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Original Article

Oestrogenic and antiandrogenic chemicals in the environment: effects on male reproductive health

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Pages 391-403 | Published online: 08 Jul 2009

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Read on this site (3)

Pınar Erkekoglu & Belma Kocer-Gumusel. (2014) Genotoxicity of phthalates. Toxicology Mechanisms and Methods 24:9, pages 616-626.
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Byung Mu Lee & Hyun Jung Koo. (2007) Hershberger Assay for Antiandrogenic Effects of Phthalates. Journal of Toxicology and Environmental Health, Part A 70:15-16, pages 1365-1370.
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O. A. H. Jones, N. Voulvoulis & J. N. Lester. (2001) Human Pharmaceuticals in the Aquatic Environment a Review. Environmental Technology 22:12, pages 1383-1394.
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Articles from other publishers (76)

Erica M Molina, Andreas N Kavazis, Mary T Mendonça & Benson T Akingbemi. (2023) Effects of chronic dichlorodiphenyldichloroethylene exposure on testosterone secretion and steroidogenic pathway in the male gonad. Biology of Reproduction 109:1, pages 65-72.
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Raquel N. Corniuk, Jennifer M. Lynch, Michael D. Arendt, Joanne Braun‐McNeill, David W. Owens, Roldán A. Valverde, John R. Kucklick & Patricia D. McClellan‐Green. (2023) Using Plasma Vitellogenin in Loggerhead Sea Turtles to Assess Reproductive Maturation and Estrogen‐Like Contaminant Exposure. Environmental Toxicology and Chemistry 42:6, pages 1309-1325.
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Luigi Montano & Antonino Guglielmino. 2023. Environment Impact on Reproductive Health. Environment Impact on Reproductive Health 211 231 .
Concetta Pironti, Maria Ricciardi, Antonio Proto, Pietro Massimiliano Bianco, Luigi Montano & Oriana Motta. (2021) Endocrine-Disrupting Compounds: An Overview on Their Occurrence in the Aquatic Environment and Human Exposure. Water 13:10, pages 1347.
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Christopher D. Kassotis, Jennifer S. Harkness, Phuc H. Vo, Danh C. Vu, Kate Hoffman, Katelyn M. Cinnamon, Jennifer N. Cornelius-Green, Avner Vengosh, Chung-Ho Lin, Donald E. Tillitt, Robin L. Kruse, Jane A. McElroy & Susan C. Nagel. (2020) Endocrine disrupting activities and geochemistry of water resources associated with unconventional oil and gas activity. Science of The Total Environment 748, pages 142236.
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Ajooni Sidhu, Neena Singla, Milindmitra Lonare & Amrit Kaur Mahal. (2020) Effect of quinestrol on body weight, vital organs, biochemicals and genotoxicity in adult male lesser bandicoot rat, Bandicota bengalensis. Pesticide Biochemistry and Physiology 165, pages 104544.
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Rajnesh Kumar Sharma, Priyanka Singh, Aarzoo Setia & Aman Kumar Sharma. (2020) Insecticides and ovarian functions. Environmental and Molecular Mutagenesis 61:3, pages 369-392.
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A Ullah, M Pirzada, S Jahan, H Ullah, S Razak, N Rauf, MJ Khan & SZ Mahboob. (2019) Prenatal BPA and its analogs BPB, BPF, and BPS exposure and reproductive axis function in the male offspring of Sprague Dawley rats. Human & Experimental Toxicology 38:12, pages 1344-1365.
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Yiyan Wang, Chaobo Ni, Xiaoheng Li, Zhenkun Lin, Qiqi Zhu, Linxi Li & Ren-Shan Ge. (2019) Phthalate-Induced Fetal Leydig Cell Dysfunction Mediates Male Reproductive Tract Anomalies. Frontiers in Pharmacology 10.
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Xiuxiu Chen, Qiqi Zhu, Xiaoheng li, Tongliang Huang, Songxue Wang, Yiyan Wang, Xianwu Chen, Zhenkun Lin & Ren-shan Ge. (2019) Pubertal exposure to tebuconazole increases testosterone production via inhibiting testicular aromatase activity in rats. Chemosphere 230, pages 519-526.
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Md. Mahfujur Rahman, Jehyung Wie, Jeong-Hwi Cho, Hyun-Jin Tae, Dongchoon Ahn, Seok Won Lee, In-Shik Kim & Byung-Yong Park. (2019) Diethylstilbestrol induces morphological changes in the spermatogonia, Sertoli cells and Leydig cells of adult rat. Research in Veterinary Science 124, pages 433-438.
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Ismail-H. Acir & Klaus Guenther. (2018) Endocrine-disrupting metabolites of alkylphenol ethoxylates – A critical review of analytical methods, environmental occurrences, toxicity, and regulation. Science of The Total Environment 635, pages 1530-1546.
