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Review Article

Antihypertensive effects of bioactive tripeptides—a random effects meta-analysis

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Pages 51-56 | Received 19 Jul 2011, Accepted 23 Jan 2012, Published online: 09 Mar 2012

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Giulia Fiore, Elisabetta Di Profio, Michele Sculati, Elvira Verduci & Gian Vincenzo Zuccotti. (2022) Health effects of yogurt consumption during paediatric age: a narrative review. International Journal of Food Sciences and Nutrition 73:6, pages 738-759.
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Aino Siltari, Riikka Viitanen, Sampo Kukkurainen, Heikki Vapaatalo & Jarkko Valjakka. (2014) Does the cis/trans configuration of peptide bonds in bioactive tripeptides play a role in ACE-1 enzyme inhibition?. Biologics: Targets and Therapy 8, pages 59-65.
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Nora Jaatinen, Riitta Korpela, Tuija Poussa, Anu Turpeinen, Sari Mustonen, Juho Merilahti & Katri Peuhkuri. (2014) Effects of daily intake of yoghurt enriched with bioactive components on chronic stress responses: a double-blinded randomized controlled trial. International Journal of Food Sciences and Nutrition 65:4, pages 507-514.
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Resul ADANAŞ, Vedat TÜRKOĞLU & Zehra BAŞ. (2023) Inhibition effect of Gly-Arg-Gly-Asp-Ser (GRGDS) and Arg-Gly-Asp (RGD) Bioactive Peptides on Angiotensin-Converting Enzyme Activity Purified from Human Serum. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi 13:4, pages 2847-2860.
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Osama Magouz, Nabil Mehanna, Mohamed Khalifa, Hanaa Sakr, Sabrina Gensberger-Reigl, Sevim Dalabasmaz & Monika Pischetsrieder. (2023) Profiles, antioxidative and ACE inhibitory activity of peptides released from fermented buttermilk before and after simulated gastrointestinal digestion. Innovative Food Science & Emerging Technologies 84, pages 103266.
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Shuaishuai Zhou, Teng Xu, Xu Zhang, Junjie Luo, Peng An & Yongting Luo. (2022) Effect of Casein Hydrolysate on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 14:19, pages 4207.
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Jack Penhaligan, Sally D. Poppitt & Jennifer L. Miles-Chan. (2022) The Role of Bovine and Non-Bovine Milk in Cardiometabolic Health: Should We Raise the “Baa”?. Nutrients 14:2, pages 290.
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Xinyi Cao, Wang Liao & Shaokang Wang. 2022. Emerging Sources and Applications of Alternative Proteins. Emerging Sources and Applications of Alternative Proteins 277 307 .
Nancy Auestad & Donald K Layman. (2021) Dairy bioactive proteins and peptides: a narrative review. Nutrition Reviews 79:Supplement_2, pages 36-47.
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Meisam Barati, Masoumeh Jabbari, Farshad Teymoori, Hossein Farhadnejad, Sajad khalili-Moghadam, Neda Roshanravan, Erfan Mosharkesh, Elham Kazemian, Parvin Mirmiran, Sayed Hossein Davoodi & Fereidoun Azizi. (2021) Dairy-originated digestion-resistant and bioactive peptides increase the risk of hypertension: Tehran Lipid and Glucose Study. Hypertension Research 44:9, pages 1194-1204.
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Hirofumi Tomiyama & Kazuki Shiina. (2020) Possible renoprotective effect of lactotripeptides: A brief review. Vascular Failure 4:1, pages 1-6.
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Francesco Visioli & Andrea Poli. (2020) Fatty Acids and Cardiovascular Risk. Evidence, Lack of Evidence, and Diligence. Nutrients 12:12, pages 3782.
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Xiang Jun Wang, Chao Qiang Jiang, Wei Sen Zhang, Feng Zhu, Ya Li Jin, Jean Woo, Kar Keung Cheng, Tai Hing Lam & Lin Xu. (2020) Milk consumption and risk of mortality from all-cause, cardiovascular disease and cancer in older people. Clinical Nutrition 39:11, pages 3442-3451.
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Samad Ghaffari & Neda Roshanravan. (2020) The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature. Food Research International 128, pages 108749.
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Akolade R. Oladipupo. (2020) Toxin to medicine and bioisosterism in drug development: a study of the discovery and development of ACE inhibitors from snake venom. Macedonian Pharmaceutical Bulletin 66:2, pages 15-33.
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Sally D. Poppitt. 2020. Milk Proteins. Milk Proteins 651 669 .
Paloma Manzanares, Mónica Gandía, Sandra Garrigues & Jose F. Marcos. (2019) Improving Health-Promoting Effects of Food-Derived Bioactive Peptides through Rational Design and Oral Delivery Strategies. Nutrients 11:10, pages 2545.
