1,066
Views
59
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Differential Expression of Cancer Stem Cell Markers ALDH1 and CD133 in Various Lung Cancer Subtypes

, , &
Pages 294-302 | Received 21 Aug 2014, Accepted 17 Mar 2015, Published online: 05 Jun 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Yu Ning Chen, Yang Li & Wen Bin Wei. (2020) Research Progress of Cancer Stem Cells in Uveal Melanoma. OncoTargets and Therapy 13, pages 12243-12252.
Read now
Raheleh Roudi, Mahboubeh Barodabi, Zahra Madjd, Giandomenico Roviello, Silvia Paola Corona & Mahshid Panahi. (2020) Expression patterns and clinical significance of the potential cancer stem cell markers OCT4 and NANOG in colorectal cancer patients. Molecular & Cellular Oncology 7:5.
Read now
Guodong Xiao, Boxiang Zhang, Jinying Meng, Jichang Wang, Chongwen Xu, Shou-Ching Tang, Xiang Li, Jing Zhang, Rui Liang, Hong Ren & Xin Sun. (2017) miR-367 stimulates Wnt cascade activation through degrading FBXW7 in NSCLC stem cells. Cell Cycle 16:24, pages 2374-2385.
Read now

Articles from other publishers (56)

Xiaoyu Zhang & Ching-Ti Liu. (2023) Information-incorporated sparse convex clustering for disease subtyping. Bioinformatics 39:7.
Crossref
Horacio Eduardo Romeo & María Laura Barreiro Arcos. (2023) Clinical relevance of stem cells in lung cancer. World Journal of Stem Cells 15:6, pages 576-588.
Crossref
Xuejia Kang, Sanika Jadhav, Manjusha Annaji, Chung-Hui Huang, Rajesh Amin, Jianzhong Shen, Charles R. AshbyJr.Jr., Amit K. Tiwari, R. Jayachandra Babu & Pengyu Chen. (2023) Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems. Pharmaceutics 15:6, pages 1567.
Crossref
Salma A. Al-Shamma, Dana M. Zaher, Fatema Hersi, Nour N. Abu Jayab & Hany A. Omar. (2023) Targeting aldehyde dehydrogenase enzymes in combination with chemotherapy and immunotherapy: An approach to tackle resistance in cancer cells. Life Sciences 320, pages 121541.
Crossref
Anam Arif, Ameer A. Alameri, Umer Bin Tariq, Shakeel Ahmed Ansari, Hader Ibrahim Sakr, Maytham T. Qasim, Fadhil F.M. Aljoborae, Andrés Alexis Ramírez-Coronel, Hijran Sanaan Jabbar, Gamal A. Gabr, Rasoul Mirzaei & Sajad Karampoor. (2023) The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer. International Immunopharmacology 114, pages 109581.
Crossref
Wen Zhou, Junjun Ma, Lifeng Meng, Dabei Liu & Jun Chen. (2022) Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer. BMC Cancer 22:1.
Crossref
Wenwen Guo, Tianyun Qiao & Tian Li. (2022) The role of stem cells in small-cell lung cancer: Evidence from chemoresistance to immunotherapy. Seminars in Cancer Biology 87, pages 160-169.
Crossref
Yaolu Wei, Yan Li, Yenan Chen, Pei Liu, Sheng Huang, Yuping Zhang, Yanling Sun, Zhe Wu, Meichun Hu, Qian Wu, Hongnian Wu, Fuxing Liu, Tonghui She & Zhifeng Ning. (2022) ALDH1: A potential therapeutic target for cancer stem cells in solid tumors. Frontiers in Oncology 12.
Crossref
Jinyao Zhang, Xujie Sun, Li Liu, Jiyan Dong, Lei Deng, Xin Wang, Yiying Guo, Jianming Ying, Puyuan Xing, Junling Li & Lin Yang. (2022) Clinical significance of ALDH1A1 expression and its association with E-cadherin and N-cadherin in resected large cell neuroendocrine carcinoma. Translational Oncology 19, pages 101379.
