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Review Article

Biotechnological production and applications of Cordyceps militaris, a valued traditional Chinese medicine

Pages 475-484 | Received 07 Apr 2013, Accepted 09 Nov 2013, Published online: 25 Mar 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Cen Chen, Yanli Han, Shuyan Li, Rongrong Wang & Cheng Tao. (2021) Nutritional, antioxidant, and quality characteristics of novel cookies enriched with mushroom (Cordyceps militaris) flour. CyTA - Journal of Food 19:1, pages 137-145.
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Eunhyun Choi, Junsang Oh & Gi-Ho Sung. (2020) Antithrombotic and Antiplatelet Effects of Cordyceps militaris. Mycobiology 48:3, pages 228-232.
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Chia-Wei Phan, Joon-Keong Wang, Shiau-Chuen Cheah, Murali Naidu, Pamela David & Vikineswary Sabaratnam. (2018) A review on the nucleic acid constituents in mushrooms: nucleobases, nucleosides and nucleotides. Critical Reviews in Biotechnology 38:5, pages 762-777.
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Mohd Adnan, Syed Amir Ashraf, Saif Khan, Eyad Alshammari & Amir Mahgoub Awadelkareem. (2017) Effect of pH, temperature and incubation time on cordycepin production from Cordyceps militaris using solid-state fermentation on various substrates. CyTA - Journal of Food 15:4, pages 617-621.
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Articles from other publishers (66)

Trung Thanh Nguyen, Thi Nguyen-Gia Le & Thuan Huy Nguyen. (2023) First report of emerging fungal pathogens of Cordyceps militaris in Vietnam. Scientific Reports 13:1.
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Minghao Li, Li Wang, Siyuan Guo, Nan Huang & Heng Ai. (2023) Cordycepin buffers anisomycin-induced fear memory deficit by restoring hippocampal BDNF. Biochemical and Biophysical Research Communications 665, pages 118-123.
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Yao Wang, Quan-Ying Dong, Run Luo, Qi Fan, Dong-E Duan, Van-Minh Dao, Yuan-Bing Wang & Hong Yu. (2023) Molecular Phylogeny and Morphology Reveal Cryptic Species in the Cordyceps militaris Complex from Vietnam. Journal of Fungi 9:6, pages 676.
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Nachon Raethong, Roypim Thananusak, Pattsarun Cheawchanlertfa, Pranesha Prabhakaran, Kittipong Rattanaporn, Kobkul Laoteng, Mattheos Koffas & Wanwipa Vongsangnak. (2023) Functional genomics and systems biology of Cordyceps species for biotechnological applications. Current Opinion in Biotechnology 81, pages 102939.
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Roypim Thananusak, Kobkul Laoteng, Nachon Raethong, Mattheos Koffas & Wanwipa Vongsangnak. (2022) Dissecting Metabolic Regulation in Mycelial Growth and Fruiting Body Developmental Stages of Cordyceps militaris through Integrative Transcriptome Analysis. Biotechnology and Bioprocess Engineering 28:3, pages 406-418.
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Hongyan Pei, Zhongmei He, Weijia Chen, Yan Zhao, Jianming Li, Ruibing Wang, Ying Zong & Rui Du. (2023) Network pharmacology and molecular docking analysis on the mechanism of Cordyceps militaris polysaccharide regulating immunity through TLR4/TNF‐α pathwayss . Journal of Biochemical and Molecular Toxicology 37:6.
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Li Yuan, Ling-Ling Tong, Yue Wang, Yuan-Hang Du, Meng-Zhen Liu, Shao-Jie He, Shi-Xiang Wei, Yi-Dan Zhang, Zi-Lei Chen, Su-Xing Jin & Dong-Sheng Guo. (2023) Enhancing polysaccharide production by Paraisaria dubia spores batch fermentation through a pH-shift strategy based on kinetic analysis. Process Biochemistry 126, pages 292-298.
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Nooshin Arshadi, Hoda Nouri & Hamid Moghimi. (2023) Increasing the production of the bioactive compounds in medicinal mushrooms: an omics perspective. Microbial Cell Factories 22:1.
