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International Reviews of Immunology Volume 19, 2000 - Issue 4-5
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Original Article

Lessons from BXSB and Related Mouse Models

Shozo Izui Department of Pathology, Centre Medical Universitaire, University of Geneva, 7277, Geneva, 4, Switzerland
,
Nabila Ibnou-Zekri Department of Pathology, Centre Medical Universitaire, University of Geneva, 7277, Geneva, 4, Switzerland
,
Liliane Fossati-jimack Department of Pathology, Centre Medical Universitaire, University of Geneva, 7277, Geneva, 4, Switzerland
&
Masahiro Iwamoto Department of Pathology, Centre Medical Universitaire, University of Geneva, 7277, Geneva, 4, Switzerland
Pages 447-472 | Published online: 10 Jul 2009

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Vincenzo Dinallo, Davide Di Fusco, Roberta Izzo & Giovanni Monteleone. (2016) Therapy implications for the role of IL-21 in lupus. Expert Review of Clinical Immunology 12:5, pages 487-488.
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Davide Di Fusco, Roberta Izzo, Michele M Figliuzzi, Francesco Pallone & Giovanni Monteleone. (2014) IL-21 as a therapeutic target in inflammatory disorders. Expert Opinion on Therapeutic Targets 18:11, pages 1329-1338.
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Yang Pan, Tingting Jia, Yuan Zhang, Kuo Zhang, Rui Zhang, Jinming Li & Lunan Wang. (2012) MS2 VLP-based delivery of microRNA-146a inhibits autoantibody production in lupus-prone mice. International Journal of Nanomedicine 7, pages 5957-5967.
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Massimiliano Sarra, Eleonora Franzè, Francesco Pallone & Giovanni Monteleone. (2011) Targeting interleukin-21 in inflammatory diseases. Expert Opinion on Therapeutic Targets 15:6, pages 695-702.
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Yasuharu Abe, Mareki Ohtsuji, Naomi Ohtsuji, Qingshun Lin, Hiromichi Tsurui, Susumu Nakae, Toshikazu Shirai, Katsuko Sudo & Sachiko Hirose. (2009) Ankylosing enthesitis associated with up-regulated IFN-γ and IL-17 production in (BXSB × NZB) F1 male mice: a new mouse model. Modern Rheumatology 19:3, pages 316-322.
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Abdullah M. Shbeer & Ibrahim Ahmed Robadi. (2024) The role of Interleukin-21 in autoimmune Diseases: Mechanisms, therapeutic Implications, and future directions. Cytokine 173, pages 156437.
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Ben JE Raveney, Yosif El‐Darawish, Wakiro Sato, Yoshiyuki Arinuma, Kunihiro Yamaoka, Shohei Hori, Takashi Yamamura & Shinji Oki. (2022) Neuropilin‐1 ( NRP1 ) expression distinguishes self‐reactive helper T cells in systemic autoimmune disease . EMBO Molecular Medicine 14:10.
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Sachiko Hirose, Qingshun Lin, Mareki Ohtsuji, Hiroyuki Nishimura & J Sjef Verbeek. (2019) Monocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis. International Immunology 31:11, pages 687-696.
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Christoph Jandl & Cecile King. (2016) Cytokines in the Germinal Center Niche. Antibodies 5:1, pages 5.
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Tohid Gharibi, Jafar Majidi, Tohid Kazemi, Rashedeh Dehghanzadeh, Morteza Motallebnezhad & Zohreh Babaloo. (2016) Biological effects of IL-21 on different immune cells and its role in autoimmune diseases. Immunobiology 221:2, pages 357-367.
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Marisa Klein-Gitelman & Jerome Charles Lane. 2016. Textbook of Pediatric Rheumatology. Textbook of Pediatric Rheumatology 285 317.e14 .
Caroline G. McPhee, Jason A. Bubier, Thomas J. Sproule, Giljun Park, Martin P. Steinbuck, William H. Schott, Gregory J. Christianson, Herbert C. MorseIIIIII & Derry C. Roopenian. (2013) IL-21 Is a Double-Edged Sword in the Systemic Lupus Erythematosus–like Disease of BXSB. Yaa Mice . The Journal of Immunology 191:9, pages 4581-4588.