Crossref
Naoki Yamashita, Tetsuya So, Takeaki Miyata, Takashi Yoshimatsu, Ryuji Nakano, Tsunehiro Oyama, Wataru Matsunaga & Akinobu Gotoh. (2022) Triple-negative expression (ALDH1A1-/CD133-/mutant p53-) cases in lung adenocarcinoma had a good prognosis. Scientific Reports 12:1.
Crossref
Elham Kalantari, Tahereh Taheri, Saba Fata, Maryam Abolhasani, Mitra Mehrazma, Zahra Madjd & Mojgan Asgari. (2022) Significant co-expression of putative cancer stem cell markers, EpCAM and CD166, correlates with tumor stage and invasive behavior in colorectal cancer. World Journal of Surgical Oncology 20:1.
Crossref
Evgenii Skurikhin, Olga Pershina, Mariia Zhukova, Darius Widera, Natalia Ermakova, Edgar Pan, Angelina Pakhomova, Sergey Morozov, Aslan Kubatiev & Alexander Dygai. (2021) Potential of Stem Cells and CART as a Potential Polytherapy for Small Cell Lung Cancer. Frontiers in Cell and Developmental Biology 9.
Crossref
Aliccia Bollig-Fischer, Bin Bao, Morenci Manning, Greg Dyson, Sharon K. Michelhaugh, Sandeep Mittal, Gerold Bepler & Hirva Mamdani. (2021) Role of novel cancer gene SLITRK3 to activate NTRK3 in squamous cell lung cancer. Molecular Biomedicine 2:1.
Crossref
Arnon Silapech, Satapat Racha, Nithikoon Aksorn, Pennapa Lafauy, Sucharat Tungsukruthai, Chanida Vinayanuwattikun, Boonchoo Sritularak & Pithi Chanvorachote. (2021) Pongol Methyl Ether Inhibits Akt and Suppresses Cancer Stem Cell Phenotypes in Lung Cancer Cells. Pharmaceuticals 14:11, pages 1085.
Crossref
Yuefan Guo, Guangxue Wang, Zhongrui Wang, Xin Ding, Lu Qian, Ya Li, Zhen Ren, Pengfei Liu, Wenjing Ma, Danni Li, Yuan Li, Qian Zhao, Jinhui Lü, Qinchuan Li, Qinhong Wang & Zuoren Yu. (2021) Reck-Notch1 Signaling Mediates miR-221/222 Regulation of Lung Cancer Stem Cells in NSCLC. Frontiers in Cell and Developmental Biology 9.
Crossref
Kyren A. Lazarus, Adam Pennycuick, Robert E. Hynds & Sam M. Janes. 2021. Lung Stem Cells in Development, Health and Disease. Lung Stem Cells in Development, Health and Disease 340 352 .
Man Wu, Xiang Tong, Dongguang Wang, Lei Wang & Hong Fan. (2020) Soluble intercellular cell adhesion molecule-1 in lung cancer: A meta-analysis. Pathology - Research and Practice 216:10, pages 153029.
Crossref
Hong Li, Jingyu Wang, Chunfu Wu, Lihui Wang, Zhe-Sheng Chen & Wei Cui. (2020) The combination of disulfiram and copper for cancer treatment. Drug Discovery Today 25:6, pages 1099-1108.
Crossref
Takeshi Namekawa, Kazuhiro Ikeda, Kuniko Horie‐Inoue, Takashi Suzuki, Koji Okamoto, Tomohiko Ichikawa, Akihiro Yano, Satoru Kawakami & Satoshi Inoue. (2019) ALDH1A1 in patient‐derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression. International Journal of Cancer 146:4, pages 1099-1113.
Crossref
Monica Piccione & Rosa Di Liddo. 2020. Cancer Stem Cells: New Horizons in Cancer Therapies. Cancer Stem Cells: New Horizons in Cancer Therapies 111 124 .
Heena Jariyal, Chanchal Gupta, Vedika Sandeep Bhat, Jayant Ramakant Wagh & Akshay Srivastava. (2019) Advancements in Cancer Stem Cell Isolation and Characterization. Stem Cell Reviews and Reports 15:6, pages 755-773.
