1,497
Views
58
CrossRef citations to date
0
Altmetric
Original Article

The Cancer Stem Cell Hypothesis: A Guide to Potential Molecular Targets

, , , , , & show all
Pages 470-495 | Received 20 Jul 2013, Accepted 14 Jun 2014, Published online: 25 Sep 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Matthew Harris, Fredrik Svensson, Liliya Kopanitsa, Graham Ladds & David Bailey. (2018) Emerging patents in the therapeutic areas of glioma and glioblastoma. Expert Opinion on Therapeutic Patents 28:7, pages 573-590.
Read now
Alessandro Allegra, Vanessa Innao, Sabina Russo, Demetrio Gerace, Andrea Alonci & Caterina Musolino. (2017) Anticancer Activity of Curcumin and Its Analogues: Preclinical and Clinical Studies. Cancer Investigation 35:1, pages 1-22.
Read now
Ya-Wen Chen, Gunn-Guang Liou, Huay-Ben Pan, Hui-Hwa Tseng, Yu-Ting Hung & Chen-Pin Chou. (2015) Specific detection of CD133-positive tumor cells with iron oxide nanoparticles labeling using noninvasive molecular magnetic resonance imaging. International Journal of Nanomedicine 10, pages 6997-7018.
Read now

Articles from other publishers (54)

Franziska Leichtle, Annika C. Betzler, Carlotta Eizenberger, Kristina Lesakova, Jasmin Ezić, Robert Drees, Jens Greve, Patrick J. Schuler, Simon Laban, Thomas K. Hoffmann, Nils Cordes, Marialuisa Lavitrano, Emanuela Grassilli & Cornelia Brunner. (2023) Influence of Bruton’s Tyrosine Kinase (BTK) on Epithelial–Mesenchymal Transition (EMT) Processes and Cancer Stem Cell (CSC) Enrichment in Head and Neck Squamous Cell Carcinoma (HNSCC). International Journal of Molecular Sciences 24:17, pages 13133.
Crossref
Yi Luo & Jian-Hui Xiao. (2023) Inflammatory auxo-action in the stem cell division theory of cancer. PeerJ 11, pages e15444.
Crossref
Mingzhu Cao, Zhi Liu, Danming You, Yingying Pan & Qingyan Zhang. (2023) TMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties. Stem Cell Research & Therapy 14:1.
Crossref
Jiahui Lu. (2023) Cancer Stem Cells and Their Drug Resistance Mechanisms. Highlights in Science, Engineering and Technology 36, pages 1334-1341.
Crossref
Sai‐Juan Chen, Xiao‐Jing Yan, Guang‐Biao Zhou & Zhu Chen. 2016. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine 1 19 .
Hong Li, Mei He, Pengyu Zhao, Ping Liu, Wei Chen & Xuewen Xu. (2022) Chelerythrine Chloride Inhibits Stemness of Melanoma Cancer Stem-Like Cells (CSCs) Potentially via Inducing Reactive Oxygen Species and Causing Mitochondria Dysfunction. Computational and Mathematical Methods in Medicine 2022, pages 1-10.
Crossref
M. Y. Terzi, H. M. Okuyan, G. Gülbol-Duran & M. Urhan-Küçük. (2022) Reduced Expression of PEDF and ALDH1A1 during Spheroid Transition of Lung Cancer Cells: An In Vitro Study. Cytology and Genetics 56:2, pages 172-178.
Crossref
Yuan Li, Zhenning Wang, Jaffer A. Ajani & Shumei Song. (2021) Drug resistance and Cancer stem cells. Cell Communication and Signaling 19:1.
Crossref
Elvan Dogan, Asli Kisim, Gizem Bati-Ayaz, Gregory J. Kubicek, Devrim Pesen-Okvur & Amir K. Miri. (2021) Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions. Advanced NanoBiomed Research 1:11.
Crossref
Faezeh Ghazaghi, Hana Saffar, Farzad Yazdani & Arghavan Etebarian. (2021) Clinical Significance and Prognostic Value of SOX2 Protein Expression in Patients With Oral Squamous Cell Carcinoma. Applied Immunohistochemistry & Molecular Morphology 29:9, pages 700-705.
Crossref
Matias Blomqvist, Ilmari Koskinen, Eliisa Löyttyniemi, Tuomas Mirtti, Peter J. Boström & Pekka Taimen. (2021) Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer. Scientific Reports 11:1.
Crossref
Ivan Chan‐Zapata & Maira Rubí Segura‐Campos. (2021) Honey and its protein components: Effects in the cancer immunology. Journal of Food Biochemistry 45:5.