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Yi Ting Koh, John C. Scatizzi, Jennifer D. Gahan, Brian R. Lawson, Roberto Baccala, K. Michael Pollard, Bruce A. Beutler, Argyrios N. Theofilopoulos & Dwight H. Kono. (2013) Role of Nucleic Acid–Sensing TLRs in Diverse Autoantibody Specificities and Anti-Nuclear Antibody–Producing B Cells. The Journal of Immunology 190:10, pages 4982-4990.
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Elisabetta Botti, Andreea N. Boca, Giulia Spallone, Giovanni Monteleone & Antonio Costanzo. (2012) The Role of IL-21 in Chronic Inflammatory Skin Diseases. Current Dermatology Reports 2:1, pages 11-17.
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Liang-Guo Xu, Lei Jin, Bi-Cheng Zhang, Linda J. Akerlund, Hong-Bing Shu & John C. Cambier. (2012) VISA Is Required for B Cell Expression of TLR7. The Journal of Immunology 188:1, pages 248-258.
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Nikola S. Kerekov, Nikolina M. Mihaylova, Ivan Grozdev, Todor A. Todorov, Milena Nikolova, Marta Baleva, Maria Nikolova, Jozsef Prechl, Anna Erdei & Andrey I. Tchorbanov. (2011) Elimination of autoreactive B cells in humanized SCID mouse model of SLE. European Journal of Immunology 41:11, pages 3301-3311.
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Matthew M. Seavey, Lily D. Lu & Kristine L. Stump. (2011) Animal Models of Systemic Lupus Erythematosus (SLE) and Ex Vivo Assay Design for Drug Discovery. Current Protocols in Pharmacology 53:1.
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Earl Silverman & Allison Eddy. 2011. Textbook of Pediatric Rheumatology. Textbook of Pediatric Rheumatology 315 343 .
Antonio Costanzo, Maria Sole Chimenti, Elisabetta Botti, Roberta Caruso, Massimiliano Sarra & Giovanni Monteleone. (2010) IL-21 in the pathogenesis and treatment of skin diseases. Journal of Dermatological Science 60:2, pages 61-66.
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Hanlu Ding, Li Wang, Xiongfei Wu, Jun Yan, Yani He, Bing Ni, Wenda Gao & Xuemei Zhong. (2009) Blockade of B-cell-activating factor suppresses lupus-like syndrome in autoimmune BXSB mice. Journal of Cellular and Molecular Medicine 14:6b, pages 1717-1725.
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Virginia PascualDamien ChaussabelJacques Banchereau. (2010) A Genomic Approach to Human Autoimmune Diseases. Annual Review of Immunology 28:1, pages 535-571.
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M. Stojakovic, Z. Tatari-Calderone, C. Maric, A. Hoang & S. Vukmanovic. (2009) Paradoxical arrest in lupus activity in BXSB mice with highly autoreactive T cells. Lupus 19:2, pages 182-191.
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Massimiliano Sarra & Giovanni Monteleone. (2010) Interleukin-21: A New Mediator of Inflammation in Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology 2010, pages 1-6.
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Kristian Hannestad & Helge Scott. (2009) The MHC Haplotype H2b Converts Two Pure Nonlupus Mouse Strains to Producers of Antinuclear Antibodies. The Journal of Immunology 183:5, pages 3542-3550.
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OY Jones, A Lacson, X Zeng, JM Jones, K Katti, RA Cahill & AA Ahmed. (2009) Long-term follow-up after non-myeloablative transplant of bone and marrow in BXSB mice. Lupus 18:9, pages 813-821.
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H. Bo, X.-Q. Wei, H. Dong, Y. Zhang, P. Lv, W. Liu, A. Koutoulaki & X.-M. Gao. (2009) Elevated Expression of Transmembrane IL-15 in Immune Cells Correlates with the Development of Murine Lupus: a Potential Target for Immunotherapy Against SLE. Scandinavian Journal of Immunology 69:2, pages 119-129.
