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Cancer Investigation Volume 29, 2011 - Issue 3
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ORIGINAL ARTICLE: CELLULAR AND MOLECULAR BIOLOGY

Human Beta-Defensin-1, -2, and -3 Exhibit Opposite Effects on Oral Squamous Cell Carcinoma Cell Proliferation

Jochen WinterDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Prosthodontics, Preclinical Education and Dental Materials Science, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany
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Annette PantelisDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Prosthodontics, Preclinical Education and Dental Materials Science, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany
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Rudolf ReichDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Prosthodontics, Preclinical Education and Dental Materials Science, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany
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Markus MartiniDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Prosthodontics, Preclinical Education and Dental Materials Science, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany
,
Dominik KrausDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Prosthodontics, Preclinical Education and Dental Materials Science, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany
,
Soeren JepsenDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Prosthodontics, Preclinical Education and Dental Materials Science, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany
,
Jean-Pierre AllamDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Prosthodontics, Preclinical Education and Dental Materials Science, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany
,
Natalija NovakDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Prosthodontics, Preclinical Education and Dental Materials Science, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany
&
Matthias WenghoeferDepartment of Oral & Maxillofacial Plastic Surgery, Department of Otorhinolaryngology/Surgery, Department of Dermatology and Allergy, Department of Prosthodontics, Preclinical Education and Dental Materials Science, Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, GermanyCorrespondence[email protected]
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Pages 196-201 | Published online: 31 Jan 2011

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Carrie Q. Sun, Rebecca S. Arnold, Chia-Ling Hsieh, Julia R. Dorin, Fei Lian, Zhenghong Li & John A. Petros. (2019) Discovery and mechanisms of host defense to oncogenesis: targeting the β-defensin-1 peptide as a natural tumor inhibitor. Cancer Biology & Therapy 20:6, pages 774-786.
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Jing Zhou, Yangheng Zhang, Lingjun Li, Huangmei Fu, Wenrong Yang & Fuhua Yan. (2018) Human β-defensin 3-combined gold nanoparticles for enhancement of osteogenic differentiation of human periodontal ligament cells in inflammatory microenvironments. International Journal of Nanomedicine 13, pages 555-567.
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J. Winter, S. Mohr, A. Pantelis, D. Kraus, J.P. Allam, N. Novak, R. Reich, M. Martini, S. Jepsen, W. Götz & M. Wenghoefer. (2012) IGF-1 Deficiency in Combination with a Low Basic hBD-2 and hBD-3 Gene Expression Might Counteract Malignant Transformation in Pleomorphic Adenomas in Vitro. Cancer Investigation 30:2, pages 106-113.
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Articles from other publishers (44)

