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Immunity in the Gut

Oral Vaccine Delivery by Recombinant Spore Probiotics

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Pages 487-505 | Published online: 02 Dec 2009

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Sergio Rosales-Mendoza & Carlos Angulo. (2015) Bacillus subtilis comes of age as a vaccine production host and delivery vehicle. Expert Review of Vaccines 14:8, pages 1135-1148.
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Articles from other publishers (53)

Muhammed Salah Uddin, Jose Ortiz Guluarte, D. Wade Abbott, G. Douglas Inglis, Le Luo Guan & Trevor W. Alexander. (2023) Development of a spore-based mucosal vaccine against the bovine respiratory pathogen Mannheimia haemolytica. Scientific Reports 13:1.
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Anella Saggese, Loredana Baccigalupi, Giuliana Donadio, Ezio Ricca & Rachele Isticato. (2023) The Bacterial Spore as a Mucosal Vaccine Delivery System. International Journal of Molecular Sciences 24:13, pages 10880.
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Chatsirin Nakharuthai, Surintorn Boonanuntanasarn, Jirawadee Kaewda & Pimpisut Manassila. (2023) Isolation of Potential Probiotic Bacillus spp. from the Intestine of Nile Tilapia to Construct Recombinant Probiotic Expressing CC Chemokine and Its Effectiveness on Innate Immune Responses in Nile Tilapia. Animals 13:6, pages 986.
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Gabriela Gonçalves, Rafaela A. Santos, Filipe Coutinho, Neide Pedrosa, Maria Curado, Marina Machado, Benjamin Costas, Lourenço Bonneville, Mónica Serrano, António Paulo Carvalho, Patricia Díaz-Rosales, Aires Oliva-Teles, Ana Couto & Cláudia R. Serra. (2022) Oral vaccination of fish against vibriosis using spore-display technology. Frontiers in Immunology 13.
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Fei Peng, Yuqiang Xiang, Hui Wang, Yanjie Hu, Rui Zhou & Yonggang Hu. (2022) Biomimetic Assembly of Spore@ZIF‐8 Microspheres for Vaccination. Small 18:38, pages 2204011.
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Nienke Koopman, Lauren Remijas, Jurgen Seppen, Peter Setlow & Stanley Brul. (2022) Mechanisms and Applications of Bacterial Sporulation and Germination in the Intestine. International Journal of Molecular Sciences 23:6, pages 3405.
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Anella Saggese, Loredana Baccigalupi & Ezio Ricca. (2021) Spore Formers as Beneficial Microbes for Humans and Animals. Applied Microbiology 1:3, pages 498-509.
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Ezio Ricca, Loredana Baccigalupi & Rachele Isticato. (2021) Spore-adsorption: Mechanism and applications of a non-recombinant display system. Biotechnology Advances 47, pages 107693.
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Michal Bodík, Daniela Krajčíková, Jakub Hagara, Eva Majkova, Imrich Barák & Peter Šiffalovič. (2021) Diffraction pattern of Bacillus subtilis CotY spore coat protein 2D crystals. Colloids and Surfaces B: Biointerfaces 197, pages 111425.
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Ana Raquel Maia, Rodrigo Reyes-Ramírez, Marjorie Pizarro-Guajardo, Anella Saggese, Ezio Ricca, Loredana Baccigalupi & Daniel Paredes-Sabja. (2020) Nasal Immunization with the C-Terminal Domain of Bcla3 Induced Specific IgG Production and Attenuated Disease Symptoms in Mice Infected with Clostridioides difficile Spores. International Journal of Molecular Sciences 21:18, pages 6696.
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Lina M. González, Nikita Mukhitov & Christopher A. Voigt. (2019) Resilient living materials built by printing bacterial spores. Nature Chemical Biology 16:2, pages 126-133.
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Arianna Mazzoli, Giuliana Donadio, Mariamichela Lanzilli, Anella Saggese, Andrea Maria Guarino, Miriam Rivetti, Raffaella Crescenzo, Ezio Ricca, Ida Ferrandino, Susanna Iossa, Alessandra Pollice & Rachele Isticato. (2019) Bacillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Scientific Reports 9:1.
