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Original Article

An Immunotherapeutic Vaccine for Multibacillary Leprosy

Pages 229-249 | Published online: 10 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Gursaran P Talwar, Jagdish C Gupta, Abu S Mustafa, Hemanta K Kar, Kiran Katoch, Shreemanta K Parida, Prabhakara P Reddi, Niyaz Ahmed, Vikram Saini & Somesh Gupta. (2017) Development of a potent invigorator of immune responses endowed with both preventive and therapeutic properties. Biologics: Targets and Therapy 11, pages 55-63.
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Gursaran P Talwar, Jagdish C Gupta, Susana B Rulli, Radhey S Sharma, Kripa N Nand, Atmaram H Bandivdekar, Nishu Atrey & Priyanka Singh. (2015) Advances in development of a contraceptive vaccine against human chorionic gonadotropin. Expert Opinion on Biological Therapy 15:8, pages 1183-1190.
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Articles from other publishers (24)

G. P. TalwarRohini SehgalMala ShrivastavaR. S. SharmaJagdish C. GuptaSatish K. GuptaKamal BucksheePriyanka PalKirti NainSunesh Kumar. (2022) The genetically engineered vaccine against human chorionic gonadotropin enters Phase I/II clinical trials faces a problem, its possible resolution. Journal of Reproductive Healthcare and Medicine 3, pages 2.
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. (2020) An Immunotherapeutic Vaccine Originally Developed Against Leprosy Is Effective Not Only Against Leprosy But Also Against Tuberculosis, Ano-genital Warts and Some Cancers – A Potent Invigorator of Immune Response. International Journal of Infectious Diseases and Research.
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Sangeeta Bhaskar & Bindu Singh. 2019. Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions. Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions 407 417 .
Yadvir Singh. 2019. Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions. Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions 171 188 .
Ashish Sharma, Mohd. Saqib, Javaid A. Sheikh, Nasreen Z. Ehtesham, Sangeeta Bhaskar, Tapan K. Chaudhuri & Seyed E. Hasnain. (2018) Mycobacterium indicus pranii protein MIP_05962 induces Th1 cell mediated immune response in mice. International Journal of Medical Microbiology 308:8, pages 1000-1008.
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Edith Hanna, Mohammed Dany, Ossama Abbas, Firas Kreidieh & Mazen Kurban. (2018) Updates on the use of vaccines in dermatological conditions. Indian Journal of Dermatology, Venereology and Leprology 84:4, pages 388.
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Ashish Sharma, Md. Javed Equbal, Saurabh Pandey, Javaid A. Sheikh, Nasreen Z. Ehtesham, Seyed E. Hasnain & Tapan K. Chaudhuri. (2017) Immunodominant protein MIP _05962 from Mycobacterium indicus pranii displays chaperone activity . The FEBS Journal 284:9, pages 1338-1354.
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R. Kamal, V. Pathak, A. Kumari, M. Natrajan, K. Katoch & H.K. Kar. (2017) Addition of Mycobacterium indicus pranii vaccine as an immunotherapeutic to standard chemotherapy in borderline leprosy: a double-blind study to assess clinical improvement (preliminary report) . British Journal of Dermatology 176:5, pages 1388-1389.
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Nilesh B. Ingle, Rashmi G. Virkar & Vidya A. Arankalle. (2017) Inter-Clade Protection Offered by Mw-Adjuvanted Recombinant HA, NP Proteins, and M2e Peptide Combination Vaccine in Mice Correlates with Cellular Immune Response. Frontiers in Immunology 7.
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Bongani M. Mayosi, Mpiko Ntsekhe, Jackie Bosch, Shaheen Pandie, Hyejung Jung, Freedom Gumedze, Janice Pogue, Lehana Thabane, Marek Smieja, Veronica Francis, Laura Joldersma, Kandithalal M. Thomas, Baby Thomas, Abolade A. Awotedu, Nombulelo P. Magula, Datshana P. Naidoo, Albertino Damasceno, Alfred Chitsa Banda, Basil Brown, Pravin Manga, Bruce Kirenga, Charles Mondo, Phindile Mntla, Jacob M. Tsitsi, Ferande Peters, Mohammed R. Essop, James B.W. Russell, James Hakim, Jonathan Matenga, Ayub F. Barasa, Mahmoud U. Sani, Taiwo Olunuga, Okechukwu Ogah, Victor Ansa, Akinyemi Aje, Solomon Danbauchi, Dike Ojji & Salim Yusuf. (2014) Prednisolone and Mycobacterium indicus pranii in Tuberculous Pericarditis . New England Journal of Medicine 371:12, pages 1121-1130.