Qi Liu, Lei Wang, Dongxia He, Yuewei Wu, Xian Liu, Yahan Yang, Zhizhi Chen, Zhan Dong, Ying Luo & Yuzhu Song. (2023) Application Value of Antimicrobial Peptides in Gastrointestinal Tumors. International Journal of Molecular Sciences 24:23, pages 16718.
Crossref
John G. Routsias, Dionysia Marinou, Maria Mavrouli, Athanasios Tsakris & Vassiliki Pitiriga. (2023) Serum β-Defensin 2, A Novel Biomarker for the Diagnosis of Acute Infections. Diagnostics 13:11, pages 1885.
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Bharat Kumar Reddy Sanapalli, Vidyasrilekha Yele, Mantosh Kumar Singh, Shilpa.N. Thumbooru, Madhukiran Parvathaneni & Veera Venkata Satyanarayana Reddy Karri. (2023) Human beta defensin-2 loaded PLGA nanoparticles impregnated in collagen-chitosan composite scaffold for the management of diabetic wounds. Biomedicine & Pharmacotherapy 161, pages 114540.
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M. Divya Lakshmanan, Swapna M. Nair & B.R. Swathi Prabhu. 2023. Antimicrobial Peptides. Antimicrobial Peptides 171 195 .
Swagatika Panda, Divya Gopinath & Newell W. Johnson. 2022. Microbes and Oral Squamous Cell Carcinoma. Microbes and Oral Squamous Cell Carcinoma 107 124 .
John Yun Niu, Iris Xiaoxue Yin, May Lei Mei, William Ka Kei Wu, Quan‐Li Li & Chun Hung Chu. (2021) The multifaceted roles of antimicrobial peptides in oral diseases. Molecular Oral Microbiology 36:3, pages 159-171.
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Wen-Juan Liu, Xiu-Jun Liu, Jian Xu, Liang Li, Yi Li, Sheng-Hua Zhang, Jia-Lin Wang, Qing-Fang Miao & Yong-Su Zhen. (2018) EGFR-targeting, β-defensin-tailored fusion protein exhibits high therapeutic efficacy against EGFR-expressed human carcinoma via mitochondria-mediated apoptosis. Acta Pharmacologica Sinica 39:11, pages 1777-1786.
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De Yang, Zhen Han & Joost J. Oppenheim. (2017) Alarmins and immunity. Immunological Reviews 280:1, pages 41-56.
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Camilla M. Ribeiro, Lucas G.A. Ferreira, Daniel S. Thimoteo, Lee B. Smith, Barry T. Hinton & Maria Christina W. Avellar. (2017) Novel androgen-induced activity of an antimicrobial β-defensin: Regulation of Wolffian duct morphogenesis. Molecular and Cellular Endocrinology 442, pages 142-152.
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D. Díaz Martín, M. Úbeda Cantera, A. López Suárez & M. Álvarez de Mon Soto. (2017) Respuesta inmune innata y sus implicaciones fisiopatológicas. Medicine - Programa de Formación Médica Continuada Acreditado 12:24, pages 1388-1397.
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Dan Xu, Bing Zhang, Chongbing Liao, Wei Zhang, Weijia Wang, Ying Chang & Yongping Shao. (2016) Human beta-defensin 3 contributes to the carcinogenesis of cervical cancer via activation of NF-κB signaling. Oncotarget 7:46, pages 75902-75913.
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T. Hoppe, D. Kraus, N. Novak, R. Probstmeier, M. Frentzen, M. Wenghoefer, S. Jepsen & J. Winter. (2016) Oral pathogens change proliferation properties of oral tumor cells by affecting gene expression of human defensins. Tumor Biology 37:10, pages 13789-13798.
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Jochen Winter, Dominik Kraus, Jan Reckenbeil & Rainer Probstmeier. (2015) Oncogenic relevant defensins: expression pattern and proliferation characteristics of human tumor cell lines. Tumor Biology 37:6, pages 7959-7966.
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Robert E.W. Hancock, Evan F. Haney & Erin E. Gill. (2016) The immunology of host defence peptides: beyond antimicrobial activity. Nature Reviews Immunology 16:5, pages 321-334.
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Crossref
J. Michael Conlon. (2015) Host-defense peptides of the skin with therapeutic potential: From hagfish to human. Peptides 67, pages 29-38.
Crossref
P. Wang, D. Duan, X. Zhou, X. Li, J. Yang, M. Deng & Y. Xu. (2015) Relationship between expression of human gingival beta-defensins and levels of periodontopathogens in subgingival plaque. Journal of Periodontal Research 50:1, pages 113-122.
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Wen-mei Wang, Pei Ye, Ya-jie Qian, Ya-fan Gao, Jing-jing Li, Fang-fang Sun, Wei-yun Zhang & Xiang Wang. (2015) Effects of whole cigarette smoke on human beta defensins expression and secretion by oral mucosal epithelial cells. Tobacco Induced Diseases 13:1, pages 3.
Crossref
Himanshu Sharma & Ramakrishanan Nagaraj. 2015. 69 97 .