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Cláudia R. Serra, Eduarda M. Almeida, Inês Guerreiro, Rafaela Santos, Daniel L. Merrifield, Fernando Tavares, Aires Oliva-Teles & Paula Enes. (2019) Selection of carbohydrate-active probiotics from the gut of carnivorous fish fed plant-based diets. Scientific Reports 9:1.
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Yan Chen, Bidisha Barat, W. Keith Ray, Richard F. Helm, Stephen B. Melville & David L. Popham. (2019) Membrane Proteomes and Ion Transporters in Bacillus anthracis and Bacillus subtilis Dormant and Germinating Spores . Journal of Bacteriology 201:6.
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Sudeep Kumar. 2019. Pharmaceuticals from Microbes. Pharmaceuticals from Microbes 39 73 .
Mariamichela Lanzilli, Giuliana Donadio, Francesca Anna Fusco, Carmen Sarcinelli, Danila Limauro, Ezio Ricca & Rachele Isticato. (2018) Display of the peroxiredoxin Bcp1 of Sulfolobus solfataricus on probiotic spores of Bacillus megaterium. New Biotechnology 46, pages 38-44.
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Ganna Petruk, Giuliana Donadio, Mariamichela Lanzilli, Rachele Isticato & Daria Maria Monti. (2018) Alternative use of Bacillus subtilis spores: protection against environmental oxidative stress in human normal keratinocytes. Scientific Reports 8:1.
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Rosanna Mattossovich, Roberta Iacono, Giuseppina Cangiano, Beatrice Cobucci-Ponzano, Rachele Isticato, Marco Moracci & Ezio Ricca. (2017) Conversion of xylan by recyclable spores of Bacillus subtilis displaying thermophilic enzymes. Microbial Cell Factories 16:1.
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Hui Dong, Yanmei Huang, Shuwen Yao, Bingshao Liang, Yan Long, Yongqiang Xie, Jialiang Mai, Sitang Gong & Zhenwen Zhou. (2017) The recombinant fusion protein of cholera toxin B and neutrophil-activating protein expressed on Bacillus subtilis spore surface suppresses allergic inflammation in mice. Applied Microbiology and Biotechnology 101:14, pages 5819-5829.
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Long Chen, Ashok Mulchandani & Xin Ge. (2017) Spore‐displayed enzyme cascade with tunable stoichiometry. Biotechnology Progress 33:2, pages 383-389.
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He Wang, Yunxiang Wang & Ruijin Yang. (2017) Recent progress in Bacillus subtilis spore-surface display: concept, progress, and future. Applied Microbiology and Biotechnology 101:3, pages 933-949.
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W.G.J. Degen & V.E.J.C. Schijns. 2017. Immunopotentiators in Modern Vaccines. Immunopotentiators in Modern Vaccines 65 84 .
Giuliana Donadio, Mariamichela Lanzilli, Teja Sirec, Ezio Ricca & Rachele Isticato. (2016) Localization of a red fluorescence protein adsorbed on wild type and mutant spores of Bacillus subtilis. Microbial Cell Factories 15:1.
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Cédric M. Vogt, Elisabeth M. Schraner, Claudio Aguilar & Catherine Eichwald. (2016) Heterologous expression of antigenic peptides in Bacillus subtilis biofilms. Microbial Cell Factories 15:1.
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B. Di LucciaE. D’ApuzzoF. VarrialeL. BaccigalupiE. RiccaA. Pollice. (2016) Bacillus megaterium SF185 induces stress pathways and affects the cell cycle distribution of human intestinal epithelial cells . Beneficial Microbes 7:4, pages 609-620.
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Rachele Isticato & Ezio Ricca. 2016. The Bacterial Spore. The Bacterial Spore 349 366 .
