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Review Article

Morphogenesis and molecular considerations on congenital cardiac septal defects

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Giulio Calcagni, Marta Unolt, Maria Cristina Digilio, Anwar Baban, Paolo Versacci, Marco Tartaglia, Antonio Baldini & Bruno Marino. (2017) Congenital heart disease and genetic syndromes: new insights into molecular mechanisms. Expert Review of Molecular Diagnostics 17:9, pages 861-870.
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Raymond N. Deepe, Jenna R. Drummond, Renélyn A. Wolters, Emily A. Fitzgerald, Hannah G. Tarolli, Andrew B. Harvey & Andy Wessels. (2022) Sox9 Expression in the Second Heart Field; A Morphological Assessment of the Importance to Cardiac Development with Emphasis on Atrioventricular Septation. Journal of Cardiovascular Development and Disease 9:11, pages 376.
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Baolei Li, Zhuoyan Li, Jianping Yang, Nanchao Hong, Lihui Jin, Yuejuan Xu, Qihua Fu, Kun Sun, Yu Yu, Yanan Lu & Sun Chen. (2022) Predisposition to atrioventricular septal defects may be caused by SOX7 variants that impair interaction with GATA4. Molecular Genetics and Genomics 297:3, pages 671-687.
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Paolo Ferrero, Isabelle Piazza, Alessandro Giamberti & Massimo Chessa. (2022) Oncogenesis in patients with congenital heart disease: A possible role of the neural crest. Annals of Pediatric Cardiology 15:3, pages 273.
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Si-Qiang Zheng, Huan-Xin Chen, Xiao-Cheng Liu, Qin Yang & Guo-Wei He. (2021) Identification of variants of ISL1 gene promoter and cellular functions in isolated ventricular septal defects . American Journal of Physiology-Cell Physiology 321:3, pages C443-C452.
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Haruko Nakano, Viviana M. Fajardo & Atsushi Nakano. (2021) The role of glucose in physiological and pathological heart formation. Developmental Biology 475, pages 222-233.
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Joshua C. Peterson, Tim P. Kelder, Marie José T. H. Goumans, Monique R. M. Jongbloed & Marco C. DeRuiter. (2021) The Role of Cell Tracing and Fate Mapping Experiments in Cardiac Outflow Tract Development, New Opportunities through Emerging Technologies. Journal of Cardiovascular Development and Disease 8:5, pages 47.
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Sarah M. M Alyousif, Fisal T Aldokhel, Omar Khalid Alkhanbashi, Majed Hayf A Alqahtani, Abdulrahman Mohammed M Aladawi, Abdullah Abdulrahman Ashmawi, Ada Al-Qunaibet & Emad Masuadi. (2021) The Incidence of Congenital Heart Defects in Offspring Among Women With Diabetes in Saudi Arabia. Cureus.
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Si‐Qiang Zheng, Huan‐Xin Chen, Xiao‐Cheng Liu, Qin Yang & Guo‐Wei He. (2021) Genetic analysis of the CITED2 gene promoter in isolated and sporadic congenital ventricular septal defects. Journal of Cellular and Molecular Medicine 25:4, pages 2254-2261.
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Flaminia Pugnaloni, Maria Cristina Digilio, Carolina Putotto, Enrica De Luca, Bruno Marino & Paolo Versacci. (2020) Genetics of atrioventricular canal defects. Italian Journal of Pediatrics 46:1.
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Robert E. Poelmann & Adriana C. Gittenberger‐de Groot. (2019) Development and evolution of the metazoan heart. Developmental Dynamics 248:8, pages 634-656.
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Sudha Rajderkar, Jeffrey M. Mann, Christopher Panaretos, Kenji Yumoto, Hong-Dong Li, Yuji Mishina, Benjamin Ralston & Vesa Kaartinen. (2019) Trim33 is required for appropriate development of pre-cardiogenic mesoderm. Developmental Biology 450:2, pages 101-114.
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Angel Dueñas, Almudena Expósito, Amelia Aranega & Diego Franco. (2019) The Role of Non-Coding RNA in Congenital Heart Diseases. Journal of Cardiovascular Development and Disease 6:2, pages 15.
