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Annals of Medicine Volume 46, 2014 - Issue 3
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DNA methylation in obesity and type 2 diabetes

Vanessa Derenji Ferreira de MelloUniversity of Eastern Finland, Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Kuopio, FinlandCorrespondence[email protected]
,
Leena PulkkinenUniversity of Eastern Finland, Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Kuopio, Finland
,
Marianne LalliUniversity of Eastern Finland, Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Kuopio, Finland
,
Marjukka KolehmainenUniversity of Eastern Finland, Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Kuopio, Finland
,
Jussi PihlajamäkiUniversity of Eastern Finland, Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Kuopio, Finland;Kuopio University Hospital, Department of Medicine, Clinical Nutrition and Obesity Centre, Kuopio, Finland
&
Matti UusitupaUniversity of Eastern Finland, Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Kuopio, Finland;Kuopio University Hospital, Research Unit, Kuopio, Finland
Pages 103-113 | Received 23 Aug 2012, Accepted 16 Oct 2013, Published online: 30 Apr 2014

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Mohamed Bakr Zaki, Ahmed Ibrahim Abulsoud, Ahmed Mohamed Elsisi, Ahmed Soliman Doghish, Ossama Abd Elmotaal Mansour, Ashraf Ismail Amin, Mahmoud Ahmed Elrebehy, Mohamed Yousef Mohamed & Mohamed Ahmed Goda. (2019) Potential role of circulating microRNAs (486-5p, 497, 509-5p and 605) in metabolic syndrome Egyptian male patients. Diabetes, Metabolic Syndrome and Obesity 12, pages 601-611.
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Vanessa D. de Mello, Ashok Matte, Alexander Perfilyev, Ville Männistö, Tina Rönn, Emma Nilsson, Pirjo Käkelä, Charlotte Ling & Jussi Pihlajamäki. (2017) Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action. Epigenetics 12:4, pages 287-295.
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Articles from other publishers (55)

Erin N. L. Smith, Merin Chandanathil & Richard M Millis. (2023) Epigenetic Mechanisms in Obesity: Broadening Our Understanding of the Disease. Cureus.
Crossref
Wenjing Pan, Wangshu Li, Huan Wu, Xinya Xie, Mingwei Xie, Qing Nie, Zhonghua Liu & Shuxian Cai. (2023) Aging-Accelerated Mouse Prone 8 (SAMP8) Mice Experiment and Network Pharmacological Analysis of Aged Liupao Tea Aqueous Extract in Delaying the Decline Changes of the Body. Antioxidants 12:3, pages 685.
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Dinh-Toi Chu, Nhat-Le Bui, Hue Vu Thi & Yen-Vy Nguyen Thi. 2023. Epigenetics in Health and Disease - Part A. Epigenetics in Health and Disease - Part A 153 170 .
Mónica Ballesteros, Pilar Gil-Lluís, Miriam Ejarque, Cristina Diaz-Perdigones, Laia Martinez-Guasch, Sonia Fernández-Veledo, Joan Vendrell & Ana Megía. (2022) DNA Methylation in Gestational Diabetes and its Predictive Value for Postpartum Glucose Disturbances. The Journal of Clinical Endocrinology & Metabolism 107:10, pages 2748-2757.
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Shuang Liu, Yangfeng Chi, Xinye Wu, Bingbing Zhu, Hao Wang, Yongping Liang & Yunman Wang. (2022) Fat Stem Cells Combined with Complement C3 Inhibits the Progress of Type 2 Diabetes in Rats. Journal of Biomaterials and Tissue Engineering 12:7, pages 1434-1439.
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Oliwia W Mlodawska, Priyanka Saini, J Brandon Parker, Jian-Jun Wei, Serdar E Bulun, Melissa A Simon & Debabrata Chakravarti. (2022) Epigenomic and enhancer dysregulation in uterine leiomyomas. Human Reproduction Update 28:4, pages 518-547.
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Chunyan Ao, Lin Gao & Liang Yu. (2022) Research Progress in Predicting DNA Methylation Modifications and the Relation with Human Diseases. Current Medicinal Chemistry 29:5, pages 822-836.
