriela Aust, Carsten Müller‐Tidow, Christof Niehrs, Gislene Pereira, Jörg Hamann, Motomu Tanaka, Judith B Zaugg & Caroline Pabst. (2022) CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia. EMBO Molecular Medicine 14:4.
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Nana Xu, Mengmeng Lu, Jiaxin Wang, Yujia Li, Xiaotian Yang, Xiajie Wei, Jiaoyang Si, Jingru Han, Xiaojuan Yao, Juanmei Zhang, Junqi Liu, Yanming Li, Hushan Yang & Dengke Bao. (2021) Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway. BMC Cancer 21:1.
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Kwai-Fong Ng, Tse-Ching Chen, Martin Stacey & Hsi-Hsien Lin. (2021) Role of ADGRG1/GPR56 in Tumor Progression. Cells 10:12, pages 3352.
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Abhishek Kumar Singh & Hsi-Hsien Lin. (2021) The role of GPR56/ADGRG1 in health and disease. Biomedical Journal 44:5, pages 534-547.
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Yunzhao Chen, Dandan Wang, Hao Peng, Xi Chen, Xueping Han, Jie Yu, Wenjie Wang, Lirong Liang, Zheng Liu, Yi Zheng, Jianming Hu, Lan Yang, Jun Li, Hong Zhou, Xiaobin Cui & Feng Li. (2019) Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression. Molecular Cancer 18:1.
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Richard L. Eckert. (2019) Transglutaminase 2 takes center stage as a cancer cell survival factor and therapy target. Molecular Carcinogenesis 58:6, pages 837-853.
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Yuanqing Tu, Fuxing Tan, Jingfeng Zhou & Jingxuan Pan. (2018) Pristimerin targeting NF‐κB pathway inhibits proliferation, migration, and invasion in esophageal squamous cell carcinoma cells. Cell Biochemistry and Function 36:4, pages 228-240.
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Zsuzsa Szondy, Ilma Korponay-Szabó, Robert Király, Zsolt Sarang & Gregory J. Tsay. (2017) Transglutaminase 2 in human diseases. BioMedicine 7:3, pages 15.
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Navneet Agnihotri & Kapil Mehta. (2016) Transglutaminase-2: evolution from pedestrian protein to a promising therapeutic target. Amino Acids 49:3, pages 425-439.
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WEI ZENG, HUI LI, YAN CHEN, HONGBO LV, LING LIU, JIHUA RAN, XIAOHONG SUN, SHAYAHATI BIEERKEHAZHI, YINING LIU, XIAOMIAO LI, WENTING LAI, JIBIEKE WATIBIEKE, MEILIWUERTI DAWULIETIHAN, XIUMEI LI & HUIWU LI. (2016) Survivin activates NF-κB p65 via the IKKβ promoter in esophageal squamous cell carcinoma. Molecular Medicine Reports 13:2, pages 1869-1880.
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Gabriela Aust, Dan Zhu, Erwin G. Van Meir & Lei Xu. 2016. Adhesion G Protein-coupled Receptors. Adhesion G Protein-coupled Receptors 369 396 .
Michael C. Yi, Brad A. Palanski, Steven A. Quintero, Nicholas M. Plugis & Chaitan Khosla. (2015) An unprecedented dual antagonist and agonist of human Transglutaminase 2. Bioorganic & Medicinal Chemistry Letters 25:21, pages 4922-4926.
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Jörg Hamann, Gabriela Aust, Demet Araç, Felix B. Engel, Caroline Formstone, Robert Fredriksson, Randy A. Hall, Breanne L. Harty, Christiane Kirchhoff, Barbara Knapp, Arunkumar Krishnan, Ines Liebscher, Hsi-Hsien Lin, David C. Martinelli, Kelly R. Monk, Miriam C. Peeters, Xianhua Piao, Simone Prömel, Torsten Schöneberg, Thue W. Schwartz, Kathleen Singer, Martin Stacey, Yuri A. Ushkaryov, Mario Vallon, Uwe Wolfrum, Mathew W. Wright, Lei Xu, Tobias Langenhan & Helgi B. Schiöth. (2015) International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors. Pharmacological Reviews 67:2, pages 338-367.
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Raghibul Hasan, Rinu Sharma, Anoop Saraya, Tushar K Chattopadhyay, Siddartha DattaGupta, Paul G Walfish, Shyam S Chauhan & Ranju Ralhan. (2014) Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis. BMC Cancer 14:1.
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Deborah T. Leicht, Tasneem Kausar, Zhuwen Wang, Daysha Ferrer-Torres, Thomas D. Wang, Dafydd G. Thomas, Jules Lin, Andrew C. Chang, Lin Lin & David G. Beer. (2014) TGM2: A Cell Surface Marker in Esophageal Adenocarcinomas. Journal of Thoracic Oncology 9:6, pages 872-881.
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Md. Raghibul Hasan, Rinu Sharma, Anoop Saraya, Tushar K. Chattopadhyay, Siddartha DattaGupta, Paul G. Walfish, Shyam S. Chauhan & Ranju Ralhan. (2013) Slug Is a Predictor of Poor Prognosis in Esophageal Squamous Cell Carcinoma Patients. PLoS ONE 8:12, pages e82846.
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Chuyong Lin, Libing Song, Hui Gong, Aibin Liu, Xi Lin, Jueheng Wu, Mengfeng Li & Jun Li. (2013) Nkx2-8 Downregulation Promotes Angiogenesis and Activates NF-κB in Esophageal Cancer. Cancer Research 73:12, pages 3638-3648.
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Xiuting Chen, Zhe Ying, Xi Lin, Huanxin Lin, Jueheng Wu, Mengfeng Li & Libing Song. (2013) Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells. Journal of Clinical Investigation 123:6, pages 2576-2589.
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Hui Gong, Libing Song, Chuyong Lin, Aibin Liu, Xi Lin, Jueheng Wu, Mengfeng Li & Jun Li. (2013) Downregulation of miR-138 Sustains NF-κB Activation and Promotes Lipid Raft Formation in Esophageal Squamous Cell Carcinoma. Clinical Cancer Research 19:5, pages 1083-1093.
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Libing Song, Hui Gong, Chuyong Lin, Chanjuan Wang, Liping Liu, Jueheng Wu, Mengfeng Li & Jun Li. (2012) Flotillin-1 Promotes Tumor Necrosis Factor-α Receptor Signaling and Activation of NF-κB in Esophageal Squamous Cell Carcinoma Cells. Gastroenterology 143:4, pages 995-1005.e12.
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Zhuo Wang & Martin Griffin. (2011) TG2, a novel extracellular protein with multiple functions. Amino Acids 42:2-3, pages 939-949.
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Krishna Sumanth Ghanta, Suresh B. Pakala, Sirigiri Divijendra Natha Reddy, Da-Qiang Li, Sujit S. Nair & Rakesh Kumar. (2011) MTA1 Coregulation of Transglutaminase 2 Expression and Function during Inflammatory Response. Journal of Biological Chemistry 286:9, pages 7132-7138.
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