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Cancer Investigation Volume 29, 2011 - Issue 4
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ORIGINAL ARTICLE: CELLULAR AND MOLECULAR BIOLOGY

15-Hydroxyprostaglandin Dehydrogenase is Downregulated and Exhibits Tumor Suppressor Activity in Gastric Cancer

Ho June Song
,
Seung-Jae MyungCorrespondence[email protected]
,
In-Wha KimAsan Digestive Disease Research Institute and Asan Institute for Life Sciences, Seoul, Korea,
,
Jin-Yong JeongAsan Digestive Disease Research Institute and Asan Institute for Life Sciences, Seoul, Korea,
,
Young Soo ParkPathology,
,
Sun Mi LeeAsan Digestive Disease Research Institute and Asan Institute for Life Sciences, Seoul, Korea,
,
Won Hee NamAsan Digestive Disease Research Institute and Asan Institute for Life Sciences, Seoul, Korea,
,
Yeon-Mi RyuAsan Digestive Disease Research Institute and Asan Institute for Life Sciences, Seoul, Korea,
,
Stephen P. FinkUniversity of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, and Department of Medicine, Ireland Cancer Center, Case Western Reserve University and Case Medical Center, Cleveland, Ohio, USA
,
Dong-Hoon Yang
,
Hwoon-Yong Jung
&
Jin-Ho Kim
 show all
Pages 257-265 | Published online: 06 Apr 2011

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Yaling Li, Junjie Li, Juanjuan Dong, Lei Zhang, Dongling Liu, Jianzheng He, Yali She, Chengxu Ma & Yongqi Liu. (2020) 15-PGDH Expression in Gastric Cancer: A Potential Role in Anti-Tumor Immunity. Cancer Management and Research 12, pages 7419-7426.
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Articles from other publishers (15)

Bahareh Farasati Far, Kimia Vakili, Mobina Fathi, Shirin Yaghoobpoor, Mohammed Bhia & M. Reza Naimi- Jamal. (2023) The role of microRNA-21 (miR-21) in pathogenesis, diagnosis, and prognosis of gastrointestinal cancers: A review. Life Sciences 316, pages 121340.
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Yaguan Fan, Libo Yang, Yi Ren, Yunhua Wu, Linhai Li & Lihua Li. (2022) Sp1-Induced SETDB1 Overexpression Transcriptionally Inhibits HPGD in a β-Catenin-Dependent Manner and Promotes the Proliferation and Metastasis of Gastric Cancer. Journal of Gastric Cancer 22:4, pages 319.
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Catarina Lopes, Carina Pereira, Mónica Farinha, Rui Medeiros & Mário Dinis-Ribeiro. (2020) Prostaglandin E2 Pathway Is Dysregulated in Gastric Adenocarcinoma in a Caucasian Population. International Journal of Molecular Sciences 21:20, pages 7680.
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Young Soo Park, Jeong Hoon Lee, Deok-Beom Jung, Han-Byul Kim, Jin-Hak Jung, Sehyung Pak, Yeon-Mi Ryu, Hye Jin Park, Yun-Yong Park, Hwoon-Yong Jung & Seung-Jae Myung. (2018) MicroRNA-21 induces loss of 15-hydroxyprostaglandin dehydrogenase in early gastric tubular adenocarcinoma. Scientific Reports 8:1.
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Lubna M. Mehdawi, Chandra Prakash Prasad, Roy Ehrnström, Tommy Andersson & Anita Sjölander. (2016) Non‐canonical WNT5A signaling up‐regulates the expression of the tumor suppressor 15‐PGDH and induces differentiation of colon cancer cells. Molecular Oncology 10:9, pages 1415-1429.
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Jonathan G. Hiller, Marie-Odile Parat & Shamgar Ben-Eliyahu. (2015) The Role of Perioperative Pharmacological Adjuncts in Cancer Outcomes: Beta-Adrenergic Receptor Antagonists, NSAIDs and Anti-fibrinolytics. Current Anesthesiology Reports 5:3, pages 291-304.
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Sang Hyuk Seo, Mi Seon Kang, Kwang Hee Kim, Min Sung An, Tae Kwun Ha, Ki Beom Bae, Min Kyung Oh, Chang Soo Choi, Sang Hoon Oh & Young Kil Choi. (2015) Correlation of 15-prostagladin dehydrogenase expression with clinicopathological factors and survival rate in gastric adenocarcinoma. International Journal of Surgery 13, pages 96-101.
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Jae Hyun KangSang Hyun KangSang Hyuk SeoJae Ho ShinMin Sung AnTae Kwun HaKi Beom BaeTae Hyun KimChang Soo ChoiSang Hoon OhMi Seon KangKwang Hee Kim. (2014) Relationship between 15-hydroxyprostaglandin dehydrogenase and gastric adenocarcinoma. Annals of Surgical Treatment and Research 86:6, pages 302.
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Jee Eun YangEunji ParkHyo Jeong LeeHyo Jeong KangKang Mo KimEunsil YuDanbi LeeJu Hyun ShimYoung-Suk LimHan Chu LeeYoung-Hwa ChungYung Sang Lee. (2014) Role of 15-hydroxyprostaglandin dehydrogenase down-regulation on the prognosis of hepatocellular carcinoma. Clinical and Molecular Hepatology 20:1, pages 28.
Crossref
Tao Shou. (2013) Effect of 15‑hydroxyprostaglandin dehydrogenase gene on the proliferation of gastric cancer cell murine forestomach carcinoma. Experimental and Therapeutic Medicine.
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Luis Castro-S?nchez, Noelia Agra, Cristina Llorente Izquierdo, Omar Moti?o, Marta Casado, Lisardo Bosc?Paloma Mart?n-Sanz. (2013) Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma. The International Journal of Biochemistry & Cell Biology 45:11, pages 2501-2511.
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Yeon-Mi Ryu, Seung-Jae Myung, Young Soo Park, Dong-Hoon Yang, Ho June Song, Jin-Yong Jeong, Sun Mi Lee, Miyeoun Song, Do Hoon Kim, Hyo-Jeong Lee, Soo-Kyung Park, Stephen P. Fink, Sandy D. Markowitz, Kee Wook Jung, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Hwoon-Yong Jung, Suk-Kyun Yang & Jin-Ho Kim. (2013) Inhibition of 15-Hydroxyprostaglandin Dehydrogenase by Helicobacter pylori in Human Gastric Carcinogenesis . Cancer Prevention Research 6:4, pages 349-359.
Crossref
Ying Wang, Xiushan Zheng, Zhiyong Zhang, Jinfeng Zhou, Guohong Zhao, Jianjun Yang, Limin Xia, Rui Wang, Xiqiang Cai, Hao Hu, Cailin Zhu, Yongzhan Nie, Kaichun Wu, Dexin Zhang & Daiming Fan. (2012) MicroRNA-149 Inhibits Proliferation and Cell Cycle Progression through the Targeting of ZBTB2 in Human Gastric Cancer. PLoS ONE 7:10, pages e41693.
Crossref
Yokananth Sekar & A. Dean Befus. (2012) Protein tyrosine nitration of 15-hydroxy prostaglandin dehydrogenase in the human mast cell line LAD2. Nitric Oxide 26:1, pages 74-80.
Crossref
Hsin-Hsiung Tai. (2011) Prostaglandin catabolic enzymes as tumor suppressors. Cancer and Metastasis Reviews 30:3-4, pages 409-417.
Crossref

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