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Hui Zhang, Ping Chen, Lin Xu, De Xu, Wendi Hu, Yong Cheng & Shengli Yang. (2022) Construction of Cordycepin High-Production Strain and Optimization of Culture Conditions. Current Microbiology 80:1.
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Nuriye Hilal Taştekin & Nadire Özenver. 2023. Mushrooms with Therapeutic Potentials. Mushrooms with Therapeutic Potentials 345 367 .
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Bai‐Xiong Chen, Ling‐Na Xue, Tao Wei, Na Wang, Jing‐Ru Zhong, Zhi‐Wei Ye, Li‐Qiong Guo & Jun‐Fang Lin. (2022) Multiplex gene precise editing and large DNA fragment deletion by the CRISPR‐Cas9‐TRAMA system in edible mushroom Cordyceps militaris . Microbial Biotechnology 15:12, pages 2982-2991.
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Sotirios Pilafidis, Panagiota Diamantopoulou, Konstantinos Gkatzionis & Dimitris Sarris. (2022) Valorization of Agro-Industrial Wastes and Residues through the Production of Bioactive Compounds by Macrofungi in Liquid State Cultures: Growing Circular Economy. Applied Sciences 12:22, pages 11426.
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Yingyi Zheng, Ruoqi Li & Xiang Fan. (2022) Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach. Antioxidants 11:9, pages 1811.
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Bai-Xiong Chen, Ling-Na Xue, Tao Wei, Zhi-Wei Ye, Xue-Hai Li, Li-Qiong Guo & Jun-Fang Lin. (2022) Enhancement of ergothioneine production by discovering and regulating its metabolic pathway in Cordyceps militaris. Microbial Cell Factories 21:1.
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Pattsarun Cheawchanlertfa, Suwalak Chitcharoen, Nachon Raethong, Qing Liu, Pramote Chumnanpuen, Panyawarin Soommat, Yuanda Song, Mattheos Koffas, Kobkul Laoteng & Wanwipa Vongsangnak. (2022) Enhancing Genome-Scale Model by Integrative Exometabolome and Transcriptome: Unveiling Carbon Assimilation towards Sphingolipid Biosynthetic Capability of Cordyceps militaris. Journal of Fungi 8:8, pages 887.
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Khamphe Phoungthong, Waraporn Aiphuk, Tharakorn Maneerat, Thitipone Suwunwong, Patcharanan Choto & Putarak Chomnunti. (2022) Utilization of Corncob Biochar in Cultivation Media for Cordycepin Production and Biomass of Cordyceps militaris. Sustainability 14:15, pages 9362.
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Yuan Li, Miao Miao, Fan Yin, Nuo Shen, Wen-Qian Yu & Shou-Dong Guo. (2022) The polysaccharide–peptide complex from mushroom Cordyceps militaris ameliorates atherosclerosis by modulating the lncRNA–miRNA–mRNA axis . Food & Function 13:6, pages 3185-3197.
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Abdul-Rehman Phull, Madiha Ahmed & Hye-Jin Park. (2022) Cordyceps militaris as a Bio Functional Food Source: Pharmacological Potential, Anti-Inflammatory Actions and Related Molecular Mechanisms. Microorganisms 10:2, pages 405.
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Thanh Tung Nguyen. (2022) Application of microcontroller and Blynk for cultured cordyceps. Journal of Physics: Conference Series 2199:1, pages 012013.
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Ling-Ling Tong, Yue Wang, Li Yuan, Meng-Zhen Liu, Yuan-Hang Du, Xin-Ya Mu, Qing-Hao Yang, Shi-Xiang Wei, Jun-Ya Li, Mian Wang & Dong-Sheng Guo. (2022) Enhancement of polysaccharides production using microparticle enhanced technology by Paraisaria dubia. Microbial Cell Factories 21:1.
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Yue Yu, Qiang Wen, Ao Song, Yang Liu, Fei Wang & Bin Jiang. (2022) Isolation and immune activity of a new acidic Cordyceps militaris exopolysaccharide. International Journal of Biological Macromolecules 194, pages 706-714.
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Fan Yin, Ping Lin, Wen-Qian Yu, Nuo Shen, Yuan Li & Shou-Dong Guo. (2021) The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR(-/-) Mice by Improving Hyperlipidemia. Frontiers in Molecular Biosciences 8.