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Ignacio Bejarano, Ana B. Rodríguez & José A. Pariente. (2018) Apoptosis Is a Demanding Selective Tool During the Development of Fetal Male Germ Cells. Frontiers in Cell and Developmental Biology 6.
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Ellen Webb, Julie Moon, Larysa Dyrszka, Brian Rodriguez, Caroline Cox, Heather Patisaul, Sheila Bushkin & Eric London. (2018) Neurodevelopmental and neurological effects of chemicals associated with unconventional oil and natural gas operations and their potential effects on infants and children. Reviews on Environmental Health 33:1, pages 3-29.
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Xiaokun Li. 2018. Fibroblast Growth Factors. Fibroblast Growth Factors 315 337 .
Ahmet Ayaz, Narasimhan Kothandaraman, Ralf Henkel & Suresh C. Sikka. 2018. Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health. Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health 335 353 .
Bing-Bing Chen, B.R. Zirkin & Ren-Shan Ge. 2018. Comprehensive Toxicology. Comprehensive Toxicology 96 111 .
Khaled Habas, Martin H. Brinkworth & Diana Anderson. (2017) Diethylstilbestrol induces oxidative DNA damage, resulting in apoptosis of spermatogonial stem cells in vitro. Toxicology 382, pages 117-121.
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Christopher D. Kassotis, Luke R. Iwanowicz, Denise M. Akob, Isabelle M. Cozzarelli, Adam C. Mumford, William H. Orem & Susan C. Nagel. (2016) Endocrine disrupting activities of surface water associated with a West Virginia oil and gas industry wastewater disposal site. Science of The Total Environment 557-558, pages 901-910.
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Ki-Ho Lee. (2015) Exogenous Exposure to Estradiol Benzoate or Flutamide at the Weaning Age Alters Expression of Connexin Isoforms in the Initial Segment of Male Rat. Development & Reproduciton 19:1, pages 43-51.
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Irina Szmelskyj, Lianne Aquilina & Alan O. Szmelskyj. 2015. Acupuncture for IVF and Assisted Reproduction. Acupuncture for IVF and Assisted Reproduction 161 184 .
Te Liu, Na Li, Jian Zhu, Guangyan Yu, Kun Guo, Liting Zhou, Dongchun Zheng, Xiaofeng Qu, Jian Huang, Xin Chen, Shuyue Wang & Lin Ye. (2014) Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-ovarian axis in adult female rats. Reproductive Toxicology 46, pages 141-147.
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Leping Ye, Xiaomin Chen, Xiaoheng Li, Qiqi Zhu, Lin Yu, Jingjing Guo, Bingbing Chen, Benson T. Akingbemi, Ren-Shan Ge & Hui Li. (2014) Effects of methoxychlor and its metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on human and rat 17α-hydroxylase/17,20-lyase activity. Toxicology Letters 225:3, pages 407-412.
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Do-Yeal Ryu, Ye-Ji Kim, June-Sub Lee, Md Rahman, Woo-Sung Kwon, Sung-Jae Yoon & Myung-Geol Pang. (2014) Capacitation and acrosome reaction differences of bovine, mouse and porcine spermatozoa in responsiveness to estrogenic compounds. Journal of Animal Science and Technology 56:1, pages 26.
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Leping Ye, Jingjing Guo & Ren-Shan Ge. 2014. Endocrine Disrupters. Endocrine Disrupters 349 390 .
Thea M. Edwards, Hilary D. Miller, Gunnar Toft & Louis J. GuilletteJr.Jr.. (2013) Seasonal reproduction of male Gambusia holbrooki (eastern mosquitofish) from two Florida lakes. Fish Physiology and Biochemistry 39:5, pages 1165-1180.
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Osvaldo J. Ponzo & Carbone Silvia. (2013) Evidence of reproductive disruption associated with neuroendocrine changes induced by UV–B filters, phtalates and nonylphenol during sexual maturation in rats of both gender. Toxicology 311:1-2, pages 41-51.
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Pasquale Ventrice, Domenica Ventrice, Emilio Russo & Giovambattista De Sarro. (2013) Phthalates: European regulation, chemistry, pharmacokinetic and related toxicity. Environmental Toxicology and Pharmacology 36:1, pages 88-96.
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Jingjing Guo, Xing-Wang Li, Yong Liang, Yufei Ge, Xiaomin Chen, Qing-Quan Lian & Ren-Shan Ge. (2013) The increased number of Leydig cells by di(2-ethylhexyl) phthalate comes from the differentiation of stem cells into Leydig cell lineage in the adult rat testis. Toxicology 306, pages 9-15.
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Lukas Ded, Natasa Sebkova, Martina Cerna, Fatima Elzeinova, Pavla Dostalova, Jana Peknicova & Katerina Dvorakova-Hortova. (2013) In vivo exposure to 17β-estradiol triggers premature sperm capacitation in cauda epididymis. REPRODUCTION 145:3, pages 255-263.
