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Annals of Medicine Volume 44, 2012 - Issue 5
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Research Articles

Drug Burden Index associated with function in community-dwelling older people in Finland: A cross-sectional study

Danijela GnjidicDepartments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, St Leonards, New South Wales, Australia;Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia;Centre for Education and Research on Ageing (CERA), Concord RG Hospital, Concord, New South Wales, AustraliaCorrespondence[email protected]
,
J. Simon BellQuality Use of Medicines and Pharmacy Research Centre, Sansom Institute, University of South Australia, Adelaide, South Australia, Australia;Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland;Clinical Pharmacology and Geriatric Pharmacotherapy Unit, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
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Sarah N. HilmerDepartments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, St Leonards, New South Wales, Australia;Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
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Eija LönnroosKuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland;Clinical Pharmacology and Geriatric Pharmacotherapy Unit, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland;Institute of Public Health and Clinical Nutrition, Department of Geriatrics, University of Eastern Finland, Kuopio, Finland
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Raimo SulkavaInstitute of Public Health and Clinical Nutrition, Department of Geriatrics, University of Eastern Finland, Kuopio, Finland;Department of Neurology, Kuopio University Hospital, Kuopio, Finland
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Sirpa HartikainenKuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland;Clinical Pharmacology and Geriatric Pharmacotherapy Unit, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland;Leppävirta Health Centre, Leppävirta, Finland
Pages 458-467 | Received 16 Nov 2010, Accepted 28 Feb 2011, Published online: 15 Apr 2011

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Mohammed A Mohammed, Rebekah J Moles & Timothy F Chen. (2021) Factors Associated with Medication-Related Burden Quality of Life (MRB-QoL) in Community-Dwelling Adults with Long-Term Conditions: An Exploratory Study. Patient Related Outcome Measures 12, pages 55-63.
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Lisa Kouladjian, Danijela Gnjidic, Timothy F Chen, Arduino A Mangoni & Sarah N Hilmer. (2014) Drug Burden Index in older adults: theoretical and practical issues. Clinical Interventions in Aging 9, pages 1503-1515.
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Articles from other publishers (48)

Bonnie M. Liu, Lisa Kouladjian O'Donnell, Mitchell R. Redston, Kenji Fujita, Janani Thillainadesan, Danijela Gnjidic & Sarah N. Hilmer. (2023) Association of the Drug Burden Index ( DBI ) exposure with outcomes: A systematic review . Journal of the American Geriatrics Society.
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Hamish Jamieson, Prasad S Nishtala, Hans Ulrich Bergler, Susan K Weaver, John W Pickering, Nagham J Ailabouni, Rebecca Abey-Nesbit, Carolyn Gullery, Joanne Deely, Susan B Gee, Sarah N Hilmer & Dee Mangin. (2023) Deprescribing Anticholinergic and Sedative Drugs to Reduce Polypharmacy in Frail Older Adults Living in the Community: A Randomized Controlled Trial. The Journals of Gerontology: Series A 78:9, pages 1692-1700.
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Kenji Fujita, Patrick Hooper, Nashwa Masnoon, Sarita Lo, Danijela Gnjidic, Christopher Etherton-Beer, Emily Reeve, Parker Magin, J. Simon Bell, Kenneth Rockwood, Lisa Kouladjian O’Donnell, Mouna Sawan, Melissa Baysari & Sarah N. Hilmer. (2023) Impact of a Comprehensive Intervention Bundle Including the Drug Burden Index on Deprescribing Anticholinergic and Sedative Drugs in Older Acute Inpatients: A Non-randomised Controlled Before-and-After Pilot Study. Drugs & Aging 40:7, pages 633-642.
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M. Petrovic. 2022. Geriatrie in de fysiotherapie en kinesitherapie. Geriatrie in de fysiotherapie en kinesitherapie 213 222 .
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Hans Wouters, Jos P. Van Campen, Marloes J. Kuitert, Lisette Kikkert, Sarah N. Hilmer, Katja Taxis, Helene G. Van der Meer & Claudine J. C. Lamoth. (2021) Anticholinergic and Sedative Medications and Dynamic Gait Parameters in Older Patients. Drugs & Aging 38:12, pages 1087-1096.
