Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 39, 2010 - Issue 4-5
114
Views
44
CrossRef citations to date
0
Altmetric
Research Articles

Heat-Labile Enterotoxins as Adjuvants or Anti-Inflammatory Agents

&
Pages 449-467 | Published online: 07 May 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Catherine J. Y. Tsai, Jacelyn M. S. Loh, Kohtaro Fujihashi & Hiroshi Kiyono. (2023) Mucosal vaccination: onward and upward. Expert Review of Vaccines 22:1, pages 885-899.
Read now
Mary-Peyton A. Knapp, Taylor A. Johnson, Madison K. Ritter, Robert O. Rainer, Steven E. Fiester, Jennifer T. Grier, Terry D. Connell & Sergio Arce. (2021) Immunomodulatory regulation by heat-labile enterotoxins and potential therapeutic applications. Expert Review of Vaccines 20:8, pages 975-987.
Read now
Rajat Mudgal, Sanketkumar Nehul & Shailly Tomar. (2020) Prospects for mucosal vaccine: shutting the door on SARS-CoV-2. Human Vaccines & Immunotherapeutics 16:12, pages 2921-2931.
Read now
Soudabeh Sabetian, Navid Nezafat, Hesam Dorosti, Mahboubeh Zarei & Younes Ghasemi. (2019) Exploring dengue proteome to design an effective epitope-based vaccine against dengue virus. Journal of Biomolecular Structure and Dynamics 37:10, pages 2546-2563.
Read now
Nicolae Miron, Vasile Feldrihan, Ioana Berindan-Neagoe & Victor Cristea. (2014) The role of staphylococcal enterotoxin A in achieving oral tolerance to myelin basic protein in adult mice. Immunological Investigations 43:3, pages 267-277.
Read now
Arvind Mahajan & David Gally. (2011) Escherichia coli and the mucosal immune system. Expert Review of Clinical Immunology 7:6, pages 743-745.
Read now
Michael W. Russell & Pearay L. Ogra. (2010) Mucosal Decisions: Tolerance and Responsiveness at Mucosal Surfaces. Immunological Investigations 39:4-5, pages 297-302.
Read now

Articles from other publishers (37)

Raju Sunagar, Amit Singh & Sudeep Kumar. (2023) SARS-CoV-2: Immunity, Challenges with Current Vaccines, and a Novel Perspective on Mucosal Vaccines. Vaccines 11:4, pages 849.
Crossref
Lazar D. Nesovic, Akhilesh K. Shakya & Harvinder S. Gill. (2022) Treating allergies via skin – Recent advances in cutaneous allergen immunotherapy. Advanced Drug Delivery Reviews 190, pages 114458.
Crossref
Chi-Hsun Chen, Chung-Chu Chen, Wei-Bo Wang, Vania Lionel, Chia-Chyi Liu, Li-Min Huang & Suh-Chin Wu. (2022) Intranasal Immunization with Zika Virus Envelope Domain III-Flagellin Fusion Protein Elicits Systemic and Mucosal Immune Responses and Protection against Subcutaneous and Intravaginal Virus Challenges. Pharmaceutics 14:5, pages 1014.
Crossref
Kacper Karczmarzyk & Małgorzata Kęsik-Brodacka. (2022) Attacking the Intruder at the Gate: Prospects of Mucosal Anti SARS-CoV-2 Vaccines. Pathogens 11:2, pages 117.
Crossref
Bassel Akache, Felicity C. Stark, Gerard Agbayani, Tyler M. Renner & Michael J. McCluskie. 2022. Vaccine Design. Vaccine Design 179 231 .
Haiyue Xu, Lucy Cai, Stephanie Hufnagel & Zhengrong Cui. (2021) Intranasal vaccine: Factors to consider in research and development. International Journal of Pharmaceutics 609, pages 121180.
Crossref
Camila Henrique, Maria Alice Pimentel Falcão, Luciana De Araújo Pimenta, Adolfo Luís Almeida Maleski, Carla Lima, Thais Mitsunari, Sandra Coccuzzo Sampaio, Mônica Lopes-Ferreira & Roxane Maria Fontes Piazza. (2021) Heat-Labile Toxin from Enterotoxigenic Escherichia coli Causes Systemic Impairment in Zebrafish Model. Toxins 13:6, pages 419.
