Advanced search
Publication Cover
Annals of Medicine Volume 46, 2014 - Issue 3
Submit an article Journal homepage
2,539
Views
56
CrossRef citations to date
0
Altmetric
Review Articles

Uncovering the pathogenesis of large granular lymphocytic leukemia—novel STAT3 and STAT5b mutations

Hanna L. M. RajalaHematology Research Unit, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
,
Kimmo PorkkaHematology Research Unit, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
,
Jaroslaw P. MaciejewskiDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA
,
Thomas P. Loughran JrUniversity of Virginia Cancer Center, University of Virginia, Charlottesville, VA, USA
&
Satu MustjokiHematology Research Unit, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, FinlandCorrespondence[email protected]
Pages 114-122 | Received 16 Sep 2013, Accepted 02 Jan 2014, Published online: 11 Feb 2014

Citations (56)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Teodora Statuto, Fiorella D’Auria, Luigi Del Vecchio, Giovanna Rosaria Mansueto, Oreste Villani, Anna Vittoria Lalinga, Luciana Possidente, Filomena Nozza, Gabriella Vona, Luciana Rago, Giovanni Storto, Vanessa Rebecca Gasparini, Renato Zambello, Giovanni D’Arena & Luciana Valvano. (2020) Atypical Mature T-Cell Neoplasms: The Relevance of the Role of Flow Cytometry. OncoTargets and Therapy 13, pages 7605-7614.
Read now
Cristina Bagacean, Adrian Tempescul, Mariana Patiu, Bogdan Fetica, Horia Bumbea & Mihnea Zdrenghea. (2017) Atypical aleukemic presentation of large granular lymphocytic leukemia: a case report. OncoTargets and Therapy 10, pages 31-34.
Read now
Kristine C. Olson, Paige M. Kulling, Thomas L. Olson, Su-Fern Tan, Rebecca J. Rainbow, David J. Feith & Thomas P. Loughran$suffix/text()$suffix/text(). (2017) Vitamin D decreases STAT phosphorylation and inflammatory cytokine output in T-LGL leukemia. Cancer Biology & Therapy 18:5, pages 290-303.
Read now

Articles from other publishers (53)

Warren J. Leonard & Jian-Xin Lin. (2023) Strategies to therapeutically modulate cytokine action. Nature Reviews Drug Discovery.
Crossref
Joseph Mackie, Cindy S Ma, Stuart G Tangye & Antoine Guerin. (2023) The ups and downs of STAT3 function: too much, too little and human immune dysregulation. Clinical and Experimental Immunology 212:2, pages 107-116.
Crossref
David C. Dale, Audrey Anna Bolyard, James A. ShannonIVIV, James A. Connelly, Daniel C. Link, Mary Ann Bonilla & Peter E. Newburger. (2022) Outcomes for patients with severe chronic neutropenia treated with granulocyte colony-stimulating factor. Blood Advances 6:13, pages 3861-3869.
Crossref
Young Min Cho, Erik W. Anderson, Sara Guevara, Santiago J. Miyara, Aqsa Iqbal, Judith Aronsohn, Ernesto P. Molmenti, James M. Mumford, Barbara Keber, Farideh Zonouzi-Zadeh, Yousoun Ha, Petros G. Nikolinakos & Brent Flickinger. (2021) Upadacitinib as Novel Treatment for Rheumatoid Arthritis with T-Cell Granular Lymphocytic Leukemia: A Case Report and Narrative Review. Journal of Clinical Rheumatology and Immunology 22:01, pages 22-30.
Crossref
Paula Savola, Dipabarna Bhattacharya & Jani Huuhtanen. (2022) The spectrum of somatic mutations in large granular lymphocyte leukemia, rheumatoid arthritis, and Felty's syndrome. Seminars in Hematology 59:3, pages 123-130.
Crossref
Jorn L. J. C. Assmann, Leticia G. Leon, Christiaan J. Stavast, Sanne E. van den Bogaerdt, Joyce Schilperoord-Vermeulen, Yorick Sandberg, Mar Bellido, Stefan J. Erkeland, David J. Feith, Thomas P. Loughran Jr & Anton W. Langerak. (2021) miR-181a is a novel player in the STAT3-mediated survival network of TCRαβ+ CD8+ T large granular lymphocyte leukemia. Leukemia 36:4, pages 983-993.
Crossref
Dipabarna Bhattacharya, Antonella Teramo, Vanessa Rebecca Gasparini, Jani Huuhtanen, Daehong Kim, Jason Theodoropoulos, Gianluca Schiavoni, Gregorio Barilà, Cristina Vicenzetto, Giulia Calabretto, Monica Facco, Toru Kawakami, Hideyuki Nakazawa, Brunangelo Falini, Enrico Tiacci, Fumihiro Ishida, Gianpietro Semenzato, Tiina Kelkka, Renato Zambello & Satu Mustjoki. (2022) Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia. Blood Cancer Journal 12:2.