Crossref
Somayeh Shafiei, Elham Kalantari, Leili Saeednejad Zanjani, Maryam Abolhasani, Mohammad Hossein Asadi Lari & Zahra Madjd. (2019) Increased expression of DCLK1, a novel putative CSC maker, is associated with tumor aggressiveness and worse disease-specific survival in patients with bladder carcinomas. Experimental and Molecular Pathology 108, pages 164-172.
Crossref
Zhi Yang, Fang Guo, Andreas E. Albers, Jalid Sehouli & Andreas M. Kaufmann. (2019) Disulfiram modulates ROS accumulation and overcomes synergistically cisplatin resistance in breast cancer cell lines. Biomedicine & Pharmacotherapy 113, pages 108727.
Crossref
Asieh Sadeghi, Raheleh Roudi, Alireza Mirzaei, Ali Zare Mirzaei, Zahra Madjd & Maryam Abolhasani. (2019) CD44 epithelial isoform inversely associates with invasive characteristics of colorectal cancer. Biomarkers in Medicine 13:6, pages 419-426.
Crossref
Gui-Min Wen, Fei-Fei Mou, Wei Hou, Dan Wang & Pu Xia. (2018) Integrative Analysis of CD133 mRNA in Human Cancers Based on Data Mining. Stem Cell Reviews and Reports 15:1, pages 23-34.
Crossref
Akshay Malhotra, Uttam Sharma, Shyamly Puhan, Naga Chandra Bandari, Anjali Kharb, P.P. Arifa, Lovlesh Thakur, Hridayesh Prakash, Karen M. Vasquez & Aklank Jain. (2019) Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy. Biochimie 156, pages 148-157.
Crossref
Mariel E Toledo-Guzmán, Gabriele D Bigoni-Ordóñez, Miguel Ibáñez Hernández & Elizabeth Ortiz-Sánchez. (2018) Cancer stem cell impact on clinical oncology. World Journal of Stem Cells 10:12, pages 183-195.
Crossref
Arezoo Rasti, Mitra Mehrazma, Zahra Madjd, Maryam Abolhasani, Leili Saeednejad Zanjani & Mojgan Asgari. (2018) Co-expression of Cancer Stem Cell Markers OCT4 and NANOG Predicts Poor Prognosis in Renal Cell Carcinomas. Scientific Reports 8:1.
Crossref
Zahra Fathi, Seyed Ali Javad Mousavi, Raheleh Roudi & Farideh Ghazi. (2018) Distribution of KRAS, DDR2, and TP53 gene mutations in lung cancer: An analysis of Iranian patients. PLOS ONE 13:7, pages e0200633.
Crossref
Zahra Fathi, Nicholas L. Syn, Jian-Guo Zhou & Raheleh Roudi. (2018) Molecular epidemiology of lung cancer in Iran: implications for drug development and cancer prevention. Journal of Human Genetics 63:7, pages 783-794.
Crossref
Dan Wang, Gui-Min Wen, Wei Hou & Pu Xia. (2018) The roles of CD133 expression in the patients with non-small cell lung cancer. Cancer Biomarkers 22:3, pages 385-394.
Crossref
N. S Alkon, A. E Ivanova, E. I Frolova & S. P Chumakov. (2018) Therapeutic strategies for targeting cancer stem cells. Genes & Cells 13:2, pages 25-34.
Crossref
Subbroto Saha, Kyeongseok Kim, Gwang-Mo Yang, Hye Choi & Ssang-Goo Cho. (2018) Cytokeratin 19 (KRT19) has a Role in the Reprogramming of Cancer Stem Cell-Like Cells to Less Aggressive and More Drug-Sensitive Cells. International Journal of Molecular Sciences 19:5, pages 1423.
Crossref
Arezoo Rasti, Zahra Madjd, Maryam Abolhasani, Mitra Mehrazma, Leila Janani, Leili Saeednejad Zanjani & Mojgan Asgari. (2017) Cytoplasmic expression of Twist1, an EMT-related transcription factor, is associated with higher grades renal cell carcinomas and worse progression-free survival in clear cell renal cell carcinoma. Clinical and Experimental Medicine 18:2, pages 177-190.
