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Original Article

O6-Methylguanine-DNA Methyltransferase in Normal and Malignant Tissue of the Breast

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Pages 605-610 | Published online: 11 Jun 2009

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George C. Bobustuc, Amin B. Kassam, Richard A. Rovin, Sheila Jeudy, Joshua S. Smith, Beth Isley, Maharaj Singh, Ameya Paranjpe, Kalkunte S. Srivenugopal & Santhi D. Konduri. (2018) MGMT inhibition in ER positive breast cancer leads to CDC2, TOP2A, AURKB, CDC20, KIF20A, Cyclin A2, Cyclin B2, Cyclin D1, ERα and Survivin inhibition and enhances response to temozolomide. Oncotarget 9:51, pages 29727-29742.
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Roberto Gutierrez, Yesenia Thompson & Timothy R. O’Connor. (2018) DNA direct repair pathways in cancer. AIMS Medical Science 5:3, pages 284-302.
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Nan Ge, Liqiang Guo, Jie Zhang, Zhaomin Lin, Yan Li, Yuqiang Liu, Feng Kong, Xiaolei Fang & Shengtian Zhao. (2015) Impact of O 6 -methylguanine-DNA methyltransferase expression on the drug resistance of clear cell renal cell carcinoma . Japanese Journal of Clinical Oncology 45:9, pages 860-866.
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SAYURI ISONO, MAKOTO FUJISHIMA, TATSUYA AZUMI, YUKIHIKO HASHIMOTO, YOSHIFUMI KOMOIKE, MASAO YUKAWA & MASAHIRO WATATANI. (2014) O6-methylguanine-DNA methyltransferase as a prognostic and predictive marker for basal-like breast cancer treated with cyclophosphamide-based chemotherapy. Oncology Letters 7:6, pages 1778-1784.
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Gennaro Altamura, Maria Strazzullo, Annunziata Corteggio, Romina Francioso, Franco Roperto, Maurizio D'Esposito & Giuseppe Borzacchiello. (2012) O6-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis. BMC Veterinary Research 8:1.
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George C Bobustuc, Joshua S Smith, Sreeram Maddipatla, Sheila Jeudy, Arati Limaye, Beth Isley, Maria-Lourdes M Caparas, Susan M Constantino, Nikita Shah, Cheryl H Baker, Kalkunte S Srivenugopal, Said Baidas & Santhi D Konduri. (2012) MGMT Inhibition Restores ERα Functional Sensitivity to Antiestrogen Therapy. Molecular Medicine 18:6, pages 913-929.
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Markus Christmann, Barbara Verbeek, Wynand P. Roos & Bernd Kaina. (2011) O6-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1816:2, pages 179-190.
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M Clemons, J Kelly, A J Watson, A Howell, R S McElhinney, T B H McMurry & G P Margison. (2005) O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts. British Journal of Cancer 93:10, pages 1152-1156.
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Mark Clemons, Malcolm Ranson, Jennifer M. Margison, Hassan El Teraifi, Audrey Griffiths, Jane Kelly, Charles Q. Morris, Anthony Howell & Geoffrey P. Margison. (2002) Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole‐4‐carboxamide–bischloroethylnitrosourea combination therapy in patients with advanced breast cancer. International Journal of Cancer 103:5, pages 686-692.
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M J Clemons, M C Bibby, H El Teraifi, G Forster, J Kelly, S Banerjee, B Cadman, W D J Ryder, A Howell & G P Margison. (2002) Heterogeneity of O6-alkylguanine DNA-alkyltransferase expression in human breast tumours. British Journal of Cancer 86:11, pages 1797-1802.
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Stanton L. Gerson. (2002) Clinical Relevance of MGMT in the Treatment of Cancer . Journal of Clinical Oncology 20:9, pages 2388-2399.
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Javed Musarrat, Jasna A. Wilson & Altaf A. Wani. (1996) Localization of O6-alkylguanine transferase in cancer susceptible cells of human female breast. Cancer Letters 108:1, pages 111-118.
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Anthony E. Pegg, M. Eileen Dolan & Robert C. Moschel. 1995. 167 223 .

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