891
Views
64
CrossRef citations to date
0
Altmetric
Research Article

Genetics of Age-Related Macular Degeneration: Current Concepts, Future Directions

, , &
Pages 77-93 | Received 21 Jun 2010, Accepted 29 Mar 2011, Published online: 24 May 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Ginte Daniute, Alvita Vilkeviciute, Greta Gedvilaite, Loresa Kriauciuniene & Rasa Liutkeviciene. (2022) RP1L1 rs3924612 gene polymorphism and RP1L1 protein associations among patients with early age-related macular degeneration. Ophthalmic Genetics 43:2, pages 164-171.
Read now
A. N. Tsiloulis, F. Zacharaki, M. G. Kotoula, D. Z. Chatzoulis, M. A. Morrison, K. Mayne, E. Dardiotis, I. L. Stefanidis, P. Almpanidou, M. M. DeAngelis & E. E. Tsironi. (2016) Genetic variants in complement pathway and ARMS2/HTRA1 genes and risk of age-related macular degeneration in a homogeneous population from central Greece. Ophthalmic Genetics 37:3, pages 339-344.
Read now
Justin Kanoff & Joan Miller. (2013) Pharmacogenetics of the Treatment Response of Age-Related Macular Degeneration with Ranibizumab and Bevacizumab. Seminars in Ophthalmology 28:5-6, pages 355-360.
Read now
Renpan Zeng, Feng Wen, Xiongze Zhang, Chengguo Zuo, Meng Li, Hui Chen & Kunfang Wu. (2012) An rs9621532 Variant Near the TIMP3 Gene is not Associated with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in a Chinese Han Population. Ophthalmic Genetics 33:3, pages 139-143.
Read now

Articles from other publishers (58)

Weixiong He, Xikun Han, Jue-Sheng Ong, Yeda Wu, Alex W. Hewitt, David A. Mackey, Puya Gharahkhani & Stuart MacGregor. (2023) Genome-wide meta-analysis identifies novel loci and improves disease prediction of age-related macular degeneration. Ophthalmology.
Crossref
Luz D. Orozco, Leah A. Owen, Jeffrey Hofmann, Amy D. Stockwell, Jianhua Tao, Susan Haller, Vineeth T. Mukundan, Christine Clarke, Jessica Lund, Akshayalakshmi Sridhar, Oleg Mayba, Julie L. Barr, Rylee A. Zavala, Elijah C. Graves, Charles Zhang, Nadine Husami, Robert Finley, Elizabeth Au, John H. Lillvis, Michael H. Farkas, Akbar Shakoor, Richard Sherva, Ivana K. Kim, Joshua S. Kaminker, Michael J. Townsend, Lindsay A. Farrer, Brian L. Yaspan, Hsu-Hsin Chen & Margaret M. DeAngelis. (2023) A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration. Cell Genomics 3:6, pages 100302.
Crossref
Lyvia Zhang, Elon H. C. Van Dijk, Enrico Borrelli, Serena Fragiotta & Mark P. Breazzano. (2023) OCT and OCT Angiography Update: Clinical Application to Age-Related Macular Degeneration, Central Serous Chorioretinopathy, Macular Telangiectasia, and Diabetic Retinopathy. Diagnostics 13:2, pages 232.
Crossref
T.A. Vasilyeva, V.V. Kadyshev, A.V. Marakhonov, I.V. Kanivets, S.A. Korostelev, P.A. Koshkin, D.V. Pyankov, N.V. Petrova, S.I. Kutsev & R.A. Zinchenko. (2023) Molecular genetics in diagnosis of Coats disease: combination of oligogenic variants associated with different forms of hereditary retinal dystrophy. Vestnik oftal'mologii 139:1, pages 69.
Crossref
Tadeusz J. Kaczynski, Elizabeth D. Au & Michael H. Farkas. (2022) Exploring the lncRNA localization landscape within the retinal pigment epithelium under normal and stress conditions. BMC Genomics 23:1.