Crossref
Neema Tiwari, AnandN Srivastava, Nishi Tandon, Nirupma Lal, Shailendra Yadav, Surya Kant & Manoj Jain. (2018) A prospective study of association of cancer stem cell marker aldehyde dehydrogenase 1 with clinicopathological profile in lung carcinoma patients. Indian Journal of Pathology and Microbiology 61:4, pages 489.
Crossref
Kayla C. Lewis & Yi Liu. 2018. Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs. Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs 141 149 .
Elham Kalantari, Mohammad Hossein Asadi Lari, Raheleh Roudi, Alireza Korourian & Zahra Madjd. (2017) Lgr5High/DCLK1High phenotype is more common in early stage and intestinal subtypes of gastric carcinomas. Cancer Biomarkers 20:4, pages 563-573.
Crossref
Ghada E. Esheba, Amal A. Hassan, Mona Z. El Bostany & Mohamed H. Aly. (2017) Prognostic value of cancer stem cell markers and E-cadherin expression in non-small-cell lung cancer. Egyptian Journal of Pathology 37:2, pages 281-288.
Crossref
Ahmad H. Othman, Manish Tandon, Imad Tarhoni, Jeffrey A. Borgia & Jitesh Pratap. (2017) Lung Cancer Stem Cells: Insights into Characterization and Regulatory Mechanisms. Current Molecular Biology Reports 3:4, pages 247-253.
Crossref
Ahad Mokhtarzadeh, Soodabeh Hassanpour, Zahra Farajzadeh Vahid, Maryam Hejazi, Maryam Hashemi, Javad Ranjbari, Maryam Tabarzad, Saeed Noorolyai & Miguel de la Guardia. (2017) Nano-delivery system targeting to cancer stem cell cluster of differentiation biomarkers. Journal of Controlled Release 266, pages 166-186.
Crossref
Alireza Korourian, Raheleh Roudi, Ahmad Shariftabrizi, Elham Kalantari, Kambiz Sotoodeh & Zahra Madjd. (2016) Differential role of Wnt signaling and base excision repair pathways in gastric adenocarcinoma aggressiveness. Clinical and Experimental Medicine 17:4, pages 505-517.
Crossref
Leili Saeednejad Zanjani, Zahra Madjd, Maryam Abolhasani, Yvonne Andersson, Arezoo Rasti, Ahmad Shariftabrizi & Mojgan Asgari. (2017) Cytoplasmic expression of CD133 stemness marker is associated with tumor aggressiveness in clear cell renal cell carcinoma. Experimental and Molecular Pathology 103:2, pages 218-228.
Crossref
Elham Kalantari, Faezeh H. Saadi, Mojgan Asgari, Ahmad Shariftabrizi, Raheleh Roudi & Zahra Madjd. (2017) Increased Expression of ALDH1A1 in Prostate Cancer is Correlated With Tumor Aggressiveness: A Tissue Microarray Study of Iranian Patients. Applied Immunohistochemistry & Molecular Morphology 25:8, pages 592-598.
Crossref
Raheleh Roudi, Marzieh Ebrahimi, Ahmad Shariftabrizi & Zahra Madjd. (2017) Cancer stem cell research in Iran: potentials and challenges. Future Oncology 13:20, pages 1809-1826.
Crossref
Raheleh Roudi, Shahla Roudbar Mohammadi, Maryam Roudbary & Monireh Mohsenzadegan. (2017) Lung cancer and β-glucans: review of potential therapeutic applications. Investigational New Drugs 35:4, pages 509-517.
Crossref
Mozhdeh Foroozan, Raheleh Roudi, Maryam Abolhasani, Elmira Gheytanchi & Mitra Mehrazma. (2017) Clinical significance of endothelial cell marker CD34 and mast cell marker CD117 in prostate adenocarcinoma. Pathology - Research and Practice 213:6, pages 612-618.
