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Annals of Medicine Volume 45, 2013 - Issue 7
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Original Article

Prognostic value of serum MMP-8, -9 and TIMP-1 in patients with hepatocellular carcinoma

Marko LempinenClinic of Surgery, Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki FinlandCorrespondence[email protected]
,
Ilaana LyytinenClinic of Surgery, Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki Finland
,
Arno NordinClinic of Surgery, Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki Finland
,
Taina TervahartialaDepartment of Oral and Maxillofacial Disease, Institute of Dentistry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
,
Heikki MäkisaloClinic of Surgery, Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki Finland
,
Timo SorsaDepartment of Oral and Maxillofacial Disease, Institute of Dentistry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
&
Helena IsoniemiClinic of Surgery, Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki Finland
 show all
Pages 482-487 | Received 02 May 2013, Accepted 08 Jul 2013, Published online: 20 Aug 2013

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Shengya Cao, Shuo Zhu, Wei Yin, Heng Xu, Jianzhong Wu & Qiang Wang. (2020) Relevance of EGFR Between Serum VEGF and MMP-9 in Primary Hepatocellular Carcinoma Patients with Transarterial Chemoembolization. OncoTargets and Therapy 13, pages 9407-9417.
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Vishnu Mohan, Dalit Talmi-Frank, Valeria Arkadash, Niv Papo & Irit Sagi. (2016) Matrix metalloproteinase protein inhibitors: highlighting a new beginning for metalloproteinases in medicine. Metalloproteinases in Medicine 3, pages 31-47.
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Yi-Chun Yeh & Bor-Shyang Sheu. (2014) Matrix metalloproteinases and their inhibitors in the gastrointestinal cancers: current knowledge and clinical potential. Metalloproteinases in Medicine 1, pages 3-13.
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Articles from other publishers (25)