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Whitney L. Do, Jazib Gohar, Lauren E. McCullough, Karla I. Galaviz, Karen N. Conneely & K. M. Venkat Narayan. (2021) Examining the association between adiposity and DNA methylation: A systematic review and meta‐analysis. Obesity Reviews 22:10.
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Marjukka Kolehmainen. 2021. Whole Grains and Health. Whole Grains and Health 389 392 .
Lisardo Fernández, Mariano Pérez & Juan M. Orduña. (2020) A comparison study of wavelet transforms for the visualization of differentially methylated regions in DNA samples. The Journal of Supercomputing 77:3, pages 2609-2623.
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Sanabil Ali Hassan Ahmed, Suraiya Anjum Ansari, Eric P. K. Mensah-Brown & Bright Starling Emerald. (2020) The role of DNA methylation in the pathogenesis of type 2 diabetes mellitus. Clinical Epigenetics 12:1.
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Mojgan Gharipour, Majid Barekatain, Johoon Sung, Naghmeh Emami, Ladan Sadeghian, Minoo Dianatkhah, Nizal Sarrafzadegan & Shayesteh Jahanfar. (2020) The Epigenetic Overlap between Obesity and Mood Disorders: A Systematic Review. International Journal of Molecular Sciences 21:18, pages 6758.
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César González, Mariano Pérez, Juan M Orduña, Javier Chaves & Ana-Bárbara García. (2019) HPG-HMapper : A DNA hydroxymethylation analysis tool . The International Journal of High Performance Computing Applications 34:1, pages 57-65.
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Amir Hossein Abdolghaffari, Mohammad Hosein Farzaei, Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Nazgol-Sadat Haddadi, Amit Kumar Singh, Harvesh Kumar Rana, Abhay K. Pandey & Saeideh Momtaz. 2020. Nutrients and Nutraceuticals for Active & Healthy Ageing. Nutrients and Nutraceuticals for Active & Healthy Ageing 111 145 .
Aida Bao-Caamano, Aitor Rodriguez-Casanova & Angel Diaz-Lagares. 2020. Circulating Tumor Cells in Breast Cancer Metastatic Disease. Circulating Tumor Cells in Breast Cancer Metastatic Disease 117 134 .
Zhe Zhang, Wei Wang, Jian‐Bo Liu, Ying Wang, Jin‐Dong Hao, Yi‐Jie Huang, Yan Gao, Hao Jiang, Bao Yuan & Jia‐Bao Zhang. (2019) ssc‐miR‐204 regulates porcine preadipocyte differentiation and apoptosis by targeting TGFBR1 and TGFBR2. Journal of Cellular Biochemistry 121:1, pages 609-620.
Crossref
Lisardo Fernández, Luis Orduña, Mariano Pérez & Juan M. Orduña. (2019) A new approach for the visualization of DNA methylation results. Computational and Mathematical Methods 2:1.
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Sheila J. Barton, Phillip E. Melton, Philip Titcombe, Robert Murray, Sebastian Rauschert, Karen A. Lillycrop, Rae-Chi Huang, Joanna D. Holbrook & Keith M. Godfrey. (2019) In Epigenomic Studies, Including Cell-Type Adjustments in Regression Models Can Introduce Multicollinearity, Resulting in Apparent Reversal of Direction of Association. Frontiers in Genetics 10.
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Sara M. Ahmed, Dina Johar, Mohamed Medhat Ali & Nagwa El-Badri. (2019) Insights into the Role of DNA Methylation and Protein Misfolding in Diabetes Mellitus. Endocrine, Metabolic & Immune Disorders - Drug Targets 19:6, pages 744-753.
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Catalina Picó, Francisca Serra, Ana María Rodríguez, Jaap Keijer & Andreu Palou. (2019) Biomarkers of Nutrition and Health: New Tools for New Approaches. Nutrients 11:5, pages 1092.
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Valentina Salvestrini, Christian Sell & Antonello Lorenzini. (2019) Obesity May Accelerate the Aging Process. Frontiers in Endocrinology 10.
