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Articles

Cardiovascular Risk of Essential Hypertension: Influence of Class, Number, and Treatment-Time Regimen of Hypertension Medications

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Pages 315-327 | Received 20 Dec 2011, Accepted 11 Feb 2012, Published online: 25 Oct 2012

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Ramón C. Hermida, Artemio Mojón, José R. Fernández, Ramón G. Hermida-Ayala, Juan J. Crespo, María T. Ríos, Manuel Domínguez-Sardiña, Alfonso Otero & Michael H. Smolensky. (2023) Elevated asleep blood pressure and non-dipper 24h patterning best predict risk for heart failure that can be averted by bedtime hypertension chronotherapy: A review of the published literature. Chronobiology International 40:1, pages 63-82.
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Raquel Del Pozo-Valero, José Ángel Martín-Oterino & Alicia Rodríguez-Barbero. (2021) Influence of elevated sleep-time blood pressure on vascular risk and hypertension-mediated organ damage. Chronobiology International 38:3, pages 367-377.
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Ramón C. Hermida, Ramón G. Hermida-Ayala, Michael H. Smolensky, Artemio Mojón & José R. Fernández. (2020) Ingestion-time – relative to circadian rhythms – differences in the pharmacokinetics and pharmacodynamics of hypertension medications. Expert Opinion on Drug Metabolism & Toxicology 16:12, pages 1159-1173.
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Ramón C. Hermida, Michael H. Smolensky, Artemio Mojón, Juan J. Crespo, María T. Ríos, Manuel Domínguez-Sardiña, Alfonso Otero & José R. Fernández. (2020) New perspectives on the definition, diagnosis, and treatment of true arterial hypertension. Expert Opinion on Pharmacotherapy 21:10, pages 1167-1178.
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Ramón C. Hermida, Artemio Mojón & José R. Fernández. (2020) Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as documented by MAPEC and Hygia Chronotherapy outcomes trials. Chronobiology International 37:5, pages 731-738.
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Michael H. Smolensky, Ramon C. Hermida, Alain Reinberg, Linda Sackett-Lundeen & Francesco Portaluppi. (2016) Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention. Chronobiology International 33:8, pages 1101-1119.
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Ramón C. Hermida, Michael H. Smolensky, Diana E. Ayala & Francesco Portaluppi. (2015) Ambulatory Blood Pressure Monitoring (ABPM) as the reference standard for diagnosis of hypertension and assessment of vascular risk in adults. Chronobiology International 32:10, pages 1329-1342.
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Ramón C. Hermida, Michael H. Smolensky, Diana E. Ayala, Francesco Portaluppi, Juan J. Crespo, Fabio Fabbian, Erhard Haus, Roberto Manfredini, Artemio Mojón, Ana Moyá, Luis Piñeiro, María T. Ríos, Alfonso Otero, Horia Balan & José R. Fernández. (2013) 2013 Ambulatory Blood Pressure Monitoring Recommendations for the Diagnosis of Adult Hypertension, Assessment of Cardiovascular and other Hypertension-associated Risk, and Attainment of Therapeutic Goals. Chronobiology International 30:3, pages 355-410.
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Diana E. Ayala, Rafael Ucieda & Ramón C. Hermida. (2013) Chronotherapy With Low-Dose Aspirin for Prevention of Complications in Pregnancy. Chronobiology International 30:1-2, pages 260-279.
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Fabio Fabbian, Michael H. Smolensky, Ruana Tiseo, Marco Pala, Roberto Manfredini & Francesco Portaluppi. (2013) Dipper and Non-Dipper Blood Pressure 24-Hour Patterns: Circadian Rhythm–Dependent Physiologic and Pathophysiologic Mechanisms. Chronobiology International 30:1-2, pages 17-30.
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Roberto Manfredini, Benedetta Boari, Raffaella Salmi, Fabio Fabbian, Marco Pala, Ruana Tiseo & Francesco Portaluppi. (2013) Twenty-Four-Hour Patterns in Occurrence and Pathophysiology of Acute Cardiovascular Events and Ischemic Heart Disease. Chronobiology International 30:1-2, pages 6-16.
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Francesco Portaluppi, Erhard Haus & Michael H. Smolensky. (2013) Ambulatory Blood Pressure Monitoring: Killing the Elephant to Get Its Hair? No More, Please!. Chronobiology International 30:1-2, pages 1-5.
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Ramón C. Hermida, Diana E. Ayala, José R. Fernández, Artemio Mojón, Michael H. Smolensky, Fabio Fabbian & Francesco Portaluppi. (2013) Administration-Time Differences in Effects of Hypertension Medications on Ambulatory Blood Pressure Regulation. Chronobiology International 30:1-2, pages 280-314.