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Frederic Gervais, Virginie Dauphinot, Christelle Mouchoux & Pierre Krolak-Salmon. (2021) Exposure to Anticholinergic and Sedative Drugs and Healthcare Costs in Older Patients with Neurocognitive Disorders. Journal of Alzheimer's Disease 80:4, pages 1515-1524.
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Marta Lavrador, Ana C. Cabral, Isabel V. Figueiredo, Manuel T. Veríssimo, M. Margarida Castel-Branco & Fernando Fernandez-Llimos. (2020) Size of the associations between anticholinergic burden tool scores and adverse outcomes in older patients. International Journal of Clinical Pharmacy 43:1, pages 128-136.
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Marta Lavrador, M. Margarida Castel-Branco, Ana C. Cabral, Manuel T. Veríssimo, Isabel V. Figueiredo & Fernando Fernandez-Llimos. (2021) Association between anticholinergic burden and anticholinergic adverse outcomes in the elderly: Pharmacological basis of their predictive value for adverse outcomes. Pharmacological Research 163, pages 105306.
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Susan J. Blalock, Chelsea P. Renfro, Jessica M. Robinson, Joel F. Farley, Jan Busby-Whitehead & Stefanie P. Ferreri. (2020) Using the Drug Burden Index to identify older adults at highest risk for medication-related falls. BMC Geriatrics 20:1.
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Juliette O’Connell, Martin C. Henman, Éilish Burke, Clare Donegan, Philip McCallion, Mary McCarron & Máire O’Dwyer. (2019) Association of Drug Burden Index with grip strength, timed up and go and Barthel index activities of daily living in older adults with intellectual disabilities: an observational cross-sectional study. BMC Geriatrics 19:1.
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Catherine J. Byrne, Caroline Walsh, Caitriona Cahir & Kathleen Bennett. (2019) Impact of drug burden index on adverse health outcomes in Irish community-dwelling older people: a cohort study. BMC Geriatrics 19:1.
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Eric Anson, Elizabeth Thompson, Samuel C. Karpen, Brian L. Odle, Edith Seier, John Jeka & Peter C. Panus. (2018) Visual biofeedback training reduces quantitative drugs index scores associated with fall risk. BMC Research Notes 11:1.
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Syed Shahzad Hasan, Annita Shi Chin Liew, David Weng Kwai Chong, Kaeshaelya Thiruchelvam & Zaheer-Ud-Din Babar. (2018) Associations between Drug Burden Index, medication appropriateness and patient-reported outcomes in the community pharmacy setting in Malaysia. Drugs & Therapy Perspectives 34:9, pages 437-443.
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Catherine J Byrne, Caroline Walsh, Caitriona Cahir, Cristín Ryan, David J Williams & Kathleen Bennett. (2018) Anticholinergic and sedative drug burden in community-dwelling older people: a national database study. BMJ Open 8:7, pages e022500.
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Tomas J. Welsh, Veronika van der Wardt, Grace Ojo, Adam L. Gordon & John R. F. Gladman. (2018) Anticholinergic Drug Burden Tools/Scales and Adverse Outcomes in Different Clinical Settings: A Systematic Review of Reviews. Drugs & Aging 35:6, pages 523-538.
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Juliette O'Connell, Éilish Burke, Niamh Mulryan, Claire O'Dwyer, Clare Donegan, Philip McCallion, Mary McCarron, Martin C. Henman & Máire O'Dwyer. (2018) Drug burden index to define the burden of medicines in older adults with intellectual disabilities: An observational cross-sectional study. British Journal of Clinical Pharmacology 84:3, pages 553-567.
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Nashwa Masnoon, Sepehr Shakib, Lisa Kalisch-Ellett & Gillian E. Caughey. (2018) Tools for Assessment of the Appropriateness of Prescribing and Association with Patient-Related Outcomes: A Systematic Review. Drugs & Aging 35:1, pages 43-60.
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L. M. J. Sanders, T. Hortobágyi, G. van Staveren, K. Taxis, F. Boersma, H. C. Klein, W. J. R. Bossers, C. G. Blankevoort, E. J. A. Scherder, E. A. Van der Zee & M. J. G. van Heuvelen. (2017) Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia. European Journal of Clinical Pharmacology 73:12, pages 1633-1642.
