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Annals of Medicine Volume 22, 1990 - Issue 5
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Original Article

Drugs to Decrease Alcohol Drinking

J. D. Sinclair Research Laboratories, Alko Ltd, Helsinki, Finland
Pages 357-362 | Published online: 08 Jul 2009

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Hugo López-Pelayo, Paola Zuluaga, Elsa Caballeria, Wim Van den Brink, Karl Mann & Antoni Gual. (2020) Safety of nalmefene for the treatment of alcohol use disorder: an update. Expert Opinion on Drug Safety 19:1, pages 9-17.
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Jorge Juárez & Eliana Barrios De Tomasi. (2008) Naltrexone treatment produces dose-related effects on food and water intake but daily alcohol consumption is not affected. Nutritional Neuroscience 11:4, pages 183-192.
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Andrew J. Lawrence. (2007) Therapeutics for alcoholism: what's the future?. Drug and Alcohol Review 26:1, pages 3-8.
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Roberta Agabio, Giancarlo Colombo, Mauro AM Carai & Gian Luigi Gessa. (2001) Novel pharmacotherapies and patents for alcohol abuse and alcoholism 1998-2001. Expert Opinion on Therapeutic Patents 11:10, pages 1497-1521.
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Sarz Maxwell & MarcS. Shinderman. (2000) Use of Naltrexone in the Treatment of Alcohol Use Disorders in Patients with Concomitant Major Mental Illness. Journal of Addictive Diseases 19:3, pages 61-69.
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John David Sinclair. (1998) New treatment options for substance abuse from a public health viewpoint. Annals of Medicine 30:4, pages 406-411.
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Melissa R. Schick, Nichea S. Spillane & Katherine L. Hostetler. (2020) A Call to Action: A Systematic Review Examining the Failure to Include Females and Members of Minoritized Racial/Ethnic Groups in Clinical Trials of Pharmacological Treatments for Alcohol Use Disorder. Alcoholism: Clinical and Experimental Research 44:10, pages 1933-1951.
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Dana E. Feldman, Katherine L. McPherson, Catherine L. Biesecker, Corinde E. Wiers, Peter Manza, Nora D. Volkow & Gene-Jack Wang. (2020) Neuroimaging of inflammation in alcohol use disorder: a review. Science China Information Sciences 63:7.
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Anita C. Hansson, Gerhard Gründer, Natalie Hirth, Hamid R. Noori, Rainer Spanagel & Wolfgang H. Sommer. (2019) Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies. Neuroscience & Biobehavioral Reviews 106, pages 141-164.
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Alan F. Schatzberg & Charles DeBattista. 2019. Schatzberg’s Manual of Psychopharmacology. Schatzberg’s Manual of Psychopharmacology.
Alan F. Schatzberg & Charles DeBattista. 2019. Schatzberg’s Manual of Psychopharmacology. Schatzberg’s Manual of Psychopharmacology.
Sonja Brünen, Nina Kim Bekier, Christoph Hiemke, Felix Korf, Klaus Wiedemann, Holger Jahn & Falk Kiefer. (2019) Therapeutic Drug Monitoring of Naltrexone and 6β-Naltrexol During Anti-craving Treatment in Alcohol Dependence: Reference Ranges. Alcohol and Alcoholism 54:1, pages 51-55.
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Gerald A. DeehanJr.Jr., David L. McKinzie, F. Ivy Carroll, William J. McBride & Zachary A. Rodd. (2012) The long-lasting effects of JDTic, a kappa opioid receptor antagonist, on the expression of ethanol-seeking behavior and the relapse drinking of female alcohol-preferring (P) rats. Pharmacology Biochemistry and Behavior 101:4, pages 581-587.
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Katherine G. Hill, Helen J. K. Sable, Frank M. Ferraro III & Stephen W. Kiefer. (2010) Chronic Naltrexone Treatment and Ethanol Responsivity in Outbred Rats. Alcoholism: Clinical and Experimental Research 34:2, pages 272-279.