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Artemio Mojón, Diana E. Ayala, Luis Piñeiro, Alfonso Otero, Juan J. Crespo, Ana Moyá, Julia Bóveda, Jesús Pérez de Lis, José R. Fernández & Ramón C. Hermida. (2013) Comparison of Ambulatory Blood Pressure Parameters of Hypertensive Patients With and Without Chronic Kidney Disease. Chronobiology International 30:1-2, pages 145-158.
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Ana Moyá, Juan J. Crespo, Diana E. Ayala, María T. Ríos, Lorenzo Pousa, Pedro A. Callejas, José L. Salgado, Artemio Mojón, José R. Fernández & Ramón C. Hermida. (2013) Effects of Time-of-Day of Hypertension Treatment on Ambulatory Blood Pressure and Clinical Characteristics of Patients With Type 2 Diabetes. Chronobiology International 30:1-2, pages 116-131.
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Ramón C. Hermida, Diana E. Ayala, Artemio Mojón & José R. Fernández. (2013) Ambulatory Blood Pressure Thresholds for Diagnosis of Hypertension in Patients With and Without Type 2 Diabetes Based on Cardiovascular Outcomes. Chronobiology International 30:1-2, pages 132-144.
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Ramón C. Hermida, Diana E. Ayala, José R. Fernández & Artemio Mojón. (2013) Sleep-Time Blood Pressure: Prognostic Value and Relevance as a Therapeutic Target for Cardiovascular Risk Reduction. Chronobiology International 30:1-2, pages 68-86.
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Ramón C. Hermida, Diana E. Ayala, Artemio Mojón & José R. Fernández. (2013) Role of Time-of-Day of Hypertension Treatment on the J-Shaped Relationship Between Blood Pressure and Cardiovascular Risk. Chronobiology International 30:1-2, pages 328-339.
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Diana E. Ayala, Ana Moyá, Juan J. Crespo, Carmen Castiñeira, Manuel Domínguez-Sardiña, Sonia Gomara, Elvira Sineiro, Artemio Mojón, María J. Fontao & Ramón C. Hermida. (2013) Circadian Pattern of Ambulatory Blood Pressure in Hypertensive Patients With and Without Type 2 Diabetes. Chronobiology International 30:1-2, pages 99-115.
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Ramón C. Hermida, Diana E. Ayala, Artemio Mojón, María J. Fontao, Luisa Chayán & José R. Fernández. (2013) Differences Between Men and Women in Ambulatory Blood Pressure Thresholds for Diagnosis of Hypertension Based on Cardiovascular Outcomes. Chronobiology International 30:1-2, pages 221-232.
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Ramón C. Hermida, María T. Ríos, Juan J. Crespo, Ana Moyá, Manuel Domínguez-Sardiña, Alfonso Otero, Juan J. Sánchez, Artemio Mojón, José R. Fernández & Diana E. Ayala. (2013) Treatment-Time Regimen of Hypertension Medications Significantly Affects Ambulatory Blood Pressure and Clinical Characteristics of Patients With Resistant Hypertension. Chronobiology International 30:1-2, pages 192-206.
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Juan J. Crespo, Luis Piñeiro, Alfonso Otero, Carmen Castiñeira, María T. Ríos, Antonio Regueiro, Artemio Mojón, Sonia Lorenzo, Diana E. Ayala & Ramón C. Hermida. (2013) Administration-Time-Dependent Effects of Hypertension Treatment on Ambulatory Blood Pressure in Patients With Chronic Kidney Disease. Chronobiology International 30:1-2, pages 159-175.
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Ramón C. Hermida, Diana E. Ayala, María J. Fontao, Artemio Mojón,José R. Fernández. (2013) Ambulatory Blood Pressure Monitoring: Importance of Sampling Rate and Duration—48 Versus 24 Hours—on the Accurate Assessment of Cardiovascular Risk. Chronobiology International 30:1-2, pages 55-67.
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Diana E. Ayala, Ramón C. Hermida, Artemio Mojón & José R. Fernández. (2013) Cardiovascular Risk of Resistant Hypertension: Dependence on Treatment-Time Regimen of Blood Pressure–Lowering Medications. Chronobiology International 30:1-2, pages 340-352.
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María T. Ríos, Manuel Domínguez-Sardiña, Diana E. Ayala, Sonia Gomara, Elvira Sineiro, Lorenzo Pousa, Pedro A. Callejas, María J. Fontao, José R. Fernández & Ramón C. Hermida. (2013) Prevalence and Clinical Characteristics of Isolated-Office and True Resistant Hypertension Determined by Ambulatory Blood Pressure Monitoring. Chronobiology International 30:1-2, pages 207-220.
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Ramón C. Hermida, Diana E. Ayala, Artemio Mojón & José R. Fernández. (2013) Blunted Sleep-Time Relative Blood Pressure Decline Increases Cardiovascular Risk Independent of Blood Pressure Level—The “Normotensive Non-dipper” Paradox. Chronobiology International 30:1-2, pages 87-98.
