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Original Article

Should the single-blind placebo responder exclusion phase be omitted from clinical trials?

Pages 159-165 | Published online: 12 Jul 2009

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L. Tanum & U. F. Malt. (1996) A New Pharmacologic Treatment of Functional Gastrointestinal Disorder: A Double-Blind Placebo-Controlled Study with Mianserin. Scandinavian Journal of Gastroenterology 31:4, pages 318-325.
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Rikke Meyer, Kenneth Skov, Inderjeet Kaur Dhillon, Emilie Olsson, Niels Albert Graudal, Lone Baandrup & Gesche Jürgens. (2022) Onset of Action of Selected Second-Generation Antipsychotics (Pines)–A Systematic Review and Meta-Analyses. Biomedicines 11:1, pages 82.
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Ingunn F Tvete, Inge C Olsen, Morten W Fagerland, Nils Meland, Magne Aldrin, Knut T Smerud & Lars Holden. (2012) An approach to combining parallel and cross-over trials with and without run-in periods using individual patient data. Clinical Trials 9:2, pages 164-175.
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Robert H. DworkinJennifer KatzMichael J. Gitlin. (2005) Placebo response in clinical trials of depression and its implications for research on chronic neuropathic pain. Neurology 65:12_suppl_4.
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Sandra Lee, John R. Walker, Laura Jakul & Kathryn Sexton. (2004) Does elimination of placebo responders in a placebo run-in increase the treatment effect in randomized clinical trials? A meta-analytic evaluation. Depression and Anxiety 19:1, pages 10-19.
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Roger P. Greenberg, Seymour Fisher & James A. Riter. (2016) Placebo Washout is not a Meaningful Part of Antidepressant Drug Trials. Perceptual and Motor Skills 81:2, pages 688-690.
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