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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 29, 2012 - Issue 7
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Research Article

Circadian System Functionality, Hippocampal Oxidative Stress, and Spatial Memory in the APPswe/PS1dE9 Transgenic Model of Alzheimer Disease: Effects of Melatonin or Ramelteon

Beatriz Baño Otalora Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain
,
Natalija Popovic Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia, Spain
,
Juan Gambini Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
,
Miroljub Popovic Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia, Spain
,
José Viña Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
,
Vicent Bonet-Costa Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
,
Russel J. Reiter Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA
,
Pedro Javier Camello Department of Physiology, Nursing School, University of Extremadura, Cáceres, Spain
,
Maria Ángeles Rol Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain
&
Juan Antonio Madrid Department of Physiology, Faculty of Biology, University of Murcia, Murcia, SpainCorrespondence[email protected]
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Pages 822-834 | Received 08 Sep 2011, Accepted 20 Apr 2012, Published online: 23 Jul 2012

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Fabio Di Domenico, Eugenio Barone, Marzia Perluigi & D Allan Butterfield. (2015) Strategy to reduce free radical species in Alzheimer’s disease: an update of selected antioxidants. Expert Review of Neurotherapeutics 15:1, pages 19-40.
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Luisa Müller, Timo Kirschstein, Rüdiger Köhling, Angela Kuhla & Stefan Teipel. (2021) Neuronal Hyperexcitability in APPSWE/PS1dE9 Mouse Models of Alzheimer’s Disease. Journal of Alzheimer's Disease 81:3, pages 855-869.
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Patrick W. Sheehan & Erik S. Musiek. (2020) Evaluating Circadian Dysfunction in Mouse Models of Alzheimer’s Disease: Where Do We Stand?. Frontiers in Neuroscience 14.
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G. O’Neal-Moffitt, V. Delic, P. C. Bradshaw & J. Olcese. (2015) Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice. Molecular Neurodegeneration 10:1.
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Brianne A. Kent. (2014) Synchronizing an aging brain: can entraining circadian clocks by food slow Alzheimer’s disease?. Frontiers in Aging Neuroscience 6.
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Andrew N. Coogan, Barbora Schutová, Susanne Husung, Karolina Furczyk, Bernhard T. Baune, Peter Kropp, Frank Häßler & Johannes Thome. (2013) The Circadian System in Alzheimer’s Disease: Disturbances, Mechanisms, and Opportunities. Biological Psychiatry 74:5, pages 333-339.
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Natasa Dragicevic, Vedad Delic, Chuanhai Cao, Neil Copes, Xiaoyang Lin, Maggie Mamcarz, Li Wang, Gary W. Arendash & Patrick C. Bradshaw. (2012) Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells. Neuropharmacology 63:8, pages 1368-1379.
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