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Peder af Geijerstam, Jan Engvall, Carl Johan Östgren, Fredrik H Nyström & Karin Rådholm. (2022) Home Blood Pressure Compared With Office Blood Pressure in Relation to Dysglycemia. American Journal of Hypertension 35:9, pages 810-819.
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Jing Zhao, Yuanyuan Zeng, Jieqiong Weng, Jingfang Zhang, Tingting Yao, Mengfei Yuan & Xiaoxu Shen. (2022) Evening versus morning administration of drug therapy for hypertension: A meta-analysis of randomized controlled trials. European Journal of Integrative Medicine 50, pages 102111.
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Michael H. Smolensky & Ramón C. Hermida. (2021) Commentary on Bowles and Shea: Further perspectives and clinical implications of ingestion-time differences in the efficacy of blood pressure-lowering medications. Sleep Medicine Reviews 59, pages 101540.
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Ramón C. Hermida, Artemio MojónMichael H. SmolenskyJosé R. Fernández. (2021) Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension—Pro Side of the Argument. Hypertension 78:3, pages 879-893.
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Tomáš Baka, Peter Stanko & Fedor Šimko. (2021) Hypertension chronotherapy: does dosing antihypertensive medication at bedtime determine cardiovascular prognosis?. Klinická farmakologie a farmacie 35:2, pages 74-77.
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Ramón C. Hermida, Ramón G. Hermida-Ayala, Michael H. Smolensky, Artemio Mojón, Juan J. Crespo, Alfonso Otero, María T. Ríos, Manuel Domínguez-Sardiña & José R. Fernández. (2020) Does Timing of Antihypertensive Medication Dosing Matter?. Current Cardiology Reports 22:10.
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Ramón C. Hermida, Ramón G. Hermida-Ayala & Michael Smolensky. (2020) Cronoterapia para reducción de riesgo cardiovascular. Medicina Clínica 154:12, pages 505-511.
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Ramón C. Hermida, Ramón G. Hermida-Ayala & Michael Smolensky. (2020) Chronotherapy for reduction of cardiovascular risk. Medicina Clínica (English Edition) 154:12, pages 505-511.
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Ramón C Hermida, Juan J Crespo & Manuel Domínguez-Sardiña. (2020) Improved reduction of cardiovascular risk by bedtime ingestion of ARB and ACEI medication class therapies. European Heart Journal 41:16, pages 1602-1603.
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Ramón C. Hermida, Diana E. Ayala, José R. Fernández, Artemio Mojón & Michael H. Smolensky. (2018) Hypertension: New perspective on its definition and clinical management by bedtime therapy substantially reduces cardiovascular disease risk. European Journal of Clinical Investigation 48:5.
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Michael H. Smolensky, Ramón C. Hermida, Diana E. Ayala, Artemio Mojón & José R. Fernández. (2017) Bedtime Chronotherapy with Conventional Hypertension Medications to Target Increased Asleep Blood Pressure Results in Markedly Better Chronoprevention of Cardiovascular and Other Risks than Customary On-awakening Therapy. Heart Failure Clinics 13:4, pages 775-792.
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Ramón C. Hermida, Diana E. Ayala, Michael H. Smolensky, José R. Fernández, Artemio Mojón & Francesco Portaluppi. (2017) Sleep-time blood pressure: Unique sensitive prognostic marker of vascular risk and therapeutic target for prevention. Sleep Medicine Reviews 33, pages 17-27.
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Michael H. Smolensky, Ramón C. Hermida & Francesco Portaluppi. (2017) Circadian mechanisms of 24-hour blood pressure regulation and patterning. Sleep Medicine Reviews 33, pages 4-16.
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Ran-Hui Cha, Hajeong Lee, Jung Pyo Lee, Eunjeong Kang, Young Rim Song, Yon Su Kim & Sung Gyun Kim. (2017) Changes of blood pressure patterns and target organ damage in patients with chronic kidney disease. Journal of Hypertension 35:3, pages 593-601.
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Ramón C Hermida, Diana E Ayala, Michael H Smolensky, José R Fernández, Artemio Mojón & Francesco Portaluppi. (2015) Chronotherapy with conventional blood pressure medications improves management of hypertension and reduces cardiovascular and stroke risks. Hypertension Research 39:5, pages 277-292.
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Gagandeep Kaur, Yuh-Lin Gan, Craig L Phillips, Keith Wong & Bandana Saini. (2015) Chronotherapy in practice: the perspective of the community pharmacist. International Journal of Clinical Pharmacy 38:1, pages 171-182.
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Ramón C. Hermida, Diana E. Ayala, Artemio Mojón & José R. Fernández. (2015) Bedtime ingestion of hypertension medications reduces the risk of new-onset type 2 diabetes: a randomised controlled trial. Diabetologia 59:2, pages 255-265.
