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Annals of Medicine Volume 46, 2014 - Issue 8
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Review Article

Taking aim at Alzheimer's disease through the mammalian target of rapamycin

Kenneth MaieseCellular and Molecular Signaling, Newark, New Jersey 07101, USACorrespondence[email protected]
Pages 587-596 | Received 19 Apr 2014, Accepted 28 Jun 2014, Published online: 08 Aug 2014

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Kenneth Maiese. (2020) Cognitive impairment with diabetes mellitus and metabolic disease: innovative insights with the mechanistic target of rapamycin and circadian clock gene pathways. Expert Review of Clinical Pharmacology 13:1, pages 23-34.
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Antonella Tramutola, Chiara Lanzillotta & Fabio Di Domenico. (2017) Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies. Expert Review of Neurotherapeutics 17:1, pages 33-45.
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Articles from other publishers (45)

Kenneth Maiese. (2023) Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK. Cells 12:22, pages 2595.
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Kenneth Maiese. (2023) The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk. Frontiers in Immunology 14.
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Suzanne M. de la Monte. (2023) Malignant Brain Aging: The Formidable Link Between Dysregulated Signaling Through Mechanistic Target of Rapamycin Pathways and Alzheimer’s Disease (Type 3 Diabetes). Journal of Alzheimer's Disease, pages 1-37.
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Kenneth Maiese. (2023) Cognitive Impairment in Multiple Sclerosis. Bioengineering 10:7, pages 871.
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Kenneth Maiese. (2023) Cellular Metabolism: A Fundamental Component of Degeneration in the Nervous System. Biomolecules 13:5, pages 816.
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Mutali Musa, Marco Zeppieri, George Nnamdi Atuanya, Ehimare S. Enaholo, Efioshiomoshi Kings Topah, Oluwasola Michael Ojo & Carlo Salati. (2023) Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies. Life 13:5, pages 1120.
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Meysam Amidfar, Michelle Lima Garcez & Yong-Ku Kim. (2023) The shared molecular mechanisms underlying aging of the brain, major depressive disorder, and Alzheimer's disease: The role of circadian rhythm disturbances. Progress in Neuro-Psychopharmacology and Biological Psychiatry 123, pages 110721.
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Shilu Deepa Thomas, Niraj Kumar Jha, Shreesh Ojha & Bassem Sadek. (2023) mTOR Signaling Disruption and Its Association with the Development of Autism Spectrum Disorder. Molecules 28:4, pages 1889.
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Jia-Bing Li, Xiao-Yu Hu, Mu-Wen Chen, Cai-Hong Xiong, Na Zhao, Yan-Hui Ge, Hao Wang, Xiao-Ling Gao, Nan-Jie Xu, Lan-Xue Zhao, Zhi-Hua Yu, Hong-Zhuan Chen & Yu Qiu. (2023) p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer’s disease. Translational Neurodegeneration 12:1.
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Anusha Jayaraman & Richard Reynolds. (2022) Diverse pathways to neuronal necroptosis in Alzheimer's disease. European Journal of Neuroscience 56:9, pages 5428-5441.
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Kenneth Maiese. (2022) Biomarkers for Parkinson’s Disease and Neurodegenerative Disorders: A Role for Non-coding RNAs. Current Neurovascular Research 19:2, pages 127-130.
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Kenneth Maiese. (2022) A Common Link in Neurovascular Regenerative Pathways: Protein Kinase B (Akt). Current Neurovascular Research 19:1, pages 1-4.
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Dapinder Kaur, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Vishnu Nayak Badavath, Syed Shams ul Hassan, Mohammad Mehedi Hasan, Saurabh Bhatia, Ahmed Al-Harassi, Haroon Khan & Simona Bungau. (2021) Unravelling the potential neuroprotective facets of erythropoietin for the treatment of Alzheimer’s disease. Metabolic Brain Disease 37:1, pages 1-16.
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Hui Wang, Feng Yang, Shidong Zhang, Ruihua Xin & Yan Sun. (2021) Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation. npj Parkinson's Disease 7:1.
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Kenneth Maiese. (2021) Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways. Biomolecules 11:7, pages 1002.
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Kenneth Maiese. 2021. Sirtuin Biology in Cancer and Metabolic Disease. Sirtuin Biology in Cancer and Metabolic Disease 3 23 .
Kenneth Maiese. 2021. Sirtuin Biology in Medicine. Sirtuin Biology in Medicine 3 21 .
Ayse Basak Engin & Atilla Engin. 2021. Protein Kinase-mediated Decisions Between Life and Death. Protein Kinase-mediated Decisions Between Life and Death 285 321 .
Kenneth Maiese. (2020) New Challenges and Strategies for Cardiac Disease: Autophagy, mTOR, and AMP-activated Protein Kinase. Current Neurovascular Research 17:2, pages 111-112.
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Ramsey Najm, Kelly A. Zalocusky, Misha Zilberter, Seo Yeon Yoon, Yanxia Hao, Nicole Koutsodendris, Maxine Nelson, Antara Rao, Alice Taubes, Emily A. Jones & Yadong Huang. (2020) In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons. Cell Reports 32:4, pages 107962.
