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International Reviews of Immunology Volume 16, 1998 - Issue 3-4
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Original Article

Interleukin-7 (IL-7) Knockout Mice. Implications for Lymphopoiesis and Organ-Specific Immunity

Markus J. Maeurer Department of Medical Microbiology, University of Mainz, Hochhaus Augustusplatz, Mainz, FRG, 55101, USACorrespondence[email protected]
&
Michaelt Lotze Departments of Surgery, Biochemistry and Molecular Genetics, University of Pittsburgh Medical School, Pittsburgh, PA, USA
Pages 309-322 | Received 20 Dec 1996, Published online: 10 Jul 2009

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Sumiko Watanabe. (1998) Signal transduction of the cytokine receptor. Korean Journal of Biological Sciences 2:2, pages 153-164.
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Kenta Teruya, Ayumi Oguma, Satoko Takahashi, Miki Watanabe-Matsui, Sachiyo Tsuji-Kawahara, Masaaki Miyazawa & Katsumi Doh-ura. (2022) Anti-prion activity of cellulose ether is impaired in mice lacking pre T-cell antigen receptor α, T-cell receptor δ, or lytic granule function. International Immunopharmacology 107, pages 108672.
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Kyungyoon J. Kwon, Andrew E. TimmonsSrona Sengupta, Francesco R. Simonetti, Hao ZhangRebecca Hoh, Steven G. Deeks, Janet D. Siliciano & Robert F. Siliciano. (2020) Different human resting memory CD4 + T cell subsets show similar low inducibility of latent HIV-1 proviruses . Science Translational Medicine 12:528.
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Jarrod A. Dudakov & Marcel R.M. van den Brink. 2019. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation 89 105 .
Jahahreeh Finley. (2017) Elimination of cancer stem cells and reactivation of latent HIV-1 via AMPK activation: Common mechanism of action linking inhibition of tumorigenesis and the potential eradication of HIV-1. Medical Hypotheses 104, pages 133-146.
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Alexandra J. Murray, Kyungyoon J. Kwon, Donna L. Farber & Robert F. Siliciano. (2016) The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence. The Journal of Immunology 197:2, pages 407-417.
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Mrinmoy Sanyal, Marie Morimoto, Alireza Baradaran-Heravi, Kunho Choi, Neeraja Kambham, Kent Jensen, Suparna Dutt, Kira Y. Dionis-Petersen, Lan Xiang Liu, Katie Felix, Christy Mayfield, Benjamin Dekel, Arend Bokenkamp, Helen Fryssira, Encarna Guillen-Navarro, Giuliana Lama, Milena Brugnara, Thomas Lücke, Ann Haskins Olney, Tracy E. Hunley, Ayse Ipek Polat, Uluc Yis, Radovan Bogdanovic, Katarina Mitrovic, Susan Berry, Lydia Najera, Behzad Najafian, Mattia Gentile, C. Nur Semerci, Michel Tsimaratos, David B. Lewis & Cornelius F. Boerkoel. (2015) Lack of IL7Rα expression in T cells is a hallmark of T-cell immunodeficiency in Schimke immuno-osseous dysplasia (SIOD). Clinical Immunology 161:2, pages 355-365.
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Noha Mousaad Elemam, Radwa Yehia Mekky, Nada Magdy El-Ekiaby, Shereen Ahmed El Sobky, Mohammad Ahmad Mohey El Din, Gamal Esmat & Ahmed Ihab Abdelaziz. (2015) Repressing PU.1 by miR-29a∗ in NK cells of HCV patients, diminishes its cytolytic effect on HCV infected cell models. Human Immunology 76:9, pages 687-694.
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Miguel-Angel Perales, Alan M. Hanash, Jarrod A. Dudakov & Marcel R.M. van den Brink. 2013. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation 123 142 .
Lily Zhang, Judith Sliker Belkowski, Tammi Briscoe & Thomas J. Rogers. (2012) Regulation of Mu Opioid Receptor Expression in Developing T Cells. Journal of Neuroimmune Pharmacology 7:4, pages 835-842.
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Hector L Aguila, Se Hwan Mun, Judith Kalinowski, Douglas J Adams, Joseph A Lorenzo & Sun‐Kyeong Lee. (2012) Osteoblast‐specific overexpression of human interleukin‐7 rescues the bone mass phenotype of interleukin‐7–deficient female mice. Journal of Bone and Mineral Research 27:5, pages 1030-1042.
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Chibing Tan, Ashlee A Taylor, Matthew Z Coburn, Julie H Marino, C Justin Van De Wiele & T Kent Teague. (2011) Ten-Color flow cytometry reveals distinct patterns of expression of CD124 and CD126 by developing thymocytes. BMC Immunology 12:1.
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Deanna A. Mele, James F. Sampson & Brigitte T. Huber. (2011) Th17 differentiation is the default program for DPP2-deficient T-cell differentiation. European Journal of Immunology 41:6, pages 1583-1593.
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Julie H. Marino, Chibing Tan, Ashlee A. Taylor, Caroline Bentley, C. Justin Van De Wiele, Richard Ranne, Marco Paliotta, Thomas A. Broughan & T. Kent Teague. (2010) Differential IL-7 responses in developing human thymocytes. Human Immunology 71:4, pages 329-333.
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Yann M Kerdiles, Daniel R Beisner, Roberto Tinoco, Anne S Dejean, Diego H Castrillon, Ronald A DePinho & Stephen M Hedrick. (2009) Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nature Immunology 10:2, pages 176-184.
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Jean Daniel Lelièvre & Yves Lévy. (2007) Perspectives on interleukin-7 therapy in HIV infection. Current Opinion in HIV and AIDS 2:3, pages 228-233.