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Yadvir Singh, Sakshi Kohli, Divya Tej Sowpati, Syed Asad Rahman, Anil K. Tyagi & Seyed E. Hasnain. (2014) Gene cooption in Mycobacteria and search for virulence attributes: Comparative proteomic analyses of Mycobacterium tuberculosis, Mycobacterium indicus pranii and other mycobacteria. International Journal of Medical Microbiology 304:5-6, pages 742-748.
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G. P. Talwar. (2013) A unique vaccine for control of fertility and therapy of advanced-stage terminal cancers ectopically expressing human chorionic gonadotropin. Annals of the New York Academy of Sciences 1283:1, pages 50-56.
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G.P. Talwar. (2013) Making of a vaccine preventing pregnancy without impairment of ovulation and derangement of menstrual regularity and bleeding profiles. Contraception 87:3, pages 280-287.
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Bongani M. Mayosi, Mpiko Ntsekhe, Jackie Bosch, Janice Pogue, Freedom Gumedze, Motasim Badri, Hyejung Jung, Shaheen Pandie, Marek Smieja, Lehana Thabane, Veronica Francis, Kandithal M. Thomas, Baby Thomas, Abolade A. Awotedu, Nombulelo P. Magula, Datshana P. Naidoo, Albertino Damasceno, Alfred Chitsa Banda, Arthur Mutyaba, Basil Brown, Patrick Ntuli, Phindile Mntla, Lucas Ntyintyane, Rohan Ramjee, Pravin Manga, Bruce Kirenga, Charles Mondo, James B.W. Russell, Jacob M. Tsitsi, Ferande Peters, Mohammed R. Essop, Ayub Felix Barasa, Muhammad S. Mijinyawa, Mahmoud U. Sani, Taiwo Olunuga, Okechukwu Ogah, Adewole Adebiyi, Akinyemi Aje, Victor Ansa, Dike Ojji, Solomon Danbauchi, James Hakim, Jonathan Matenga & Salim Yusuf. (2013) Rationale and design of the Investigation of the Management of Pericarditis (IMPI) trial: A 2 × 2 factorial randomized double-blind multicenter trial of adjunctive prednisolone and Mycobacterium w immunotherapy in tuberculous pericarditis. American Heart Journal 165:2, pages 109-115.e3.
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Vikram Saini, Saurabh Raghuvanshi, Jitendra P. Khurana, Niyaz Ahmed, Seyed E. Hasnain, Akhilesh K. Tyagi & Anil K. Tyagi. (2012) Massive gene acquisitions in Mycobacterium indicus pranii provide a perspective on mycobacterial evolution. Nucleic Acids Research 40:21, pages 10832-10850.
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Anil K. Tyagi, Prachi Nangpal & Vijaya Satchidanandam. (2011) Development of vaccines against tuberculosis. Tuberculosis 91:5, pages 469-478.
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Shilpi Purswani, G.P. Talwar, Richa Vohra, Rahul Pal, Amulya K. Panda, Nirmal K. Lohiya & Jagdish C. Gupta. (2011) Mycobacterium indicus pranii is a potent immunomodulator for a recombinant vaccine against human chorionic gonadotropin. Journal of Reproductive Immunology 91:1-2, pages 24-30.
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Gursaran P. Talwar, Jagdish C. Gupta & Neha V. Shankar. (2011) Immunological Approaches Against Human Chorionic Gonadotropin for Control of Fertility and Therapy of Advanced-Stage Cancers Expressing hCG/Subunits. American Journal of Reproductive Immunology 66:1, pages 26-39.
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Rajeev Kumar Pandey, Kunal H. Bhatt, Yogesh Dahiya & Ajit Sodhi. (2011) Mycobacterium indicus pranii Supernatant Induces Apoptotic Cell Death in Mouse Peritoneal Macrophages In Vitro. PLoS ONE 6:2, pages e17093.
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Gursaran Pran Talwar, Niyaz Ahmed & Vikram Saini. (2008) The use of the name Mycobacterium w for the leprosy immunotherapeutic bacillus creates confusion with M. tuberculosis-W (Beijing strain): A suggestion. Infection, Genetics and Evolution 8:1, pages 100-101.
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Samuel L. Moschella. (2004) An update on the diagnosis and treatment of leprosy. Journal of the American Academy of Dermatology 51:3, pages 417-426.
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Zhou Xing. 2004. Tuberculosis. Tuberculosis 881 892 .
Anil K. Tyagi & Neeraj Dhar. 2003. Biotechnology in India I. Biotechnology in India I 211 273 .
Redda Tekle Haimanot & Zenebe Melaku. (2000) Leprosy. Current Opinion in Neurology 13:3, pages 317-322.
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