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Original Article

The transcription factor Egr-1: a potential drug in wound healing and tissue repair

Pages 313-318 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Lianbo Zhang, Haiyan Qin, Zhuoxia Wu, Wanying Chen & Guang Zhang. (2018) Identification of the potential targets for keloid and hypertrophic scar prevention. Journal of Dermatological Treatment 29:6, pages 600-605.
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Anthony J. Hutchinson, Serena C. Coons, Chih-Ling Chou, Wei Xu, W. Daniel Stamer, David F. Woodward & John W. Regan. (2010) Induction of Angiogenic Immediate Early Genes by Activation of FP Prostanoid Receptors in Cultured Human Ciliary Smooth Muscle Cells. Current Eye Research 35:5, pages 408-418.
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Sabine A Eming, Thomas Krieg & Jeffrey M Davidson. (2004) Gene transfer in tissue repair: status, challenges and future directions. Expert Opinion on Biological Therapy 4:9, pages 1373-1386.
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Articles from other publishers (34)

Kinga Orlińska, Katarzyna Komosińska-Vassev, Krystyna Olczyk, Marcin Glaesel & Paweł Olczyk. (2023) Wound healing – characteristics of the ideal dressing. Annales Academiae Medicae Silesiensis 77, pages 197-203.
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Elke S. Bergmann-Leitner, Alexander G. Bobrov, Jessica S. Bolton, Michael D. Rouse, Lanier Heyburn, Radmila Pavlovic, Brittany I. Garry, Yonas Alamneh, Joseph Long, Brett Swierczewski, Stuart Tyner, Derese Getnet, Venkatasivasai S. Sajja & Vlado Antonic. (2022) Blast Waves Cause Immune System Dysfunction and Transient Bone Marrow Failure in a Mouse Model. Frontiers in Bioengineering and Biotechnology 10.
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Lucienne Juillerat-Jeanneret, Petra Tafelmeyer & Dela Golshayan. (2021) Regulation of Fibroblast Activation Protein-α Expression: Focus on Intracellular Protein Interactions. Journal of Medicinal Chemistry 64:19, pages 14028-14045.
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Sven Seiwerth, Marija Milavic, Jaksa Vukojevic, Slaven Gojkovic, Ivan Krezic, Lovorka Batelja Vuletic, Katarina Horvat Pavlov, Andrea Petrovic, Suncana Sikiric, Hrvoje Vranes, Andreja Prtoric, Helena Zizek, Tajana Durasin, Ivan Dobric, Mario Staresinic, Sanja Strbe, Mario Knezevic, Marija Sola, Antonio Kokot, Marko Sever, Eva Lovric, Anita Skrtic, Alenka Boban Blagaic & Predrag Sikiric. (2021) Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. Frontiers in Pharmacology 12.
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Tong-tong Li, Man-ru Liu & Dong-sheng Pei. (2019) Friend or foe, the role of EGR-1 in cancer. Medical Oncology 37:1.
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Tian Zhu Li, Sung Min Kim, Wonhee Hur, Jung Eun Choi, Jung-Hee Kim, Sung Woo Hong, Eun Byul Lee, Joon Ho Lee & Seung Kew Yoon. (2017) Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition. Gut and Liver 11:1, pages 102-111.
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Hye Jin Choi, Kee Hun Do, Jae-Hong Park, Juil Kim, Mira Yu, Seong-Hwan Park & Yuseok Moon. (2016) Early Epithelial Restitution by Nonsteroidal Anti-Inflammatory Drug–Activated Gene 1 Counteracts Intestinal Ulcerative Injuries. The Journal of Immunology 197:4, pages 1415-1424.
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Korneliusz Golebski, Danielle van Egmond, Esther J. de Groot, Kristina I.L. Roschmann, Wytske J. Fokkens & Cornelis M. van Drunen. (2015) EGR-1 and DUSP-1 are important negative regulators of pro-allergic responses in airway epithelium. Molecular Immunology 65:1, pages 43-50.
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Carmen Álvarez-Fernández, Srividya Tamirisa, Federico Prada, Ariel Chernomoretz, Osvaldo Podhajcer, Enrique Blanco & Enrique Martín-Blanco. (2015) Identification and Functional Analysis of Healing Regulators in Drosophila. PLOS Genetics 11:2, pages e1004965.
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T. Press, S. Viale-Bouroncle, O. Felthaus, M. Gosau & C. Morsczeck. (2015) EGR1 supports the osteogenic differentiation of dental stem cells. International Endodontic Journal 48:2, pages 185-192.
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Kana Lin, Sanhua Fang, Beilei Cai, Xueqin Huang, Xiayan Zhang, Yunbi Lu, Weiping Zhang & Erqing Wei. (2014) ERK/Egr-1 signaling pathway is involved in CysLT2 receptor-mediated IL-8 production in HEK293 cells. European Journal of Cell Biology 93:7, pages 278-288.
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Gerald Thiel, Isabelle Müller & Oliver G. Rössler. (2014) Expression, signaling and function of Egr transcription factors in pancreatic β-cells and insulin-responsive tissues. Molecular and Cellular Endocrinology 388:1-2, pages 10-19.
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Saranya Revathy Kasthuri, H.K.A. Premachandra, Navaneethaiyer Umasuthan, Ilson Whang & Jehee Lee. (2013) Structural characterization and expression analysis of a beta-thymosin homologue (Tβ) in disk abalone, Haliotis discus discus. Gene 527:1, pages 376-383.
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Nathaniel A. Dyment, Chia-Feng Liu, Namdar Kazemi, Lindsey E. Aschbacher-Smith, Keith Kenter, Andrew P. Breidenbach, Jason T. Shearn, Christopher Wylie, David W. Rowe & David L. Butler. (2013) The Paratenon Contributes to Scleraxis-Expressing Cells during Patellar Tendon Healing. PLoS ONE 8:3, pages e59944.