Crossref
Elham Zeinalzadeh, Alexey Valerievich Yumashev, Heshu Sulaiman Rahman, Faroogh Marofi, Navid Shomali, Hossein Samadi Kafil, Saeed Solali, Mehdi Sajjadi-Dokht, Sajjad Vakili-Samiani, Mostafa Jarahian & Majid Farshdousti Hagh. (2021) The Role of Janus Kinase/STAT3 Pathway in Hematologic Malignancies With an Emphasis on Epigenetics. Frontiers in Genetics 12.
Crossref
Daehong Kim, Giljun Park, Jani Huuhtanen, Bishwa Ghimire, Hanna Rajala, Richard Moriggl, Wing C. Chan, Matti Kankainen, Mikko Myllymäki & Satu Mustjoki. (2021) STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation. Leukemia 35:12, pages 3430-3443.
Crossref
Laura Faletti, Stephan Ehl & Maximilian Heeg. (2021) Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype. Biomedical Journal 44:4, pages 412-421.
Crossref
Christo Tsilifis, Alexandra F. Freeman & Andrew R. Gennery. (2021) STAT3 Hyper-IgE Syndrome—an Update and Unanswered Questions. Journal of Clinical Immunology 41:5, pages 864-880.
Crossref
Klara Klein, Dagmar Stoiber, Veronika Sexl & Agnieszka Witalisz-Siepracka. (2021) Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies?. Cancers 13:11, pages 2611.
Crossref
Inge Lodewijckx & Jan Cools. (2021) Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies. Pharmaceuticals 14:5, pages 443.
Crossref
Karolina H. Dziewulska, Katharine B. Moosic, HeeJin Cheon, Kristine C. Olson, David J. Feith & Thomas P. LoughranJrJr. 2021. The Peripheral T‐Cell Lymphomas. The Peripheral T‐Cell Lymphomas 183 201 .
Claudio Ortolani. 2021. Flow Cytometry of Hematological Malignancies. Flow Cytometry of Hematological Malignancies 301 427 .
Vadim Romanovich Gorodetskiy, Yulia Vladimirovna Sidorova, Natalia Alexandrovna Kupryshina, Vladimir Ivanovich Vasilyev, Natalya Alexandrovna Probatova, Natalya Valerievna Ryzhikova & Andrey Borisovich Sudarikov. (2020) Analysis of a single-institution cohort of patients with Felty's syndrome and T-cell large granular lymphocytic leukemia in the setting of rheumatoid arthritis. Rheumatology International 41:1, pages 147-156.
Crossref
Patricia C. Tsang. 2021. Practical Oncologic Molecular Pathology. Practical Oncologic Molecular Pathology 377 401 .
Antonella Teramo, Cristina Vicenzetto, Gregorio Barilà, Giulia Calabretto, Vanessa Rebecca Gasparini, Gianpietro Semenzato & Renato Zambello. 2021. Indolent Lymphomas. Indolent Lymphomas 231 246 .
Kristine C. Olson, Katharine B. Moosic, Marieke K. Jones, Paige M. K. Larkin, Thomas L. Olson, Mariella F. Toro, Todd E. Fox, David J. Feith & Thomas P. LoughranJrJr. (2020) Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations. Cancer Medicine 9:18, pages 6533-6549.
Crossref
Jefferson Terry, Sylvie Langlois, Rosemarie Rupps & Harinder Gill. (2019) Prenatal Autoimmune Disease, Multisystem, Infantile Onset-like Phenotype and Proximal Renal Tubular Dysplasia Associated With STAT3 Mutation . Pediatric and Developmental Pathology 23:4, pages 306-311.
Crossref
Max Mimpen, Joost Smolders, Raymond Hupperts & Jan Damoiseaux. (2020) Natural killer cells in multiple sclerosis: A review. Immunology Letters 222, pages 1-11.
Crossref
Vanessa Rebecca Gasparini, Andrea Binatti, Alessandro Coppe, Antonella Teramo, Cristina Vicenzetto, Giulia Calabretto, Gregorio Barilà, Annica Barizza, Edoardo Giussani, Monica Facco, Satu Mustjoki, Gianpietro Semenzato, Renato Zambello & Stefania Bortoluzzi. (2020) A high definition picture of somatic mutations in chronic lymphoproliferative disorder of natural killer cells. Blood Cancer Journal 10:4.
