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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 44, 2015 - Issue 7
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Original Articles

Differential Gene Expression Profiles Reflecting Macrophage Polarization in Aging and Periodontitis Gingival Tissues

O. A. GonzalezCenter for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA,
,
M. J. NovakCenter for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA,
,
S. KirakoduCenter for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA,
,
A. StrombergDepartment of Statistics, College of Arts and Sciences, University of Kentucky, Lexington, KY, USA,
,
R. NagarajanDepartment of Biostatistics, College of Public Health, University of Puerto Rico, San Juan, PR, USA,
,
C. B. HuangCenter for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA,
,
K. C. ChenMicroarray Core Facility, College of Medicine, University of Puerto Rico, San Juan, PR, USA,
,
L. OrracaSchool of Dental Medicine, University of Puerto Rico, San Juan, PR, USA, and
,
J. Martinez-GonzalezCaribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA
&
J. L. EbersoleCenter for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA, Correspondence[email protected]
 show all
Pages 643-664 | Received 07 Apr 2015, Accepted 23 Jun 2015, Published online: 23 Sep 2015

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. (2018) Thematic 2018 Letter from the Editor. Immunological Investigations 47:8, pages 765-769.
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. (2017) Letter from the Editor 2017. Immunological Investigations 46:8, pages 759-764.
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Kate Rittenhouse-Olson. (2016) Letter from the Editor 2016. Immunological Investigations 45:8, pages 703-707.
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Xiao-Tao Chen, Li-Li Chen, Jing-Yi Tan, Dan-Hui Shi, Ting Ke & Li-Hong Lei. (2016) Th17 and Th1 Lymphocytes Are Correlated with Chronic Periodontitis. Immunological Investigations 45:3, pages 243-254.
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Articles from other publishers (61)

J. L. Ebersole, S. S. Kirakodu, L. M. Nguyen & O. A. Gonzalez. (2023) Periodontitis‐resistant and ‐susceptible matriline regulation of gingival transcriptome in nonhuman primates. Journal of Periodontal Research 58:6, pages 1171-1187.
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O. A. Gonzalez, S. Kirakodu, L. Nguyen & J. L. Ebersole. (2023) Macrophage‐related gingival transcriptomic patterns and microbiome alterations in experimental periodontitis in nonhuman primates. Journal of Periodontal Research 58:6, pages 1148-1170.
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O. A. Gonzalez, S. S. Kirakodu & J. L. Ebersole. (2023) DAMPs and alarmin gene expression patterns in aging healthy and diseased mucosal tissues. Frontiers in Oral Health 4.
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Mohamed M. Meghil & Christopher W. Cutler. (2023) Influence of Vitamin D on Periodontal Inflammation: A Review. Pathogens 12:9, pages 1180.
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Hisashi Goto, Takeshi Kikuchi, Yuhei Takayanagi, Yosuke Kamiya, Yuki Suzuki, Shotaro Kawamura, Noritaka Sawada, Jun‐ichiro Hayashi & Akio Mitani. (2023) Ebi3 knockout aggravates experimental periodontitis via Th17 polarization . Journal of Clinical Periodontology.
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Sarah Metcalfe, Michelle Panasiewicz & Jason G Kay. (2023) Inflammatory macrophages exploited by oral streptococcus increase IL-1B release via NLRP6 inflammasome. Journal of Leukocyte Biology.
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Octavio A Gonzalez, Sreenatha S Kirakodu, Linh M Nguyen & Jeffrey L Ebersole. (2023) Gingival transcriptomic patterns of macrophage polarization during initiation, progression, and resolution of periodontitis. Clinical and Experimental Immunology 211:3, pages 248-268.
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Jeffrey L. Ebersole & Octavio A. Gonzalez. (2022) Mucosal circadian rhythm pathway genes altered by aging and periodontitis. PLOS ONE 17:12, pages e0275199.
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Limin Peng, Hang Chen, Zhenxiang Wang, Yujuan He & Xiaonan Zhang. (2022) Identification and validation of a classifier based on hub aging-related genes and aging subtypes correlation with immune microenvironment for periodontitis. Frontiers in Immunology 13.
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Linying Yin, Xinzhu Li & Jin Hou. (2022) Macrophages in periodontitis: A dynamic shift between tissue destruction and repair. Japanese Dental Science Review 58, pages 336-347.
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Wenlong Zhao, Di Xu, Wei Hong, Lin Zhang, Qinyan Wu, Mingzhe Gao & Junsong Wang. (2022) Grossamide attenuates inflammation by balancing macrophage polarization through metabolic reprogramming of macrophages in mice. International Immunopharmacology 112, pages 109190.