Dongchan Kim, Bhavya Gupta & Geoffrey Yuet Mun Wong. (2023) Prognostic circulating proteomic biomarkers in colorectal liver metastases. Computational and Structural Biotechnology Journal 21, pages 2129-2136.
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Mieczysław Dutka, Rafał Bobiński, Tomasz Francuz, Wojciech Garczorz, Karolina Zimmer, Tomasz Ilczak, Michał Ćwiertnia & Maciej B. Hajduga. (2022) SGLT-2 Inhibitors in Cancer Treatment—Mechanisms of Action and Emerging New Perspectives. Cancers 14:23, pages 5811.
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Mirjami Kaasinen, Jaana Hagström, Harri Mustonen, Timo Sorsa, Malin Sund, Caj Haglund & Hanna Seppänen. (2022) Matrix Metalloproteinase 8 Expression in a Tumour Predicts a Favourable Prognosis in Pancreatic Ductal Adenocarcinoma. International Journal of Molecular Sciences 23:6, pages 3314.
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Kehinde Umeizudike, Ismo Räisänen, Shipra Gupta, Solomon Nwhator, Andreas Grigoriadis, Dimitra Sakellari & Timo Sorsa. (2021) Active matrix metalloproteinase‐8: A potential biomarker of oral systemic link. Clinical and Experimental Dental Research 8:1, pages 359-365.
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Pauliina Reijonen, Reetta Peltonen, Taina Tervahartiala, Timo Sorsa & Helena Isoniemi. (2021) Serum Matrix Metalloproteinase-8 and Myeloperoxidase Predict Survival after Resection of Colorectal Liver Metastases. Oncology 99:12, pages 766-779.
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Reetta Peltonen, Jaana Hagström, Taina Tervahartiala, Timo Sorsa, Caj Haglund & Helena Isoniemi. (2021) High Expression of MMP-9 in Primary Tumors and High Preoperative MPO in Serum Predict Improved Prognosis in Colorectal Cancer with Operable Liver Metastases. Oncology 99:3, pages 144-160.
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Hanna Hämetoja, Antti Mäkitie, Leif Bäck, Ilmo Leivo, Caj Haglund, Timo Sorsa & Jaana Hagström. (2021) Matrix metalloproteinase-7, -8, -9, -15, and -25 in minor salivary gland adenoid cystic carcinoma. Pathology - Research and Practice 217, pages 153293.
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Gurudeeban Selvaraj, Satyavani Kaliamurthi, Shuhuang Lin, Keren Gu & Dong-Qing Wei. (2020) Prognostic Impact of Tissue Inhibitor of Metalloproteinase-1 in Non- Small Cell Lung Cancer: Systematic Review and Meta-Analysis. Current Medicinal Chemistry 26:42, pages 7694-7713.
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Feng, Chen, Hua, Sun, Chen, Liu, Fan, Zhao, Zhao, Xu & Yang. (2019) The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis. Biomolecules 9:10, pages 570.
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Juurikka, Butler, Salo, Nyberg & Åström. (2019) The Role of MMP8 in Cancer: A Systematic Review. International Journal of Molecular Sciences 20:18, pages 4506.
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Timo Carpén, Timo Sorsa, Lauri Jouhi, Taina Tervahartiala, Caj Haglund, Stina Syrjänen, Jussi Tarkkanen, Hesham Mohamed, Antti Mäkitie, Jaana Hagström & Petri S. Mattila. (2019) High levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) in the serum are associated with poor prognosis in HPV-negative squamous cell oropharyngeal cancer. Cancer Immunology, Immunotherapy 68:8, pages 1263-1272.
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Takumi Kawaguchi, Dan Nakano, Shusuke Okamura, Shigeo Shimose, Masako Hayakawa, Takashi Niizeki, Hironori Koga & Takuji Torimura. (2018) Spontaneous regression of hepatocellular carcinoma with reduction in angiogenesis‐related cytokines after treatment with sodium‐glucose cotransporter 2 inhibitor in a cirrhotic patient with diabetes mellitus. Hepatology Research 49:4, pages 479-486.
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Camilla Böckelman, Ines Beilmann-Lehtonen, Tuomas Kaprio, Selja Koskensalo, Taina Tervahartiala, Harri Mustonen, Ulf-Håkan Stenman, Timo Sorsa & Caj Haglund. (2018) Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer. BMC Cancer 18:1.
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Leonardo Lorente. (2018) New prognostic biomarkers of mortality in patients undergoing liver transplantation for hepatocellular carcinoma. World Journal of Gastroenterology 24:37, pages 4230-4242.
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Alli Laitinen, Jaana Hagström, Harri Mustonen, Arto Kokkola, Taina Tervahartiala, Timo Sorsa, Camilla Böckelman & Caj Haglund. (2018) Serum MMP-8 and TIMP-1 as prognostic biomarkers in gastric cancer. Tumor Biology 40:9, pages 101042831879926.
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Janice M. Kraniak, Raymond R. Mattingly & Bonnie F. Sloane. 2018. Extracellular Targeting of Cell Signaling in Cancer. Extracellular Targeting of Cell Signaling in Cancer 411 446 .
Päivi Sirniö, Anne Tuomisto, Taina Tervahartiala, Timo Sorsa, Kai Klintrup, Toni Karhu, Karl-Heinz Herzig, Jyrki Mäkelä, Tuomo J. Karttunen, Tuula Salo, Markus J. Mäkinen & Juha P. Väyrynen. (2018) High-serum MMP-8 levels are associated with decreased survival and systemic inflammation in colorectal cancer. British Journal of Cancer 119:2, pages 213-219.
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Houyong Long, Xingjun Guo, Shen Qiao & Qingxing Huang. (2017) Tumor LXR Expression is a Prognostic Marker for Patients with Hepatocellular Carcinoma. Pathology & Oncology Research 24:2, pages 339-344.
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Esam Elshimi, Mostafa Abdel-Samed Mostafa Sakr, Wesam Saber Morad & Lobna Mohammad. (2018) Optimizing the Diagnostic Role of Alpha-Fetoprotein and Abdominal Ultrasound by Adding Overexpressed Blood mRNA Matrix Metalloproteinase-12 for Diagnosis of HCV-Related Hepatocellular Carcinoma. Gastrointestinal Tumors 5:3-4, pages 100-108.
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A. Daniele, I. Abbate, C. Oakley, P. Casamassima, E. Savino, A. Casamassima, G. Sciortino, V. Fazio, G. Gadaleta-Caldarola, A. Catino, F. Giotta, R. De Luca & R. Divella. (2016) Clinical and prognostic role of matrix metalloproteinase-2, -9 and their inhibitors in breast cancer and liver diseases: A review. The International Journal of Biochemistry & Cell Biology 77, pages 91-101.
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Stefania Moz, Daniela Basso, Andrea Padoan, Dania Bozzato, Paola Fogar, Carlo-Federico Zambon, Michela Pelloso, Cosimo Sperti, Saula Vigili de Kreutzenberg, Claudio Pasquali, Sergio Pedrazzoli, Angelo Avogaro & Mario Plebani. (2016) Blood expression of matrix metalloproteinases 8 and 9 and of their inducers S100A8 and S100A9 supports diagnosis and prognosis of PDAC-associated diabetes mellitus. Clinica Chimica Acta 456, pages 24-30.
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Guihui Qin, Min Luo, Junze Chen, Yiwu Dang, Gang Chen, Li Li, Jing Zeng, Yi Lu & Jie Yang. (2016) Reciprocal activation between MMP-8 and TGF-β1 stimulates EMT and malignant progression of hepatocellular carcinoma. Cancer Letters 374:1, pages 85-95.
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Hao Chen, Chun-Hui Yuan, Yi-Fei Yang, Chang-Qing Yin, Qing Guan, Fu-Bing Wang & Jian-Cheng Tu. (2016) Subtractive Cell-SELEX Selection of DNA Aptamers Binding Specifically and Selectively to Hepatocellular Carcinoma Cells with High Metastatic Potential. BioMed Research International 2016, pages 1-9.
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Tao Song, Changwei Dou, Yuli Jia, Kangsheng Tu & Xin Zheng. (2015) TIMP-1 activated carcinoma-associated fibroblasts inhibit tumor apoptosis by activating SDF1/CXCR4 signaling in hepatocellular carcinoma. Oncotarget 6:14, pages 12061-12079.
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Zsolt Horváth, Ilona Kovalszky, Alexandra Fullár, Katalin Kiss, Zsuzsa Schaff, Renato V. Iozzo & Kornélia Baghy. (2014) Decorin deficiency promotes hepatic carcinogenesis. Matrix Biology 35, pages 194-205.
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