Crossref
Marie Brachet-Botineau, Marion Polomski, Heidi Neubauer, Ludovic Juen, Damien Hédou, Marie-Claude Viaud-Massuard, Gildas Prié & Fabrice Gouilleux. (2020) Pharmacological Inhibition of Oncogenic STAT3 and STAT5 Signaling in Hematopoietic Cancers. Cancers 12:1, pages 240.
Crossref
T. Tiffany Wang, Jun Yang, Shubha Dighe, Matthew W. Schmachtenberg, Nathan T. Leigh, Emily Farber, Suna Onengut-Gumuscu, David J. Feith, Aakrosh Ratan, Thomas P. LoughranJr.Jr. & Thomas L. Olson. (2020) Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation. Cancers 12:1, pages 126.
Crossref
Ling Zhang, Lugen Chen & Serhan Alkan. 2020. Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver. Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver 171 184 .
Dagmar Gotthardt, Jana Trifinopoulos, Veronika Sexl & Eva Maria Putz. (2019) JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation. Frontiers in Immunology 10.
Crossref
T. Tiffany Wang, Jun Yang, Yong Zhang, Meili Zhang, Sigrid Dubois, Kevin C. Conlon, Yutaka Tagaya, Cait E. Hamele, Shubha Dighe, Thomas L. Olson, David J. Feith, Nazli Azimi, Thomas A. Waldmann & Thomas P. LoughranJr.Jr.. (2018) IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective γ-chain cytokines, decreases leukemic T-cell viability. Leukemia 33:5, pages 1243-1255.
Crossref
Jian-Xin LinWarren J. Leonard. (2019) Fine-Tuning Cytokine Signals. Annual Review of Immunology 37:1, pages 295-324.
Crossref
Cassandra M. Kerr, Michael J. Clemente, Peter W. Chomczynski, Bartlomiej Przychodzen, Yasunobu Nagata, Vera Adema, Valeria Visconte, Alan E. LichtinSatu Mustjoki, Tomas Radivoyevitch, Mikkael A. SekeresJaroslaw P. Maciejewski. (2019) Subclonal STAT3 mutations solidify clonal dominance. Blood Advances 3:6, pages 917-921.
Crossref
Juliane Lokau & Christoph Garbers. 2019. Intracellular Signalling Proteins. Intracellular Signalling Proteins 283 309 .
Austin B. Henslee & Timothy A. Steele. (2018) Combination statin and chemotherapy inhibits proliferation and cytotoxicity of an aggressive natural killer cell leukemia. Biomarker Research 6:1.
Crossref
Jadee L. Neff, Aruna Rangan, Dragan Jevremovic, Phuong L. Nguyen, April Chiu, Ronald S. Go, Dong Chen, William G. Morice & Min Shi. (2018) Mixed-phenotype large granular lymphocytic leukemia: a rare subtype in the large granular lymphocytic leukemia spectrum. Human Pathology 81, pages 96-104.
Crossref
Kristine C. Olson, Paige M. Kulling Larkin, Rossana Signorelli, Cait E. Hamele, Thomas L. Olson, Mark R. Conaway, David J. Feith & Thomas P. LoughranJr.Jr.. (2018) Vitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural killer leukemic large granular lymphocytes. Cytokine 111, pages 551-562.
Crossref
Tian Mi, Zhengqi Wang & Kevin Bunting. (2018) The Cooperative Relationship between STAT5 and Reactive Oxygen Species in Leukemia: Mechanism and Therapeutic Potential. Cancers 10:10, pages 359.
Crossref
Jun Yang, Francis R. LeBlanc, Shubha A. Dighe, Cait E. Hamele, Thomas L. Olson, David J. Feith & Thomas P. LoughranJrJr. (2018) TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia. Blood 131:25, pages 2803-2815.
Crossref
Bettina Wingelhofer, Barbara Maurer, Elizabeth C. Heyes, Abbarna A. Cumaraswamy, Angelika Berger-Becvar, Elvin D. de Araujo, Anna Orlova, Patricia Freund, Frank Ruge, Jisung Park, Gary Tin, Siawash Ahmar, Charles-Hugues Lardeau, Irina Sadovnik, Dávid Bajusz, György Miklós Keserű, Florian Grebien, Stefan Kubicek, Peter Valent, Patrick T. Gunning & Richard Moriggl. (2018) Pharmacologic inhibition of STAT5 in acute myeloid leukemia. Leukemia 32:5, pages 1135-1146.
Crossref
Nahid Shahmarvand, Alexandra Nagy, Jahanbanoo Shahryari & Robert S. Ohgami. (2018) Mutations in the signal transducer and activator of transcription family of genes in cancer. Cancer Science 109:4, pages 926-933.
