Advanced search
Publication Cover
Critical Reviews in Biotechnology Volume 34, 2014 - Issue 3
Submit an article Journal homepage
866
Views
59
CrossRef citations to date
0
Altmetric
Review Article

Advances in research of the artificial cultivation of Ophiocordyceps sinensis in China

Xuan-Wei ZhouPlant Biotechnology Research Centre, School of Agriculture and Biology, Shanghai Jiao Tong University Shanghai 200240People’s Republic of China;Tibet Shengniu Biotechnology Co., Ltd. Lhasa, Tibet 85000People’s Republic of ChinaCorrespondence[email protected] [email protected]
,
Lin-Jun LiKey Laboratory for Urban Habitat Environment Science and Technology, School of Environment and Energy, Shenzhen Graduate School of Peking University Shenzhen 518005People’s Republic of China
&
En-Wei TianKey Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences Guangzhou 510650People’s Republic of China
Pages 233-243 | Received 26 Apr 2012, Accepted 12 Feb 2013, Published online: 22 Jul 2013

Citations (59)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Li-Wei Zhou, Masoomeh Ghobad-Nejhad, Xue-Mei Tian, Yi-Fei Wang & Fang Wu. (2022) Current Status of ‘Sanghuang’ as a Group of Medicinal Mushrooms and Their Perspective in Industry Development. Food Reviews International 38:4, pages 589-607.
Read now
Xiao Li, Qing Liu, Wenjia Li, Quanping Li, Zhengming Qian, Xingzhong Liu & Caihong Dong. (2019) A breakthrough in the artificial cultivation of Chinese cordyceps on a large-scale and its impact on science, the economy, and industry. Critical Reviews in Biotechnology 39:2, pages 181-191.
Read now
Jian Dong Cui. (2015) Biotechnological production and applications of Cordyceps militaris, a valued traditional Chinese medicine. Critical Reviews in Biotechnology 35:4, pages 475-484.
Read now
Caihong Dong, Suping Guo, Wenfeng Wang & Xingzhong Liu. (2015) Cordyceps industry in China. Mycology 6:2, pages 121-129.
Read now

Articles from other publishers (55)

Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu & Jinlin Guo. (2024) Histopathological observations and comparative transcriptome analysis of Ophiocordyceps sinensis infection of Hepialus xiaojinensis in the early stage. Developmental & Comparative Immunology 150, pages 105067.
Crossref
Aakriti Sharma, Ekjot Kaur, Robin Joshi, Pooja Kumari, Abhishek Khatri, Mohit Kumar Swarnkar, Dinesh Kumar, Vishal Acharya & Gireesh Nadda. (2023) Systematic analyses with genomic and metabolomic insights reveal a new species, Ophiocordyceps indica sp. nov. from treeline area of Indian Western Himalayan region. Frontiers in Microbiology 14.
Crossref
Tshering Dorji, Deki Yangzom, Nima Norbu, Sangay Rinchen, Jambay Dorjee & Tenzin Tenzin. (2023) Understanding the impact of climate change and resilience among highlanders in northern parts of Bhutan: A case study in Gasa district. PLOS Climate 2:4, pages e0000079.
Crossref
Kun Ran, Zixi Fu, Mengjun Wu, Xiaoxiao Chen, Sha Xu, Cuiping Tong, Yao Chen, Yun Zhang, Hong Wang, Weiguang Shan, Wei Mao & Youmin Ying. (2023) Secondary metabolites from the Cordceps-colonizing fungus aspergillus versicolor ZJUTE2. Fitoterapia, pages 105501.
Crossref
Ting Peng, Pan Yue, Wen B. Ma, Mei L. Zhao, Jin L. Guo & Xin X. Tong. (2023) Growth characteristics and phylogenetic analysis of the isolate mycelium, Ophiocordyceps sinensis. Biologia.
Crossref
Chaoqun Tong, Tian Li, Shisui Luo, Ruoni Chen, Shijiang Chen, Junhong Wei, Yuling Qing, Shaorong Qin, Guoqing Pan, Chunfeng Li & Zeyang Zhou. (2023) Detection of the pathogenic fungus Cordyceps farinosa in the Thitarodes armoricanus soil-rearing environment based on nucleic acid targets . Canadian Journal of Microbiology 69:3, pages 136-145.