Crossref
José Luis Palacios‐Ferrer, María Belén García‐Ortega, María Gallardo‐Gómez, María Ángel García, Caridad Díaz, Houria Boulaiz, Javier Valdivia, José Miguel Jurado, Francisco M. Almazan‐Fernandez, Salvador Arias‐Santiago, Víctor Amezcua, Héctor Peinado, Francisca Vicente, José Pérez del Palacio & Juan A. Marchal. (2020) Metabolomic profile of cancer stem cell‐derived exosomes from patients with malignant melanoma. Molecular Oncology 15:2, pages 407-428.
Crossref
Changhwan Yoon, Jun Lu, Brendan C. Yi, Kevin K. Chang, M. Celeste Simon, Sandra Ryeom & Sam S. Yoon. (2021) PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas. Oncogenesis 10:1.
Crossref
Nicola Luigi Bragazzi & Maha Sellami. 2021. 27 47 .
Andrea Angius, Paolo Cossu-Rocca, Caterina Arru, Maria Rosaria Muroni, Vincenzo Rallo, Ciriaco Carru, Paolo Uva, Giovanna Pira, Sandra Orrù & Maria Rosaria De Miglio. (2020) Modulatory Role of microRNAs in Triple Negative Breast Cancer with Basal-Like Phenotype. Cancers 12:11, pages 3298.
Crossref
Narges Ghazi, Narges Aali, Vahid-Reza Shahrokhi, Farnaz Mohajertehran & Nasrollah Saghravanian. (2020) Relative Expression of SOX2 and OCT4 in Oral Squamous Cell Carcinoma and Oral Epithelial Dysplasia. Reports of Biochemistry and Molecular Biology 9:2, pages 171-179.
Crossref
Ebrahim Razi, Mehran Radak, Maryam Mahjoubin-Tehran, Samaneh Talebi, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, Hossein Sharifi, Nousin Mousavi, Mostafa Sarvizadeh, Majid Nejati, Mohsen Taghizadeh & Faezeh Ghasemi. (2019) Cancer stem cells as therapeutic targets of pancreatic cancer. Fundamental & Clinical Pharmacology 34:2, pages 202-212.
Crossref
Leontine Sandforth, Nourhane Ammar, Lisa Antonia Dinges, Christoph Röcken, Alexander Arlt, Susanne Sebens & Heiner Schäfer. (2020) Impact of the Monocarboxylate Transporter-1 (MCT1)-Mediated Cellular Import of Lactate on Stemness Properties of Human Pancreatic Adenocarcinoma Cells. Cancers 12:3, pages 581.
Crossref
Si Si Yu & Nicola Cirillo. (2019) The molecular markers of cancer stem cells in head and neck tumors. Journal of Cellular Physiology 235:1, pages 65-73.
Crossref
Giannone, Attademo, Scotto, Genta, Ghisoni, Tuninetti, Aglietta, Pignata & Valabrega. (2019) Endometrial Cancer Stem Cells: Role, Characterization and Therapeutic Implications. Cancers 11:11, pages 1820.
Crossref
Gangyue Wang, Yi Dong, Heng Liu, Nan Ji, Jilei Cao, Aihui Liu, Xin Tang & Yu Ren. (2019) Loss of miR‑873 contributes to gemcitabine resistance in triple‑negative breast cancer via targeting ZEB1. Oncology Letters.
Crossref
Maria João Carvalho, Mafalda Laranjo, Ana Margarida Abrantes, João Casalta-Lopes, Daniela Sarmento-Santos, Tânia Costa, Beatriz Serambeque, Nuno Almeida, Telmo Gonçalves, Catarina Mamede, João Encarnação, Rui Oliveira, Artur Paiva, Rui de Carvalho, Filomena Botelho & Carlos Oliveira. (2018) Endometrial Cancer Spheres Show Cancer Stem Cells Phenotype and Preference for Oxidative Metabolism. Pathology & Oncology Research 25:3, pages 1163-1174.
Crossref
Ta-Chin Lin, Kai-Hung Wang, Kuo-Hsiang Chuang, An-Pei Kao & Tsung-Cheng Kuo. (2019) Modulation of tumor stem cell characteristics by 17β-estradiol in human mesenchymal stem cells derived from ovarian endometrioma. Taiwanese Journal of Obstetrics and Gynecology 58:3, pages 338-344.
Crossref
Tsunehiko Ikeda, Kimitoshi Nakamura, Hidehiro Oku, Taeko Horie, Teruyo Kida & Shinji Takai. (2019) Immunohistological Study of Monkey Foveal Retina. Scientific Reports 9:1.