Crossref
Paige M. Kulling, Kristine C. Olson, Thomas L. Olson, Cait E. Hamele, Kathryn N. Carter, David J. Feith & Thomas P. LoughranJr.Jr.. (2018) Calcitriol-mediated reduction in IFN-γ output in T cell large granular lymphocytic leukemia requires vitamin D receptor upregulation. The Journal of Steroid Biochemistry and Molecular Biology 177, pages 140-148.
Crossref
Paige M. Kulling, Kristine C. Olson, Cait E. Hamele, Mariella F. Toro, Su-Fern Tan, David J. Feith & Thomas P. Loughran. (2018) Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia. PLOS ONE 13:2, pages e0193429.
Crossref
Sa A. Wang. 2018. Diagnosis of Blood and Bone Marrow Disorders. Diagnosis of Blood and Bone Marrow Disorders 281 328 .
Megan Parilla & Girish Venkataraman. 2018. Atlas of Bone Marrow Pathology. Atlas of Bone Marrow Pathology 77 102 .
Elizabeth A. Morgan, Mark N. Lee, Daniel J. DeAngelo, David P. Steensma, Richard M. Stone, Frank C. Kuo, Jon C. Aster, Christopher J. Gibson & R. Coleman Lindsley. (2017) Systematic STAT3 sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia. Blood Advances 1:21, pages 1786-1789.
Crossref
A Coppe, E I Andersson, A Binatti, V R Gasparini, S Bortoluzzi, M Clemente, M Herling, J Maciejewski, S Mustjoki & S Bortoluzzi. (2017) Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach. Leukemia 31:5, pages 1243-1246.
Crossref
Thomas A. WaldmannJing Chen. (2017) Disorders of the JAK/STAT Pathway in T Cell Lymphoma Pathogenesis: Implications for Immunotherapy. Annual Review of Immunology 35:1, pages 533-550.
Crossref
Jing ChenYong ZhangMichael N. PetrusWenming XiaoAlina NicolaeMark RaffeldStefania PittalugaRichard N. BamfordMasao NakagawaSunny Tianyi OuyangAlan L. EpsteinMarshall E. KadinAnnarose Del MistroRichard Woessner, Elaine S. JaffeThomas A. Waldmann. (2017) Cytokine receptor signaling is required for the survival of ALK− anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations. Proceedings of the National Academy of Sciences 114:15, pages 3975-3980.
Crossref
Ling Zhang, Magali Van Den BerghLubomir Sokol. (2018) CD4-Positive T-Cell Large Granular Lymphocytosis Mimicking Sézary Syndrome in a Patient with Mycosis Fungoides. Cancer Control 24:2, pages 207-212.
Crossref
Thierry Lamy, Aline Moignet & Thomas P. LoughranJrJr. (2017) LGL leukemia: from pathogenesis to treatment. Blood 129:9, pages 1082-1094.
Crossref
C Evangelisti, C Evangelisti, F Buontempo, A Lonetti, E Orsini, F Chiarini, J T Barata, S Pyne, N J Pyne & A M Martelli. (2016) Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. Leukemia 30:11, pages 2142-2151.
Crossref
Yi Li, Jia Wei, Xia Mao, Qingping Gao, Longlong Liu, Ping Cheng, Limei Liu, Xinhua Zhang, Ke Zhang, Jin Wang, Li Zhu, Jianfeng Zhou, Yicheng Zhang, Li Meng, Hanying Sun, Dengju Li, Mei Huang, Wei Huang, Jinniu Deng & Donghua Zhang. (2016) Flow Cytometric Immunophenotyping Is Sensitive for the Early Diagnosis of De Novo Aggressive Natural Killer Cell Leukemia (ANKL): A Multicenter Retrospective Analysis. PLOS ONE 11:8, pages e0158827.
Crossref
Camilla Pilati & Jessica Zucman-Rossi. (2015) Mutations leading to constitutive active gp130/JAK1/STAT3 pathway. Cytokine & Growth Factor Reviews 26:5, pages 499-506.
Crossref
Tiphanie P. Vogel, Joshua D. Milner & Megan A. Cooper. (2015) The Ying and Yang of STAT3 in Human Disease. Journal of Clinical Immunology 35:7, pages 615-623.
Crossref
Dagmar Gotthardt, Eva M. Putz, Elisabeth Straka, Petra Kudweis, Mario Biaggio, Valeria Poli, Birgit Strobl, Mathias Müller & Veronika Sexl. (2014) Loss of STAT3 in murine NK cells enhances NK cell–dependent tumor surveillance. Blood 124:15, pages 2370-2379.
Crossref
Faramarz Naeim, P. Nagesh Rao, Sophie X. Song & Ryan T. Phan. 2008. Atlas of Hematopathology. Atlas of Hematopathology 673 691 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.