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Jiaqi Liu, Ruichen Dan, Xueman Zhou, Jie Xiang, Jun Wang & Jin Liu. (2022) Immune senescence and periodontitis: From mechanism to therapy. Journal of Leukocyte Biology 112:5, pages 1025-1040.
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Rui Zhu, Zihan Zhang, Boyao Lu, Peng Zhang, Weiqing Liu & Xing Liang. (2022) Unloading of occlusal force aggravates alveolar bone loss in periodontitis. Journal of Periodontal Research 57:5, pages 1070-1082.
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Liguang Hou, Yu Ye, Huiqing Gou, Hui Tang, Yi Zhou, Xuanwen Xu & Yan Xu. (2022) A20 inhibits periodontal bone resorption and NLRP3-mediated M1 macrophage polarization. Experimental Cell Research 418:1, pages 113264.
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Jeffrey L. Ebersole, Linh M. Nguyen & Octavio A. Gonzalez. (2022) Gingival tissue antibody gene utilization in aging and periodontitis. Journal of Periodontal Research 57:4, pages 780-798.
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Jeffrey L. Ebersole, Radhakrishnan Nagarajan, Sreenatha S. Kirakodu & Octavio A. Gonzalez. (2022) Immunoglobulin gene expression profiles and microbiome characteristics in periodontitis in nonhuman primates. Molecular Immunology 148, pages 18-33.
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Aliakbar Yousefi-Ahmadipour, Mohadeseh Sartipi, Hassan Khodadadi, Mehdi Shariati-Kohbanani & Mohammad Kazemi Arababadi. (2022) Toll-like receptor 4 and the inflammation during aging. Journal of Gerontology and Geriatrics 70:2, pages 1-8.
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Y. Han, Y. Huang, P. Gao, Q. Yang, L. Jia, Y. Zheng & W. Li. (2022) Leptin Aggravates Periodontitis by Promoting M1 Polarization via NLRP3. Journal of Dental Research 101:6, pages 675-685.
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Octavio A. Gonzalez, Sreenatha Kirakodu, Linh M. Nguyen, Luis Orraca, Michael J. Novak, Janis Gonzalez-Martinez & Jeffrey L. Ebersole. (2022) Comparative Analysis of Gene Expression Patterns for Oral Epithelial Cell Functions in Periodontitis. Frontiers in Oral Health 3.
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Jeffrey L. Ebersole, Sreenatha Kirakodu, Linh Nguyen & Octavio A. Gonzalez. (2022) Gingival Transcriptome of Innate Antimicrobial Factors and the Oral Microbiome With Aging and Periodontitis. Frontiers in Oral Health 3.
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Hengfang Zhang, Shuang Zhang, Xuan Dang, Lexun Lin, Liping Ren & Rong Song. (2022) GPNMB plays an active role in the M1/M2 balance. Tissue and Cell 74, pages 101683.
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Sarah Metcalfe, Natalie Anselmi, Alejandro Escobar, Michelle B. Visser & Jason G. Kay. (2022) Innate Phagocyte Polarization in the Oral Cavity. Frontiers in Immunology 12.
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Nazanin Jafari, Arezoo Khoradmehr, Reza Moghiminasr & Mina Seyed Habashi. (2022) Mesenchymal Stromal/Stem Cells-Derived Exosomes as an Antimicrobial Weapon for Orodental Infections. Frontiers in Microbiology 12.
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Sameena Parveen. (2021) Impact of calorie restriction and intermittent fasting on periodontal health. Periodontology 2000 87:1, pages 315-324.
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Daniel Clark, Eftychia Kotronia & Sheena E. Ramsay. (2021) Frailty, aging, and periodontal disease: Basic biologic considerations. Periodontology 2000 87:1, pages 143-156.
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Bo Zhang, Yang Yang, Jianru Yi, Zhihe Zhao & Rui Ye. (2021) Hyperglycemia modulates M1/M2 macrophage polarization via reactive oxygen species overproduction in ligature‐induced periodontitis. Journal of Periodontal Research 56:5, pages 991-1005.
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Tingting Liu, Qingbin Han, Yan Pan, Jingyuan Li & Hui Song. (2021) Carbon Monoxide-Releasing Molecule-3 Regulates the Polarization of Lipopolysaccharide-Induced Macrophages. Inflammation 44:5, pages 1737-1749.
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Jeffrey L. Ebersole, Radhakrishnan Nagarajan, Sreenatha Kirakodu & Octavio A. Gonzalez. (2021) Oral Microbiome and Gingival Gene Expression of Inflammatory Biomolecules With Aging and Periodontitis. Frontiers in Oral Health 2.