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Simon Moosmang, Aino Siltari, Marie-Theres Bolzer, Stefan Kiechl, Sonja Sturm & Hermann Stuppner. (2019) Development, validation, and application of a fast, simple, and robust SPE-based LC-MS/MS method for quantification of angiotensin I-converting enzyme inhibiting tripeptides Val-Pro-Pro, Ile-Pro-Pro, and Leu-Pro-Pro in yoghurt and other fermented dairy products. International Dairy Journal 97, pages 31-39.
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Aino Siltari, Heikki Vapaatalo & Riitta Korpela. (2019) Milk and milk‐derived peptides combat against hypertension and vascular dysfunction: a review. International Journal of Food Science & Technology 54:6, pages 1920-1929.
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Carmen Lammi, Gilda Aiello, Giovanna Boschin & Anna Arnoldi. (2019) Multifunctional peptides for the prevention of cardiovascular disease: A new concept in the area of bioactive food-derived peptides. Journal of Functional Foods 55, pages 135-145.
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D. A. Hobbs, D. I. Givens & J. A. Lovegrove. (2018) Yogurt consumption is associated with higher nutrient intake, diet quality and favourable metabolic profile in children: a cross-sectional analysis using data from years 1–4 of the National diet and Nutrition Survey, UK. European Journal of Nutrition 58:1, pages 409-422.
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John P. Gleeson, Jesús M. Frías, Sinéad M. Ryan & David J. Brayden. (2018) Sodium caprate enables the blood pressure-lowering effect of Ile-Pro-Pro and Leu-Lys-Pro in spontaneously hypertensive rats by indirectly overcoming PepT1 inhibition. European Journal of Pharmaceutics and Biopharmaceutics 128, pages 179-187.
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Anna Iwaniak, Małgorzata Darewicz & Piotr Minkiewicz. (2018) Peptides Derived from Foods as Supportive Diet Components in the Prevention of Metabolic Syndrome. Comprehensive Reviews in Food Science and Food Safety 17:1, pages 63-81.
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B. Miralles, B. Hernández-Ledesma, S. Fernández-Tomé, L. Amigo & I. Recio. 2018. Proteins in Food Processing. Proteins in Food Processing 523 568 .
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Davide Tagliazucchi, Sherif Shamsia, Ahmed Helal & Angela Conte. (2017) Angiotensin-converting enzyme inhibitory peptides from goats' milk released by in vitro gastro-intestinal digestion. International Dairy Journal 71, pages 6-16.
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John P. Gleeson, David J. Brayden & Sinéad M. Ryan. (2017) Evaluation of PepT1 transport of food-derived antihypertensive peptides, Ile-Pro-Pro and Leu-Lys-Pro using in vitro, ex vivo and in vivo transport models. European Journal of Pharmaceutics and Biopharmaceutics 115, pages 276-284.
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Chibuike C. Udenigwe, Ifeanyi D. Nwachukwu & Rickey Y. Yada. 2017. Global Food Security and Wellness. Global Food Security and Wellness 195 219 .
Zhipeng Yu, Wenzhu Zhao, Long Ding, Yaqi Wang, Feng Chen & Jingbo Liu. (2017) Short- and long-term antihypertensive effect of egg protein-derived peptide QIGLF. Journal of the Science of Food and Agriculture 97:2, pages 551-555.
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Giuseppina Sefora Rutella, Lisa Solieri, Serena Martini & Davide Tagliazucchi. (2016) Release of the Antihypertensive Tripeptides Valine-Proline-Proline and Isoleucine-Proline-Proline from Bovine Milk Caseins during in Vitro Gastrointestinal Digestion. Journal of Agricultural and Food Chemistry 64:45, pages 8509-8515.
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A. Siltari, R. Korpela & H. Vapaatalo. (2016) Bradykinin –induced vasodilatation: Role of age, ACE1-inhibitory peptide, mas- and bradykinin receptors. Peptides 85, pages 46-55.
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Anna E. Stanhewicz, Billie K. Alba, W. Larry Kenney & Lacy M. Alexander. (2016) Dairy cheese consumption ameliorates single-meal sodium-induced cutaneous microvascular dysfunction by reducing ascorbate-sensitive oxidants in healthy older adults. British Journal of Nutrition 116:4, pages 658-665.
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L.M. Beltrán-Barrientos, A. Hernández-Mendoza, M.J. Torres-Llanez, A.F. González-Córdova & B. Vallejo-Córdoba. (2016) Invited review: Fermented milk as antihypertensive functional food. Journal of Dairy Science 99:6, pages 4099-4110.
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Chibuike C. Udenigwe. (2014) Bioinformatics approaches, prospects and challenges of food bioactive peptide research. Trends in Food Science & Technology 36:2, pages 137-143.
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Aurora García-Tejedor, Laura Sánchez-Rivera, María Castelló-Ruiz, Isidra Recio, Juan B. Salom & Paloma Manzanares. (2014) Novel Antihypertensive Lactoferrin-Derived Peptides Produced by Kluyveromyces marxianus : Gastrointestinal Stability Profile and In Vivo Angiotensin I-Converting Enzyme (ACE) Inhibition . Journal of Agricultural and Food Chemistry 62:7, pages 1609-1616.
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