Crossref
Li Yuan, Ling-Ling Tong, Yue Wang, Yuan-Hang Du, Meng-Zhen Liu, Shao-Jie He, Shi-Xiang Wei, Yi-Dan Zhang, Zi-Lei Chen, Su-Xing Jin & Dong-Sheng Guo. (2023) Enhancing polysaccharide production by Paraisaria dubia spores batch fermentation through a pH-shift strategy based on kinetic analysis. Process Biochemistry 126, pages 292-298.
Crossref
Bo Ding, Yiwen Tao, Jianjun Xie, Guangfeng Zeng & Hongbo Huang. (2022) Traceability Evaluation of Wild and Cultivated Cordyceps sinensis by Elemental Analysis and GasBench II Coupled to Stable Isotope Ratio Mass Spectrometry. Food Analytical Methods 16:3, pages 515-524.
Crossref
Qing-Hua Liu, Yu-Dong Zhang, Zhang-Wen Ma, Zheng-Ming Qian, Zhi-Hong Jiang, Wei Zhang & Liang Wang. (2023) Fractional extraction and structural characterization of glycogen particles from the whole cultivated caterpillar fungus Ophiocordyceps sinensis. International Journal of Biological Macromolecules.
Crossref
Guiqing Liu, Li Cao & Richou Han. (2022) Plant quercetin degradation by gut bacterium Raoultella terrigena of ghost moth Thitarodes xiaojinensis. Frontiers in Microbiology 13.
Crossref
Chaoqun Tong, Junhong Wei, Guoqing Pan, Chunfeng Li & Zeyang Zhou. (2022) Study of Pathogenesis Using Fluorescent Strain of Cordyceps farinosa Revealed Infection of Thitarodes armoricanus Larvae via Digestive Tract. Insects 13:11, pages 1039.
Crossref
Manting Lin, Shan Guo, Di Xie, Sheng Li & Hankun Hu. (2022) Lipidomic profiling of wild cordyceps and its substituents by liquid chromatography-electrospray ionization-tandem mass spectrometry. LWT 163, pages 113497.
Crossref
Ling-Ling Tong, Yue Wang, Li Yuan, Meng-Zhen Liu, Yuan-Hang Du, Xin-Ya Mu, Qing-Hao Yang, Shi-Xiang Wei, Jun-Ya Li, Mian Wang & Dong-Sheng Guo. (2022) Enhancement of polysaccharides production using microparticle enhanced technology by Paraisaria dubia. Microbial Cell Factories 21:1.
Crossref
Fang Xie, Li He, Qiang Jun Su, Ying Xia, Gang Zhou & Zhao He Chen. (2022) Transcriptome Sequencing to Identify Candidate Genes for Mycelium Period Metabolism of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes), Exposed to Light Treatment. International Journal of Medicinal Mushrooms 24:8, pages 81-97.
Crossref
Guo-Dong Wu, An Pan, Xu Zhang, Yuan-Yuan Cai, Qi Wang, Feng-Qing Huang, Raphael N. Alolga, Jing Li, Lian-Wen Qi & Qun Liu. (2022) Cordyceps Improves Obesity and its Related Inflammation via Modulation of Enterococcus cecorum Abundance and Bile Acid Metabolism . The American Journal of Chinese Medicine 50:03, pages 817-838.
Crossref
Hailin Long, Xuehong Qiu, Li Cao & Richou Han. (2021) Discovery of the signal pathways and major bioactive compounds responsible for the anti-hypoxia effect of Chinese cordyceps. Journal of Ethnopharmacology 277, pages 114215.
Crossref
Guiqing Liu, Xuehong Zheng, Hailin Long, Zhongchen Rao, Li Cao & Richou Han. (2021) Gut Bacterial and Fungal Communities of the Wild and Laboratory-Reared Thitarodes Larvae, Host of the Chinese Medicinal Fungus Ophiocordyceps sinensis on Tibetan Plateau. Insects 12:4, pages 327.
Crossref
Hailin Long, Xuehong Qiu, Li Cao, Guiqing Liu, Zhongchen Rao & Richou Han. (2021) Toxicological safety evaluation of the cultivated Chinese cordyceps. Journal of Ethnopharmacology 268, pages 113600.