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Ramón C. Hermida & Diana E. Ayala. (2016) Presión arterial ambulatoria, cronoterapia de la hipertensión y glaucoma. Medicina Clínica 146:1, pages 30-34.
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Ramón C. Hermida & Diana E. Ayala. (2016) Ambulatory blood pressure, chronotherapy of hypertension and glaucoma. Medicina Clínica (English Edition) 146:1, pages 30-34.
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Michael H. Smolensky, Francesco Portaluppi & Ramón C. Hermida. 2016. Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics. Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics 105 127 .
Ramón C. Hermida, Diana E. Ayala, Michael H. Smolensky & Francesco Portaluppi. 2016. Circadian Clocks: Role in Health and Disease. Circadian Clocks: Role in Health and Disease 295 334 .
Godfred Odei Boateng, Isaac N. Luginaah & Mary-Margaret Taabazuing. (2015) Examining the Risk Factors Associated With Hypertension Among the Elderly in Ghana. Journal of Aging and Health 27:7, pages 1147-1169.
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Ramón C. Hermida, Ana Moyá & Diana E. Ayala. (2015) Monitorización ambulatoria de la presión arterial en diabetes para valoración y control de riesgo vascular. Endocrinología y Nutrición 62:8, pages 400-410.
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Ramón C. Hermida, Ana Moyá & Diana E. Ayala. (2015) Ambulatory blood pressure monitoring in diabetes for the assessment and control of vascular risk. Endocrinología y Nutrición (English Edition) 62:8, pages 400-410.
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Faye S. Routledge, Alan L. Hinderliter, Judith McFetridge-Durdle, James A. Blumenthal, Nicola J. Paine & Andrew Sherwood. (2015) Endothelial function in postmenopausal women with nighttime systolic hypertension. Menopause 22:8, pages 857-863.
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Patrick A Gladding, Alasdair Patrick, Paul Manley, Laura Mash, Phillip Shepherd, Rinki Murphy, Silas Vilas-Boas & Todd T Schlegel. (2015) Personalized hypertension management in practice. Personalized Medicine 12:3, pages 297-311.
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Paul M. Stranges, Amy M. Drew, Patricia Rafferty, Jerrica E. Shuster & Amie D. Brooks. (2014) Treatment of Hypertension With Chronotherapy. Annals of Pharmacotherapy 49:3, pages 323-334.
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R C Hermida, D E Ayala, A Mojón, M H Smolensky, F Portaluppi & J R Fernández. (2014) Sleep-time ambulatory blood pressure as a novel therapeutic target for cardiovascular risk reduction. Journal of Human Hypertension 28:10, pages 567-574.
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Mei Cheng, Shu-Ling Cheng, Qing Zhang, He Jiang, Ji-Yan Cong, Xiao-Ying Zang & Yue Zhao. (2014) The effect of continuous nursing intervention guided by chronotherapeutics on ambulatory blood pressure of older hypertensive patients in the community. Journal of Clinical Nursing 23:15-16, pages 2247-2255.
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Ramón C. Hermida, Diana E. Ayala, María T. Ríos, José R. Fernández, Artemio Mojón & Michael H. Smolensky. (2014) Around-the-clock Ambulatory Blood Pressure Monitoring is Required to Properly Diagnose Resistant Hypertension and Assess Associated Vascular Risk. Current Hypertension Reports 16:7.
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R. C. Hermida, M. H. Smolensky, D. E. Ayala, J. R. Fernandez, A. Moya, J. J. Crespo, A. Mojon, M. T. Rios, F. Fabbian & F. Portaluppi. (2013) Abnormalities in chronic kidney disease of ambulatory blood pressure 24 h patterning and normalization by bedtime hypertension chronotherapy. Nephrology Dialysis Transplantation 29:6, pages 1160-1167.
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Ramón C. Hermida, Diana E. Ayala, Michael H. Smolensky, José R. Fernández, Artemio Mojón, Juan J. Crespo, María T. Ríos, Ana Moyá & Francesco Portaluppi. (2014) Chronotherapeutics of Conventional Blood Pressure-Lowering Medications: Simple, Low-Cost Means of Improving Management and Treatment Outcomes of Hypertensive-Related Disorders. Current Hypertension Reports 16:2.
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George C. Roush, Ramdeep Kaur & Michael E. Ernst. (2013) Diuretics. Journal of Cardiovascular Pharmacology and Therapeutics 19:1, pages 5-13.
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Shona Brothwell, Mary Dutton, Charles Ferro, Stephanie Stringer & Paul Cockwell. (2013) Optimising the accuracy of blood pressure monitoring in chronic kidney disease: the utility of BpTRU. BMC Nephrology 14:1.
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