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Andrea G. Izquierdo & Ana B. Crujeiras. (2019) Obesity-Related Epigenetic Changes After Bariatric Surgery. Frontiers in Endocrinology 10.
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Ning Ding, Ashley R. Maiuri & Heather M. O’Hagan. (2019) The emerging role of epigenetic modifiers in repair of DNA damage associated with chronic inflammatory diseases. Mutation Research/Reviews in Mutation Research 780, pages 69-81.
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Lisardo Fernández, Mariano Pérez & Juan M. Orduña. (2018) Visualization of DNA methylation results through a GPU-based parallelization of the wavelet transform. The Journal of Supercomputing 75:3, pages 1496-1509.
Crossref
Andrea G. Izquierdo & Ana B. Crujeiras. (2019) Role of epigenomic mechanisms in the onset and management of insulin resistance. Reviews in Endocrine and Metabolic Disorders 20:1, pages 89-102.
Crossref
Xiaodan Li, Peipei Tu, Muhammad Umar, Qiqi Liu, Wenya Luo, Xingkai Yang, Jianghong Zhu, Deling Kong & Minggang Li. (2019) A Study on Molecular Mechanisms of Adiposis Induced by Long-Term Treatment of High-Fat and High-Sucrose in C57BL/6J Mice. Physiological Research, pages 75-87.
Crossref
Andrea G. Izquierdo & Ana B. Crujeiras. 2019. Prognostic Epigenetics. Prognostic Epigenetics 269 287 .
Kazuhiko Nakabayashi. 2019. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 2203 2217 .
Natalie M. Hohos, Alicia K. Smith, Varun Kilaru, Hea Jin Park, Dorothy B. Hausman, Lynn B. Bailey, Richard D. Lewis, Bradley G. Phillips & Richard B. Meagher. (2018) CD4 + and CD8 + T-Cell-Specific DNA Cytosine Methylation Differences Associated With Obesity . Obesity 26:8, pages 1312-1321.
Crossref
Adam Russell‐Hallinan, Chris J. Watson & John A. Baugh. 2011. Comprehensive Physiology. Comprehensive Physiology 451 491 .
M. Samblas, F. I. Milagro, M. L. Mansego, A. Marti & J. A. Martinez. (2018) PTPRS and PER3 methylation levels are associated with childhood obesity: results from a genome-wide methylation analysis . Pediatric Obesity 13:3, pages 149-158.
Crossref
Emily C Bruggeman, John T Garretson, Rui Wu, Hang Shi & Bingzhong Xue. (2018) Neuronal Dnmt1 Deficiency Attenuates Diet-Induced Obesity in Mice. Endocrinology 159:1, pages 145-162.
Crossref
Mark L. DreherMark L. Dreher. 2018. Dietary Fiber in Health and Disease. Dietary Fiber in Health and Disease 251 272 .
Kazuhiko Nakabayashi. 2017. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 1 15 .
Cesar L. Moreno & Charles V. Mobbs. (2017) Epigenetic mechanisms underlying lifespan and age-related effects of dietary restriction and the ketogenic diet. Molecular and Cellular Endocrinology 455, pages 33-40.
Crossref
Bodo Speckmann, Sarah Schulz, Franziska Hiller, Deike Hesse, Fabian Schumacher, Burkhard Kleuser, Jürgen Geisel, Rima Obeid, Tilman Grune & Anna P. Kipp. (2017) Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice. The Journal of Nutritional Biochemistry 48, pages 112-119.
Crossref
César González, Mariano Pérez, Juan M. Orduña, Javier Chaves & Ana-Bárbara García. 2017. Algorithms and Architectures for Parallel Processing. Algorithms and Architectures for Parallel Processing 513 522 .
Kazuhiko Nakabayashi. 2017. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 1 15 .
Prasad P. Devarshi & Tara M. Henagan. 2017. Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases. Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases 51 62 .
Nana Yamada-Obara, Sho-ichi Yamagishi, Kensei Taguchi, Yusuke Kaida, Miyuki Yokoro, Yosuke Nakayama, Ryotaro Ando, Katsuhiko Asanuma, Takanori Matsui, Seiji Ueda, Seiya Okuda & Kei Fukami. (2016) Maternal exposure to high-fat and high-fructose diet evokes hypoadiponectinemia and kidney injury in rat offspring. Clinical and Experimental Nephrology 20:6, pages 853-861.