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Hans Wouters, Helene van der Meer & Katja Taxis. (2016) Quantification of anticholinergic and sedative drug load with the Drug Burden Index: a review of outcomes and methodological quality of studies. European Journal of Clinical Pharmacology 73:3, pages 257-266.
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Clare L Clarke & Miles D Witham. (2017) The Effects of Medication on Activity and Rehabilitation of Older People – Opportunities and Risks. Rehabilitation Process and Outcome 6, pages 117957271771143.
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Daniela C. Moga, Heidi Taipale, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Qishan Wu, Gregory A. Jicha & Danijela Gnjidic. (2016) A Comparison of Sex Differences in Psychotropic Medication Use in Older People with Alzheimer’s Disease in the US and Finland. Drugs & Aging 34:1, pages 55-65.
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Philippe Martin, Robyn Tamblyn, Sara Ahmed, Andrea Benedetti & Cara Tannenbaum. (2015) A consumer-targeted, pharmacist-led, educational intervention to reduce inappropriate medication use in community older adults (D-PRESCRIBE trial): study protocol for a cluster randomized controlled trial. Trials 16:1.
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Tanja Mayer, Walter E Haefeli & Hanna M Seidling. (2015) Different methods, different results—how do available methods link a patient’s anticholinergic load with adverse outcomes?. European Journal of Clinical Pharmacology 71:11, pages 1299-1314.
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Carina Michalek, Martin Wehling, Jeanina Schlitzer & Helmut Frohnhofen. (2014) Effects of “Fit fOR The Aged” (FORTA) on pharmacotherapy and clinical endpoints—a pilot randomized controlled study. European Journal of Clinical Pharmacology 70:10, pages 1261-1267.
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Prasad S. Nishtala, Sujita W. Narayan, Ting Wang & Sarah N. Hilmer. (2014) Associations of drug burden index with falls, general practitioner visits, and mortality in older people. Pharmacoepidemiology and Drug Safety 23:7, pages 753-758.
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Sarah N. Hilmer, Danijela Gnjidic & Darrell R. Abernethy. (2014) Drug Burden Index for International Assessment of the Functional Burden of Medications in Older People. Journal of the American Geriatrics Society 62:4, pages 791-792.
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Danijela Gnjidic, Sarah N. Hilmer, Sirpa Hartikainen, Anna-Maija Tolppanen, Heidi Taipale, Marjaana Koponen & J. Simon Bell. (2014) Impact of High Risk Drug Use on Hospitalization and Mortality in Older People with and without Alzheimer’s Disease: A National Population Cohort Study. PLoS ONE 9:1, pages e83224.
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Danijela Gnjidic, David G Le Couteur, Sallie-Anne Pearson, Andrew J McLachlan, Rosalie Viney, Sarah N Hilmer, Fiona M Blyth, Grace Joshy & Emily Banks. (2013) High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level. BMC Public Health 13:1.
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Clare V Bostock, Roy L Soiza & Arduino A Mangoni. (2013) Associations between different measures of anticholinergic drug exposure and Barthel Index in older hospitalized patients. Therapeutic Advances in Drug Safety 4:6, pages 235-245.
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Sujita W. Narayan, Sarah N. Hilmer, Simon Horsburgh & Prasad S. Nishtala. (2013) Anticholinergic Component of the Drug Burden Index and the Anticholinergic Drug Scale as Measures of Anticholinergic Exposure in Older People in New Zealand: A Population-Level Study. Drugs & Aging 30:11, pages 927-934.
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O. Best, D. Gnjidic, S. N. Hilmer, V. Naganathan & A. J. McLachlan. (2013) Investigating polypharmacy and drug burden index in hospitalised older people. Internal Medicine Journal 43:8, pages 912-918.
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Pasi Lampela, Piia Lavikainen, J. Arturo Garcia-Horsman, J. Simon Bell, Risto Huupponen & Sirpa Hartikainen. (2013) Anticholinergic Drug Use, Serum Anticholinergic Activity, and Adverse Drug Events Among Older People: A Population-Based Study. Drugs & Aging 30:5, pages 321-330.
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J. Simon Bell, Jouni Ahonen, Piia Lavikainen & Sirpa Hartikainen. (2012) Potentially inappropriate drug use among older persons in Finland: application of a new national categorization. European Journal of Clinical Pharmacology 69:3, pages 657-664.
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