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Seminars in Ophthalmology Volume 26, 2011 - Issue 3
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Research Article

Retinal Pigment Epithelial Detachments in Age-Related Macular Degeneration: Classification and Therapeutic Options

Kathryn PeppleDuke Eye Center, Durham, NC, USA
&
Prithvi MruthyunjayaDuke Eye Center, Durham, NC, USACorrespondence[email protected]
Pages 198-208 | Received 12 Jan 2011, Accepted 07 Mar 2011, Published online: 24 May 2011

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Ozgun Melike Gedar Totuk, Okan Toygar, Fulya Cosan, Ozge Yabas Kiziloglu & Baha Toygar. (2017) Coexistence of bilateral multifocal retinal pigment epithelial detachment and ankylosing spondylitis. Modern Rheumatology Case Reports 1:2, pages 64-67.
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Pelagia Kalouda, Anastasios Anastasakis, Chrysanthi Tsika & K. Miltiadis Tsilimbaris. (2015) The Effect of Intravitreal Anti-VEGF on the Pigment Epithelial Detachment in Eyes with the Exudative Type of Age-Related Macular Degeneration. Seminars in Ophthalmology 30:1, pages 6-10.
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Georgios D Panos, Zisis Gatzioufas, Ioannis K Petropoulos, Doukas Dardabounis, Gabriele Thumann & Farhad Hafezi. (2013) Effect of ranibizumab on serous and vascular pigment epithelial detachments associated with exudative age-related macular degeneration. Drug Design, Development and Therapy 7, pages 565-569.
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Articles from other publishers (28)

