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ORIGINAL ARTICLEClinical Translational Therapeutics

Anticancer Properties of Zoledronic Acid

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Pages 944-957 | Published online: 29 Sep 2010

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Noémie Joalland, Laura Lafrance, Thibauld Oullier, Séverine Marionneau-Lambot, Delphine Loussouarn, Ulrich Jarry & Emmanuel Scotet. (2019) Combined chemotherapy and allogeneic human Vγ9Vδ2 T lymphocyte-immunotherapies efficiently control the development of human epithelial ovarian cancer cells in vivo. OncoImmunology 8:11.
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Ramakrishna Dasari & Sunil Misra. (2019) Zoledronic acid induces cytogenetic toxicity in male germline cells of Swiss albino mice. Drug and Chemical Toxicology 42:4, pages 371-377.
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Liliya I. Vagapova, Evgeniya A. Burilova, Anna G. Strelnik, Alexander R. Burilov & Michael A. Pudovik. (2019) Novel advances in the synthesis of bisphosphonates, containing heterocyclic and macrocyclic structure. Phosphorus, Sulfur, and Silicon and the Related Elements 194:4-6, pages 482-486.
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Mariusz Sandomierski, Marcel Jakubowski, Maria Ratajczak, Monika Pokora & Adam Voelkel. (2023) Zinc Zeolite as a Carrier for Tumor Targeted and pH-responsive Drug Delivery. Journal of Inorganic and Organometallic Polymers and Materials 33:6, pages 1667-1674.
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Mehtap Kara. (2022) Evaluation of the Effect of Zoledronic Acid Exposure on Nerve Cell in SH-SY5Y Neuroblastoma Cells. Turkish Journal of Osteoporosis 28:2, pages 153-157.
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Zaynab Fatfat, Maamoun Fatfat & Hala Gali-Muhtasib. (2021) Therapeutic potential of thymoquinone in combination therapy against cancer and cancer stem cells. World Journal of Clinical Oncology 12:7, pages 522-543.
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Fink-Eriksen E, Ianssen T & Husebye EE. (2021) IV. Bisphosphonates promote healing of complicated stress fractures in the foot. Open Journal of Orthopedics and Rheumatology, pages 057-061.
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Joice Castelo Branco Santos, Jonathas Alves de Melo, Sweta Maheshwari, Wendy Marina Toscano Queiroz de Medeiros, Johny Wysllas de Freitas Oliveira, Cláudia Jassica Moreno, L. Mario Amzel, Sandra B. Gabelli & Marcelo Sousa Silva. (2020) Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs. Molecules 25:11, pages 2602.
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Aaron Torres-Huerta, Tiffany G. Chan, Andrew J. P. White & Ramon Vilar. (2020) Molecular recognition of bisphosphonate-based drugs by di-zinc receptors in aqueous solution and on gold nanoparticles. Dalton Transactions 49:18, pages 5939-5948.
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Marietta Landgraf, Christoph A. Lahr, Alvaro Sanchez-Herrero, Christoph Meinert, Ali Shokoohmand, Pamela M. Pollock, Dietmar W. Hutmacher, Abbas Shafiee & Jacqui A. McGovern. (2019) Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of zoledronic acid in vivo. Bone Research 7:1.
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Biagio Ricciuti, Jennifer Foglietta, Vanessa Bianconi, Amirhossein Sahebkar & Matteo Pirro. (2019) Enzymes involved in tumor-driven angiogenesis: A valuable target for anticancer therapy. Seminars in Cancer Biology 56, pages 87-99.
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Junho Jung, Jung Soo Park, Leonardo Righesso, Andreas Max Pabst, Bilal Al-Nawas, Yong-Dae Kwon & Christian Walter. (2018) Effects of an oral bisphosphonate and three intravenous bisphosphonates on several cell types in vitro. Clinical Oral Investigations 22:7, pages 2527-2534.