Crossref
Anna Hernández-Aguilera, Salvador Fernández-Arroyo, Elisabet Cuyàs, Fedra Luciano-Mateo, Noemi Cabre, Jordi Camps, Jose Lopez-Miranda, Javier A. Menendez & Jorge Joven. (2016) Epigenetics and nutrition-related epidemics of metabolic diseases: Current perspectives and challenges. Food and Chemical Toxicology 96, pages 191-204.
Crossref
Lucie Marandel, Olivier Lepais, Eva Arbenoits, Vincent Véron, Karine Dias, Marie Zion & Stéphane Panserat. (2016) Remodelling of the hepatic epigenetic landscape of glucose-intolerant rainbow trout (Oncorhynchus mykiss) by nutritional status and dietary carbohydrates. Scientific Reports 6:1.
Crossref
Qiwei Yang, Aymara Mas, Michael P. Diamond & Ayman Al-Hendy. (2016) The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development. Reproductive Sciences 23:2, pages 163-175.
Crossref
Carolina Soriano-Tárraga, Jordi Jiménez-Conde, Eva Giralt-Steinhauer, Marina Mola-Caminal, Rosa M. Vivanco-Hidalgo, Angel Ois, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Sergi Sayols-Baixeras, Roberto Elosua & Jaume Roquer. (2016) Epigenome-wide association study identifies TXNIP gene associated with type 2 diabetes mellitus and sustained hyperglycemia . Human Molecular Genetics 25:3, pages 609-619.
Crossref
Wenyi XuFengzhong WangZhongsheng YuFengjiao Xin. (2016) Epigenetics and Cellular Metabolism. Genetics & Epigenetics 8, pages GEG.S32160.
Crossref
Mette J. Jacobsen, Caroline M. Junker Mentzel, Ann Sofie Olesen, Thierry Huby, Claus B. Jørgensen, Romain Barrès, Merete Fredholm & David Simar. (2016) Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity. Journal of Diabetes Research 2016, pages 1-11.
Crossref
Ana B. Crujeiras & Angel Diaz-Lagares. 2016. Epigenetic Biomarkers and Diagnostics. Epigenetic Biomarkers and Diagnostics 313 329 .
Esther Zimmermann, Michael Gamborg, Thorkild I.A. SørensenJennifer L. Baker. (2015) Sex Differences in the Association Between Birth Weight and Adult Type 2 Diabetes. Diabetes 64:12, pages 4220-4225.
Crossref
Sara H. G. Sinclair, Srinivasan Yegnasubramanian & J. Stephen Dumler. (2015) Global DNA methylation changes and differential gene expression in Anaplasma phagocytophilum-infected human neutrophils. Clinical Epigenetics 7:1.
Crossref
Omar Ali, Diana Cerjak, Jack W KentJrJr, Roland James, John Blangero, Melanie A Carless & Yi Zhang. (2015) An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome. Clinical Epigenetics 7:1.
Crossref
Marc Jung & Gerd P Pfeifer. (2015) Aging and DNA methylation. BMC Biology 13:1.
Crossref
Kyle J Burghardt, Jacyln M Goodrich, Dana C Dolinoy & Vicki L Ellingrod. (2015) DNA methylation, insulin resistance and second-generation antipsychotics in bipolar disorder. Epigenomics 7:3, pages 343-352.
Crossref
Ching-Shu Lai, Jia-Ching Wu & Min-Hsiung Pan. (2015) Molecular mechanism on functional food bioactives for anti-obesity. Current Opinion in Food Science 2, pages 9-13.
Crossref
Henry J. Thompson. 2015. Murine Models, Energy Balance, and Cancer. Murine Models, Energy Balance, and Cancer 175 196 .
Jacob Vander Velden & Danielle Maria Osborne. (2022) Prolonged Diet-Induced Obesity Modifies DNA Methylation and Gene Expression in the Hippocampus. SSRN Electronic Journal.
Crossref

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