Crossref
Anawinla Ta Anyu, Wen-Hui Zhang & Qi-He Xu. (2021) Cultivated Cordyceps: A Tale of Two Treasured Mushrooms. Chinese Medicine and Culture 4:4, pages 221-227.
Crossref
Hua Wu, Zhong-Chen Rao, Li Cao, Patrick De Clercq & Ri-Chou Han. (2020) Infection of Ophiocordyceps sinensis Fungus Causes Dramatic Changes in the Microbiota of Its Thitarodes Host. Frontiers in Microbiology 11.
Crossref
Zhengyang Wang, Meng Li, Wenbin Ju, Wenqing Ye, Longhai Xue, David E. Boufford, Xinfen Gao, Bisong Yue, Yong Liu & Naomi E. Pierce. (2020) The entomophagous caterpillar fungus Ophiocordyceps sinensis is consumed by its lepidopteran host as a plant endophyte. Fungal Ecology 47, pages 100989.
Crossref
Chetan Ram, Ankush Kumar Jha, Aparajita Ghosh, Shobhit Gairola, Abu Mohammad Syed, Upadhyayula Suryanarayana Murty, V.G.M. Naidu & Bidya Dhar Sahu. (2020) Targeting NLRP3 inflammasome as a promising approach for treatment of diabetic nephropathy: Preclinical evidences with therapeutic approaches. European Journal of Pharmacology 885, pages 173503.
Crossref
Zhiyong Li, Caifeng Li, Xiaobo Zhang, Shihuan Tang, Hongjun Yang, Xiuming Cui & Luqi Huang. (2020) Policies and Problems of Modernizing Ethnomedicine in China: A Focus on the Yi and Dai Traditional Medicines of Yunnan Province. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-14.
Crossref
Zhengyang Wang, Darong Yang, Rawal Janak & Naomi E Pierce. (2020) Report on the Emergence Time of a Species of Thitarodes Ghost Moth (Lepidoptera: Hepialidae), Host of the Caterpillar Fungus Ophiocordyceps sinensis (Ascomycota: Ophiocordycipitaceae) in Uttarakhand, India. Journal of Economic Entomology 113:4, pages 2031-2034.
Crossref
Kanchana Samarasinghe & Viduranga Y. Waisundara. 2020. Apolipoproteins, Triglycerides and Cholesterol. Apolipoproteins, Triglycerides and Cholesterol.
Xueyan Sun, Dongmei Liu, Yuanyuan Wang & Aimin Ma. (2020) Biogenesis of macrofungal sclerotia: influencing factors and molecular mechanisms. Applied Microbiology and Biotechnology 104:10, pages 4227-4234.
Crossref
Guiqing Liu, Li Cao, Xuehong Qiu & Richou Han. (2020) Quorum Sensing Activity and Hyphal Growth by External Stimuli in the Entomopathogenic Fungus Ophiocordyceps sinensis. Insects 11:4, pages 205.
Crossref
Guiqing Liu, Li Cao, Zhongchen Rao, Xuehong Qiu & Richou Han. (2020) Identification of the genes involved in growth characters of medicinal fungus Ophiocordyceps sinensis based on Agrobacterium tumefaciens–mediated transformation. Applied Microbiology and Biotechnology 104:6, pages 2663-2674.
Crossref
Miaomiao Li, Qian Meng, Huan Zhang, Ruoyao Ni, Guiling Zhou, Yanni Zhao, Peipei Wu, Ruihao Shu, Qilian Qin & Jihong Zhang. (2020) Vegetative development and host immune interaction of Ophiocordyceps sinensis within the hemocoel of the ghost moth larva, Thitarodes xiaojinensis. Journal of Invertebrate Pathology 170, pages 107331.
Crossref
Zhongchen Rao, Li Cao, Hua Wu, Xuehong Qiu, Guiqing Liu & Richou Han. (2019) Comparative Transcriptome Analysis of Thitarodes Armoricanus in Response to the Entomopathogenic Fungi Paecilomyces Hepiali and Ophiocordyceps Sinensis. Insects 11:1, pages 4.