Adone Baroni, Elisabetta Buommino, Vincenzo Piccolo, Marco Adriano Chessa, Teresa Russo, Valentina Cozza & Vincenzo Ruocco. (2014) Alterations of skin innate immunity in lymphedematous limbs: Correlations with opportunistic diseases. Clinics in Dermatology 32:5, pages 592-598.
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Satoko Uraki, Kazushi Sugimoto, Katsuya Shiraki, Masahiko Tameda, Yuji Inagaki, Suguru Ogura, Chika Kasai, Keiichiro Nojiri, Misao Yoneda, Norihiko Yamamoto, Yoshiyuki Takei, Tsutomu Nobori & Masaaki Ito. (2014) Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression. International Journal of Oncology.
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Crossref
Guangshun Wang. (2014) Human Antimicrobial Peptides and Proteins. Pharmaceuticals 7:5, pages 545-594.
Crossref
Qi Han, Ruinan Wang, Chongkui Sun, Xin Jin, Dongjuan Liu, Xin Zhao, Lili Wang, Ning Ji, Jing Li, Yu Zhou, Ling Ye, Xinhua Liang, Lu Jiang, Ga Liao, Hongxia Dan, Xin Zeng & Qianming Chen. (2014) Human Beta-Defensin-1 Suppresses Tumor Migration and Invasion and Is an Independent Predictor for Survival of Oral Squamous Cell Carcinoma Patients. PLoS ONE 9:3, pages e91867.
Crossref
O. Gerashchenko, V. Kovalchuk, O. Boidunik, M. Soldatkina & P. Pogrebnoy. (2014) Fusion expression of recombinant human beta-defensin-3 and analysis of its biological activity. Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology 68:3, pages 98-102.
Crossref
Wei Meng, Rong Du, Yanjiao Wang, Zhifang Chen & Yan Ding. (2013) Human β-Defensin Messenger RNA is Overexpressed in the Cervical Epithelia of Patients With Nongonococcal Cervicitis. Journal of Lower Genital Tract Disease 17:4, pages 440-445.
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Vui King Vincent-Chong, Lee Peng Karen-Ng, Zainal Ariff Abdul Rahman, Yi-Hsin Yang, Arif Anwar, Zubaidah Zakaria, Padmaja Jayaprasad Pradeep, Thomas George Kallarakkal, Keng Kiong Tay, Mannil Thomas Abraham, Siti Mazlipah Ismail & Rosnah Binti Zain. (2013) Distinct pattern of chromosomal alterations and pathways in tongue and cheek squamous cell carcinoma. Head & Neck, pages n/a-n/a.
Crossref
Whasun Lim & Gwonhwa Song. (2013) Discovery of Prognostic Factors for Diagnosis and Treatment of Epithelial-Derived Ovarian Cancer from Laying Hens. Journal of Cancer Prevention 18:3, pages 209-220.
Crossref
Jun Sato, Michiko Nishimura, Mami Yamazaki, Kouki Yoshida, Yoshihito Kurashige, Masato Saitoh & Yoshihiro Abiko. (2013) Expression profile of drosomycin-like defensin in oral epithelium and oral carcinoma cell lines. Archives of Oral Biology 58:3, pages 279-285.
Crossref
Jochen Winter, Annette Pantelis, Dominik Kraus, Jan Reckenbeil, Rudolf Reich, Soeren Jepsen, Hans-Peter Fischer, Jean-Pierre Allam, Natalija Novak & Matthias Wenghoefer. (2012) Human α-defensin (DEFA) gene expression helps to characterise benign and malignant salivary gland tumours. BMC Cancer 12:1.
Crossref
N. Scola, T. Gambichler, H. Saklaoui, F.G. Bechara, D. Georgas, M. Stücker, R. Gläser & A. Kreuter. (2012) The expression of antimicrobial peptides is significantly altered in cutaneous squamous cell carcinoma and precursor lesions. British Journal of Dermatology 167:3, pages 591-597.
Crossref
Niharika Swain, Shwetha V. Kumar, Richa & Jigna Pathak. (2012) DEFENSINS: Potent biomarkers in Oral Squamous cell Carcinoma. Oral Oncology 48:8, pages e29-e30.
Crossref
Johann Röhrl, Barbara Huber, Gudrun E. Koehl, Edward K. Geissler & Thomas Hehlgans. (2012) Mouse β-Defensin 14 ( Defb14 ) Promotes Tumor Growth by Inducing Angiogenesis in a CCR6-Dependent Manner . The Journal of Immunology 188:10, pages 4931-4939.
Crossref
D. Kraus, J. Deschner, A. Jäger, M. Wenghoefer, S. Bayer, S. Jepsen, J. P. Allam, N. Novak, R. Meyer & J. Winter. (2011) Human β‐defensins differently affect proliferation, differentiation, and mineralization of osteoblast‐like MG63 cells. Journal of Cellular Physiology 227:3, pages 994-1003.
Crossref
Jochen Winter & Matthias Wenghoefer. (2012) Human Defensins: Potential Tools for Clinical Applications. Polymers 4:1, pages 691-709.
Crossref
Marco R. Kesting, Mechthild Stoeckelhuber, Alexandra Kuppek, Rafael Hasler, Nils Rohleder, Klaus-Dietrich Wolff & Markus Nieberler. (2012) Human β-Defensins and Psoriasin/S100A7 Expression in Salivary Glands. BioDrugs 26:1, pages 33-42.
Crossref
Fiona Semple & Julia R. Dorin. (2012) ß-Defensins: Multifunctional Modulators of Infection, Inflammation and More?. Journal of Innate Immunity 4:4, pages 337-348.
Crossref

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