Crossref
Alexander Martinez, Joseph J. Pizzimenti, Drake W. Lem & Pinakin Gunvant Davey. 2022. Recent Advances and New Perspectives in Managing Macular Degeneration. Recent Advances and New Perspectives in Managing Macular Degeneration.
Guoda Zazeckyte, Greta Gedvilaite, Alvita Vilkeviciute, Loresa Kriauciuniene, Vilma Jurate Balciuniene, Ruta Mockute & Rasa Liutkeviciene. (2022) Associations of Tumor Necrosis Factor-Alpha Gene Polymorphisms (TNF)-α TNF-863A/C (rs1800630), TNF-308A/G (rs1800629), TNF-238A/G (rs361525), and TNF-Alpha Serum Concentration with Age-Related Macular Degeneration. Life 12:7, pages 928.
Crossref
David J. Wilson, José-Alain Sahel, Alfred Brini & Daniel M. Albert. 2022. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 6315 6379 .
Rylee A. Zavala, Patrice M. Hicks, John Lillvis, Charles Zhang, Michael H. Farkas, Leah A. Owen & Margaret M. DeAngelis. 2022. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 3509 3563 .
Arunbalaji Pugazhendhi, Margaret Hubbell, Pooja Jairam & Balamurali Ambati. (2021) Neovascular Macular Degeneration: A Review of Etiology, Risk Factors, and Recent Advances in Research and Therapy. International Journal of Molecular Sciences 22:3, pages 1170.
Crossref
Rylee A. Zavala, Patrice M. Hicks, John Lillvis, Charles Zhang, Michael H. Farkas, Leah A. Owen & Margaret M. DeAngelis. 2020. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 1 55 .
Zhuoting Zhu, Huan Liao, Sen Liu, Jian Zhang, Yifan Chen & Wei Wang. (2020) Cross-sectional study of the association between age-related macular degeneration and arthritis in the National Health and Nutrition Examination Survey 2005–2008. BMJ Open 10:12, pages e035805.
Crossref
Patrice M. Hicks, Benjamin Haaland, Michael Feehan, Alan S. Crandall, Jeff H. Pettey, Elizabeth Nuttall, William Self, Mary Elizabeth Hartnett, Paul Bernstein, Albert Vitale, Akbar Shakoor, Julia P. Shulman, Sandra F. Sieminski, Ivana Kim, Leah A. Owen, Maureen A. Murtaugh, Albert Noyes & Margaret M. DeAngelis. (2020) Systemic Disease and Ocular Comorbidity Analysis of Geographically Isolated Federally Recognized American Indian Tribes of the Intermountain West. Journal of Clinical Medicine 9:11, pages 3590.
Crossref
Tanu Parmar, Joseph T Ortega & Beata Jastrzebska. (2020) Retinoid analogs and polyphenols as potential therapeutics for age-related macular degeneration. Experimental Biology and Medicine 245:17, pages 1615-1625.
Crossref
Junyu Zhang & Yu Zhou. (2020) Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration. Journal of Ophthalmology 2020, pages 1-10.
Crossref
David J. Wilson, José-Alain Sahel, Alfred Brini & Daniel M. Albert. 2020. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 1 66 .
Laura Hellinen, Kazuki Sato, Mika Reinisalo, Heidi Kidron, Kirsi Rilla, Masanori Tachikawa, Yasuo Uchida, Tetsuya Terasaki & Arto Urtti. (2019) Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters. Investigative Opthalmology & Visual Science 60:15, pages 5022.
Crossref
Su Zhao, Lu Lu, Qing Liu, Jun Chen, Qi Yuan, Shunmei Qiu & Xian Wang. (2019) MiR‐505 promotes M2 polarization in choroidal neovascularization model mice by targeting transmembrane protein 229B. Scandinavian Journal of Immunology 90:6.
Crossref
Pallavi Gupta & Khushwant S. Yadav. (2019) Applications of microneedles in delivering drugs for various ocular diseases. Life Sciences 237, pages 116907.