Crossref
Guillermo Prado-Vázquez, Angelo Gámez-Pozo, Lucía Trilla-Fuertes, Jorge M. Arevalillo, Andrea Zapater-Moros, María Ferrer-Gómez, Mariana Díaz-Almirón, Rocío López-Vacas, Hilario Navarro, Paloma Maín, Jaime Feliú, Pilar Zamora, Enrique Espinosa & Juan Ángel Fresno Vara. (2019) A novel approach to triple-negative breast cancer molecular classification reveals a luminal immune-positive subgroup with good prognoses. Scientific Reports 9:1.
Crossref
Manpreet Sambi & Myron R. Szewczuk. 2019. Current Applications for Overcoming Resistance to Targeted Therapies. Current Applications for Overcoming Resistance to Targeted Therapies 1 33 .
Shaoyun Wang, Peiwei Chai, Ruobing Jia & Renbing Jia. (2018) Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword. Molecular Cancer 17:1.
Crossref
Anine Crous, Elvin Chizenga, Natasha Hodgkinson & Heidi Abrahamse. (2018) Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells. International Journal of Optics 2018, pages 1-9.
Crossref
Wuniqiemu Tulake, Reziwanguli Yuemaier, Lei Sheng, Mingfang Ru, Dilare Lidifu & Abulizi Abudula. (2018) Upregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma. Oncology Letters.
Crossref
Kevin K. Chang, Changhwan Yoon, Brendan C. Yi, William D. Tap, M. Celeste Simon & Sam S. Yoon. (2018) Platelet-derived growth factor receptor-α and -β promote cancer stem cell phenotypes in sarcomas. Oncogenesis 7:6.
Crossref
Shreeja Mehrotra, Susrutha K. Wickremesekera, Helen D. Brasch, Bede Van Schaijik, Reginald W. Marsh, Swee T. Tan & Tinte Itinteang. (2018) Expression and Localization of Cathepsins B, D and G in Cancer Stem Cells in Liver Metastasis From Colon Adenocarcinoma. Frontiers in Surgery 5.
Crossref
V. Innao, A. Allegra, S. Russo, D. Gerace, D. Vaddinelli, A. Alonci, A.G. Allegra & C. Musolino. (2017) Standardisation of minimal residual disease in multiple myeloma. European Journal of Cancer Care 26:6, pages e12732.
Crossref
Fanping Wang, Wenjun Wang, Junpeng Li, Jingjing Zhang, Xia Wang & Mingyong Wang. (2017) Sulforaphane reverses gefitinib tolerance in human lung cancer cells via modulation of sonic hedgehog signaling. Oncology Letters.
Crossref
Dongmei Zhang, Mingjing Fu, Lingyan Li, Huan Ye, Zhiqi Song & Yongjun Piao. (2017) PKC-δ attenuates the cancer stem cell among squamous cell carcinoma cells through down-regulating p63. Pathology - Research and Practice 213:9, pages 1119-1124.
Crossref
Jahahreeh Finley. (2017) Elimination of cancer stem cells and reactivation of latent HIV-1 via AMPK activation: Common mechanism of action linking inhibition of tumorigenesis and the potential eradication of HIV-1. Medical Hypotheses 104, pages 133-146.
Crossref
Alessandro Allegra, Vanessa Innao, Giuseppa Penna, Demetrio Gerace, Andrea G. Allegra & Caterina Musolino. (2017) Telomerase and telomere biology in hematological diseases: A new therapeutic target. Leukemia Research 56, pages 60-74.
Crossref
Tao Jiang, Xiao Chen, Wei Zhou, Guoxin Fan, Peilin Zhao, Shengxiang Ren, Caicun Zhou & Jun Zhang. (2017) Immunotherapy with Dendritic Cells Modified with Tumor-Associated Antigen Gene Demonstrates Enhanced Antitumor Effect Against Lung Cancer. Translational Oncology 10:2, pages 132-141.
Crossref
You Zou, Xiaolan Li, Deding Tao, Junbo Hu & Jianping Gong. (2017) Epidermal growth factor enhances chemosensitivity of colon cancer by inducing cancer stem cells to enter the cell cycle. Oncology and Translational Medicine 3:2, pages 86-90.
Crossref
Qi Cui, Hailing Shi, Peng Ye, Li Li, Qiuhao Qu, Guoqiang Sun, Guihua Sun, Zhike Lu, Yue Huang, Cai-Guang Yang, Arthur D. Riggs, Chuan He & Yanhong Shi. (2017) m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells. Cell Reports 18:11, pages 2622-2634.
Crossref
Sai‐Juan Chen, Xiao‐Jing Yan, Guang‐Biao Zhou & Zhu Chen. 2016. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine 1 15 .