Crossref
C. Allison Stewart, Pan Tong, Robert J. Cardnell, Triparna Sen, Lerong Li, Carl M. Gay, Fatemah Masrorpour, You Fan, Rasha O. Bara, Ying Feng, Yuanbin Ru, Junya Fujimoto, Samrat T. Kundu, Leonard E. Post, Karen Yu, Yuqiao Shen, Bonnie S. Glisson, Ignacio Wistuba, John V. Heymach, Don L. Gibbons, Jing Wang & Lauren Averett Byers. (2017) Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer. Oncotarget 8:17, pages 28575-28587.
Crossref
Shirin Sedaghat, Elmira Gheytanchi, Mojgan Asgari, Raheleh Roudi, Hossein Keymoosi & Zahra Madjd. (2017) Expression of Cancer Stem Cell Markers OCT4 and CD133 in Transitional Cell Carcinomas. Applied Immunohistochemistry & Molecular Morphology 25:3, pages 196-202.
Crossref
Niamh Lynam-Lennon, Susan Heavey, Gary Sommerville, Becky A.S. Bibby, Brendan Ffrench, Jennifer Quinn, Claudia Gasch, John J. O’Leary, Michael F. Gallagher, John V. Reynolds & Stephen G. Maher. (2016) MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype. Oncotarget 8:7, pages 11400-11413.
Crossref
Elham Kalantari, Mojgan Asgari, Seyedehmoozhan Nikpanah, Naghme Salarieh, Mohammad Hossein Asadi Lari & Zahra Madjd. (2017) Co-Expression of Putative Cancer Stem Cell Markers CD44 and CD133 in Prostate Carcinomas. Pathology & Oncology Research.
Crossref
Soumyabrata Roy, Kai Lu, Mukti Kant Nayak, Avishek Bhuniya, Tithi Ghosh, Suman Kundu, Sarbari Ghosh, Rathindranath Baral, Partha Sarathi Dasgupta & Sujit Basu. (2017) Activation of D2 Dopamine Receptors in CD133+ve Cancer Stem Cells in Non-small Cell Lung Carcinoma Inhibits Proliferation, Clonogenic Ability, and Invasiveness of These Cells. Journal of Biological Chemistry 292:2, pages 435-445.
Crossref
Arezoo Rasti, Maryam Abolhasani, Leili Saeednejad Zanjani, Mojgan Asgari, Mitra Mehrazma & Zahra Madjd. (2016) Reduced expression of CXCR4, a novel renal cancer stem cell marker, is associated with high-grade renal cell carcinoma. Journal of Cancer Research and Clinical Oncology 143:1, pages 95-104.
Crossref
Zhenbo Tu, Songping Xie, Meng Xiong, Yinchu Liu, Xiangyong Yang, Kingsley Tembo, Jie Huang, Weidong Hu, Xiaoxing Huang, Shan Pan, Pan Liu, Ehtisham Altaf, Ganjun Kang, Jie Xiong & Qiuping Zhang. (2016) CXCR4 is involved in CD133-induced EMT in non-small cell lung cancer. International Journal of Oncology.
Crossref
Raheleh Roudi, Zahra Madjd, Marzieh Ebrahimi, Ali Najafi, Alireza Korourian, Ahmad Shariftabrizi & Ali Samadikuchaksaraei. (2016) Evidence for embryonic stem-like signature and epithelial-mesenchymal transition features in the spheroid cells derived from lung adenocarcinoma. Tumor Biology 37:9, pages 11843-11859.
Crossref
Marta Di Martile, Marianna Desideri, Teresa De Luca, Chiara Gabellini, Simonetta Buglioni, Adriana Eramo, Giovanni Sette, Michele Milella, Dante Rotili, Antonello Mai, Simone Carradori, Daniela Secci, Ruggero De Maria, Donatella Del Bufalo & Daniela Trisciuoglio. (2016) Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells. Oncotarget 7:10, pages 11332-11348.
Crossref
Elham Erfani, Raheleh Roudi, Azadeh Rakhshan, Mehrdad Nasrollahzadeh Sabet, Ahmad Shariftabrizi & Zahra Madjd. (2016) Comparative Expression Analysis of Putative Cancer Stem Cell Markers CD44 and ALDH1A1 in Various Skin Cancer Subtypes. The International Journal of Biological Markers 31:1, pages 53-61.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.