Samira Ghaedmohammadi, Garshasb Rigi, Reza Zadmard, Ezio Ricca & Gholamreza Ahmadian. (2015) Immobilization of Bioactive Protein A from Staphylococcus aureus (SpA) on the Surface of Bacillus subtilis Spores. Molecular Biotechnology 57:8, pages 756-766.
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Anne Richter, Wooil Kim, June-Hyung Kim & Wolfgang Schumann. (2015) Disulfide Bonds of Proteins Displayed on Spores of Bacillus subtilis Can Occur Spontaneously. Current Microbiology 71:1, pages 156-161.
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Roberta Bonavita, Rachele Isticato, Francesco Maurano, Ezio Ricca & Mauro Rossi. (2015) Mucosal immunity induced by gliadin-presenting spores of Bacillus subtilis in HLA-DQ8-transgenic mice. Immunology Letters 165:2, pages 84-89.
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S.K. Falahati-Pour, A.S. Lotfi, G. Ahmadian & A. Baghizadeh. (2015) Covalent immobilization of recombinant organophosphorus hydrolase on spores of Bacillus subtilis . Journal of Applied Microbiology 118:4, pages 976-988.
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Giuseppe Pesce, Giulia Rusciano, Gianluigi Zito, Antonio Sasso, Rachele Isticato, Teja Sirec & Ezio Ricca. (2015) Characterization of surface properties of bacterial spores using Optical Tweezers. Characterization of surface properties of bacterial spores using Optical Tweezers.
Ezio Ricca, Loredana Baccigalupi, Giuseppina Cangiano, Maurilio De Felice & Rachele Isticato. (2014) Mucosal vaccine delivery by non-recombinant spores of Bacillus subtilis. Microbial Cell Factories 13:1.
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Giuseppina Cangiano, Teja Sirec, Cristina Panarella, Rachele Isticato, Loredana Baccigalupi, Maurilio De Felice & Ezio Ricca. (2014) The sps Gene Products Affect the Germination, Hydrophobicity, and Protein Adsorption of Bacillus subtilis Spores . Applied and Environmental Microbiology 80:23, pages 7293-7302.
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Tao Jiang, Bijay Singh, Sushila Maharjan, Hui-Shan Li, Sang-Kee Kang, Jin-Duck Bok, Chong-Su Cho & Yun-Jaie Choi. (2014) Oral delivery of probiotic expressing M cell homing peptide conjugated BmpB vaccine encapsulated into alginate/chitosan/alginate microcapsules. European Journal of Pharmaceutics and Biopharmaceutics 88:3, pages 768-777.
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Rachele Isticato & Ezio Ricca. (2014) Spore Surface Display. Microbiology Spectrum 2:5.
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Wishwas Abhyankar, Leo J. de Koning, Stanley Brul & Chris G. de Koster. (2014) Spore proteomics: the past, present and the future. FEMS Microbiology Letters 358:2, pages 137-144.
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Teja Sirec, Giuseppina Cangiano, Loredana Baccigalupi, Ezio Ricca & Rachele Isticato. (2014) The spore surface of intestinal isolates of Bacillus subtilis . FEMS Microbiology Letters 358:2, pages 194-201.
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Praveen K. Singh & Wilfried J.J. Meijer. (2014) Diverse regulatory circuits for transfer of conjugative elements. FEMS Microbiology Letters 358:2, pages 119-128.
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Krzysztof Hinc, Małgorzata Stasiłojć, Iwona Piątek, Grażyna Peszyńska-Sularz, Rachele Isticato, Ezio Ricca, Michał Obuchowski & Adam Iwanicki. (2014) Mucosal Adjuvant Activity of IL-2 Presenting Spores of Bacillus subtilis in a Murine Model of Helicobacter pylori Vaccination. PLoS ONE 9:4, pages e95187.
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Giuseppe Pesce, Giulia Rusciano, Antonio Sasso, Rachele Isticato, Teja Sirec & Ezio Ricca. (2014) Surface charge and hydrodynamic coefficient measurements of Bacillus subtilis spore by optical tweezers. Colloids and Surfaces B: Biointerfaces 116, pages 568-575.