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Joanna Rankin, Joseph J. Boyle, S. Jane Rose, Luisa Gabriel, Margarita Lewis, Vasuky Thiruudaian, Nicola J. Rogers, Shozo Izui & Bernard J. Morley. (2007) The Bxs6 Locus of BXSB Mice Is Sufficient for High-Level Expression of gp70 and the Production of gp70 Immune Complexes . The Journal of Immunology 178:7, pages 4395-4401.
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Lucie Baudino, Samareh Azeredo da Silveira, Munehiro Nakata & Shozo Izui. (2006) Molecular and cellular basis for pathogenicity of autoantibodies: lessons from murine monoclonal autoantibodies. Springer Seminars in Immunopathology 28:2, pages 175-184.
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Cory Teuscher, Rajkumar Noubade, Karen Spach, Benjamin McElvany, Janice Y. BunnParley D. Fillmore, James F. Zachary & Elizabeth P. Blankenhorn. (2006) Evidence that the Y chromosome influences autoimmune disease in male and female mice. Proceedings of the National Academy of Sciences 103:21, pages 8024-8029.
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Kui Liu & Chandra Mohan. (2006) What do mouse models teach us about human SLE?. Clinical Immunology 119:2, pages 123-130.
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Hanlu Ding, Xiongfei Wu, Jun Wu, Hideo Yagita, Yani He, Jianguo Zhang, Jiangwen Ren & Wenda Gao. (2006) Delivering PD-1 inhibitory signal concomitant with blocking ICOS co-stimulation suppresses lupus-like syndrome in autoimmune BXSB mice. Clinical Immunology 118:2-3, pages 258-267.
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Kirthi Raman Kumar, Jiankun Zhu, Madhavi Bhaskarabhatla, Mei Yan & Chandra Mohan. (2005) Enhanced expression of stem cell antigen-1 (Ly-6A/E) in lymphocytes from lupus prone mice correlates with disease severity. Journal of Autoimmunity 25:3, pages 215-222.
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M Abedi-Valugerdi, C Nilsson, A Zargari, F Gharibdoost, J W DePierre & M Hassan. (2005) Bacterial lipopolysaccharide both renders resistant mice susceptible to mercury-induced autoimmunity and exacerbates such autoimmunity in susceptible mice. Clinical and Experimental Immunology 141:2, pages 238-247.
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Robert J. Rigby & Timothy J. Vyse. (2004) Models of systemic lupus erythematosus. Drug Discovery Today: Disease Models 1:4, pages 445-449.
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. 2004. Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical Approach - Volume I: Principles and Methods of Immunotoxicology. Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical Approach - Volume I: Principles and Methods of Immunotoxicology 205 217 .
Marie-Laure Santiago-Raber, Catherine Laporte, Luc Reininger & Shozo Izui. (2004) Genetic basis of murine lupus. Autoimmunity Reviews 3:1, pages 33-39.
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Ram Raj Singh. (2003) IL-4 and many roads to lupuslike autoimmunity. Clinical Immunology 108:2, pages 73-79.
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John Sam Babu, Tiedan Sun, Luting Xu & Syamal K. Datta. (2002) B Cell Stimulatory Effects of α-Enolase That Is Differentially Expressed in NZB Mouse B Cells. Clinical Immunology 104:3, pages 293-304.
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Shu-Hong Han, Bo Li, Yun-Tao Chen & Xiao-Ming Gao. (2002) Isolation and Functional Analysis of Autoreactive T cells from BXSB Mice with Murine Lupus. Journal of Autoimmunity 19:1-2, pages 45-54.
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Brian R. Lawson, Dwight H. Kono & Argyrios N. Theofilopoulos. (2002) Deletion of p21 (WAF-1/Cip1) Does Not Induce Systemic Autoimmunity in Female BXSB Mice. The Journal of Immunology 168:11, pages 5928-5932.
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Toshikazu Shirai, Hiroyuki Nishimura, Yi Jiang & Sachiko Hirose. (2002) Genome Screening for Susceptibility Loci in Systemic Lupus Erythematosus. American Journal of PharmacoGenomics 2:1, pages 1-12.
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Hidehiro Kishimoto & Jonathan Sprent. (2001) A defect in central tolerance in NOD mice. Nature Immunology 2:11, pages 1025-1031.
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B H Hahn. (2016) Lessons in lupus: the mighty mouse. Lupus 10:9, pages 589-593.
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