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Review Article

Prognostic significance of elevated troponin in non-cardiac hospitalized patients: A systematic review and meta-analysis

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Pages 653-663 | Received 09 May 2014, Accepted 25 Aug 2014, Published online: 13 Oct 2014

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Christian Bjurman, Matteus Zywczyk, Soza Zangana, Sabin Salahuddin, Martin Holzmann, Tobias Carlson & Ola Hammarsten. (2021) Patients discharged with elevated baseline high-sensitive cardiac troponin T from the emergency department. Biomarkers 26:5, pages 410-416.
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Ásthildur Árnadóttir, Christine Falk Klein & Kasper Iversen. (2017) Head-to-head comparison of cardiac troponin T and troponin I in patients without acute coronary syndrome: a systematic review. Biomarkers 22:8, pages 701-708.
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Weaam Alazrag, Hanan Idris, Yousef ME Saad, Aisha Etaher, Shiquan Ren, Ian Ferguson, Craig Juergens, Derek P Chew, James Otton, Paul M Middleton & John K French. (2023) Management and outcomes with 5‐year mortality of patients with mildly elevated high‐sensitivity troponin T levels not meeting criteria for myocardial infarction. Emergency Medicine Australasia.
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Shuqi Yu, Shiyao Cheng, Jinhong Si, Huajing Peng, Jiachen Wan, Jiaojie Xue, Zhichong Chen, Sutian Hu, Ling Zhou, Yitao Zhang & Weijie Zeng. (2023) Risk factors of preoperative myocardial injury in patients with gastrointestinal tumors. BMC Cardiovascular Disorders 23:1.
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Nitesh Kumar, Kapil Gupta, Madhu Kiran, Sushant Chhabra & Mahish Mehta. (2022) Prevalence, Determinants and Clinical Significance of Cardiac Troponin-I Elevation among Individuals with Hypertensive Emergency: A Prospective Observational Study. Indian Journal of Critical Care Medicine 26:7, pages 786-790.
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Yuehua Li, Hanjun Pei, Chenghui Zhou & Ying Lou. (2022) Myocardial Injury Predicts Risk of Short-Term All-Cause Mortality in Patients With COVID-19: A Dose–Response Meta-Analysis. Frontiers in Cardiovascular Medicine 9.
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Yitao Zhang, Jiaojie Xue, Ling Zhou, Jinhong Si, Shiyao Cheng, Kanglin Cheng, Shuqi Yu, Mao Ouyang, Zhichong Chen, Daici Chen & Weijie Zeng. (2021) The predictive value of high-sensitive troponin I for perioperative risk in patients undergoing gastrointestinal tumor surgery. EClinicalMedicine 40, pages 101128.
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Giuseppe Lippi, Gianfranco Cervellin & Fabian Sanchis-Gomar. (2021) Predicting mortality with cardiac troponins: recent insights from meta-analyses. Diagnosis 8:1, pages 37-49.
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Lucia Malloggi, Piero Cappelletti, Maria A. Burgio, Martina Di Pietro, Marco Moretti, Francesca Veneziani, Massimiliano Manno, Elisabetta Stenner, Alessio Gamboni, Matteo Cassin, Margherita Morandini, Giulio Marino, Deborah Mazzei, Jessica Viola, Dina Di Maria, Daniela Rubin & Gianni A. Galli. (2021) Raccomandazioni del GdS MM SIPMeL per l'uso dei marcatori miocardiaci nella diagnostica di NSTEMI. Parte terza: prognosi e stratificazione del rischio. La Rivista Italiana della Medicina di Laboratorio 16:4.
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Jonathan Hinton, Mark Mariathas, Lavinia Gabara, Zoe Nicholas, Rick Allan, Sanjay Ramamoorthy, Mamas A Mamas, Michael Mahmoudi, Paul Cook & Nick Curzen. (2020) Distribution of contemporary sensitivity troponin in the emergency department and relationship to 30-day mortality: The CHARIOT-ED substudy. Clinical Medicine 20:6, pages 528-534.
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Mohamed A. Saleh, Samar A. Antar, Reem M. Hazem & Mona F. El-Azab. (2020) Pirfenidone and Vitamin D Ameliorate Cardiac Fibrosis Induced by Doxorubicin in Ehrlich Ascites Carcinoma Bearing Mice: Modulation of Monocyte Chemoattractant Protein-1 and Jun N-terminal Kinase-1 Pathways. Pharmaceuticals 13:11, pages 348.
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Osama Mahmoud, Hadi Mahmaljy, Mohamed Youniss, Edwin Hernandez Campoverde, Hadi Elias, Matthew Stanton, Maulin Patel, Insia Hashmi, Katelyn Young, Rajesh Kuppuraju, Steven Jacobs & Amro Alsaid. (2020) Comparative outcome analysis of stable mildly elevated high sensitivity troponin T in patients presenting with chest pain. A single-center retrospective cohort study. IJC Heart & Vasculature 30, pages 100586.
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Bum Sung Kim, Chang Hee Kwon, Haseong Chang, Sung Hea Kim, Hyun-Joong Kim, Hweung Kon Hwang & Sang-Man Chung. (2020) Usefulness of High-Sensitivity Troponin I to Predict Outcome in Patients With Newly Detected Atrial Fibrillation. The American Journal of Cardiology 125:5, pages 744-750.
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Ayman El-Menyar, Ahmed F. Ramzee, Mohammad Asim, Salvatore Di Somma & Hassan Al-Thani. (2020) Comparative analysis for the implication of serum cardiac troponin measurements by conventional versus high-sensitivity assays in patients with traumatic brain injury. Minerva Cardioangiologica 68:1.