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Wei Shen, Dazhao Shi, Deng Wang & Yongwang Guo. (2012) Inhibitive effects of quinestrol on male testes in Mongolian gerbils (Meriones unguiculatus). Research in Veterinary Science 93:2, pages 907-913.
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Yan Zhao, Hong Ao, Li Chen, Chantal M. Sottas, Ren-shan Ge, Luxi Li & Yunhui Zhang. (2012) Mono-(2-ethylhexyl) phthalate affects the steroidogenesis in rat Leydig cells through provoking ROS perturbation. Toxicology in Vitro 26:6, pages 950-955.
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Kaiming Yuan, Binghai Zhao, Xing-Wang Li, Guo-Xin Hu, Ying Su, Yanhui Chu, Benson T. Akingbemi, Qing-Quan Lian & Ren-Shan Ge. (2012) Effects of phthalates on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase 3 activities in human and rat testes. Chemico-Biological Interactions 195:3, pages 180-188.
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S. Carbone, Y.A. Samaniego, R. Cutrera, R. Reynoso, N. Cardoso, P. Scacchi, J.A. Moguilevsky & O.J. Ponzo. (2012) Different effects by sex on hypothalamic–pituitary axis of prepubertal offspring rats produced by in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP). NeuroToxicology 33:1, pages 78-84.
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Leping Ye, Zhi-Jian Su & Ren-Shan Ge. (2011) Inhibitors of Testosterone Biosynthetic and Metabolic Activation Enzymes. Molecules 16:12, pages 9983-10001.
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G.-X. Hu, B. Zhao, Y. Chu, X.-H. Li, B. T. Akingbemi, Z.-Q. Zheng & R. S. Ge. (2011) Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes. International Journal of Andrology 34:2, pages 138-144.
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El-Sayed A. Mohamed, Yoo-Jin Park, Won-Hee Song, Dong-Ha Shin, Young-Ah You, Buom-Yong Ryu & Myung-Geol Pang. (2011) Xenoestrogenic compounds promote capacitation and an acrosome reaction in porcine sperm. Theriogenology 75:6, pages 1161-1169.
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JØRN OLSEN, JIN LIANG ZHU & CECILIA H. RAMLAU-HANSEN. (2011) Has fertility declined in recent decades?. Acta Obstetricia et Gynecologica Scandinavica 90:2, pages 129-135.
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Guo-Xin Hu, Bing-Hai Zhao, Yan-Hui Chu, Hong-Yu Zhou, Benson T. Akingbemi, Zhi-Qiang Zheng & Ren-Shan Ge. (2010) Effects of genistein and equol on human and rat testicular 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase 3 activities. Asian Journal of Andrology 12:4, pages 519-526.
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Rosa Sirianni, Adele Chimento, Arianna De Luca, Ivan Casaburi, Pietro Rizza, Arianna Onofrio, Domenico Iacopetta, Francesco Puoci, Sebastiano Andò, Marcello Maggiolini & Vincenzo Pezzi. (2010) Oleuropein and hydroxytyrosol inhibit MCF‐7 breast cancer cell proliferation interfering with ERK1/2 activation. Molecular Nutrition & Food Research 54:6, pages 833-840.
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Mohammad Shah Alam, Seiichiroh Ohsako, Takashi Matsuwaki, Xiao Bo Zhu, Naoki Tsunekawa, Yoshiakira Kanai, Hideko Sone, Chiharu Tohyama & Masamichi Kurohmaru. (2010) Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effect of di(n-butyl) phthalate. REPRODUCTION 139:2, pages 427-437.
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Binghai Zhao, Yanhui Chu, Yadong Huang, Dianne O. Hardy, Shaoqiang Lin & Ren-Shan Ge. (2010) Structure-dependent inhibition of human and rat 11β-hydroxysteroid dehydrogenase 2 activities by phthalates. Chemico-Biological Interactions 183:1, pages 79-84.
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Bing-bing Chen, B.R. Zirkin & Ren-Shan Ge. 2010. Comprehensive Toxicology. Comprehensive Toxicology 131 148 .
Maria Petrou Ikonomopoulou, Henry Olszowy, Mary Hodge & Adrian J. Bradley. (2009) The effect of organochlorines and heavy metals on sex steroid-binding proteins in vitro in the plasma of nesting green turtles, Chelonia mydas. Journal of Comparative Physiology B 179:5, pages 653-662.
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Han Lin, Qing-Quan Lian, Guo-Xin Hu, Yuan Jin, Yunhui Zhang, Dianne O. Hardy, Guo-Rong Chen, Zhong-Qiu Lu, Chantal M. Sottas, Matthew P. Hardy & Ren-Shan Ge. (2009) In Utero and Lactational Exposures to Diethylhexyl-Phthalate Affect Two Populations of Leydig Cells in Male Long-Evans Rats1. Biology of Reproduction 80:5, pages 882-888.
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Jae-Ho SHIN, Tae Sung KIM, Il Hyun KANG, Tae Seok KANG, Hyun Ju MOON & Soon-Young HAN. (2009) Effects of Postnatal Administration of Diethylstilbestrol on Puberty and Thyroid Function in Male Rats. Journal of Reproduction and Development 55:5, pages 461-466.
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