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Review Article

Microsomal transfer protein (MTP) inhibition—a novel approach to the treatment of homozygous hypercholesterolemia

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Pages 464-474 | Received 17 Sep 2013, Accepted 21 May 2014, Published online: 02 Jul 2014

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M. Ruscica, N. Ferri, C. Macchi, A. Corsini & C. R. Sirtori. (2018) Lipid lowering drugs and inflammatory changes: an impact on cardiovascular outcomes?. Annals of Medicine 50:6, pages 461-484.
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Amanda J. Berberich & Robert A. Hegele. (2017) Lomitapide for the treatment of hypercholesterolemia. Expert Opinion on Pharmacotherapy 18:12, pages 1261-1268.
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Articles from other publishers (19)

Tianhang Peng, Meng Ding, Hanhui Yan, Qiufang Li, Ping Zhang, Rui Tian & Lan Zheng. (2022) Exercise Training Upregulates Cardiac mtp Expression in Drosophila melanogaster with HFD to Improve Cardiac Dysfunction and Abnormal Lipid Metabolism. Biology 11:12, pages 1745.
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Laura D’Erasmo, Antonina Giammanco, Patrizia Suppressa, Chiara Pavanello, Gabriella Iannuzzo, Alessia Di Costanzo, Daniele Tramontano, Ilenia Minicocci, Simone Bini, Anja Vogt, Kim Stewards, Jeanine Roeters Van Lennep, Stefano Bertolini & Marcello Arca. (2022) Efficacy of Long-Term Treatment of Autosomal Recessive Hypercholesterolemia With Lomitapide: A Subanalysis of the Pan-European Lomitapide Study. Frontiers in Genetics 13.
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Aashiq Hussain, Jihong Lian, Russell Watts, Tomás Gutiérrez, Randal Nelson, Ing Swie Goping & Richard Lehner. (2022) Attenuation of obesity-induced hyperlipidemia reduces tumor growth. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1867:4, pages 159124.
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Shifa Jebari-Benslaiman, Unai Galicia-Garcia, Asier Larrea-Sebal, Kepa B. Uribe, Cesar Martin & Asier Benito-Vicente. 2022. Cholesterol. Cholesterol 501 524 .
Jorge Simón, Naroa Goikoetxea-Usandizaga, Marina Serrano-Maciá, David Fernández-Ramos, Diego Sáenz de Urturi, Jessica J. Gruskos, Pablo Fernández-Tussy, Sofía Lachiondo-Ortega, Irene González-Recio, Rubén Rodríguez-Agudo, Virginia Gutiérrez-de-Juan, Begoña Rodríguez-Iruretagoyena, Marta Varela-Rey, Paula Gimenez-Mascarell, María Mercado-Gomez, Beatriz Gómez-Santos, Carmen Fernandez-Rodriguez, Fernando Lopitz-Otsoa, Maider Bizkarguenaga, Sibylle Dames, Ute Schaeper, Franz Martin, Guadalupe Sabio, Paula Iruzubieta, Javier Crespo, Patricia Aspichueta, Kevan H.-Y. Chu, Daniela Buccella, César Martín, Teresa Cardoso Delgado, Luis Alfonso Martínez-Cruz & María Luz Martínez-Chantar. (2021) Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH. Journal of Hepatology 75:1, pages 34-45.
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Daisuke Yasuda, Yoshinori Hiraoka, Mikiko Ohno, Kiyoto Nishi, Hirotaka Iwasaki, Toru Kita, Eiichiro Nishi & Noriaki Kume. (2021) Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels. Biological and Pharmaceutical Bulletin 44:3, pages 363-371.
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Antonio Gordillo-Moscoso, Rafael Almendra-Pegueros & Úrsula Medina. (2021) Presente y futuro del tratamiento hipolipemiante, nuevas moléculas a la vista. Cardiovascular and Metabolic Science 32:S3, pages 225-230.
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Jorge Simon, Maitane Nuñez-García, Pablo Fernández-Tussy, Lucía Barbier-Torres, David Fernández-Ramos, Beatriz Gómez-Santos, Xabier Buqué, Fernando Lopitz-Otsoa, Naroa Goikoetxea-Usandizaga, Marina Serrano-Macia, Rubén Rodriguez-Agudo, Maider Bizkarguenaga, Imanol Zubiete-Franco, Virginia Gutiérrez-de Juan, Diana Cabrera, Cristina Alonso, Paula Iruzubieta, Manuel Romero-Gomez, Sebastiaan van Liempd, Azucena Castro, Ruben Nogueiras, Marta Varela-Rey, Juan Manuel Falcón-Pérez, Erica Villa, Javier Crespo, Shelly C. Lu, Jose M. Mato, Patricia Aspichueta, Teresa C. Delgado & María Luz Martínez-Chantar. (2020) Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly. Cell Metabolism 31:3, pages 605-622.e10.