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Wanda Dyr & Wojciech Kostowski. (2008) Warsaw high-preferring (WHP) and Warsaw low-preferring (WLP) lines of rats selectively bred for high and low voluntary ethanol intake: Preliminary phenotypic characterization. Alcohol 42:3, pages 161-170.
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Jorge Juárez & Barrios De Tomasi Eliana. (2007) Alcohol Consumption Is Enhanced After Naltrexone Treatment. Alcoholism: Clinical and Experimental Research 31:2, pages 260-264.
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Xu Wang, Steven D Douglas, Jin-Song Peng, David S Metzger, Charles P O’Brien, Ting Zhang & Wen-Zhe Ho. (2006) Naltrexone inhibits alcohol-mediated enhancement of HIV infection of T lymphocytes. Journal of Leukocyte Biology 79:6, pages 1166-1172.
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George F. Koob & Michel Le Moal. 2006. Neurobiology of Addiction. Neurobiology of Addiction 173 241 .
Kimmo Ingman, Nora Hagelberg, Sargo Aalto, Kjell Någren, Auni Juhakoski, Sakari Karhuvaara, Antero Kallio, Vesa Oikonen, Jarmo Hietala & Harry Scheinin. (2005) Prolonged Central μ-Opioid Receptor Occupancy after Single and Repeated Nalmefene Dosing. Neuropsychopharmacology 30:12, pages 2245-2253.
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Michael S. Cowen. 2005. Drugs for Relapse Prevention of Alcoholism. Drugs for Relapse Prevention of Alcoholism 49 58 .
Arthur Tomie, Kelly M. Burger, Jason Di Poce & Larissa A. Pohorecky. (2004) Social opportunity and ethanol drinking in rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry 28:7, pages 1089-1097.
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Bouza Carmen, Magro Angeles, Muñoz Ana & Amate José María. (2004) Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review. Addiction 99:7, pages 811-828.
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Tom Waller & Daphne Rumball. 2004. Treating Drinkers and Drug Users in the Community. Treating Drinkers and Drug Users in the Community 409 448 .
L.M Oswald & G.S Wand. (2004) Opioids and alcoholism. Physiology & Behavior 81:2, pages 339-358.
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Daniel L. Coonfield, Stephen W. Kiefer, Frank M. Ferraro & John David Sinclair. (2004) Ethanol Palatability and Consumption by High Ethanol-Drinking Rats: Manipulation of the Opioid System With Naltrexone.. Behavioral Neuroscience 118:5, pages 1089-1096.
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KIMMO INGMAN, SEVERO SALVADORI, LARRY LAZARUS, ESA KORPI & AAPO HONKANEN. (2006) Selective d‐opioid receptor antagonist N,N(CH 3) 2 ‐Dmt‐Tic‐OH does not reduce ethanol intake in alcohol‐preferring AA rats. Addiction Biology 8:2, pages 173-179.
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Sanna L Soini, Petri Hyytiä & Esa R Korpi. (2002) Brain regional μ-opioid receptor function in rat lines selected for differences in alcohol preference. European Journal of Pharmacology 448:2-3, pages 157-163.
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Olga N. Neznanova, Edwin E. Zvartau & Anton Y. Bespalov. (2002) Behavioral analysis of the saccharin deprivation effect in rats.. Behavioral Neuroscience 116:5, pages 747-756.
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Daniel L. Coonfield, Katherine G. Hill, Helen J. Kaczmarek, Frank M. FerraroIIIIII & Stephen W. Kiefer. (2002) Low doses of naltrexone reduce palatability and consumption of ethanol in outbred rats. Alcohol 26:1, pages 43-47.
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Stephanie S. O’Malley & Janice C. Froehlich. 2002. Recent Developments in Alcoholism. Recent Developments in Alcoholism 217 245 .
Bruce E. Hetzler & Ewa M. Bednarek. (2001) Effects of ethanol on flash-evoked potentials of rats: lack of antagonism by naltrexone. Alcohol 25:1, pages 21-30.