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Da-Yong Zhou, Jie Qin, Jian Huang, Feng Wang, Guo-Peng Xu, Yan-Tian Lv, Ji-Bin Zhang & Li-Ming Shen. (2017) Zoledronic acid inhibits infiltration of tumor-associated macrophages and angiogenesis following transcatheter arterial chemoembolization in rat hepatocellular carcinoma models. Oncology Letters 14:4, pages 4078-4084.
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L. I. Vagapova, E. M. Makhrus, A. R. Burilov & M. A. Pudovik. (2017) Synthesis of new diarylmethanes on the basis of resorcinol derivatives and amino acetals containing an aminoethylidenebisphosphonate fragment. Russian Journal of General Chemistry 87:9, pages 2103-2106.
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Cigir Biray Avci, Cansu Caliskan Kurt, Burcu Erbaykent Tepedelen, Ozgun Ozalp, Bakiye Goker, Zeynep Mutlu, Yavuz Dodurga, Levent Elmas & Cumhur Gunduz. (2015) Zoledronic acid induces apoptosis via stimulating the expressions of ERN1, TLR2, and IRF5 genes in glioma cells. Tumor Biology 37:5, pages 6673-6679.
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Heleen H. Van Acker, Sébastien Anguille, Yannick Willemen, Evelien L. Smits & Viggo F. Van Tendeloo. (2016) Bisphosphonates for cancer treatment: Mechanisms of action and lessons from clinical trials. Pharmacology & Therapeutics 158, pages 24-40.
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Issam Makhoul, Corey O. Montgomery, Dana Gaddy & Larry J. Suva. (2015) The best of both worlds — managing the cancer, saving the bone. Nature Reviews Endocrinology 12:1, pages 29-42.
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Tilman D Rachner, Andy Göbel, Stefanie Thiele, Martina Rauner, Peggy Benad-Mehner, Peyman Hadji, Thomas Bauer, Michael H Muders, Gustavo B Baretton, Franz Jakob, Regina Ebert, Martin Bornhäuser, Christian Schem & Lorenz C Hofbauer. (2014) Dickkopf-1 is regulated by the mevalonate pathway in breast cancer. Breast Cancer Research 16:1.
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Leonardo Vieira Neto, Leila Chimelli, Paulo José da M. Pereira, Emerson L. Gasparetto, José Bines, Luiz Eduardo A. Wildemberg & Mônica R. Gadelha. (2013) The Role of Temozolomide in the Treatment of a Patient With a Pure Silent Pituitary Somatotroph Carcinoma. Endocrine Practice 19:6, pages e145-e149.
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Nelson S. Yee. 2013. Impact of Genetic Targets on Cancer Therapy. Impact of Genetic Targets on Cancer Therapy 91 143 .
Somying Patntirapong, Weerachai Singhatanadgit, Chatvadee Chanruangvanit, Kwankamol Lavanrattanakul & Yodhathai Satravaha. (2012) Zoledronic acid suppresses mineralization through direct cytotoxicity and osteoblast differentiation inhibition. Journal of Oral Pathology & Medicine 41:9, pages 713-720.
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Nigel Bundred. (2012) Antiresorptive therapies in oncology and their effects on cancer progression. Cancer Treatment Reviews 38:6, pages 776-786.
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Yu-Guang Ma, Wen-Chao Liu, Shuo Dong, Cheng Du, Xiao-Jun Wang, Jin-Sheng Li, Xiao-Ping Xie, Li Wu, Da-Chang Ma, Zhi-Bin Yu & Man-Jiang Xie. (2012) Activation of BKCa Channels in Zoledronic Acid-Induced Apoptosis of MDA-MB-231 Breast Cancer Cells. PLoS ONE 7:5, pages e37451.
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Michael Gnant, Peter Dubsky & Peyman Hadji. 2012. Prevention of Bone Metastases. Prevention of Bone Metastases 65 91 .
Dehao Fu, Xianfeng He, Shuhua Yang, Weihua Xu, Tao Lin & Xiaobo Feng. (2011) Zoledronic acid inhibits vasculogenic mimicry in murine osteosarcoma cell line in vitro. BMC Musculoskeletal Disorders 12:1.
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Matthew Cozin, Bradley M. Pinker, Kimberley Solemani, Jeremy M. Zuniga, Stephen C. Dadaian, Serge Cremers, Regina Landesberg & Srikala Raghavan. (2011) Novel Therapy to Reverse the Cellular Effects of Bisphosphonates on Primary Human Oral Fibroblasts. Journal of Oral and Maxillofacial Surgery 69:10, pages 2564-2578.
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