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REVIEW ARTICLE

Epigenetic mechanisms and therapeutic targets of chemotherapy resistance in epithelial ovarian cancer

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Pages 359-369 | Received 28 Oct 2014, Accepted 15 Apr 2015, Published online: 09 Jul 2015

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Kevin Dzobo. (2019) Epigenomics-Guided Drug Development: Recent Advances in Solving the Cancer Treatment “jigsaw puzzle”. OMICS: A Journal of Integrative Biology 23:2, pages 70-85.
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