Crossref
Rasa Liutkeviciene, Alvita Vilkeviciute, Greta Gedvilaite, Kriste Kaikaryte & Loresa Kriauciuniene. (2019) Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration . Disease Markers 2019, pages 1-11.
Crossref
Na-Kyung Ryoo, Seong Joon Ahn, Kyu Hyung Park, Jeeyun Ahn, Jiyeong Seo, Ji Won Han, Ki Woong Kim & Se Joon Woo. (2018) Thickness of retina and choroid in the elderly population and its association with Complement Factor H polymorphism: KLoSHA Eye study. PLOS ONE 13:12, pages e0209276.
Crossref
Xincheng Yao, Taeyoon Son, Tae-Hoon Kim & Yiming Lu. (2018) Functional optical coherence tomography of retinal photoreceptors. Experimental Biology and Medicine 243:17-18, pages 1256-1264.
Crossref
Maureen G. Maguire. (2018) Understanding Variation in Response to Anti–Vascular Endothelial Growth Factor Therapy for Neovascular Age-Related Macular Degeneration. JAMA Ophthalmology 136:8, pages 884.
Crossref
Tao-Ran Li, Yan-Jie Jia, Chao Ma, Wen-Ying Qiu, Qun Wang, Xiao-Qiu Shao & Rui-Juan Lv. (2018) The role of the microRNA-146a/complement factor H/interleukin-1β-mediated inflammatory loop circuit in the perpetuate inflammation of chronic temporal lobe epilepsy. Disease Models & Mechanisms 11:3.
Crossref
Cassandra Kosmidou, Nikolaos E. Efstathiou, Mien V. Hoang, Shoji Notomi, Eleni K. Konstantinou, Masayuki Hirano, Kosuke Takahashi, Daniel E. Maidana, Pavlina Tsoka, Lucy Young, Evangelos S. Gragoudas, Timothy W. Olsen, Yuki Morizane, Joan W. Miller & Demetrios G. Vavvas. (2018) Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. Scientific Reports 8:1.
Crossref
桥生 刘. (2018) Advance in Risk Factors and Prevention of Dry Age-Related Macular Degeneration. Hans Journal of Ophthalmology 07:01, pages 21-27.
Crossref
Janmeet S. Saini, Barbara Corneo, Justine D. Miller, Thomas R. Kiehl, Qingjie Wang, Nathan C. Boles, Timothy A. Blenkinsop, Jeffrey H. Stern & Sally Temple. (2017) Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration. Cell Stem Cell 20:5, pages 635-647.e7.
Crossref
Fang He, Bei Liu, Qiang Meng, Yang Sun, Weiwen Wang & Chao Wang. (2016) Modulation of miR-146a /complement factor H-mediated inflammatory responses in a rat model of temporal lobe epilepsy . Bioscience Reports 36:6.
Crossref
Jessica N Cooke Bailey & Jonathan L Haines. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences 1 7 .
Svetlana V. Kyosseva. (2016) Targeting MAPK Signaling in Age-Related Macular Degeneration. Ophthalmology and Eye Diseases 8, pages OED.S32200.
Crossref
Stefano Lazzeri, Paola Orlandi, Paolo Piaggi, Maria Sole Sartini, Giamberto Casini, Gianluca Guidi, Michele Figus, Anna Fioravanti, Teresa Di Desidero, Guido Ripandelli, Mariacristina Parravano, Monica Varano, Marco Nardi & Guido Bocci. (2016) IL-8 and VEGFR-2 polymorphisms modulate long-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration . Pharmacogenomics 17:1, pages 35-9.
Crossref
Ursula Schmidt-Erfurth & Sebastian M. Waldstein. (2016) A paradigm shift in imaging biomarkers in neovascular age-related macular degeneration. Progress in Retinal and Eye Research 50, pages 1-24.
Crossref
Lisa V. Stottlemyer & Alan Polnariev. 2016. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions 503 512 .
Richard D. Semba, Maggie Lam, Kai Sun, Pingbo Zhang, Debra A. Schaumberg, Luigi Ferrucci, Peipei Ping & Jennifer E. Van Eyk. (2015) Priorities and trends in the study of proteins in eye research, 1924–2014. PROTEOMICS – Clinical Applications 9:11-12, pages 1105-1122.