Crossref
Neos Tang, Chun-Yi Lu, Shih-Che Sue, Ting-Hsuan Chen, Jia-Tsrong Jan, Ming-Hsi Huang, Chung-Hsiung Huang, Chung-Chu Chen, Bor-Luen Chiang, Li-Min Huang & Suh-Chin Wu. (2020) Type IIb Heat Labile Enterotoxin B Subunit as a Mucosal Adjuvant to Enhance Protective Immunity against H5N1 Avian Influenza Viruses. Vaccines 8:4, pages 710.
Crossref
Ivan Aranha & Yeldur P. Venkatesh. (2020) Humoral immune and adjuvant responses of mucosally-administered Tinospora cordifolia immunomodulatory protein in BALB/c mice. Journal of Ayurveda and Integrative Medicine 11:2, pages 140-146.
Crossref
Neos Tang, Shi-Wei Lin, Ting-Hsuan Chen, Jia-Tsrong Jan, Hung-Yi Wu & Suh-Chin Wu. (2019) Highly Pathogenic Avian Influenza H5 Hemagglutinin Fused with the A Subunit of Type IIb Escherichia coli Heat Labile Enterotoxin Elicited Protective Immunity and Neutralization by Intranasal Immunization in Mouse and Chicken Models. Vaccines 7:4, pages 193.
Crossref
Donghyun Kim, Yu‐Mi Kim, Wan‐Uk Kim, Jong‐Hwan Park, Gabriel Núñez & Sang‐Uk Seo. (2019) Recognition of the microbiota by Nod2 contributes to the oral adjuvant activity of cholera toxin through the induction of interleukin‐1 β . Immunology 158:3, pages 219-229.
Crossref
Vilander & Dean. (2019) Adjuvant Strategies for Lactic Acid Bacterial Mucosal Vaccines. Vaccines 7:4, pages 150.
Crossref
Gang Zhou, Morley D. Hollenberg, Harissios Vliagoftis & Kevin P. Kane. (2019) Protease-Activated Receptor 2 Agonist as Adjuvant: Augmenting Development of Protective Memory CD8 T Cell Responses Induced by Influenza Virosomes. The Journal of Immunology 203:2, pages 441-452.
Crossref
Ronald L. Schnaar. 2019. Sialic Acids, Part II: Biological and Biomedical Aspects. Sialic Acids, Part II: Biological and Biomedical Aspects 113 148 .
Nils Lycke & Cristina Lebrero-Fernández. (2018) ADP-ribosylating enterotoxins as vaccine adjuvants. Current Opinion in Pharmacology 41, pages 42-51.
Crossref
Cameron H. Flayer, Sarah S. Killingbeck, Erik Larson, Zoulfia Allakhverdi & Angela Haczku. 2018. Immunopharmacology and Inflammation. Immunopharmacology and Inflammation 57 84 .
Douglas I. JohnsonDouglas I. Johnson. 2018. Bacterial Pathogens and Their Virulence Factors. Bacterial Pathogens and Their Virulence Factors 209 239 .
S. S. Killingbeck, M. Q. Ge & A. Haczku. (2017) Patching it together: epicutaneous vaccination with heat-labile Escherichia coli toxin against birch pollen allergy . Allergy 72:1, pages 5-8.
Crossref
Michael G. Jobling. (2016) The chromosomal nature of LT-II enterotoxins solved: a lambdoid prophage encodes both LT-II and one of two novel pertussis-toxin-like toxin family members in type II enterotoxigenic Escherichia coli . Pathogens and Disease 74:3, pages ftw001.
Crossref
Nikolai Petrovsky. (2015) Comparative Safety of Vaccine Adjuvants: A Summary of Current Evidence and Future Needs. Drug Safety 38:11, pages 1059-1074.
Crossref
Javier Sanchez-Villamil & Fernando Navarro-Garcia. (2015) Role of virulence factors on host inflammatory response induced by diarrheagenic Escherichia coli pathotypes . Future Microbiology 10:6, pages 1009-1033.
Crossref
John C. Hu, Camila Mathias-Santos, Christopher J. Greene, Natalie D. King-Lyons, Juliana F. Rodrigues, George Hajishengallis, Luís C. S. Ferreira & Terry D. Connell. (2014) Intradermal Administration of the Type II Heat-Labile Enterotoxins LT-IIb and LT-IIc of Enterotoxigenic Escherichia coli Enhances Humoral and CD8+ T Cell Immunity to a Co-Administered Antigen. PLoS ONE 9:12, pages e113978.
Crossref
Yingying Xu, Pak-Wai Yuen & Jenny Lam. (2014) Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives. Pharmaceutics 6:3, pages 378-415.