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Junling Ren, Xiao Han, Hannah Lohner, Ruqiang Liang, Shuang Liang & Huizhi Wang. (2021) Serum- and Glucocorticoid-Inducible Kinase 1 Promotes Alternative Macrophage Polarization and Restrains Inflammation through FoxO1 and STAT3 Signaling. The Journal of Immunology 207:1, pages 268-280.
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Ju Young Jang, Geum Hee Choi & Suk Ji. (2021) IFN‐γ or IL‐4 polarization impacts the response of gingival fibroblasts to oral bacteria. Journal of Periodontal Research 56:3, pages 462-470.
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J L Ebersole, S S Kirakodu, L Orraca, J Gonzalez Martinez & O A Gonzalez. (2021) Gingival transcriptomics of follicular T cell footprints in progressing periodontitis. Clinical and Experimental Immunology 204:3, pages 373-395.
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Jeffrey L. Ebersole, Radhakrishnan Nagarajan, Sreenatha Kirakodu & Octavio A. Gonzalez. (2021) Transcriptomic phases of periodontitis lesions using the nonhuman primate model. Scientific Reports 11:1.
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Jeffrey L. Ebersole, Sreenatha Kirakodu, Michael J. Novak, Dolph Dawson, Arnold J. Stromberg, Luis Orraca, Janis Gonzalez‐Martinez, Armando Burgos & Octavio A. Gonzalez. (2020) Gingival tissue autophagy pathway gene expression profiles in periodontitis and aging. Journal of Periodontal Research 56:1, pages 34-45.
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Hannah Mulhall, Jeanne M. DiChiara, Matthew Deragon, Radha Iyer, Olivier Huck & Salomon Amar. (2020) Akkermansia muciniphila and Its Pili-Like Protein Amuc_1100 Modulate Macrophage Polarization in Experimental Periodontitis. Infection and Immunity 89:1.
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Zongshan Shen, Shuhong Kuang, Yong Zhang, Mingmei Yang, Wei Qin, Xuetao Shi & Zhengmei Lin. (2020) Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism. Bioactive Materials 5:4, pages 1113-1126.
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Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Elliot Neumann, Luis Orraca, Janis Gonzalez Martinez & Octavio A. Gonzalez. (2020) Oral Microbiome and Gingival Tissue Apoptosis and Autophagy Transcriptomics. Frontiers in Immunology 11.
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Liping Wang, Jing Zheng, Janak L. Pathak, Yunxin Chen, Dongliang Liang, Luxi Yang, Haobo Sun, Mei Zhong, Lihong Wu, Li Li, Shuhua Deng, Lingyun Zheng, Yongyong Yan, Dan Hou, Lijing Wang & Linhu Ge. (2020) SLIT2 Overexpression in Periodontitis Intensifies Inflammation and Alveolar Bone Loss, Possibly via the Activation of MAPK Pathway. Frontiers in Cell and Developmental Biology 8.
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Johnathan R. Yarbro, Russell S. Emmons & Brandt D. Pence. (2020) Macrophage Immunometabolism and Inflammaging: Roles of Mitochondrial Dysfunction, Cellular Senescence, CD38, and NAD. Immunometabolism 2:3.
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J. L. Ebersole & O. A. Gonzalez. 2020. Emerging Therapies in Periodontics. Emerging Therapies in Periodontics 97 111 .
Xue Li, Manlin Qi, Chunyan Li, Biao Dong, Jia Wang, Michael D. Weir, Satoshi Imazato, Liuyi Du, Christopher D. Lynch, Lin Xu, Yanmin Zhou, Lin Wang & Hockin H. K. Xu. (2019) Novel nanoparticles of cerium-doped zeolitic imidazolate frameworks with dual benefits of antibacterial and anti-inflammatory functions against periodontitis. Journal of Materials Chemistry B 7:44, pages 6955-6971.
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Ilja L. Kruglikov, Zhuzhen Zhang & Philipp E. Scherer. (2019) Caveolin-1 in skin aging – From innocent bystander to major contributor. Ageing Research Reviews 55, pages 100959.
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Helena Angelica Pereira Batatinha, Tiego Aparecido Diniz, Alexandre Abilio de Souza Teixeira, Karsten Krüger & Jose Cesar Rosa‐Neto. (2019) Regulation of autophagy as a therapy for immunosenescence‐driven cancer and neurodegenerative diseases: The role of exercise. Journal of Cellular Physiology 234:9, pages 14883-14895.
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Huang, Tian, Li & Xu. (2019) TET1 Knockdown Inhibits Porphyromonas gingivalis LPS/IFN-γ-Induced M1 Macrophage Polarization through the NF-κB Pathway in THP-1 Cells. International Journal of Molecular Sciences 20:8, pages 2023.
