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Cancer Investigation Volume 33, 2015 - Issue 9
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ORIGINAL ARTICLE

RG7112, a Small-Molecule Inhibitor of MDM2, Enhances Trabectedin Response in Soft Tissue Sarcomas

Antònia Obrador-HeviaGroup of Advanced Therapies and Biomarkers in Clinical Oncology, Institut d'Investigació Sanitària de Palma (IdISPa), Palma de Mallorca, Spain;Department of Oncology, Hospital Universitari Son Espases, Palma de Mallorca, SpainCorrespondence[email protected]
,
Esther Martinez-FontGroup of Advanced Therapies and Biomarkers in Clinical Oncology, Institut d'Investigació Sanitària de Palma (IdISPa), Palma de Mallorca, Spain
,
Irene Felipe-AbrioGroup of Molecular Oncology and New Therapies, Oncohematology and Genetics Department, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain
,
Silvia Calabuig-FariñasMolecular Oncology Laboratory, Fundación de Investigación, Hospital General Universitario de Valencia, Valencia, Spain
,
Margalida Serra-SitjarCancer Cell Biology Group, Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain
,
José Antonio López-GuerreroLaboratory of Molecular Biology, Fundación Instituto Valenciano de Oncología, Valencia, Spain
,
Rafael RamosDepartment of Pathology, Hospital Universitari Son Espases, Palma de Mallorca, Spain
,
Regina AlemanyGroup of Advanced Therapies and Biomarkers in Clinical Oncology, Institut d'Investigació Sanitària de Palma (IdISPa), Palma de Mallorca, Spain;Group of Clinical and Translational Research, Department of Biology, Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain
&
Javier Martín-BrotoGroup of Molecular Oncology and New Therapies, Oncohematology and Genetics Department, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain;Department of Oncology, Hospital Universitario Virgen del Rocío, Sevilla, Spain
 show all
Pages 440-450 | Received 29 Aug 2014, Accepted 17 Jun 2015, Published online: 17 Aug 2015