Crossref
Matthew A. Croxen, Robyn J. Law, Roland Scholz, Kristie M. Keeney, Marta Wlodarska & B. Brett Finlay. (2013) Recent Advances in Understanding Enteric Pathogenic Escherichia coli. Clinical Microbiology Reviews 26:4, pages 822-880.
Crossref
George Hajishengallis & Terry D. Connell. (2013) Type II heat-labile enterotoxins: Structure, function, and immunomodulatory properties. Veterinary Immunology and Immunopathology 152:1-2, pages 68-77.
Crossref
Andrzej Myc, Jolanta F. Kukowska-Latallo, Douglas M. Smith, Crystal Passmore, Tiffany Pham, Pamela Wong, Anna U. Bielinska & James R. BakerJr.Jr.. (2013) Nanoemulsion nasal adjuvant W805EC induces dendritic cell engulfment of antigen-primed epithelial cells. Vaccine 31:7, pages 1072-1079.
Crossref
Guangcun Deng, Jin Zeng, Minjie Jian, Wenmiao Liu, Zhong Zhang, Xiaoming Liu & Yujiong Wang. (2013) Nanoparticulated heat-stable (STa) and heat-labile B subunit (LTB) recombinant toxin improves vaccine protection against enterotoxigenic Escherichia coli challenge in mouse. Journal of Bioscience and Bioengineering 115:2, pages 147-153.
Crossref
Nils Lycke. (2012) Recent progress in mucosal vaccine development: potential and limitations. Nature Reviews Immunology 12:8, pages 592-605.
Crossref
Bert Devriendt, Bruno G. De Geest, Bruno M. Goddeeris & Eric Cox. (2012) Crossing the barrier: Targeting epithelial receptors for enhanced oral vaccine delivery. Journal of Controlled Release 160:3, pages 431-439.
Crossref
Assunta Pelosi, Robert Shepherd & Amanda M. Walmsley. (2012) Delivery of plant-made vaccines and therapeutics. Biotechnology Advances 30:2, pages 440-448.
Crossref
Michael G. Jobling & Randall K. Holmes. (2012) Type II Heat-Labile Enterotoxins from 50 Diverse Escherichia coli Isolates Belong Almost Exclusively to the LT-IIc Family and May Be Prophage Encoded. PLoS ONE 7:1, pages e29898.
Crossref
Roger W. Barrette, Steven M. Szczepanek, Debra Rood, Sreerupa Challa, Naomi Avery, Michael Vajdy, Ed Kramer, Luis Rodriguez & Lawrence K. Silbart. (2011) Use of Inactivated Escherichia coli Enterotoxins To Enhance Respiratory Mucosal Adjuvanticity during Vaccination in Swine. Clinical and Vaccine Immunology 18:11, pages 1996-1998.
Crossref
W. Zhao, Z. Zhao & M.W. Russell. (2011) Characterization of antigen‐presenting cells induced by intragastric immunization with recombinant chimeric immunogens constructed from Streptococcus mutans AgI/II and type I or type II heat‐labile enterotoxins . Molecular Oral Microbiology 26:3, pages 200-209.
Crossref
Theo P. M. Schetters. 2011. Apicomplexan Parasites. Apicomplexan Parasites 53 73 .
Qiang Gao, Kai Jin, Sheng-Hua Ying, Yongjun Zhang, Guohua Xiao, Yanfang Shang, Zhibing Duan, Xiao Hu, Xue-Qin Xie, Gang Zhou, Guoxiong Peng, Zhibing Luo, Wei Huang, Bing Wang, Weiguo Fang, Sibao Wang, Yi Zhong, Li-Jun Ma, Raymond J. St. Leger, Guo-Ping Zhao, Yan Pei, Ming-Guang Feng, Yuxian Xia & Chengshu Wang. (2011) Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi Metarhizium anisopliae and M. acridum. PLoS Genetics 7:1, pages e1001264.
Crossref
Hesham F. Nawar, Christopher J. Greene, Chang Hoon Lee, Lorrie M. Mandell, George Hajishengallis & Terry D. Connell. (2011) LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb. Vaccine 29:4, pages 721-727.
Crossref
Chiou-Feng Lin, Chia-Ling Chen, Wei-Ching Huang, Yi-Lin Cheng, Chia-Yuan Hsieh, Chi-Yun Wang & Ming-Yuan Hong. (2010) Different Types of Cell Death Induced by Enterotoxins. Toxins 2:8, pages 2158-2176.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.