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Pekka Heinälä, Hannu Alho, Kalervo Kiianmaa, Jouko Lönnqvist, Kimmo Kuoppasalmi & John D. Sinclair. (2001) Targeted Use of Naltrexone Without Prior Detoxification in the Treatment of Alcohol Dependence: A Factorial Double-Blind, Placebo-Controlled Trial. Journal of Clinical Psychopharmacology 21:3, pages 287-292.
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Jobst August-Ludwig Boening, Otto Michel Lesch, Rainer Spanagel, Jochen Wolffgramm, Minoru Narita, David Sinclair, Barbara J. Mason & Gerhard A. Wiesbeck. (2001) Pharmacological Relapse Prevention in Alcohol Dependence: From Animal Models to Clinical Trials. Alcoholism: Clinical and Experimental Research 25:s1, pages 127S-131S.
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Sara Lindholm, Martin Werme, Stefan Brené & Johan Franck. (2001) The selective κ-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat. Behavioural Brain Research 120:2, pages 137-146.
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Raymond F. Anton, Darlene H. Moak, Patricia K. Latham, L. Randolph Waid, Robert J. Malcolm, James K. Dias & James S. Roberts. (2001) Posttreatment Results of Combining Naltrexone with Cognitive-Behavior Therapy for the Treatment of Alcoholism. Journal of Clinical Psychopharmacology 21:1, pages 72-77.
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Przemyslaw Bienkowski, Pawel Krzascik, Eliza Koros, Wojciech Kostowski, Anna Scinska & Wojciech Danysz. (2001) Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat. European Journal of Pharmacology 413:1, pages 81-89.
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H Parkes & J.D Sinclair. (2000) Reduction of alcohol drinking and upregulation of opioid receptors by oral naltrexone in AA rats. Alcohol 21:3, pages 215-221.
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Roberto Ciccocioppo, Stefania Angeletti, Izabela Panocka & Maurizio Massi. (2000) Nociceptin/orphanin FQ and drugs of abuse. Peptides 21:7, pages 1071-1080.
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David H. Overstreet, Alexey B. Kampov‐Polevoy, Amir H. Rezvani, Chris Braun, Raymond T. Bartus & Fulton T. Crews. (2006) Suppression of Alcohol Intake by Chronic Naloxone Treatment in P Rats: Tolerance Development and Elevation of Opiate Receptor Binding. Alcoholism: Clinical and Experimental Research 23:11, pages 1761-1771.
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Michael S. Cowen & Andrew J. Lawrence. (1999) The role of opioid-dopamine interactions in the induction and maintenance of ethanol consumption. Progress in Neuro-Psychopharmacology and Biological Psychiatry 23:7, pages 1171-1212.
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Michael S. Cowen, Amir H. Rezvani, Bevyn Jarrott & Andrew J. Lawrence. (2006) Ethanol Consumption by Fawn‐Hooded Rats Following Abstinence Effect of Naltrexone and Changes in μ‐Opioid Receptor Density. Alcoholism: Clinical and Experimental Research 23:6, pages 1008-1014.
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Przemyslaw Bienkowski, Wojciech Kostowski & Eliza Koros. (1999) Ethanol-reinforced behaviour in the rat: effects of naltrexone. European Journal of Pharmacology 374:3, pages 321-327.
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S.L Soini, A Honkanen, P Hyytiä & E.R Korpi. (1999) [3H]Ethylketocyclazocine Binding to Brain Opioid Receptor Subtypes in Alcohol-Preferring AA and Alcohol-Avoiding ANA Rats. Alcohol 18:1, pages 27-34.
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Shigeki Matsuzawa, Tsutomu Suzuki, Miwa Misawa & Hiroshi Nagase. (1999) Roles of 5-HT3 and opioid receptors in the ethanol-induced place preference in rats exposed to conditioned fear stress. Life Sciences 64:21, pages PL241-PL249.
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Johan Franck, Sara Lindholm & Pauline Raaschou. (2006) Modulation of Volitional Ethanol Intake in the Rat by Central δ‐Opioid Receptors. Alcoholism: Clinical and Experimental Research 22:6, pages 1185-1189.
