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Annals of Medicine Volume 44, 2012 - Issue 5
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Research Articles

Complement activation in Puumala hantavirus infection correlates with disease severity

Jussi SaneInfection Biology Research Program, Department of Virology, Haartman Institute, University of Helsinki, FinlandCorrespondence[email protected]
,
Outi LaineTampere University Hospital, Tampere, Finland
,
Satu MäkeläTampere University Hospital, Tampere, Finland;Medical School, University of Tampere, Tampere, Finland
,
Antti PaakkalaTampere University Hospital, Tampere, Finland
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Hanna JarvaInfection Biology Research Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland;HUSLAB, Division of Clinical Microbiology, Helsinki, Finland
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Jukka MustonenTampere University Hospital, Tampere, Finland;Medical School, University of Tampere, Tampere, Finland
,
Olli VapalahtiInfection Biology Research Program, Department of Virology, Haartman Institute, University of Helsinki, Finland;HUSLAB, Division of Clinical Microbiology, Helsinki, Finland;Division of Microbiology and Epidemiology, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Finland
,
Seppo MeriInfection Biology Research Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland;HUSLAB, Division of Clinical Microbiology, Helsinki, Finland
&
Antti VaheriInfection Biology Research Program, Department of Virology, Haartman Institute, University of Helsinki, Finland;HUSLAB, Division of Clinical Microbiology, Helsinki, Finland
 show all
Pages 468-475 | Received 18 Nov 2010, Accepted 09 Feb 2011, Published online: 15 Apr 2011

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Jukka Mustonen, Tuula Outinen, Outi Laine, Ilkka Pörsti, Antti Vaheri & Satu Mäkelä. (2017) Kidney disease in Puumala hantavirus infection. Infectious Diseases 49:5, pages 321-332.
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Tuula K. Outinen, Outi K. Laine, Satu Mäkelä, Ilkka Pörsti, Heini Huhtala, Antti Vaheri & Jukka Mustonen. (2016) Thrombocytopenia associates with the severity of inflammation and variables reflecting capillary leakage in Puumala Hantavirus infection, an analysis of 546 Finnish patients. Infectious Diseases 48:9, pages 682-687.
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Sirpa M. Koskela, Outi K. Laine, Antti S. Paakkala, Satu M. Mäkelä & Jukka T. Mustonen. (2014) Spleen enlargement is a common finding in acute Puumala hantavirus infection and it does not associate with thrombocytopenia. Scandinavian Journal of Infectious Diseases 46:10, pages 723-726.
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Jaakko Antonen, Ilona Leppänen, Jyrki Tenhunen, Pertti Arvola, Satu Mäkelä, Antti Vaheri & Jukka Mustonen. (2013) A severe case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant. Scandinavian Journal of Infectious Diseases 45:6, pages 494-496.
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Articles from other publishers (37)

Simon Aberger, Nicolas Kozakowski, Zoltán Proházka, Thomas Pleininger & Hermann Salmhofer. (2023) Dobrava hantavirus and coinciding SARS-CoV-2 infection mimicking thrombotic microangiopathy and responding to a single dose of eculizumab. Clinical Kidney Journal 16:12, pages 2750-2753.
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Antti Vaheri, Teemu Smura, Hanna Vauhkonen, Jussi Hepojoki, Tarja Sironen, Tomas Strandin, Johanna Tietäväinen, Tuula Outinen, Satu Mäkelä, Ilkka Pörsti & Jukka Mustonen. (2023) Puumala Hantavirus Infections Show Extensive Variation in Clinical Outcome. Viruses 15:3, pages 805.
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Hong Du, Pingzhong Wang, Xuefan Bai, Jing Li, Xiaoyan Wang, Haifeng Hu, Ying Zhang, Hong Jiang, Huanjun Shen, Jiayi Zhan & Jianqi Lian. (2022) Research Progress on the Pathogenesis of Hemorrhagic Fever with Renal Syndrome. Infectious Diseases & Immunity 2:4, pages 274-281.
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Misbah Tariq & Dong-Min Kim. (2022) Hemorrhagic Fever with Renal Syndrome: Literature Review, Epidemiology, Clinical Picture and Pathogenesis. Infection & Chemotherapy 54:1, pages 1.
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Tuula K. Outinen, Satu Mäkelä, Ilkka Pörsti, Antti Vaheri & Jukka Mustonen. (2021) Severity Biomarkers in Puumala Hantavirus Infection. Viruses 14:1, pages 45.
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Sirpa Koskela, Satu Mäkelä, Tomas Strandin, Antti Vaheri, Tuula Outinen, Lotta Joutsi-Korhonen, Ilkka Pörsti, Jukka Mustonen & Outi Laine. (2021) Coagulopathy in Acute Puumala Hantavirus Infection. Viruses 13:8, pages 1553.
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Rebecca L. Brocato, Louis A. Altamura, Brian D. Carey, Casey C. Perley, Candace D. Blancett, Timothy D. Minogue & Jay W. Hooper. (2021) Comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString. PLOS Neglected Tropical Diseases 15:8, pages e0009592.