Crossref
Se Joon Woo, Jeeyun Ahn, Margaux A. Morrison, So Yeon Ahn, Jaebong Lee, Ki Woong Kim, Margaret M. DeAngelis & Kyu Hyung Park. (2015) Analysis of Genetic and Environmental Risk Factors and Their Interactions in Korean Patients with Age-Related Macular Degeneration. PLOS ONE 10:7, pages e0132771.
Crossref
Chee Wai Wong, Jiemin Liao, Gemmy C. Cheung, Chiea Chuen Khor, Eranga N. Vithana, Jie Jin Wang, Paul Mitchell, Tin Aung, Tien Y. Wong & Ching-Yu Cheng. (2015) Lens Status Influences the Association between CFH Polymorphisms and Age-Related Macular Degeneration: Findings from Two Population-Based Studies in Singapore. PLOS ONE 10:3, pages e0119570.
Crossref
Vaidehi S. Dedania, Seanna Grob, Kang Zhang & Sophie J. Bakri. (2015) PHARMACOGENOMICS OF RESPONSE TO ANTI-VEGF THERAPY IN EXUDATIVE AGE-RELATED MACULAR DEGENERATION. Retina 35:3, pages 381-391.
Crossref
Katie L. PenningtonMargaret M. Deangelis. (2016) Epigenetic Mechanisms of the Aging Human Retina. Journal of Experimental Neuroscience 9s2, pages JEN.S25513.
Crossref
N.B. Haider, N.M. Cruz, M. Allocca & J. Yuan. 2014. Pathobiology of Human Disease. Pathobiology of Human Disease 2084 2114 .
Maureen G. Maguire, Ebenezer Daniel, Ankoor R. Shah, Juan E. Grunwald, Stephanie A. Hagstrom, Robert L. Avery, Jiayan Huang, Revell W. Martin, Daniel B. Roth, Alessandro A. Castellarin, Sophie J. Bakri, Stuart L. Fine & Daniel F. Martin. (2013) Incidence of Choroidal Neovascularization in the Fellow Eye in the Comparison of Age-related Macular Degeneration Treatments Trials. Ophthalmology 120:10, pages 2035-2041.
Crossref
Jadwiga Oczos, Christian Grimm, Daniel Barthelmes, Florian Sutter, Moreno Menghini, Barbara Kloeckener-Gruissem & Wolfgang Berger. (2012) Regulatory regions of the paraoxonase 1 (PON1) gene are associated with neovascular age-related macular degeneration (AMD). AGE 35:5, pages 1651-1662.
Crossref
Richard D. Semba, Jan J. Enghild, Vidya Venkatraman, Thomas F. Dyrlund & Jennifer E. Eyk. (2013) The Human Eye Proteome Project: Perspectives on an emerging proteome. PROTEOMICS 13:16, pages 2500-2511.
Crossref
Mei Chen, Jose R. Hombrebueno, Chang Luo, Rosana Penalva, Jiawu Zhao, Liza Colhoun, Sudha Pirya Soundara Pandi, John V. Forrester & Heping Xu. (2013) Age- and Light-Dependent Development of Localised Retinal Atrophy in CCL2−/−CX3CR1GFP/GFP Mice. PLoS ONE 8:4, pages e61381.
Crossref
Stefano Lazzeri, Michele Figus, Paola Orlandi, Anna Fioravanti, Teresa Di Desidero, Elisa Agosta, Maria Sole Sartini, Chiara Posarelli, Marco Nardi, Romano Danesi & Guido Bocci. (2013) VEGF-A polymorphisms predict short-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration . Pharmacogenomics 14:6, pages 623-630.
Crossref
Stephanie A. Hagstrom, Gui-shuang Ying, Gayle J.T. Pauer, Gwen M. Sturgill-Short, Jiayan Huang, David G. Callanan, Ivana K. Kim, Michael L. Klein, Maureen G. Maguire & Daniel F. Martin. (2013) Pharmacogenetics for Genes Associated with Age-related Macular Degeneration in the Comparison of AMD Treatments Trials (CATT). Ophthalmology 120:3, pages 593-599.