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Beiyan Zhou, Stephanie Wang, Christine Mayr, David P. Bartel & Harvey F. Lodish. (2007) miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proceedings of the National Academy of Sciences 104:17, pages 7080-7085.
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Hong-Wen Huang, Yun-Jung Chiang, Shuen-Iu Hung, Chung-Leung Li & Jeffrey Jong-Young Yen. (2006) An IL-7 splicing-defect lymphopenia mouse model revealed by genome-wide mutagenesis. Journal of Biomedical Science 14:2, pages 169-181.
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Sun-Kyeong Lee, Judith F Kalinowski, Claire Jacquin, Douglas J Adams, Gloria Gronowicz & Joseph A Lorenzo. (2006) Interleukin-7 Influences Osteoclast Function In Vivo but Is Not a Critical Factor in Ovariectomy-Induced Bone Loss. Journal of Bone and Mineral Research 21:5, pages 695-702.
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James P. Di Santo. (2006) NATURAL KILLER CELL DEVELOPMENTAL PATHWAYS: A Question of Balance. Annual Review of Immunology 24:1, pages 257-286.
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Tak W. Mak & Mary E. Saunders. 2006. The Immune Response. The Immune Response 517 552 .
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Sun-Kyeong Lee & Charles D. Surh. (2005) Role of interleukin-7 in bone and T-cell homeostasis. Immunological Reviews 208:1, pages 169-180.
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Jena D. French, Christina L. Roark, Willi K. Born & Rebecca L. O'Brien. (2005) γδ T cell homeostasis is established in competition with αβ T cells and NK cells. Proceedings of the National Academy of Sciences 102:41, pages 14741-14746.
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Akira Harashima, Yoshinobu Matsuo, Hans G. Drexler, Ayumi Okochi, Ryuichi Motoda, Mitsune Tanimoto & Kunzo Orita. (2005) Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet. Leukemia Research 29:7, pages 841-848.
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Ivan Bubanovic. 2004. Origin of Anti-Tumor Immunity Failure in Mammals. Origin of Anti-Tumor Immunity Failure in Mammals 135 194 .
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Sun-Kyeong Lee, Judith F. Kalinowski, Sandra L. Jastrzebski, Lynn Puddington & Joseph A. Lorenzo. (2003) Interleukin-7 Is a Direct Inhibitor of in Vitro Osteoclastogenesis. Endocrinology 144:8, pages 3524-3531.
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I.V Bubanovic. (2003) Crossroads of extrathymic lymphocytes maturation pathways. Medical Hypotheses 61:2, pages 235-239.
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Istvan Berczi & Andor Szentivanyi. 2003. The Immune-Neuroendocrine Circuitry History and Progress. The Immune-Neuroendocrine Circuitry History and Progress 191 220 .
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Wouter J. de Jonge, Karin L. Kwikkers, Anje A. te Velde, Sander J.H. van Deventer, Martijn A. Nolte, Reina E. Mebius, Jan M. Ruijter, Marinus C. Lamers & Wouter H. Lamers. (2002) Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice. Journal of Clinical Investigation 110:10, pages 1539-1548.
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Wouter J. de Jonge, Karin L. Kwikkers, Anje A. te Velde, Sander J.H. van Deventer, Martijn A. Nolte, Reina E. Mebius, Jan M. Ruijter, Marinus C. Lamers & Wouter H. Lamers. (2002) Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice. Journal of Clinical Investigation 110:10, pages 1539-1548.
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Denis Franchimont, Jérôme Galon, Melanie S. Vacchio, Samuel Fan, Roberta Visconti, David M. Frucht, Vincent Geenen, George P. Chrousos, Jonathan D. Ashwell & John J. O’Shea. (2002) Positive Effects of Glucocorticoids on T Cell Function by Up-Regulation of IL-7 Receptor α. The Journal of Immunology 168:5, pages 2212-2218.
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B. Zheng, C. Lam, S. Im, J. Huang, W. Luk, S. Y. Lau, K. S. Yau, C. K. Wong, K. Yao & M. H. Ng. (2008) Distinct Tumour Specificity and IL‐7 Requirements of CD56 − and CD56 + Subsets of Human γδ T Cells . Scandinavian Journal of Immunology 53:1, pages 40-48.
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Veronika SexlRoland PiekorzRichard MorigglJuerg RohrerMichael P. BrownKevin D. BuntingKristen RothammerMartine F. RousselJames N. Ihle. (2000) Stat5a/b contribute to interleukin 7–induced B-cell precursor expansion, but abl- andbcr/abl-induced transformation are independent of Stat5. Blood 96:6, pages 2277-2283.
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Veronika SexlRoland PiekorzRichard MorigglJuerg RohrerMichael P. BrownKevin D. BuntingKristen RothammerMartine F. RousselJames N. Ihle. (2000) Stat5a/b contribute to interleukin 7–induced B-cell precursor expansion, but abl- andbcr/abl-induced transformation are independent of Stat5. Blood 96:6, pages 2277-2283.
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Anne Puel & Warren J Leonard. (2000) Mutations in the gene for the IL-7 receptor result in T–B+NK+ severe combined immunodeficiency disease. Current Opinion in Immunology 12:4, pages 468-473.
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Larry Cosenza, John R. Murphy, Temple Smith, Andrew Rosenbach & James V. White. (2008) Comparative model building of interleukin‐7 using interleukin‐4 as a template: A structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation. Protein Science 9:5, pages 916-926.
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