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Jeffrey L. Ebersole, Luis Orraca, Terry B. Kensler, Janis Gonzalez‐Martinez, Elisabeth Maldonado & Octavio A. Gonzalez. (2018) Periodontal disease susceptible matrilines in the Cayo Santiago Macaca mulatta macaques . Journal of Periodontal Research 54:2, pages 134-142.
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Z. Zhuang, S. Yoshizawa-Smith, A. Glowacki, K. Maltos, C. Pacheco, M. Shehabeldin, M. Mulkeen, N. Myers, R. Chong, K. Verdelis, G.P. Garlet, S. Little & C. Sfeir. (2018) Induction of M2 Macrophages Prevents Bone Loss in Murine Periodontitis Models. Journal of Dental Research 98:2, pages 200-208.
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Li‐Na Zhou, Chun‐Sheng Bi, Li‐Na Gao, Ying An, Fang Chen & Fa‐Ming Chen. (2018) Macrophage polarization in human gingival tissue in response to periodontal disease. Oral Diseases 25:1, pages 265-273.
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J. L. Ebersole, L. Orraca, M. J. Novak, S. Kirakodu, J. Gonzalez-Martinez & O. A. Gonzalez. 2019. Oral Mucosal Immunity and Microbiome. Oral Mucosal Immunity and Microbiome 143 163 .
Xing Jin, Xu Zhang, Jinchun Li, Weiyi Yu & Fangfang Chen. (2018) Activation of chicken macrophages during in vitro stimulation and expression of immune genes. American Journal of Veterinary Research 79:12, pages 1306-1312.
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Jingmei Yang, Yan Zhu, Dingyu Duan, Panpan Wang, Yuejiao Xin, Lin Bai, Yiying Liu & Yi Xu. (2018) Enhanced activity of macrophage M1/M2 phenotypes in periodontitis. Archives of Oral Biology 96, pages 234-242.
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Jeffrey L. Ebersole, D. A. DawsonIIIIII, P. Emecen Huja, S. Pandruvada, A. Basu, L. Nguyen, Y. Zhang & O. A. Gonzalez. (2018) Age and Periodontal Health—Immunological View. Current Oral Health Reports 5:4, pages 229-241.
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Fang-Yu Tsao, Ming-Yih Wu, Yih-Leong Chang, Chen-Tu Wu & Hong-Nerng Ho. (2018) M1 macrophages decrease in the deciduae from normal pregnancies but not from spontaneous abortions or unexplained recurrent spontaneous abortions. Journal of the Formosan Medical Association 117:3, pages 204-211.
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George Hajishengallis & Jonathan M. Korostoff. (2017) Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later. Periodontology 2000 75:1, pages 116-151.
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Lisbeth A Boule & Elizabeth J Kovacs. (2017) Alcohol, aging, and innate immunity. Journal of Leukocyte Biology 102:1, pages 41-55.
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Philip M. Preshaw, Karsten Henne, John J. Taylor, Ruth A. Valentine & Georg Conrads. (2017) Age‐related changes in immune function (immune senescence) in caries and periodontal diseases: a systematic review. Journal of Clinical Periodontology 44:S18.
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Anna Gmiterek, Anna Kłopot, Halina Wójtowicz, Soraya C. Trindade, Mariusz Olczak & Teresa Olczak. (2016) Immune response of macrophages induced by Porphyromonas gingivalis requires HmuY protein. Immunobiology 221:12, pages 1382-1394.
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Joslyn M. AlbrightRobert C. DunnJill A. ShultsDevin M. BoeMajid AfsharElizabeth J. Kovacs. (2016) Advanced Age Alters Monocyte and Macrophage Responses. Antioxidants & Redox Signaling 25:15, pages 805-815.
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Tsuguno Yamaguchi, Alexandru Movila, Shinsuke Kataoka, Wichaya Wisitrasameewong, Montserrat Ruiz Torruella, Michiaki Murakoshi, Shinya Murakami & Toshihisa Kawai. (2016) Proinflammatory M1 Macrophages Inhibit RANKL-Induced Osteoclastogenesis. Infection and Immunity 84:10, pages 2802-2812.
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Hanlin Zhang, Daniel J. Puleston & Anna Katharina Simon. (2016) Autophagy and Immune Senescence. Trends in Molecular Medicine 22:8, pages 671-686.
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Chifu B. Huang, Yelena Alimova & Jeffrey L. Ebersole. (2016) Macrophage polarization in response to oral commensals and pathogens. Pathogens and Disease 74:3, pages ftw011.
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