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Alejandro GiraldoOliver P. T. BarrettMarcus J. TindallStephen J. FullerEmre AmirakBonhi S. BhattacharyaPeter H. SugdenAngela Clerk. (2012) Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target. Biochemical Journal 444:2, pages 343-355.
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Hye Jin Choi, Juil Kim, Seong-Hwan Park, Kee Hun Do, Hyun Yang & Yuseok Moon. (2012) Pro-inflammatory NF-κB and early growth response gene 1 regulate epithelial barrier disruption by food additive carrageenan in human intestinal epithelial cells. Toxicology Letters 211:3, pages 289-295.
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Daniel Jönsson, Per Ramberg, Ryan T. Demmer, Moritz Kebschull, Gunnar Dahlén & Panos N. Papapanou. (2011) Gingival tissue transcriptomes in experimental gingivitis. Journal of Clinical Periodontology 38:7, pages 599-611.
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Michele T. Pritchard & Laura E. Nagy. (2010) Hepatic Fibrosis Is Enhanced and Accompanied by Robust Oval Cell Activation after Chronic Carbon Tetrachloride Administration to Egr-1-Deficient Mice. The American Journal of Pathology 176:6, pages 2743-2752.
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Zhi Xu, Haifeng Xu, Victoria A. Ploplis & Francis J. Castellino. (2010) Factor VII Deficiency Impairs Cutaneous Wound Healing in Mice. Molecular Medicine 16:5-6, pages 167-176.
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H. Yang, S. H. Park, H. J. Choi & Y. Moon. (2010) The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1/MIC-1/PTGF- ). Carcinogenesis 31:4, pages 703-711.
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. (2009) Role of PKR and EGR-1 in Induction of Interleukin-S by Type B Trichothecene Mycotoxin Deoxynivalenol in the Human Intestinal Epithelial Cells. Journal of Life Science 19:7, pages 949-955.
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Yuseok Moon, Jeung Il Kim, Hyun Yang & Thomas E. Eling. (2008) Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways. Life Sciences 82:11-12, pages 591-599.
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Michele T. Pritchard, Sanjoy Roychowdhury, Megan R. McMullen, Luping Guo, Gavin E. Arteel & Laura E. Nagy. (2007) Early growth response-1 contributes to galactosamine/lipopolysaccharide-induced acute liver injury in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology 293:6, pages G1124-G1133.
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L. Pham, O. Bezouglaia, P. M. Camargo, J. M. Nervina & S. Tetradis. (2007) Prostanoids induce egr1 gene expression in cementoblastic OCCM cells. Journal of Periodontal Research 42:5, pages 486-493.
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Vanesa Ivetić Tkalčević, Snježana Čužić, Karmen Brajša, Boris Mildner, Ana Bokulić, Kristina Šitum, Daniela Perović, Ines Glojnarić & Michael J. Parnham. (2007) Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression. European Journal of Pharmacology 570:1-3, pages 212-221.
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Pil-hoon Park, Megan R. McMullen, Honglian Huang, Varsha Thakur & Laura E. Nagy. (2007) Short-term Treatment of RAW264.7 Macrophages with Adiponectin Increases Tumor Necrosis Factor-α (TNF-α) Expression via ERK1/2 Activation and Egr-1 Expression. Journal of Biological Chemistry 282:30, pages 21695-21703.
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Varsha Thakur, Megan R McMullen, Michele T Pritchard & Laura E Nagy. (2007) Regulation of macrophage activation in alcoholic liver disease. Journal of Gastroenterology and Hepatology 22:s1, pages S53-S56.
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R. Schnettler, V. Alt, J. P. Stahl & S. Wenisch. 2006. Practice of Intramedullary Locked Nails. Practice of Intramedullary Locked Nails 7 21 .
Neera V. Gopee, Yanyan Cui, Greg Olson, Alan R. Warbritton, Barbara J. Miller, Letha H. Couch, Wayne G. Wamer & Paul C. Howard. (2005) Response of mouse skin to tattooing: use of SKH-1 mice as a surrogate model for human tattooing. Toxicology and Applied Pharmacology 209:2, pages 145-158.
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Megan R. McMullen, Michele T. Pritchard, Qifang Wang, Carrie A. Millward, Colleen M. Croniger & Laura E. Nagy. (2005) Early Growth Response-1 Transcription Factor Is Essential for Ethanol-Induced Fatty Liver Injury in Mice. Gastroenterology 128:7, pages 2066-2076.
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Tatiana Segura, Peter H. Chung & Lonnie D. Shea. (2005) DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach. Biomaterials 26:13, pages 1575-1584.
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Laura E. Nagy. (2004) MOLECULAR ASPECTS OF ALCOHOL METABOLISM: Transcription Factors Involved in Early Ethanol-Induced Liver Injury. Annual Review of Nutrition 24:1, pages 55-78.
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Luis DaSilva, Dawn Cote, Chad Roy, Mark Martinez, Steve Duniho, M.Louise M Pitt, Thomas Downey & Mark Dertzbaugh. (2003) Pulmonary gene expression profiling of inhaled ricin. Toxicon 41:7, pages 813-822.
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Timothy Molloy, Yao Wang & George A C Murrell. (2003) The Roles of Growth Factors in Tendon and Ligament Healing. Sports Medicine 33:5, pages 381-394.
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