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Akash Tiwari, Vineet Govinda Gupta & Sameer Bakhshi. (2017) Newer medical therapies for metastatic soft tissue sarcoma. Expert Review of Anticancer Therapy 17:3, pages 257-270.
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Antoine Italiano, Wilson H. MillerJrJr, Jean-Yves Blay, Jourik A. Gietema, Yung-Jue Bang, Linda R. Mileshkin, Hal W. Hirte, Brian Higgins, Steven Blotner, Gwen L. Nichols, Lin Chi Chen, Claire Petry, Qi Joy Yang, Christophe Schmitt, Candice Jamois & Lillian L. Siu. (2021) Phase I study of daily and weekly regimens of the orally administered MDM2 antagonist idasanutlin in patients with advanced tumors. Investigational New Drugs 39:6, pages 1587-1597.
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Raf Sciot. (2021) MDM2 Amplified Sarcomas: A Literature Review. Diagnostics 11:3, pages 496.
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Sara Lago, Matteo Nadai, Emanuela Ruggiero, Martina Tassinari, Maja Marušič, Beatrice Tosoni, Ilaria Frasson, Filippo M Cernilogar, Valentina Pirota, Filippo Doria, Janez Plavec, Gunnar Schotta & Sara N Richter. (2021) The MDM2 inducible promoter folds into four-tetrad antiparallel G-quadruplexes targetable to fight malignant liposarcoma . Nucleic Acids Research 49:2, pages 847-863.
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Xulin Zhang. (2021) MDM2 inhibitors: Targeting p53-MDM2 interaction to anti-cancer. E3S Web of Conferences 308, pages 02015.
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Kuan HuKuan Hu. 2021. Development of In-Tether Carbon Chiral Center-Induced Helical Peptide. Development of In-Tether Carbon Chiral Center-Induced Helical Peptide 65 99 .
Yuan Fang, Guochao Liao & Bin Yu. (2020) Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy: advances and perspectives. Acta Pharmaceutica Sinica B 10:7, pages 1253-1278.
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Paul Chih-Hsueh Chen, Chueh-Chuan Yen, Giun-Yi Hung, Chin-Chen Pan & Wei-Ming Chen. (2019) Gene amplification and tumor grading in parosteal osteosarcoma. Journal of the Chinese Medical Association 82:12, pages 889-894.
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Elizabeth Thoenen, Amanda Curl & Tomoo Iwakuma. (2019) TP53 in bone and soft tissue sarcomas. Pharmacology & Therapeutics 202, pages 149-164.
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Justyna Kocik, Monika Machula, Aneta Wisniewska, Ewa Surmiak, Tad A. Holak & Lukasz Skalniak. (2019) Helping the Released Guardian: Drug Combinations for Supporting the Anticancer Activity of HDM2 (MDM2) Antagonists. Cancers 11:7, pages 1014.
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Abdulhameed Al-GhabkariAru Narendran. (2019) In Vitro Characterization of a Potent p53-MDM2 Inhibitor, RG7112 in Neuroblastoma Cancer Cell Lines . Cancer Biotherapy and Radiopharmaceuticals 34:4, pages 252-257.
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Masayuki Akita, Keitaro Sofue, Kohei Fujikura, Kyoko Otani, Tomoo Itoh, Tetsuo Ajiki, Takumi Fukumoto & Yoh Zen. (2019) Histological and molecular characterization of intrahepatic bile duct cancers suggests an expanded definition of perihilar cholangiocarcinoma. HPB 21:2, pages 226-234.
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Regina Alemany, David S. Moura, Andres Redondo, Javier Martinez-Trufero, Silvia Calabuig, Carlos Saus, Antonia Obrador-Hevia, Rafael Ramos, Victor H. Villar, Claudia Valverde, Maria Angeles Vaz, Javier Medina, Irene Felipe-Abrio, Nadia Hindi, Miguel Taron & Javier Martin-Broto. (2018) Nilotinib as Coadjuvant Treatment with Doxorubicin in Patients with Sarcomas: A Phase I Trial of the Spanish Group for Research on Sarcoma. Clinical Cancer Research 24:21, pages 5239-5249.
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Anusha Sriraman, Antje Dickmanns, Zeynab Najafova, Steven A. Johnsen & Matthias Dobbelstein. (2018) CDK4 inhibition diminishes p53 activation by MDM2 antagonists. Cell Death & Disease 9:9.
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Sung Joo Kim, Masayuki Akita, You-Na Sung, Kohei Fujikura, Jae Hoon Lee, Shin Hwang, Eunsil Yu, Kyoko Otani, Seung-Mo Hong & Yoh Zen. (2018) MDM2 Amplification in Intrahepatic Cholangiocarcinomas. American Journal of Surgical Pathology 42:4, pages 512-521.
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Audrey Laroche, Vanessa Chaire, François Le Loarer, Marie-Paule Algéo, Christophe Rey, Kevin Tran, Carlo Lucchesi & Antoine Italiano. (2017) Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas. Journal of Hematology & Oncology 10:1.
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Olaf Merkel, Ninon Taylor, Nicole Prutsch, Philipp B. Staber, Richard Moriggl, Suzanne D. Turner & Lukas Kenner. (2017) When the guardian sleeps: Reactivation of the p53 pathway in cancer. Mutation Research/Reviews in Mutation Research 773, pages 1-13.
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Agostinho Lemos, Mariana Leão, Joana Soares, Andreia Palmeira, Madalena Pinto, Lucília Saraiva & Maria Emília Sousa. (2016) Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction. Medicinal Research Reviews 36:5, pages 789-844.
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Javier Martin-Broto & Nadia Hindi. (2016) Targeted treatments of sarcomas and connective tumors beside gastrointestinal stromal tumor. Current Opinion in Oncology 28:4, pages 338-344.
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