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Antti Vaheri, Heikki Henttonen & Jukka Mustonen. (2021) Hantavirus Research in Finland: Highlights and Perspectives. Viruses 13:8, pages 1452.
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Hongbin Wang & Mengyao Liu. (2021) Complement C4, Infections, and Autoimmune Diseases. Frontiers in Immunology 12.
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Gabriela Lupuşoru, Mircea Lupuşoru, Ioana Ailincăi, Lavinia Bernea, Andreea Berechet, Radu Spătaru & Gener Ismail. (2021) Hanta hemorrhagic fever with renal syndrome: A pathology in whose diagnosis kidney biopsy plays a major role (Review). Experimental and Therapeutic Medicine 22:3.
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Priscilla F Kerkman, Andy Dernstedt, Lalitha Tadala, Eva Mittler, Mirjam Dannborg, Christopher Sundling, Kimia T Maleki, Johanna Tauriainen, Anne Tuiskunen‐Bäck, Julia Wigren Byström, Pauline Ocaya, Therese Thunberg, Rohit K Jangra, Gleyder Román‐Sosa, Pablo Guardado‐Calvo, Felix A Rey, Jonas Klingström, Kartik Chandran, Andrea Puhar, Clas Ahlm & Mattias NE Forsell. (2021) Generation of plasma cells and CD27 − IgD − B cells during hantavirus infection is associated with distinct pathological findings . Clinical & Translational Immunology 10:7.
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Tuula K. Outinen, Paula Mantula, Pia Jaatinen, Mari Hämäläinen, Eeva Moilanen, Antti Vaheri, Heini Huhtala, Satu Mäkelä & Jukka Mustonen. (2019) Glycoprotein YKL-40 Is Elevated and Predicts Disease Severity in Puumala Hantavirus Infection. Viruses 11:9, pages 767.
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Grazielle Esteves Ribeiro, Luis Edgardo Leon, Ruth Perez, Analia Cuiza, Pablo Agustin Vial, Marcela Ferres, Gregory J. Mertz & Cecilia Vial. (2019) Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection. Viruses 11:8, pages 680.
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Madeleine K. Scammell, Caryn M. Sennett, Zoe E. Petropoulos, Jeanne Kamal & James S. Kaufman. (2019) Environmental and Occupational Exposures in Kidney Disease. Seminars in Nephrology 39:3, pages 230-243.
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Tarja Sironen, Jussi Sane, Marja-Liisa Lokki, Seppo Meri, Leif C Andersson, Timo Hautala, Heikki Kauma, Sakari Vuorinen, Johan Rasmuson, Magnus Evander, Clas Ahlm & Antti Vaheri. (2017) Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology. Open Forum Infectious Diseases 4:4.
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V. A. Anohin, E. V. Martynova, V. A. Martynov, G. A. Masgutova, A. A. Rizvanov & Svetlana F. Khaiboullina. (2016) Increased Expression of Clusterin in Kidney of a Fatal Nephropathia Epidemica Case. BioNanoScience 6:4, pages 453-456.
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Anna Papa, Antti Vaheri, James W. LeDuc, Detlev H. Krüger, Tatjana Avšič-Županc, Jiro Arikawa, Jin-Won Song, Alemka Markotić, Jan Clement, Mifang Liang, Dexin Li, Liudmila N. Yashina, Colleen B. Jonsson & Connie S. Schmaljohn. (2016) Meeting report: Tenth International Conference on Hantaviruses. Antiviral Research 133, pages 234-241.
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Tomas Strandin, Jussi Hepojoki, Outi Laine, Satu Mäkelä, Jonas Klingström, Åke Lundkvist, Ilkka Julkunen, Jukka Mustonen & Antti Vaheri. (2016) Interferons Induce STAT1–Dependent Expression of Tissue Plasminogen Activator, a Pathogenicity Factor in Puumala Hantavirus Disease. Journal of Infectious Diseases 213:10, pages 1632-1641.
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Hong Jiang, Hong Du, Li M. Wang, Ping Z. Wang & Xue F. Bai. (2016) Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. Frontiers in Cellular and Infection Microbiology 6.
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Tarja Sironen, Olli Vapalahti & Alexander Plyusnin. 2015. Human Emerging and Re‐emerging Infections. Human Emerging and Re‐emerging Infections 95 112 .
Sirpa Koskela, Outi Laine, Satu Mäkelä, Tanja Pessi, Sari Tuomisto, Heini Huhtala, Pekka J. Karhunen, Ilkka Pörsti & Jukka Mustonen. (2015) Endothelial Nitric Oxide Synthase G894T Polymorphism Associates with Disease Severity in Puumala Hantavirus Infection. PLOS ONE 10:11, pages e0142872.
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S. Skarphedinsson, H. C. Thiesson, S. A. Shakar & M. Tepel. (2015) Factors predicting kidney damage in Puumala virus infected patients in Southern Denmark. European Journal of Clinical Microbiology & Infectious Diseases 34:10, pages 2017-2021.