Caterina Musolino, Alessandro Allegra, Govanni Pioggia & Sebastiano Gangemi. (2017) Immature myeloid-derived suppressor cells: A bridge between inflammation and cancer. Oncology Reports 37:2, pages 671-683.
Crossref
Eunji Jang, Eunjung Kim, Hye-Young Son, Eun-Kyung Lim, Hwunjae Lee, Yuna Choi, Kwangyeol Park, Seungmin Han, Jin-Suck Suh, Yong-Min Huh & Seungjoo Haam. (2016) Nanovesicle-mediated systemic delivery of microRNA-34a for CD44 overexpressing gastric cancer stem cell therapy. Biomaterials 105, pages 12-24.
Crossref
Sara S. Franco, Karolina Szczesna, Maria S. Iliou, Mohammed Al-Qahtani, Ali Mobasheri, Julianna Kobolák & András Dinnyés. (2016) In vitro models of cancer stem cells and clinical applications. BMC Cancer 16:S2.
Crossref
Elia Guadagno, Giorgio Borrelli, Marialuisa Califano, Gaetano Calì, Domenico Solari & Marialaura Del Basso De Caro. (2016) Immunohistochemical expression of stem cell markers CD44 and nestin in glioblastomas: Evaluation of their prognostic significance. Pathology - Research and Practice 212:9, pages 825-832.
Crossref
Zhe Wang, Anja von Au, Martina Schnölzer, Thilo Hackert & Margot Zöller. (2016) CD44v6-competent tumor exosomes promote motility, invasion and cancer-initiating cell marker expression in pancreatic and colorectal cancer cells. Oncotarget 7:34, pages 55409-55436.
Crossref
Yang Zhao, Jing Peng, Enlong Zhang, Ning Jiang, Jiang Li, Qi Zhang, Xuening Zhang & Yuanjie Niu. (2016) CD133 expression may be useful as a prognostic indicator in colorectal cancer, a tool for optimizing therapy and supportive evidence for the cancer stem cell hypothesis: a meta-analysis. Oncotarget 7:9, pages 10023-10036.
Crossref
Qi Cui, Su Yang, Peng Ye, E. Tian, Guoqiang Sun, Jiehua Zhou, Guihua Sun, Xiaoxuan Liu, Chao Chen, Kiyohito Murai, Chunnian Zhao, Krist T. Azizian, Lu Yang, Charles Warden, Xiwei Wu, Massimo D'Apuzzo, Christine Brown, Behnam Badie, Ling Peng, Arthur D. Riggs, John J. Rossi & Yanhong Shi. (2016) Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis. Nature Communications 7:1.
Crossref
MIN WANG, DONG REN, WEI GUO, SHUAI HUANG, ZEYU WANG, QIJI LI, HONG DU, LIBING SONG & XINSHENG PENG. (2016) N-cadherin promotes epithelial-mesenchymal transition and cancer stem cell-like traits via ErbB signaling in prostate cancer cells. International Journal of Oncology 48:2, pages 595-606.
Crossref
Alireza Mirzaei, Gholamreza Tavoosidana, Afshin Abdi Rad, Farhad Rezaei, Masoumeh Tavakoli-Yaraki, Azade Amini Kadijani, Ehsan Khalili & Zahra Madjd. (2015) A new insight into cancer stem cell markers: Could local and circulating cancer stem cell markers correlate in colorectal cancer?. Tumor Biology 37:2, pages 2405-2414.
Crossref
Eckhard Klieser, Stefan Swierczynski, Christian Mayr, Tarkan Jäger, Johanna Schmidt, Daniel Neureiter, Tobias Kiesslich & Romana Illig. (2016) Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review. World Journal of Gastrointestinal Pathophysiology 7:2, pages 199.
Crossref
Bin Wu, Caixing Sun, Fang Feng, Minghua Ge & Liang Xia. (2015) Do relevant markers of cancer stem cells CD133 and Nestin indicate a poor prognosis in glioma patients? A systematic review and meta-analysis. Journal of Experimental & Clinical Cancer Research 34:1.
Crossref
Maria João Carvalho, Mafalda Laranjo, Ana Margarida Abrantes, Isabel Torgal, Maria Filomena Botelho & Carlos Freire Oliveira. (2015) Clinical translation for endometrial cancer stem cells hypothesis. Cancer and Metastasis Reviews 34:3, pages 401-416.
Crossref
Mecca Madany, Tom M. Thomas, Lincoln Edwards & John S. Yu. 2015. Stem Cell Biology in Neoplasms of the Central Nervous System. Stem Cell Biology in Neoplasms of the Central Nervous System 139 166 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.