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Robert Poelmann & Adriana Gittenberger-de Groot. (2018) Hemodynamics in Cardiac Development. Journal of Cardiovascular Development and Disease 5:4, pages 54.
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Jing Wang, Jing Luo, Qiuhong Chen, Xi Wang, Jiangyan He, Wei Zhang, Zhan Yin, Fang Zheng, Hong Pan, Tengyan Li, Qiyong Lou & Binbin Wang. (2018) Identification of LBX2 as a novel causal gene of atrial septal defect. International Journal of Cardiology 265, pages 188-194.
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Xin Yi, Xuejun Jiang, Xiaoyan Li & Ding-Sheng Jiang. (2017) Histone lysine methylation and congenital heart disease: From bench to bedside (Review). International Journal of Molecular Medicine 40:4, pages 953-964.
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Monique R.M. Jongbloed, Robert E. Poelmann & Adriana C. Gittenberger-de Groot. 2017. The Complete Reference for Scimitar Syndrome. The Complete Reference for Scimitar Syndrome 17 43 .
Adriana C. Gittenberger-de Groot, Tamara Hoppenbrouwers, Lucile Miquerol, Yasuhiro Kosaka, Robert E. Poelmann, Lambertus J. Wisse, H. Joseph Yost, Monique R.M. Jongbloed, Marco C. Deruiter & Luca Brunelli. (2016) 14-3-3epsilon controls multiple developmental processes in the mouse heart. Developmental Dynamics 245:11, pages 1107-1123.
Crossref
Rosaysela Santos, Shimako Kawauchi, Russell E. Jacobs, Martha E. Lopez-Burks, Hojae Choi, Jamie Wikenheiser, Benedikt Hallgrimsson, Heather A. Jamniczky, Scott E. Fraser, Arthur D. Lander & Anne L. Calof. (2016) Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLOS Biology 14:9, pages e2000197.
Crossref
Nina ØyenLars J. DiazElisabeth LeirgulHeather A. BoydJames PriestElisabeth R. MathiesenThomas QuertermousJan WohlfahrtMads Melbye. (2016) Prepregnancy Diabetes and Offspring Risk of Congenital Heart Disease. Circulation 133:23, pages 2243-2253.
Crossref
Firoz Abdul Samad, Bandar A. Suliman, Syed Hussain Basha, Thamilarasan Manivasagam & Musthafa Mohamed Essa. (2016) A Comprehensive In Silico Analysis on the Structural and Functional Impact of SNPs in the Congenital Heart Defects Associated with NKX2-5 Gene—A Molecular Dynamic Simulation Approach. PLOS ONE 11:5, pages e0153999.
Crossref
Wei Cheng, Ren Zhou, Yan Feng & Yan Wang. (2016) Mainstream smoke and sidestream smoke affect the cardiac differentiation of mouse embryonic stem cells discriminately. Toxicology 357-358, pages 1-10.
Crossref
Maria E. Baardman, Mathijs V. Zwier, Lambertus J. Wisse, Adriana C. Gittenberger-de Groot, Wilhelmina S. Kerstjens-Frederikse, Robert M. W. Hofstra, Angelika Jurdzinski, Beerend P. Hierck, Monique R. M. Jongbloed, Rolf M. F. Berger, Torsten Plösch & Marco C. DeRuiter. (2016) Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development . Disease Models & Mechanisms 9:4, pages 413-425.
Crossref
Lauren Waldron, Jeffrey D. Steimle, Todd M. Greco, Nicholas C. Gomez, Kerry M. Dorr, Junghun Kweon, Brenda Temple, Xinan Holly Yang, Caralynn M. Wilczewski, Ian J. Davis, Ileana M. Cristea, Ivan P. Moskowitz & Frank L. Conlon. (2016) The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation. Developmental Cell 36:3, pages 262-275.
Crossref
Emmeline E. Calkoen, Mark G. Hazekamp, Nico A. Blom, Bernadette B.L.J. Elders, Adriana C. Gittenberger-de Groot, Monique C. Haak, Margot M. Bartelings, Arno A.W. Roest & Monique R.M. Jongbloed. (2016) Atrioventricular septal defect: From embryonic development to long-term follow-up. International Journal of Cardiology 202, pages 784-795.
Crossref
. 2016. Diagnostic Imaging: Obstetrics. Diagnostic Imaging: Obstetrics 390 393 .
Lucile Houyel. 2016. Congenital Heart Diseases: The Broken Heart. Congenital Heart Diseases: The Broken Heart 329 341 .
Hannah K. Vanyai, Tim Thomas & Anne K. Voss. (2015) Mesodermal expression of Moz is necessary for cardiac septum development. Developmental Biology 403:1, pages 22-29.
Crossref

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