Zuhua Sun, Yating Yang, Bing Lin, Ying Huang, Rong Zhou, Chun Yang, Yingzi Li, Shenghai Huang & Xiaoling Liu. (2023) Comparative efficacy of aflibercept and ranibizumab in the treatment of age-related macular degeneration with retinal pigment epithelial detachment: a systematic review and network meta-analysis. BMC Ophthalmology 23:1.
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Seung Wan Nam, Zeeyoon Byun, Don-Il Ham & Mingui Kong. (2022) Response to brolucizumab treatment for refractory serous pigment epithelial detachment secondary to polypoidal choroidal vasculopathy. BMC Ophthalmology 22:1.
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Alper Bilgic, Laurent Kodjikian, Shail Vasavada, Shyamal Jha, Samaresh Srivastava, Aditya Sudhalkar & Thibaud Mathis. (2021) Brolucizumab for Choroidal Neovascular Membrane with Pigment Epithelial Tear and Subretinal Fluid. Journal of Clinical Medicine 10:11, pages 2425.
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Lydia Sauer, Alexandra S. Vitale, Natalie K. Modersitzki & Paul S. Bernstein. (2020) Fluorescence lifetime imaging ophthalmoscopy: autofluorescence imaging and beyond. Eye 35:1, pages 93-109.
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Kai Xiong Cheong, Kelvin Yi Chong Teo & Chui Ming Gemmy Cheung. (2021) Influence of pigment epithelial detachment on visual acuity in neovascular age-related macular degeneration. Survey of Ophthalmology 66:1, pages 68-97.
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Marco Nassisi & Srinivas R. Sadda. 2021. Age-related Macular Degeneration. Age-related Macular Degeneration 33 66 .
M.V. Budzinskaya, A.Zh. Fursova & E.K. Pedanova. (2020) Specific biomarkers of response to antiangiogenic therapy. Vestnik oftal'mologii 136:2, pages 117.
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Vlad Diaconita, Bo Li, Leslie Pal, Faten Bahnacy & John R. Gonder. (2019) Prospective evaluation of aflibercept in pigment epithelial detachments secondary to neovascular age related macular degeneration. Canadian Journal of Ophthalmology 54:5, pages 626-634.
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Alper Bilgic & Aditya Sudhalkar. (2019) Systemic steroids for the management of choroidal neovascular membrane with pigment epithelial tear and recalcitrant subretinal fluid. BMJ Case Reports 12:9, pages e231262.
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Stela Vujosevic, Caterina Toma, Edoardo Villani, Andrea Muraca, Emanuele Torti, Giordana Florimbi, Marco Pezzotti, Paolo Nucci & Stefano De Cillà. (2019) Quantitative choriocapillaris evaluation in intermediate age‐related macular degeneration by swept‐source optical coherence tomography angiography. Acta Ophthalmologica 97:6.
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Yu-Bai Chou, Meng-Jou Chen, Tai-Chi Lin, Shih-Jen Chen & De-Kuang Hwang. (2019) Priority options of anti-vascular endothelial growth factor agents in wet age-related macular degeneration under the National Health Insurance Program. Journal of the Chinese Medical Association 82:8, pages 659-664.
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Lydia Sauer, Christopher B. Komanski, Alexandra S. Vitale, Eric D. Hansen & Paul S. Bernstein. (2019) Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) in Eyes With Pigment Epithelial Detachments Due to Age-Related Macular Degeneration. Investigative Opthalmology & Visual Science 60:8, pages 3054.
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M. Sastre-Ibáñez, C. Martínez-Rubio, R. Molina-Pallete, P. Martínez- López-Corell, L. Wu, J.F. Arévalo & R. Gallego-Pinazo. (2019) Retinal pigment epithelial tears. Journal Français d'Ophtalmologie 42:1, pages 63-72.
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Clement K Chan, David Sarraf & Prema Abraham. (2018) Treatment outcomes of conventional or high-dose ranibizumab for vascularized pigment epithelial detachment based on lesion subtypes. European Journal of Ophthalmology 28:6, pages 677-683.
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Abed Namavari, Fang Zheng, Elie H. Motulsky, João R. de Oliveira Dias, Giovanni Gregori & Philip J. Rosenfeld. (2018) Swept-Source OCT Angiography Identifies Choroidal Neovascularization Arising From a Choroidal Nevus. Ophthalmic Surgery, Lasers and Imaging Retina 49:5, pages 360-363.
Crossref
Olivier Chevreaud, Hassiba Oubraham, Salomon Y. Cohen, Camille Jung, Rocio Blanco-Garavito, Farah Gherdaoui & Eric H. Souied. (2016) Ranibizumab for vascularized pigment epithelial detachment: 1-year anatomic and functional results. Graefe's Archive for Clinical and Experimental Ophthalmology 255:4, pages 743-751.
Crossref
Han Joo Cho, Hyoung Seok Kim, Seul Gi Yoo, Jung Il Han, Young Ju Lew, Sung Won Cho, Tae Gon Lee & Jong Woo Kim. (2016) RETINAL PIGMENT EPITHELIAL TEAR AFTER INTRAVITREAL RANIBIZUMAB TREATMENT FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina 36:10, pages 1851-1859.
Crossref
Han Joo Cho, Kyoung Min Kim, Hyoung Seok Kim, Dong Won Lee, Chul Gu Kim & Jong Woo Kim. (2016) Response of Pigment Epithelial Detachment to Anti–Vascular Endothelial Growth Factor Treatment in Age-Related Macular Degeneration. American Journal of Ophthalmology 166, pages 112-119.
Crossref
Joel Hanhart & Itay Chowers. (2015) Bilateral Refractive Changes in Vascularized Pigment Epithelial Detachment Treated by Anti-VEGF Therapy. Case Reports in Ophthalmology 6:3, pages 458-461.
Crossref
James C. MajorJr.Jr., Charles C. Wykoff, Daniel E. Croft, Rui Wang, Angeline F. Mariani, Anna E. Lehmann & David M. Brown. (2015) Aflibercept for pigment epithelial detachment for previously treated neovascular age-related macular degeneration. Canadian Journal of Ophthalmology 50:5, pages 373-377.
Crossref
Paul T. Finger, Daniel Simhaee & Ekaterina Semenova. (2015) Regression of Macular Drusenoid Retinal Pigment Epithelial Detachments After Plaque Radiation Therapy. Ophthalmic Surgery, Lasers and Imaging Retina 46:1, pages 84-86.
Crossref
Robyn Guymer & Chi LuuSamir KhandhadiaAndrew J Lotery. 2014. Current Issues in Age-Related Macular Degeneration. Current Issues in Age-Related Macular Degeneration 20 36 .
Yiannis Iordanous, Anne-Marie Powell, Alex Mao, Philip L. Hooper, Kenneth T. Eng, Carol Schwartz, Peter J. Kertes & Thomas G. Sheidow. (2014) Intravitreal ranibizumab for the treatment of fibrovascular pigment epithelial detachment in age-related macular degeneration. Canadian Journal of Ophthalmology 49:4, pages 367-376.
Crossref
Byung-Jin Kim, Terry A Braun, Robert J Wordinger & Abbot F Clark. (2013) Progressive morphological changes and impaired retinal function associated with temporal regulation of gene expression after retinal ischemia/reperfusion injury in mice. Molecular Neurodegeneration 8:1.
Crossref
Daniele Veritti, Sara Macor, Francesca Menchini & Paolo Lanzetta. (2013) EFFECTS OF VEGF INHIBITION ON RETINAL MORPHOLOGY, NEOVASCULAR NETWORK SIZE, AND VISUAL ACUITY IN PATIENTS WITH VASCULARIZED PIGMENT EPITHELIUM DETACHMENT BECAUSE OF OCCULT CHOROIDAL NEOVASCULARIZATION. Retina 33:5, pages 982-989.
Crossref
K H Patel, C C Chow, R Rathod, W F Mieler, J I Lim, L J UlanskiIIII, Y I Leiderman, V Arun & F Y Chau. (2013) Rapid response of retinal pigment epithelial detachments to intravitreal aflibercept in neovascular age-related macular degeneration refractory to bevacizumab and ranibizumab. Eye 27:5, pages 663-668.
Crossref
Carlos Alexandre de Amorim Garcia Filho, Fernando Marcondes Penha, Giovanni Gregori & Philip J. Rosenfeld. (2013) Increasing Volume of a Retinal Pigmented Epithelial Detachment as a Predictor of Submacular Hemorrhage During Anti-VEGF Therapy. Ophthalmic Surgery, Lasers and Imaging Retina 44:2, pages 204-207.
Crossref
Carlos Alexandre de Amorim Garcia Filho, Zohar Yehoshua, Giovanni Gregori, Carmen A. Puliafito & Philip J. Rosenfeld. 2013. Retina. Retina 82 110 .

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