Crossref
Rosemary E McDowell, J Graham McGeown, Alan W Stitt & Tim M Curtis. (2013) Therapeutic potential of targeting lipid aldehydes and lipoxidation end-products in the treatment of ocular disease. Future Medicinal Chemistry 5:2, pages 189-211.
Crossref
David Xu & Peter K Kaiser. (2013) Intravitreal aflibercept for neovascular age-related macular degeneration. Immunotherapy 5:2, pages 121-130.
Crossref
Brad P. Barnett & James T. Handa. (2013) Retinal Microenvironment Imbalance in Dry Age-Related Macular Degeneration: A Mini-Review. Gerontology 59:4, pages 297-306.
Crossref
Joan W. Miller. (2013) Age-Related Macular Degeneration Revisited – Piecing the Puzzle: The LXIX Edward Jackson Memorial Lecture. American Journal of Ophthalmology 155:1, pages 1-35.e13.
Crossref
Melissa M Liu, Chi-Chao Chan & Jingsheng Tuo. (2012) Genetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial genetics. Human Genomics 6:1.
Crossref
Rinki Ratna Priya, Emily Y. Chew & Anand Swaroop. (2012) Genetic Studies of Age-related Macular Degeneration. Ophthalmology 119:12, pages 2526-2536.
Crossref
Valentina Cipriani, Hin-Tak Leung, Vincent Plagnol, Catey Bunce, Jane C. Khan, Humma Shahid, Anthony T. Moore, Simon P. Harding, Paul N. Bishop, Caroline Hayward, Susan Campbell, Ana Maria Armbrecht, Baljean Dhillon, Ian J. Deary, Harry Campbell, Malcolm Dunlop, Anna F. Dominiczak, Samantha S. Mann, Sharon A. Jenkins, Andrew R. Webster, Alan C. Bird, Mark Lathrop, Diana Zelenika, Eric H. Souied, José-Alain Sahel, Thierry Léveillard, Angela J. Cree, Jane Gibson, Sarah Ennis, Andrew J. Lotery, Alan F. Wright, David G. Clayton & John R.W. Yates. (2012) Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB–FKBPL–NOTCH4 region of chromosome 6p21.3. Human Molecular Genetics 21:18, pages 4138-4150.
Crossref
Sheila West. (2012) Saving Eyes, Millions at a Time. Ophthalmology 119:9, pages 1723-1724.
Crossref
Nikolaus Dragostinoff, René Marcel Werkmeister, Semira Kaya, Günther Weigert, Berthold Pemp, Stefan Sacu, Gerhard Garhöfer, Ursula Schmidt-Erfurth & Leopold Schmetterer. (2012) Short- and mid-term repeatability of macular pigment optical density measurements using spectral fundus reflectance. Graefe's Archive for Clinical and Experimental Ophthalmology 250:9, pages 1261-1266.
Crossref
Semira Kaya, Günther Weigert, Berthold Pemp, Stefan Sacu, René Marcel Werkmeister, Nikolaus Dragostinoff, Gerhard Garhöfer, Ursula Schmidt‐Erfurth & Leopold Schmetterer. (2012) Comparison of macular pigment in patients with age‐related macular degeneration and healthy control subjects – a study using spectral fundus reflectance. Acta Ophthalmologica 90:5.
Crossref
Michael B. Gorin. (2012) Genetic insights into age-related macular degeneration: Controversies addressing risk, causality, and therapeutics. Molecular Aspects of Medicine 33:4, pages 467-486.
Crossref
Walter J. Lukiw & Peter N. Alexandrov. (2012) Regulation of Complement Factor H (CFH) by Multiple miRNAs in Alzheimer’s Disease (AD) Brain. Molecular Neurobiology 46:1, pages 11-19.
Crossref
Shiri Zayit‐Soudry & Jacque L Duncan. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.