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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 28, 2011 - Issue 9
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Short Communications

The CLOCK Gene and Mood Disorders: A Case-Control Study and Meta-analysis

Taro KishiCorrespondence[email protected]
,
Reiji Yoshimura Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
,
Yasuhisa Fukuo Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
,
Tsuyoshi Kitajima Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
,
Tomo Okochi Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
,
Shinji Matsunaga Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
,
Toshiya InadaSeiwa Hospital, Institute of Neuropsychiatry, Tokyo, Japan,
,
Hiroshi Kunugi National Center of Neurology and Psychiatry, Mental Disorder Research, National Institute of Neuroscience, Tokyo, Japan
,
Tadafumi Kato Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
,
Takeo Yoshikawa Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
,
Hiroshi Ujike Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan
,
Wakako Umene-Nakano Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
,
Jun Nakamura Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
,
Norio Ozaki Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
Alessandro Serretti Institute of Psychiatry, University of Bologna, Bologna, Italy
,
Christoph U. Correll Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, New York, USA
&
Nakao Iwata Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
 show all
Pages 825-833 | Received 19 May 2011, Accepted 27 Jul 2011, Published online: 14 Nov 2011

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Lindsay Melhuish Beaupre, Gregory M. Brown & James L. Kennedy. (2020) Circadian genes in major depressive disorder. The World Journal of Biological Psychiatry 21:2, pages 80-90.
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Trisha Chakrabarty & Lakshmi N. Yatham. (2019) Objective and biological markers in bipolar spectrum presentations. Expert Review of Neurotherapeutics 19:3, pages 195-209.
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Malgorzata Maciukiewicz, Monika Dmitrzak-Weglarz, Joanna Pawlak, Anna Leszczynska-Rodziewicz, Dorota Zaremba, Maria Skibinska & Joanna Hauser. (2014) Analysis of genetic association and epistasis interactions between circadian clock genes and symptom dimensions of bipolar affective disorder. Chronobiology International 31:6, pages 770-778.
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Francesco Portaluppi, Erhard Haus & Michael H. Smolensky. (2013) Ambulatory Blood Pressure Monitoring: Killing the Elephant to Get Its Hair? No More, Please!. Chronobiology International 30:1-2, pages 1-5.
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Niki Antypa, Laura Mandelli, Finiki A. Nearchou, Chrysostomos Vaiopoulos, Costas N. Stefanis, Alessandro Serretti & Nikos C. Stefanis. (2012) The 3111T/C Polymorphism Interacts With Stressful Life Events to Influence Patterns of Sleep in Females. Chronobiology International 29:7, pages 891-897.
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Articles from other publishers (29)