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Wen-Qian Yu, Fan Yin, Nuo Shen, Ping Lin, Bin Xia, Yan-Jie Li & Shou-Dong Guo. (2021) Polysaccharide CM1 from Cordyceps militaris hinders adipocyte differentiation and alleviates hyperlipidemia in LDLR(+/−) hamsters. Lipids in Health and Disease 20:1.
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Qing Yang, Binmei Jia, Xiaomei Liu, Jialing Fang, Luyang Zhao, Lin Xu, Min Fang, Zhiyong Gong & Hui Sun. (2021) Molecular Cloning, Expression and Macrophage Activation of an Immunoregulatory Protein from Cordyceps militaris. Molecules 26:23, pages 7107.
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Dimitrios Kontogiannatos, Georgios Koutrotsios, Savvina Xekalaki & Georgios I. Zervakis. (2021) Biomass and Cordycepin Production by the Medicinal Mushroom Cordyceps militaris—A Review of Various Aspects and Recent Trends towards the Exploitation of a Valuable Fungus. Journal of Fungi 7:11, pages 986.
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Xue Cai, Jie-Yi Jin, Bo Zhang, Zhi-Qiang Liu & Yu-Guo Zheng. (2021) Improvement of cordycepin production by an isolated Paecilomyces hepiali mutant from combinatorial mutation breeding and medium screening. Bioprocess and Biosystems Engineering 44:11, pages 2387-2398.
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Lorena Avila-Carrasco, Elda Araceli García-Mayorga, Daisy L. Díaz-Avila, Idalia Garza-Veloz, Margarita L Martinez-Fierro & Guadalupe T González-Mateo. (2021) Potential Therapeutic Effects of Natural Plant Compounds in Kidney Disease. Molecules 26:20, pages 6096.
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Jie Sun, Jiangong Ren, Xuejian Hu, Yuanhua Hou & Yan Yang. (2021) Therapeutic effects of Chinese herbal medicines and their extracts on diabetes. Biomedicine & Pharmacotherapy 142, pages 111977.
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Xiao-Ying Yu, Yuan Zou, Qian-Wang Zheng, Feng-Xian Lu, De-Huai Li, Li-Qiong Guo & Jun-Fang Lin. (2021) Physicochemical, functional and structural properties of the major protein fractions extracted from Cordyceps militaris fruit body. Food Research International 142, pages 110211.
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Yoonjin Park, Seoyoon Choi, Boyong Kim & Seung Gwan Lee. (2021) Effects of Cordyceps militaris Extracts on Macrophage as Immune Conductors. Applied Sciences 11:5, pages 2206.
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Joana Santiago, Joana V. Silva, Manuel A. S. Santos & Margarida Fardilha. (2021) Fighting Bisphenol A-Induced Male Infertility: The Power of Antioxidants. Antioxidants 10:2, pages 289.
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Q. Liu & C. H. Dong. (2020) First Report of White Mold Caused by Trichothecium crotocinigenum on Cordyceps militaris in China . Plant Disease 104:12, pages 3253-3253.
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Chun-Ting Lee, Keng-Shiang Huang, Jei-Fu Shaw, Jung-Ren Chen, Wen-Shuo Kuo, Gangxu Shen, Alexandru Mihai Grumezescu, Alina Maria Holban, Yi-Ting Wang, Jun-Sheng Wang, Yi-Ping Hsiang, Yu-Mei Lin, Hsiao-Han Hsu & Chih-Hui Yang. (2020) Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin. Frontiers in Pharmacology 11.
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Fei Li, Zhaoxia Wu & Xin Sui. (2020) Biotransformation of ginsenoside Rb1 with wild Cordyceps sinensis and Ascomycota sp. and its antihyperlipidemic effects on the diet‐induced cholesterol of zebrafish . Journal of Food Biochemistry 44:6.
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Ya Zheng, Lan Li & Tiantian Cai. (2020) Cordyceps polysaccharide ameliorates airway inflammation in an ovalbumin-induced mouse model of asthma via TGF-β1/Smad signaling pathway. Respiratory Physiology & Neurobiology 276, pages 103412.