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Günther Schönrich, Detlev H. Krüger & Martin J. Raftery. (2015) Hantavirus-induced disruption of the endothelial barrier: neutrophils are on the payroll. Frontiers in Microbiology 6.
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Tuula K. Outinen, Satu Mäkelä, Jan Clement, Antti Paakkala, Ilkka Pörsti & Jukka Mustonen. (2015) Community Acquired Severe Acute Kidney Injury Caused by Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Has a Favorable Outcome. Nephron 130:3, pages 182-190.
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N. Zhu, F. Luo, Q. Chen, N. Li, H. Xiong, Y. Feng, Z. Yang & W. Hou. (2014) Influence of HLA-DRB alleles on haemorrhagic fever with renal syndrome in a Chinese Han population in Hubei Province, China. European Journal of Clinical Microbiology & Infectious Diseases 34:1, pages 187-195.
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Jussi Hepojoki, Antti Vaheri & Tomas Strandin. (2014) The fundamental role of endothelial cells in hantavirus pathogenesis. Frontiers in Microbiology 5.
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Jussi Hepojoki, Tomas Strandin, Udo Hetzel, Tarja Sironen, Jonas Klingström, Jussi Sane, Satu Mäkelä, Jukka Mustonen, Seppo Meri, Åke Lundkvist, Olli Vapalahti, Hilkka Lankinen & Antti Vaheri. (2014) Acute hantavirus infection induces galectin-3-binding protein. Journal of General Virology 95:11, pages 2356-2364.
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Antti Vaheri, Tomas Strandin, Anne J. Jääskeläinen, Olli Vapalahti, Hanna Jarva, Marja-Liisa Lokki, Jaakko Antonen, Ilona Leppänen, Satu Mäkelä, Seppo Meri & Jukka Mustonen. (2014) Pathophysiology of a severe case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant. Antiviral Research 111, pages 23-25.
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Outi K. Laine, Sirpa M. Koskela, Tuula K. Outinen, Lotta Joutsi-Korhonen, Heini Huhtala, Antti Vaheri, Mikko A. Hurme, Juulia Jylhävä, Satu M. Mäkelä & Jukka T. Mustonen. (2014) Plasma pentraxin-3 and coagulation and fibrinolysis variables during acute Puumala hantavirus infection and associated thrombocytopenia. Blood Coagulation & Fibrinolysis 25:6, pages 612-617.
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Nathalie Charbonnel, Marie Pagès, Tarja Sironen, Heikki Henttonen, Olli Vapalahti, Jukka Mustonen & Antti Vaheri. (2014) Immunogenetic Factors Affecting Susceptibility of Humans and Rodents to Hantaviruses and the Clinical Course of Hantaviral Disease in Humans. Viruses 6:5, pages 2214-2241.
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Tuisku-Tuulia Koivula, Anni Tuulasvaara, Iivo Hetemäki, Satu Marjo Mäkelä, Jukka Mustonen, Tarja Sironen, Antti Vaheri & T. Petteri Arstila. (2014) Regulatory T cell response correlates with the severity of human hantavirus infection. Journal of Infection 68:4, pages 387-394.
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Jukka Mustonen, Satu Mäkelä, Tuula Outinen, Outi Laine, Juulia Jylhävä, Petteri T. Arstila, Mikko Hurme & Antti Vaheri. (2013) The pathogenesis of nephropathia epidemica: New knowledge and unanswered questions. Antiviral Research 100:3, pages 589-604.
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Tuula K. Outinen, Laura Tervo, Satu Mäkelä, Reetta Huttunen, Niina Mäenpää, Heini Huhtala, Antti Vaheri, Jukka Mustonen & Janne Aittoniemi. (2013) Plasma Levels of Soluble Urokinase-Type Plasminogen Activator Receptor Associate with the Clinical Severity of Acute Puumala Hantavirus Infection. PLoS ONE 8:8, pages e71335.
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Antti Vaheri, Tomas Strandin, Jussi Hepojoki, Tarja Sironen, Heikki Henttonen, Satu Mäkelä & Jukka Mustonen. (2013) Uncovering the mysteries of hantavirus infections. Nature Reviews Microbiology 11:8, pages 539-550.
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Meiliang Wang, Jiuping Wang, Tianping Wang, Jing Li, Ling Hui & Xiaoqin Ha. (2013) Thrombocytopenia as a Predictor of Severe Acute Kidney Injury in Patients with Hantaan Virus Infections. PLoS ONE 8:1, pages e53236.
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Antti Vaheri, Heikki Henttonen, Liina Voutilainen, Jukka Mustonen, Tarja Sironen & Olli Vapalahti. (2012) Hantavirus infections in Europe and their impact on public health. Reviews in Medical Virology 23:1, pages 35-49.
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T. K. Outinen, S. Mäkelä, H. Huhtala, M. Hurme, S. Meri, I. Pörsti, J. Sane, A. Vaheri, J. Syrjänen & J. Mustonen. (2011) High pentraxin-3 plasma levels associate with thrombocytopenia in acute Puumala hantavirus-induced nephropathia epidemica. European Journal of Clinical Microbiology & Infectious Diseases 31:6, pages 957-963.
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