H. Findeis, H. Oster, M. Bauer & P. Ritter. (2022) Chronobiologische Aspekte der bipolaren StörungChronobiological aspects of bipolar disorder. Der Nervenarzt 93:9, pages 873-881.
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Michael J. McCarthy, John F. Gottlieb, Robert Gonzalez, Colleen A. McClung, Lauren B. Alloy, Sean Cain, Davide Dulcis, Bruno Etain, Benicio N. Frey, Corrado Garbazza, Kyle D. Ketchesin, Dominic Landgraf, Heon‐Jeong Lee, Cynthia Marie‐Claire, Robin Nusslock, Alessandra Porcu, Richard Porter, Philipp Ritter, Jan Scott, Daniel Smith, Holly A. Swartz & Greg Murray. (2021) Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi‐disciplinary literature review and agenda for future research from the ISBD task force on chronobiology. Bipolar Disorders 24:3, pages 232-263.
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Müge Yalçin, Annakarina Mundorf, Freya Thiel, Sandra Amatriain-Fernández, Ida Schulze Kalthoff, Jan-Carl Beucke, Henning Budde, Susan Garthus-Niegel, Jutta Peterburs & Angela Relógio. (2022) It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health. Frontiers in Physiology 13.
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Dorka Gyorik, Nora Eszlari, Zsofia Gal, Dora Torok, Daniel Baksa, Zsuliet Kristof, Sara Sutori, Peter Petschner, Gabriella Juhasz, Gyorgy Bagdy & Xenia Gonda. (2021) Every Night and Every Morn: Effect of Variation in CLOCK Gene on Depression Depends on Exposure to Early and Recent Stress. Frontiers in Psychiatry 12.
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Diana Armbruster, Burkhard Brocke, Clemens Kirschbaum, Stephanie H. Witt, Klaus-Peter Lesch & Alexander Strobel. (2020) Rhythm and blues: Influence of CLOCK T3111C on peripheral electrophysiological indicators of negative affective processing. Physiology & Behavior 219, pages 112831.
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Ryan W. Logan, Puja K. Parekh, Gabrielle N. Kaplan, Darius D. Becker-Krail, Wilbur P. WilliamsIIIIII, Shintaro Yamaguchi, Jun Yoshino, Micah A. Shelton, Xiyu Zhu, Hui Zhang, Spencer Waplinger, Ethan Fitzgerald, Jeffrey Oliver-Smith, Poornima Sundarvelu, John F. EnwrightIIIIII, Yanhua H. Huang & Colleen A. McClung. (2018) NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward. Molecular Psychiatry 24:11, pages 1668-1684.
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Mira Park, Soon Ae Kim, Jaeyong Yee, Jieun Shin, Kyu Young Lee & Eun-Jeong Joo. (2019) Significant role of gene–gene interactions of clock genes in mood disorder. Journal of Affective Disorders 257, pages 510-517.
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Qian Gao, Juan Sheng, Song Qin & Luoying Zhang. (2020) Chronotypes and affective disorders: A clock for mood?. Brain Science Advances 5:3, pages 145-160.
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Yeni KimKrishna C. VadodariaZsolt LenkeiTadafumi KatoFred H. GageMaria C. MarchettoRenata Santos. (2019) Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders. Antioxidants & Redox Signaling 31:4, pages 275-317.
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Xenia Gonda, Peter Petschner, Nora Eszlari, Daniel Baksa, Andrea Edes, Peter Antal, Gabriella Juhasz & Gyorgy Bagdy. (2019) Genetic variants in major depressive disorder: From pathophysiology to therapy. Pharmacology & Therapeutics 194, pages 22-43.
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Gordana Nedic Erjavec, Dubravka Svob Strac, Lucija Tudor, Marcela Konjevod, Marina Sagud & Nela Pivac. 2019. Frontiers in Psychiatry. Frontiers in Psychiatry 53 93 .
Maria Shadrina, Elena A. Bondarenko & Petr A. Slominsky. (2018) Genetics Factors in Major Depression Disease. Frontiers in Psychiatry 9.
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Massimiliano Buoli, Marta Serati, Silvia Grassi, Laura Pergoli, Laura Cantone, A. Carlo Altamura & Valentina Bollati. (2018) The role of clock genes in the etiology of Major Depressive Disorder. Journal of Affective Disorders 234, pages 351-357.
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Jaqueline B. Schuch, Julia P. Genro, Clarissa R. Bastos, Gabriele Ghisleni & Luciana Tovo-Rodrigues. (2018) The role of CLOCK gene in psychiatric disorders: Evidence from human and animal research . American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177:2, pages 181-198.
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Shen He, Xiaohua Liu, Kaida Jiang, Daihui Peng, Wu Hong, Yiru Fang, Yiping Qian, Shunying Yu & Huafang Li. (2016) Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder. Journal of Psychiatric Research 78, pages 65-71.
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Consuelo Walss-Bass. 2016. Bipolar Disorders. Bipolar Disorders 144 168 .
Luoying ZhangArisa HiranoPei-Ken HsuChristopher R. JonesNoriaki SakaiMasashi OkuroThomas McMahonMaya YamazakiYing XuNoriko SaigohKazumasa SaigohShu-Ting LinKrista KaasikSeiji NishinoLouis J. Ptáček & Ying-Hui Fu. (2016) A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait . Proceedings of the National Academy of Sciences 113:11.
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S-q Shi, M J White, H M Borsetti, J S Pendergast, A Hida, C M Ciarleglio, P A de Verteuil, A G Cadar, C Cala, D G McMahon, R C Shelton, S M Williams & C H Johnson. (2016) Molecular analyses of circadian gene variants reveal sex-dependent links between depression and clocks. Translational Psychiatry 6:3, pages e748-e748.
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Xiaochen Luo, Nikolaos Stavrakakis, Brenda W. Penninx, Fokko J. Bosker, Willem A. Nolen, Dorret I. Boomsma, Eco J. de Geus, Johan H. Smit, Harold Snieder, Ilja M. Nolte & Catharina A. Hartman. (2016) Does refining the phenotype improve replication rates? A review and replication of candidate gene studies on Major Depressive Disorder and Chronic Major Depressive Disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171:2, pages 215-236.
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Timo Partonen. 2016. Melatonin, Neuroprotective Agents and Antidepressant Therapy. Melatonin, Neuroprotective Agents and Antidepressant Therapy 319 334 .
Monika Paulina Dmitrzak-Weglarz, Joanna Maria Pawlak, Malgorzata Maciukiewicz, Jerzy Moczko, Monika Wilkosc, Anna Leszczynska-Rodziewicz, Dorota Zaremba & Joanna Hauser. (2014) Clock gene variants differentiate mood disorders. Molecular Biology Reports 42:1, pages 277-288.
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Jonathan Flint & Kenneth S. Kendler. (2014) The Genetics of Major Depression. Neuron 81:3, pages 484-503.
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Laura Mandelli & Alessandro Serretti. (2013) Gene environment interaction studies in depression and suicidal behavior: An update. Neuroscience & Biobehavioral Reviews 37:10, pages 2375-2397.
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Nicole Edgar & Colleen A. McClung. (2013) Major depressive disorder: A loss of circadian synchrony?. BioEssays 35:11, pages 940-944.
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Yun-Kang YangXiao-Dong Peng, Yong-Hong Li, Zheng-Rong WangHuang Chang-quanWang HuiQing-Xiu Liu. (2023) The Polymorphism of CLOCK Gene 3111T/C C>T is Associated with Susceptibility of Alzheimer Disease in Chinese Population. Journal of Investigative Medicine 61:7, pages 1084-1087.
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D. Pringuey, E. Fakra, F. Cherikh, F. Jover, B. Giordana, C. Clad, F. Kohl & J.M. Azorin. (2012) Endophénotypes des rythmes biologiques et du sommeil dans la dépression. L'Encéphale 38, pages S116-S120.
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Alexander Dueck, Johannes Thome & Frank Haessler. (2012) The role of sleep problems and circadian clock genes in childhood psychiatric disorders. Journal of Neural Transmission 119:10, pages 1097-1104.
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Timo Partonen. (2012) Clock gene variants in mood and anxiety disorders. Journal of Neural Transmission 119:10, pages 1133-1145.
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Ryan W. Logan, Puja K. Parekh, Wilbur Williams III, Gabrielle Kaplan, Darius Becker-Krail, Shintaro Yamaguchi, Jun Yoshino, Micah A. Shelton, Xiyu Zhu, Hui Zhang, Spencer Waplinger, Ethan Fitzgerald, Jeffrey Oliver-Smith, Poornima Sundarvelu, John F. Enwright III & Colleen A. McClung. (2018) Diurnal Rhythms of Tyrosine Hydroxylase Expression are Regulated by NAD Cellular Redox and SIRT1. SSRN Electronic Journal.
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