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Chengyi Liu, Meng Qi, Lin Li, Yuan Yuan, Xiaoping Wu & Junsheng Fu. (2020) Natural cordycepin induces apoptosis and suppresses metastasis in breast cancer cells by inhibiting the Hedgehog pathway. Food & Function 11:3, pages 2107-2116.
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Xue Wang, Yang-Le Gao, Ming-Liang Zhang, Huai-Dong Zhang, Jian-Zhong Huang & Li Li. (2020) Genome mining and biosynthesis of the Acyl-CoA:cholesterol acyltransferase inhibitor beauveriolide I and III in Cordyceps militaris. Journal of Biotechnology 309, pages 85-91.
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Bao-Lin He, Qian-Wang Zheng, Li-Qiong Guo, Jen-Yi Huang, Fan Yun, Shi-Shi Huang & Jun-Fang Lin. (2020) Structural characterization and immune-enhancing activity of a novel high-molecular-weight polysaccharide from Cordyceps militaris. International Journal of Biological Macromolecules 145, pages 11-20.
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Nachon Raethong, Hao Wang, Jens Nielsen & Wanwipa Vongsangnak. (2020) Optimizing cultivation of Cordyceps militaris for fast growth and cordycepin overproduction using rational design of synthetic media. Computational and Structural Biotechnology Journal 18, pages 1-8.
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Yueyue Li, Huandong Yang, Hailong Yang, Jing Wang & Hangjun Chen. (2018) Assessment of drying methods on the physiochemical property and antioxidant activity of Cordyceps militaris. Journal of Food Measurement and Characterization 13:1, pages 513-520.
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Lu Liu, Yang Chen, Qing Luo, Ning Xu, Mengzhou Zhou, Bing Gao, Chao Wang & Yong Shi. (2018) Fermenting liquid vinegar with higher taste, flavor and healthy value by using discarded Cordyceps militaris solid culture medium. LWT 98, pages 654-660.
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Jiapeng Tang, Zhenqing Qian & Hui Wu. (2018) Enhancing cordycepin production in liquid static cultivation of Cordyceps militaris by adding vegetable oils as the secondary carbon source. Bioresource Technology 268, pages 60-67.
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Qinqin Zhou, Zhang Zhang, Liyan Song, Chunhua Huang, Qi Cheng, Sixue Bi, Xianjing Hu & Rongmin Yu. (2018) Cordyceps militaris fraction inhibits the invasion and metastasis of lung cancer cells through the protein kinase B/glycogen synthase kinase 3β/β‑catenin signaling pathway. Oncology Letters.
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Bai-Xiong Chen, Tao Wei, Zhi-Wei Ye, Fan Yun, Lin-Zhi Kang, Hong-Biao Tang, Li-Qiong Guo & Jun-Fang Lin. (2018) Efficient CRISPR-Cas9 Gene Disruption System in Edible-Medicinal Mushroom Cordyceps militaris. Frontiers in Microbiology 9.
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Juan Yin, Xiang-Dong Xin, Yu-Jie Weng, Shao-Hui Li, Jun-Qiang Jia & Zhong-Zheng Gui. (2018) Genotypic analysis of degenerative Cordyceps militaris cultured in the pupa of Bombyx mori . Entomological Research 48:3, pages 137-144.
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Joonyeob Lee, Kyungjin Cho, Seung Gu Shin, Hyokwan Bae, Taewoan Koo, Gyuseong Han & Seokhwan Hwang. (2016) Nutrient Recovery of Starch Processing Waste to Cordyceps militaris: Solid State Cultivation and Submerged Liquid Cultivation. Applied Biochemistry and Biotechnology 180:2, pages 274-288.
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Zhen-Yuan Zhu, Xiao-Cui Liu, Feng-Ying Dong, Ming-Zhu Guo, Xiao-Ting Wang, Zheng Wang & Yong-Min Zhang. (2015) Influence of fermentation conditions on polysaccharide production and the activities of enzymes involved in the polysaccharide synthesis of Cordyceps militaris. Applied Microbiology and Biotechnology 100:9, pages 3909-3921.
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