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Xingliang Pan, Xiuzhen Chen, Xiaoyun Su, Yuan Feng, Yong Tao & Zhiyang Dong. (2014) Involvement of SpoVG in hemolysis caused by Bacillus subtilis. Biochemical and Biophysical Research Communications 443:3, pages 899-904.
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Samir Gautam & David A. Spiegel. 2014. Micro- and Nanoengineering of the Cell Surface. Micro- and Nanoengineering of the Cell Surface 63 97 .
Rachele Isticato, Teja Sirec, Lucia Treppiccione, Francesco Maurano, Maurilio De Felice, Mauro Rossi & Ezio Ricca. (2013) Non-recombinant display of the B subunit of the heat labile toxin of Escherichia coli on wild type and mutant spores of Bacillus subtilis. Microbial Cell Factories 12:1.
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Krzysztof Hinc, Adam Iwanicki & Michał Obuchowski. (2013) New stable anchor protein and peptide linker suitable for successful spore surface display in B. subtilis. Microbial Cell Factories 12:1.
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Yin-Guang Cao, Zhi-Hui Li, Ying-Ying Yue, Nan-Nan Song, Li Peng, Le-Xin Wang & Xinxin Lu. (2013) Construction and evaluation of a novel Bacillus subtilis spores-based enterovirus 71 vaccine. Journal of Applied Biomedicine 11:2, pages 105-113.
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Ana B. Abecasis, Mónica Serrano, Renato Alves, Leonor Quintais, José B. Pereira-Leal & Adriano O. Henriques. (2013) A Genomic Signature and the Identification of New Sporulation Genes. Journal of Bacteriology 195:9, pages 2101-2115.
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Nicola Manzo, Blanda Di Luccia, Rachele Isticato, Enrica D’Apuzzo, Maurilio De Felice & Ezio Ricca. (2013) Pigmentation and Sporulation Are Alternative Cell Fates in Bacillus pumilus SF214. PLoS ONE 8:4, pages e62093.
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Peter T. McKenney, Adam Driks & Patrick Eichenberger. (2012) The Bacillus subtilis endospore: assembly and functions of the multilayered coat. Nature Reviews Microbiology 11:1, pages 33-44.
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Teja Sirec, Andrea Strazzulli, Rachele Isticato, Maurilio De Felice, Marco Moracci & Ezio Ricca. (2012) Adsorption of β-galactosidase of Alicyclobacillus acidocaldarius on wild type and mutants spores of Bacillus subtilis. Microbial Cell Factories 11:1.
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Hellen Amuguni, Sangun Lee, Kathryn Kerstein, David Brown, Boris Belitsky, John Herrmann, Gerald Keusch, Abraham Sonenshein & Saul Tzipori. (2012) Sublingual immunization with an engineered Bacillus subtilis strain expressing tetanus toxin fragment C induces systemic and mucosal immune responses in piglets. Microbes and Infection 14:5, pages 447-456.
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Nicola Manzo, Enrica D'Apuzzo, Pedro M Coutinho, Simon M Cutting, Bernard Henrissat & Ezio Ricca. (2011) Carbohydrate-active enzymes from pigmented Bacilli: a genomic approach to assess carbohydrate utilization and degradation. BMC Microbiology 11:1.
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Guo Chen, Yang Dai, Jianxiang Chen, Xiaoting Wang, Bo Tang, Yinchang Zhu & Zichun Hua. (2011) Oral Delivery of the Sj23LHD-GST Antigen by Salmonella typhimurium Type III Secretion System Protects against Schistosoma japonicum Infection in Mice. PLoS Neglected Tropical Diseases 5:9, pages e1313.
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Krzysztof Hinc, Rachele Isticato, Marcin Dembek, Joanna Karczewska, Adam Iwanicki, Grażyna Peszyńska-Sularz, Maurilio De Felice, Michał Obuchowski & Ezio Ricca. (2010) Expression and display of UreA of Helicobacter acinonychis on the surface of Bacillus subtilis spores. Microbial Cell Factories 9:1.
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