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Xingyi Cheng, Chaochun Song, Yanjiao Du, Uma Gaur & Mingyao Yang. (2020) Pharmacological Treatment of Alzheimer’s Disease: Insights from Drosophila melanogaster. International Journal of Molecular Sciences 21:13, pages 4621.
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Kenneth Maiese. (2020) Healing the Heart with Sirtuins and Mammalian Forkhead Transcription Factors. Current Neurovascular Research 17:1, pages 1-2.
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Maryam Majidinia, Ansar Karimian, Forough Alemi, Bahman Yousefi & Amin Safa. (2020) Targeting miRNAs by polyphenols: Novel therapeutic strategy for aging. Biochemical Pharmacology 173, pages 113688.
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Kenneth Maiese. 2020. Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating neurodegenerative diseases as metabolic diseases. Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating neurodegenerative diseases as metabolic diseases 1 35 .
Aliza K. De Nobrega, Kristine V. Luz & Lisa C. Lyons. 2020. Reviews on New Drug Targets in Age-Related Disorders. Reviews on New Drug Targets in Age-Related Disorders 193 265 .
Katerina Papanikolopoulou & Efthimios M. C. Skoulakis. 2020. Proteostasis and Disease. Proteostasis and Disease 177 194 .
Christina Lee Chung, Ibiyonu Lawrence, Melissa Hoffman, Dareen Elgindi, Kumar Nadhan, Manali Potnis, Annie Jin, Catlin Sershon, Rhonda Binnebose, Antonello Lorenzini & Christian Sell. (2019) Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial. GeroScience 41:6, pages 861-869.
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Xia Wang, Wenchao Xia, Kai Li, Yusheng Zhang, Wei Ge & Chao Ma. (2019) Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse. Journal of the Neurological Sciences 399, pages 125-139.
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Nasim Javdan, Seyed Abdulmajid Ayatollahi, Muhammad Iqbal Choudhary, Safaa Al-Hasani, Farzad Kobarfard, Kobra Mokhtarian, Majid Khoshmirsafa & Athar Ata. (2019) Tsc1/Tsc2 complex: A molecular target of capsaicin for protection against testicular torsion induced injury in rats. Chinese Herbal Medicines 11:2, pages 216-221.
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Gerwyn Morris, Michael Berk, Michael Maes & Basant K. Puri. (2018) Could Alzheimer’s Disease Originate in the Periphery and If So How So?. Molecular Neurobiology 56:1, pages 406-434.
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Ji Cheng, Brian J. North, Tao Zhang, Xiangpeng Dai, Kaixiong Tao, Jianping Guo & Wenyi Wei. (2018) The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease. Aging Cell 17:5, pages e12801.
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Kenneth Maiese. (2018) The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders. Biochemical Society Transactions 46:2, pages 351-360.
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Kenneth Maiese. 2018. Autophagy and Cardiometabolic Diseases. Autophagy and Cardiometabolic Diseases 187 197 .
Elena Szefer, Donghuan Lu, Farouk Nathoo, Mirza Faisal Beg & Jinko Graham. (2017) Multivariate association between single-nucleotide polymorphisms in Alzgene linkage regions and structural changes in the brain: discovery, refinement and validation. Statistical Applications in Genetics and Molecular Biology 16:5-6.
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Matthew V. Green & Stanley A. Thayer. (2016) NMDARs Adapt to Neurotoxic HIV Protein Tat Downstream of a GluN2A–Ubiquitin Ligase Signaling Pathway. The Journal of Neuroscience 36:50, pages 12640-12649.
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Paul E. van der Vet & Harm Nijveen. (2016) Propagation of errors in citation networks: a study involving the entire citation network of a widely cited paper published in, and later retracted from, the journal Nature. Research Integrity and Peer Review 1:1.
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Kenneth Maiese. (2016) Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders. British Journal of Clinical Pharmacology 82:5, pages 1245-1266.
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Hamidreza Pazoki-Toroudi, Hamed Amani, Marjan Ajami, Seyed Fazel Nabavi, Nady Braidy, Pandima Devi Kasi & Seyed Mohammad Nabavi. (2016) Targeting mTOR signaling by polyphenols: A new therapeutic target for ageing. Ageing Research Reviews 31, pages 55-66.
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Kenneth Maiese. (2016) Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR. Neural Regeneration Research 11:3, pages 372.
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Kenneth Maiese. 2016. Molecules to Medicine with mTOR. Molecules to Medicine with mTOR 3 22 .
F. Rahimi, H. Li, S. Sinha & G. Bitan. 2016. Developing Therapeutics for Alzheimer's Disease. Developing Therapeutics for Alzheimer's Disease 97 191 .
Wenjia Wang, Jonas Mandel, Jan Bouaziz, Daniel Commenges, Serguei Nabirotchkine, Ilya Chumakov, Daniel Cohen & Mickaël Guedj. (2015) A Multi-Marker Genetic Association Test Based on the Rasch Model Applied to Alzheimer’s Disease. PLOS ONE 10:9, pages e0138223.
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Kenneth Maiese. (2015) Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease. Neural Regeneration Research 10:4, pages 518.
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Kenneth Maiese. (2015) New Insights for Oxidative Stress and Diabetes Mellitus. Oxidative Medicine and Cellular Longevity 2015, pages 1-17.
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Kenneth Maiese. (2015) FoxO Proteins in the Nervous System. Analytical Cellular Pathology 2015, pages 1-15.
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