Crossref
Guiqing Liu, Richou Han & Li Cao. (2019) Artificial Cultivation of the Chinese Cordyceps From Injected Ghost Moth Larvae. Environmental Entomology 48:5, pages 1088-1094.
Crossref
Shao, Lai, Jiang, Wang, Hong, Chen, Tan & Guo. (2019) Diversity and Co-Occurrence Patterns of Soil Bacterial and Fungal Communities of Chinese Cordyceps Habitats at Shergyla Mountain, Tibet: Implications for the Occurrence. Microorganisms 7:9, pages 284.
Crossref
Wen Zhang, Xiaona Li, Lina Ma, Uzair Urrehman, Xilinqiqige Bao, Yujing Zhang, Chen-Yu Zhang, Dongxia Hou & Zhen Zhou. (2018) Identification of microRNA-like RNAs in Ophiocordyceps sinensis. Science China Life Sciences 62:3, pages 349-356.
Crossref
Zhongchen Rao, Li Cao, Xuehong Qiu & Richou Han. (2019) Comparative transcriptome analysis reveals molecular strategies of ghost moth Thitarodes armoricanus in response to hypoxia and anoxia. Journal of Insect Physiology 112, pages 23-34.
Crossref
Chao Wang, Xiao-xia Hou, Hong-liang Rui, Li-jing Li, Jing Zhao, Min Yang, Li-jun Sun, Hong-rui Dong, Hong Cheng & Yi-Pu Chen. (2018) Artificially Cultivated Ophiocordyceps sinensis Alleviates Diabetic Nephropathy and Its Podocyte Injury via Inhibiting P2X7R Expression and NLRP3 Inflammasome Activation . Journal of Diabetes Research 2018, pages 1-16.
Crossref
Ping Zhang, Shenghui Cui, Xiu Ren, Shuai Kang, Feng Wei, Shuangcheng Ma & Bin Liu. (2018) Discriminatory Power Evaluation of Nuclear Ribosomal RNA Barcoding Sequences Through Ophiocordyceps sinensis Related Samples. Frontiers in Microbiology 9.
Crossref
Qi-Qing CHENG, Chun-Song CHENG, Yue OUYANG, Chi-Chou LAO, Hao CUI, Yu XIAN, Zhi-Hong JIANG, Wen-Jia LI & Hua ZHOU. (2018) Discovery of differential sequences for improving breeding and yield of cultivated Ophiocordyceps sinensis through ITS sequencing and phylogenetic analysis. Chinese Journal of Natural Medicines 16:10, pages 749-755.
Crossref
Lin Chen, Yuetao Liu, Qingfeng Guo, Qingxia Zheng & Wancun Zhang. (2018) Metabolomic comparison between wild Ophiocordyceps sinensis and artificial cultured Cordyceps militaris . Biomedical Chromatography 32:9, pages e4279.
Crossref
Ping Zhang, Saina Li, Juan Li, Feng Wei, Xianlong Cheng, Guifeng Zhang, Shuangcheng Ma & Bin Liu. (2018) Identification of Ophiocordyceps sinensis and Its Artificially Cultured Ophiocordyceps Mycelia by Ultra-Performance Liquid Chromatography/Orbitrap Fusion Mass Spectrometry and Chemometrics. Molecules 23:5, pages 1013.
Crossref
Zihong Chen, Ling Xu, Hong Yu, Wenbo Zeng, Yongdong Dai & Yuanbing Wang. Phylogeny and active ingredients of artificial Ophiocordyceps lanpingensis ascomata. Phylogeny and active ingredients of artificial Ophiocordyceps lanpingensis ascomata.
Lian-Xian Guo, Xiao-Ming Xu, Yue-Hui Hong, Yan Li & Jiang-Hai Wang. (2017) Stable Carbon Isotope Composition of the Lipids in Natural Ophiocordyceps sinensis from Major Habitats in China and Its Substitutes. Molecules 22:9, pages 1567.
Crossref
Xuan-Wei Zhou. 2017. Edible and Medicinal Mushrooms. Edible and Medicinal Mushrooms 385 413 .