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Alfred Z. Wang, Jason T. Schaffer, Daniel B. Holt, Keaton L. Morgan & Benton R. Hunter. (2019) Troponin Testing and Coronary Syndrome in Geriatric Patients With Nonspecific Complaints: Are We Overtesting?. Academic Emergency Medicine 27:1, pages 6-14.
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Sörensen, Ludwig, Makarova, Neumann, Lehmacher, Hartikainen, Haller, Keller, Blankenberg, Westermann, Zeller & Schofer. (2019) Prognostic Value of a Novel and Established High-Sensitivity Troponin I Assay in Patients Presenting with Suspected Myocardial Infarction. Biomolecules 9:9, pages 469.
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Claudio Passino, Alberto Aimo, Silvia Masotti, Veronica Musetti, Concetta Prontera, Michele Emdin & Aldo Clerico. (2019) Cardiac troponins as biomarkers for cardiac disease. Biomarkers in Medicine 13:5, pages 325-330.
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Ayman El-Menyar, Brijesh Sathian, Bianca M. Wahlen & Hassan Al-Thani. (2019) Serum cardiac troponins as prognostic markers in patients with traumatic and non-traumatic brain injuries: A meta-analysis. The American Journal of Emergency Medicine 37:1, pages 133-142.
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Ayman El-MenyarMohammad AsimRifat LatifiShrikant I. Bangdiwala & Hassan Al-Thani. (2018) Predictive value of positive high-sensitivity troponin T in intubated traumatic brain injury patients. Journal of Neurosurgery 129:6, pages 1541-1549.
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Jian-Tong Shen, Miao Xu, Yan Wu, Shi-Hong Wen, Xiang Li, Bing-Cheng Zhao & Wen-Qi Huang. (2018) Association of pre-operative troponin levels with major adverse cardiac events and mortality after noncardiac surgery. European Journal of Anaesthesiology 35:11, pages 815-824.
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Ásthildur Árnadóttir, Kirstine Roll Vestergaard, Jannik Pallisgaard, György Sölétormos, Rolf Steffensen, Jens P. Goetze & Kasper Iversen. (2018) High-sensitivity cardiac troponin T is superior to troponin I in the prediction of mortality in patients without acute coronary syndrome. International Journal of Cardiology 259, pages 186-191.
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E. Shields, I. Seiden-Long, S. Massie & R. Leguillette. (2018) 24-Hour Kinetics of Cardiac Troponin-T Using a “High-Sensitivity” Assay in Thoroughbred Chuckwagon Racing Geldings after Race and Associated Clinical Sampling Guidelines. Journal of Veterinary Internal Medicine 32:1, pages 433-440.
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Ayman El-Menyar, Abhishek Goyal, Rifat Latifi, Hassan Al-Thani & William Frishman. (2017) Brain-Heart Interactions in Traumatic Brain Injury. Cardiology in Review 25:6, pages 279-288.
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Andreas Roos, Nadia Bandstein, Magnus Lundbäck, Ola Hammarsten, Rickard Ljung & Martin J. Holzmann. (2017) Stable High-Sensitivity Cardiac Troponin T Levels and Outcomes in Patients With Chest Pain. Journal of the American College of Cardiology 70:18, pages 2226-2236.
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Marlies Ostermann, Salma Ayis, Emma Tuddenham, Jessica Lo, Katie Lei, John Smith, Barnaby Sanderson, Carl Moran, Paul Collinson, Janet Peacock, Andrew Rhodes & David Treacher. (2017) Cardiac Troponin Release is Associated with Biomarkers of Inflammation and Ventricular Dilatation During Critical Illness. SHOCK 47:6, pages 702-708.
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Giuseppe Lippi & Gianfranco Cervellin. (2017) High-sensitivity cardiac troponin in the emergency department: The perfect storm?. International Journal of Cardiology 234, pages 113.
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Andreas Roos, Anton Hellgren, Farshid Rafatnia, Ola Hammarsten, Rickard Ljung, Axel C. Carlsson & Martin J. Holzmann. (2017) Investigations, findings, and follow-up in patients with chest pain and elevated high-sensitivity cardiac troponin T levels but no myocardial infarction. International Journal of Cardiology 232, pages 111-116.
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John V McGowan, Robin Chung, Angshuman Maulik, Izabela Piotrowska, J Malcolm Walker & Derek M Yellon. (2017) Anthracycline Chemotherapy and Cardiotoxicity. Cardiovascular Drugs and Therapy 31:1, pages 63-75.
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David E. Winchester, Lucas Burke, Nayan Agarwal, Carsten Schmalfuss & Carl J. Pepine. (2016) Predictors of short‐ and long‐term mortality in hospitalized veterans with elevated troponin. Journal of Hospital Medicine 11:11, pages 773-777.
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Robin Chung, Angshuman Maulik, Ashraf Hamarneh, Daniel Hochhauser, Derek J. Hausenloy, J. Malcolm Walker & Derek M. Yellon. (2016) Effect of Remote Ischaemic Conditioning in Oncology Patients Undergoing Chemotherapy: Rationale and Design of the ERIC‐ONC Study—A Single‐Center, Blinded, Randomized Controlled Trial. Clinical Cardiology 39:2, pages 72-82.
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