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Samantha Zaunz, Jonathan De Smedt, Lukas Lauwereins, Lana Cleuren, Charlie Laffeber, Manmohan Bajaj, Joyce H. G. Lebbink, Jurgen A. Marteijn, Kim De Keersmaecker & Catherine Verfaillie. (2023) APEX1 Nuclease and Redox Functions are Both Essential for Adult Mouse Hematopoietic Stem and Progenitor Cells. Stem Cell Reviews and Reports 19:6, pages 2052-2072.
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Matilde Clarissa Malfatti, Alessia Bellina, Giulia Antoniali & Gianluca Tell. (2023) Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons. Cells 12:14, pages 1895.
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Suravi Pramanik, Yingling Chen, Heyu Song, Irine Khutsishvili, Luis A Marky, Sutapa Ray, Amarnath Natarajan, Pankaj K Singh & Kishor K Bhakat. (2022)
The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates
KRAS
expression in pancreatic ductal adenocarcinoma cells
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Silpa Gampala, Fenil Shah, Xiaoyu Lu, Hye-ran Moon, Olivia Babb, Nikkitha Umesh Ganesh, George Sandusky, Emily Hulsey, Lee Armstrong, Amber L. Mosely, Bumsoo Han, Mircea Ivan, Jing-Ruey Joanna Yeh, Mark R. Kelley, Chi Zhang & Melissa L. Fishel. (2021) Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target. Journal of Experimental & Clinical Cancer Research 40:1.
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Gang Ning, Yongqiang Li, Wenji Chen, Wenjuan Tang, Diwen Shou, Qingling Luo, Huiting Chen & Yongjian Zhou. (2021) CpG Island Methylator Phenotype Modulates the Immune Response of the Tumor Microenvironment and Influences the Prognosis of Pancreatic Cancer Patients. Journal of Oncology 2021, pages 1-19.
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Gabriella D. Hartman, Nathan A. Lambert-Cheatham, Mark R. Kelley & Timothy W. Corson. (2021) Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy. International Journal of Molecular Sciences 22:19, pages 10279.
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Yuxiao Wang, Xuemei Li, Liang Zhang, Mengxia Li, Nan Dai, Hao Luo, Jinlu Shan, Xueqin Yang, Mingfang Xu, Yan Feng, Chengxiong Xu, Chengyuan Qian & Dong Wang. (2020) A randomized, double-blind, placebo-controlled study of B-cell lymphoma 2 homology 3 mimetic gossypol combined with docetaxel and cisplatin for advanced non-small cell lung cancer with high expression of apurinic/apyrimidinic endonuclease 1. Investigational New Drugs 38:6, pages 1862-1871.
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Rita Manguinhas, Ana S. Fernandes, João G. Costa, Nuno Saraiva, Sérgio P. Camões, Nuno Gil, Rafael Rosell, Matilde Castro, Joana P. Miranda & Nuno G. Oliveira. (2020) Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion. Antioxidants 9:6, pages 550.
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Matilde Clarissa Malfatti, Giulia Antoniali, Marta Codrich, Silvia Burra, Giovanna Mangiapane, Emiliano Dalla & Gianluca Tell. (2020) New perspectives in cancer biology from a study of canonical and non-canonical functions of base excision repair proteins with a focus on early steps. Mutagenesis 35:1, pages 129-149.
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Dilara Ayyildiz, Giulia Antoniali, Chiara D’Ambrosio, Giovanna Mangiapane, Emiliano Dalla, Andrea Scaloni, Gianluca Tell & Silvano Piazza. (2020) Architecture of The Human Ape1 Interactome Defines Novel Cancers Signatures. Scientific Reports 10:1.
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Guowen Ding, Yu Chen, Huiwen Pan, Hao Qiu, Weifeng Tang & Shuchen Chen. (2019) Association between apurinic/apyrimidinic endonuclease 1 rs1760944 T>G polymorphism and susceptibility of cancer: a meta-analysis involving 21764 subjects. Bioscience Reports 39:12.
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Melissa L. Fishel, Hanyu Xia, Jack McGeown, David W. McIlwain, May Elbanna, Ariel A. Craft, Hristos Z. Kaimakliotis, George E. Sandusky, Chi Zhang, Roberto Pili, Mark R. Kelley & Travis J. Jerde. (2019) Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer. Molecular Cancer Therapeutics 18:11, pages 1947-1960.
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Marta Codrich, Marina Comelli, Matilde Clarissa Malfatti, Catia Mio, Dilara Ayyildiz, Chi Zhang, Mark R. Kelley, Giovanni Terrosu, Carlo E.M. Pucillo & Gianluca Tell. (2019) Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway. DNA Repair 82, pages 102675.
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Hifza Afzal, Shahzad Yousaf, Faisal Rahman, Malik Waqar Ahmed, Zertashia Akram, Mahmood Akhtar Kayani & Ishrat Mahjabeen. (2019) PARP1: A potential biomarker for gastric cancer. Pathology - Research and Practice 215:8, pages 152472.
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Zhigang Cai, Jonathan J. Kotzin, Baskar Ramdas, Sisi Chen, Sai Nelanuthala, Lakshmi Reddy Palam, Ruchi Pandey, Raghuveer Singh Mali, Yan Liu, Mark R. Kelley, George Sandusky, Morvarid Mohseni, Adam Williams, Jorge Henao-Mejia & Reuben Kapur. (2018) Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis. Cell Stem Cell 23:6, pages 833-849.e5.
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David W. McIlwain, Melissa L. Fishel, Alexander Boos, Mark R. Kelley & Travis J. Jerde. (2017) APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells. Oncotarget 9:13, pages 10962-10977.
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Shan‑Tong Jiang, Shu‑Yan Han, Li‑Na Pang, Yan‑Na Jiao, Xi‑Ran He & Ping‑Ping Li. (2018) Bu-Fei decoction and modified Bu-Fei decoction inhibit the growth of non-small cell lung cancer, possibly via inhibition of apurinic/apyrimidinic endonuclease 1. International Journal of Molecular Medicine.
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Jill C. Fehrenbacher, Chunlu Guo, Mark R. Kelley & Michael R. Vasko. (2017) DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1. Neuroscience 366, pages 23-35.
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Fenil Shah, Emery Goossens, Nadia M. Atallah, Michelle Grimard, Mark R. Kelley & Melissa L. Fishel. (2017)
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Fenil Shah, Derek Logsdon, Richard A. Messmann, Jill C. Fehrenbacher, Melissa L. Fishel & Mark R. Kelley. (2017) Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic. npj Precision Oncology 1:1.
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