Lian-Xian Guo, Yue-Hui Hong, Qian-Zhi Zhou, Qing Zhu, Xiao-Ming Xu & Jiang-Hai Wang. (2017) Fungus-larva relation in the formation of Cordyceps sinensis as revealed by stable carbon isotope analysis. Scientific Reports 7:1.
Crossref
Poyu Huang & Shoji Ohga. (2017) Utilization of Ceramic Beads for Edible Mushrooms Cultivation. Advances in Microbiology 07:12, pages 853-862.
Crossref
Xin Wei, Hankun Hu, Baogeng Zheng, Zikri Arslan, Hung-Chung Huang, Weidong Mao & Yi-Ming Liu. (2017) Profiling metals in Cordyceps sinensis by using inductively coupled plasma mass spectrometry. Analytical Methods 9:4, pages 724-728.
Crossref
Xincong Kang, Yongquan Hu, Jiang Hu, Liqin Hu, Feng Wang & Dongbo Liu. (2017) The mitochondrial genome of the lepidopteran host cadaver (Thitarodes sp.) of Ophiocordyceps sinensis and related phylogenetic analysis. Gene 598, pages 32-42.
Crossref
Fei Xia, Xin Chen, Meng-Yuan Guo, Xiao-Hui Bai, Yan Liu, Guang-Rong Shen, Yu-Ling Li, Juan Lin & Xuan-Wei Zhou. (2016) High-throughput sequencing-based analysis of endogenetic fungal communities inhabiting the Chinese Cordyceps reveals unexpectedly high fungal diversity. Scientific Reports 6:1.
Crossref
Fei Xia, Yan Liu, Meng-Yuan Guo, Guang-Rong Shen, Juan Lin & Xuan-Wei Zhou. (2016) Pyrosequencing analysis revealed complex endogenetic microorganism community from natural DongChong XiaCao and its microhabitat. BMC Microbiology 16:1.
Crossref
Jin Xu, Ying Huang, Xiang-Xiang Chen, Shuai-Chao Zheng, Peng Chen & Ming-He Mo. (2016) The Mechanisms of Pharmacological Activities of Ophiocordyceps sinensis Fungi . Phytotherapy Research 30:10, pages 1572-1583.
Crossref
Guiqing Liu, Xuehong Qiu, Li Cao, Yi Zhang, Zubing Zhan & Richou Han. (2016) Evaluation of Reference Genes for Reverse Transcription Quantitative PCR Studies of Physiological Responses in the Ghost Moth, Thitarodes armoricanus (Lepidoptera, Hepialidae). PLOS ONE 11:7, pages e0159060.
Crossref
Zui Tao, Li Cao, Yi Zhang, Yunshou Ye & Richou Han. (2016) Laboratory Rearing of Thitarodes armoricanus and Thitarodes jianchuanensis (Lepidoptera: Hepialidae), Hosts of the Chinese Medicinal Fungus Ophiocordyceps sinensis (Hypocreales: Ophiocordycipitaceae) . Journal of Economic Entomology 109:1, pages 176-181.
Crossref
Tianyi He, Ruxing Zhao, Yiran Lu, Wenjuan Li, Xinguo Hou, Yu Sun, Ming Dong & Li Chen. (2016) Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases. Evidence-Based Complementary and Alternative Medicine 2016, pages 1-9.
Crossref
Lian-Xian Guo, Xiao-Ming Xu, Fu-Rui Liang, Jian-Ping Yuan, Juan Peng, Chou-Fei Wu & Jiang-Hai Wang. (2015) Morphological Observations and Fatty Acid Composition of Indoor-Cultivated Cordyceps sinensis at a High-Altitude Laboratory on Sejila Mountain, Tibet. PLOS ONE 10:5, pages e0126095.
Crossref
Fei XiaYan LiuGuang-Rong ShenLian-Xian GuoXuan-Wei Zhou. (2015) Investigation and analysis of microbiological communities in natural Ophiocordyceps sinensis . Canadian Journal of Microbiology 61:2, pages 104-111.
Crossref
G. M. Shashidhar, P. Giridhar & B. Manohar. (2015) Functional polysaccharides from medicinal mushroom Cordyceps sinensis as a potent food supplement: extraction, characterization and therapeutic potentials – a systematic review. RSC Advances 5:21, pages 16050-16066.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.