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Michael J. Eckardt, Sandra E. File, Gian Luigi Gessa, Kathleen A. Grant, Consuelo Guerri, Paula L. Hoffman, Harold Kalant, George F. Koob, Ting‐Kai Li & Boris Tabakoff. (2006) Effects of Moderate Alcohol Consumption on the Central Nervous System*. Alcoholism: Clinical and Experimental Research 22:5, pages 998-1040.
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S.L Soini, T Ovaska, A Honkanen, P Hyytiä & E.R Korpi. (1998) Brain Opioid Receptor Binding of [3H]CTOP and [3H]Naltrindole in Alcohol-Preferring AA and Alcohol-Avoiding ANA Rats. Alcohol 15:3, pages 227-232.
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Dena Davidson & Zalman Amit. (1997) Effect of ethanol drinking and naltrexone on subsequent drinking in rats. Alcohol 14:6, pages 581-584.
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Tamara J. Phillips, Charlotte D. Wenger & Janet D. Dorow. (2006) Naltrexone Effects on Ethanol Drinking Acquisition and on Established Ethanol Consumption in C57BL/6J Mice. Alcoholism: Clinical and Experimental Research 21:4, pages 691-702.
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D. Davidson & Z. Amit. (2006) Naltrexone Blocks Acquisition of Voluntary Ethanol Intake in Rats. Alcoholism: Clinical and Experimental Research 21:4, pages 677-683.
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Rainer Spanagel & Walter Zieglgänsberger. (1997) Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends in Pharmacological Sciences 18:2, pages 54-59.
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H. Rommelspacher. 1997. Alkoholismus als psychische Störung. Alkoholismus als psychische Störung 33 59 .
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J. David Sinclair. (1996) High and Low Drinking Rat Lines: Contributions to Current Understanding and Future Development. Alcoholism: Clinical and Experimental Research 20:s8, pages 109a-112a.
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Larry D. Reid, Luis R. Gardell, Soma Chattopadhyay & Christopher L. Hubbell. (2006) Periodic Naltrexone and Propensity To Take Alcoholic Beverage. Alcoholism: Clinical and Experimental Research 20:8, pages 1329-1334.
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Dena Davidson, Robert Swift & Eric Fitz. (2006) Naltrexone Increases the Latency to Drink Alcohol in Social Drinkers. Alcoholism: Clinical and Experimental Research 20:4, pages 732-739.
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Dena Davidson & Zalman Amit. (2006) Effects of Naloxone on Limited‐Access Ethanol Drinking in Rats. Alcoholism: Clinical and Experimental Research 20:4, pages 664-669.
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Aapo Honkanen, Laura Vilamo, Katri Wegelius, Maija Sarviharju, Petri Hyytiä & Esa R. Korpi. (1996) Alcohol drinking is reduced by a μ1- but not by a δ-opioid receptor antagonist in alcohol-preferring rats. European Journal of Pharmacology 304:1-3, pages 7-13.
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Ann‐Charlotte Ekman, Olli Vakkuri, Olli Vuolteenaho & Juhani Leppäluoto. (2006) Delayed Pro‐Opiomelanocortin Activation after Ethanol Intake in Man. Alcoholism: Clinical and Experimental Research 18:5, pages 1226-1229.
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Barbara J. Mason, Eva C. Ritvo, Robert O. Morgan, Femando R. Salvato, Gloria Goldberg, Bruce Welch & Emilio Mantero‐Atienza. (2006) A Double‐Blind, Placebo‐Controlled Pilot Study to Evaluate the Efficacy and Safety of Oral Nalmefene HCI for Alcohol Dependence. Alcoholism: Clinical and Experimental Research 18:5, pages 1162-1167.
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P. Hyytiä. (1993) Involvement of μ-opioid receptors in alcohol drinking by alcohol-preferring AA rats. Pharmacology Biochemistry and Behavior 45:3, pages 697-701.
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P. Hyytiä & J. D. Sinclair. (2006) Responding for Oral Ethanol after Naloxone Treatment by Alcohol‐Preferring AA Rats. Alcoholism: Clinical and Experimental Research 17:3, pages 631-636.
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