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Angela Pirillo, Giuseppe D. Norata & Alberico L. Catapano. 2020.
Ricardo Rodriguez-Calvo & Luis Masana. (2019) Review of the scientific evolution of gene therapy for the treatment of homozygous familial hypercholesterolaemia: past, present and future perspectives. Journal of Medical Genetics 56:11, pages 711-717.
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Juan M. Suárez-Rivero, Carmen J. Pastor-Maldonado, Mario de la Mata, Marina Villanueva-Paz, Suleva Povea-Cabello, Mónica Álvarez-Córdoba, Irene Villalón-García, Alejandra Suárez-Carrillo, Marta Talaverón-Rey, Manuel Munuera & José A. Sánchez-Alcázar. (2019) Atherosclerosis and Coenzyme Q10. International Journal of Molecular Sciences 20:20, pages 5195.
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Asier Benito-Vicente, Kepa Uribe, Shifa Jebari, Unai Galicia-Garcia, Helena Ostolaza & Cesar Martin. (2018) Familial Hypercholesterolemia: The Most Frequent Cholesterol Metabolism Disorder Caused Disease. International Journal of Molecular Sciences 19:11, pages 3426.
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Xin Liu, Peng Men, Yuhui Wang, Suodi Zhai, Zhigang Zhao & George Liu. (2017) Efficacy and Safety of Lomitapide in Hypercholesterolemia. American Journal of Cardiovascular Drugs 17:4, pages 299-309.
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Laura D’Erasmo, Angelo Baldassare Cefalù, Davide Noto, Antonina Giammanco, Maurizio Averna, Paolo Pintus, Paolo Medde, Giovanni Battista Vigna, Cesare Sirtori, Laura Calabresi, Chiara Pavanello, Marco Bucci, Carlo Sabbà, Patrizia Suppressa, Francesco Natale, Paolo Calabrò, Tiziana Sampietro, Federico Bigazzi, Francesco Sbrana, Katia Bonomo, Fulvio Sileo & Marcello Arca. (2017) Efficacy of Lomitapide in the Treatment of Familial Homozygous Hypercholesterolemia: Results of a Real-World Clinical Experience in Italy. Advances in Therapy 34:5, pages 1200-1210.
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Caroline S. Bruikman, Robert M. Stoekenbroek, G. Kees Hovingh & John P. Kastelein. (2017) New Drugs for Atherosclerosis. Canadian Journal of Cardiology 33:3, pages 350-357.
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Dirk J. Blom, Zahi A. Fayad, John J.P. Kastelein, Dominique Larrey, Lukas Makris, Charles Schwamlein, LeAnne Bloeden & James Underberg. (2016) LOWER, a registry of lomitapide-treated patients with homozygous familial hypercholesterolemia: Rationale and design. Journal of Clinical Lipidology 10:2, pages 273-282.
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John J P Kastelein, Joost Besseling, Sukrut Shah, Jean Bergeron, Gisle Langslet, G Kees Hovingh, Naab Al-Saady, Michiel Koeijvoets, John Hunter, Amy O Johnson-Levonas, Jennifer Fable, Aditi Sapre & Yale Mitchel. (2015) Anacetrapib as lipid-modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study. The Lancet 385:9983, pages 2153-2161.
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Genovefa Kolovou, Ioannis Vasiliadis, Nikos Gontoras, Vana Kolovou & Georgios Hatzigeorgiou. (2015) Microsomal Transfer Protein Inhibitors, New Approach for Treatment of Familial Hypercholesterolemia, Review of the Literature, Original Findings, and Clinical Significance. Cardiovascular Therapeutics 33:2, pages 71-78.
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Jorge Simon, Maitane Nuñez-García, Pablo Fernández-Tussy, Lucía Barbier-Torres, David Fernández-Ramos, Beatriz Gómez-Santos, Xabier Buqué, Fernando Lopitz-Otsoa, Imanol Zubiete-Franco, Virginia Gutiérrez-de Juan, Diana Cabrera, Cristina Alonso, Paula Iruzubieta, Sebastiaan van Liempd, Azucena Castro, Marta Varela-Rey, Juan Manuel Falcón-Pérez, Erica Villa, Javier Crespo, Shelly C. Lu, Jose María Mato, Patricia Aspichueta, Teresa Cardoso Delgado & María Luz Martínez Chantar. (2018) Targeting Hepatic Glutaminase 1 Ameliorates Non-Alcoholic Steatohepatitis by Restoring Disrupted Hepatic Very-Low Density Lipoproteins Triglyceride Assembly. SSRN Electronic Journal.
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