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Research Article

Chimeric Antigen Receptors in Cancer Immuno-Gene Therapy: Current Status and Future Directions

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Pages 294-311 | Published online: 07 Nov 2011

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Luiza de Macedo Abdo, Luciana Rodrigues Carvalho Barros, Mariana Saldanha Viegas, Luisa Vieira Codeço Marques, Priscila de Sousa Ferreira, Leonardo Chicaybam & Martín Hernán Bonamino. (2020) Development of CAR-T cell therapy for B-ALL using a point-of-care approach. OncoImmunology 9:1.
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Mayna S. Gomide, Thais T. Sales, Luciana R. C. Barros, Cintia G. Limia, Marco A. de Oliveira, Lilian H. Florentino, Leila M. G. Barros, Maria L. Robledo, Gustavo P. C. José, Mariana S. M. Almeida, Rayane N. Lima, Stevens K. Rehen, Cristiano Lacorte, Eduardo O. Melo, André M. Murad, Martín H. Bonamino, Cintia M. Coelho & Elibio Rech. (2020) Genetic switches designed for eukaryotic cells and controlled by serine integrases. Communications Biology 3:1.
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Leonardo Chicaybam, Luiza Abdo, Mariana Viegas, Luisa Vieira Codeço Marques, Priscila de Sousa, Leonardo Ribeiro Batista-Silva, Viviane Alves-Monteiro, Simone Bonecker, Bárbara Monte-Mór & Martín Hernán Bonamino. (2020) Transposon-mediated generation of CAR-T cells shows efficient anti B-cell leukemia response after ex vivo expansion. Gene Therapy 27:1-2, pages 85-95.
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Guoping Ding, Tao Shen, Chen Yan, Mingjie Zhang, Zhengrong Wu & Liping Cao. (2019) IFN-γ down-regulates the PD-1 expression and assist nivolumab in PD-1-blockade effect on CD8+ T-lymphocytes in pancreatic cancer. BMC Cancer 19:1.
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Leonardo Chicaybam, Luiza Abdo, Mayra Carneiro, Bárbara Peixoto, Mariana Viegas, Priscila de Sousa, Márcia C. Fornazin, Maria C. Spago, Angelo Brunelli Albertoni Laranjeira, Pedro O. de Campos-Lima, Alexandre Nowill, Luciana Rodrigues Carvalho Barros & Martín H. Bonamino. (2019) CAR T Cells Generated Using Sleeping Beauty Transposon Vectors and Expanded with an EBV-Transformed Lymphoblastoid Cell Line Display Antitumor Activity In Vitro and In Vivo . Human Gene Therapy 30:4, pages 511-522.
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Luciana Barros, Marco Antonio Pretti, Leonardo Chicaybam, Luiza Abdo, Mariana Boroni & Martin Hernán Bonamino. (2018) Immunological-based approaches for cancer therapy. Clinics 73, pages e429s.
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Jinjing Xu, Qing Zhang, Kang Tian, Haiyu Wang, Hong Yin & Junnian Zheng. (2017) Current status and future prospects of the strategy of combining CAR‑T with PD‑1 blockade for antitumor therapy (Review). Molecular Medicine Reports.
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José Eduardo Vargas, Leonardo Chicaybam, Renato Tetelbom Stein, Amilcar Tanuri, Andrés Delgado-Cañedo & Martin H. Bonamino. (2016) Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives. Journal of Translational Medicine 14:1.
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Binh Thanh Vu, Dat Tan Le & Phuc Van Pham. (2016) Synergistic effect of chimeric antigen receptors and cytokineinduced killer cells: An innovative combination for cancer therapy. Biomedical Research and Therapy 3:6.
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Antonio PalumboJrJr, Nathalia de Oliveira Meireles Da Costa, Martin Hernan Bonamino, Luis Felipe Ribeiro Pinto & Luiz Eurico Nasciutti. (2015) Genetic instability in the tumor microenvironment: a new look at an old neighbor. Molecular Cancer 14:1.
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Liza B. John, Christel Devaud, Connie P.M. Duong, Carmen S. Yong, Paul A. Beavis, Nicole M. Haynes, Melvyn T. Chow, Mark J. Smyth, Michael H. Kershaw & Phillip K. Darcy. (2013) Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells. Clinical Cancer Research 19:20, pages 5636-5646.
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Leonardo Chicaybam, Andressa Laino Sodre, Bianca Azevedo Curzio & Martin Hernan Bonamino. (2013) An Efficient Low Cost Method for Gene Transfer to T Lymphocytes. PLoS ONE 8:3, pages e60298.
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