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Laboratory Study

Protective Effects of N-Acetylcysteine Amide (NACA) on Gentamicin-Induced Apoptosis in LLC-PK1 Cells

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Pages 487-494 | Received 09 Nov 2011, Accepted 02 Jan 2012, Published online: 10 Apr 2012

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Esmaeel Babaeenezhad, Omid Dezfoulian, Forouzan Hadipour Moradi, Sobhan Rahimi Monfared, Mohammad Davood Fattahi, Maryam Nasri, Abdolhakim Amini & Hassan Ahmadvand. (2023) Exogenous glutathione protects against gentamicin-induced acute kidney injury by inhibiting NF-κB pathway, oxidative stress, and apoptosis and regulating PCNA. Drug and Chemical Toxicology 46:3, pages 441-450.
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Motahareh Mahi-Birjand, Sajad Yaghoubi, Meghdad Abdollahpour-Alitappeh, Zahra Keshtkaran, Nader Bagheri, Aliyar Pirouzi, Mehrdad Khatami, Koushan Sineh Sepehr, Payam Peymani & Iman Karimzadeh. (2020) Protective effects of pharmacological agents against aminoglycoside-induced nephrotoxicity: A systematic review. Expert Opinion on Drug Safety 19:2, pages 167-186.
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K. Sunitha, M. Hemshekhar, R. M. Thushara, M. Sebastin Santhosh, M. Yariswamy, K. Kemparaju & K. S. Girish. (2013) N-Acetylcysteine amide: a derivative to fulfill the promises of N-Acetylcysteine. Free Radical Research 47:5, pages 357-367.
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Articles from other publishers (13)

Ruibin Bai, Jingmin Fan, Yanping Wang, Yan Wang, Xue Li & Fangdi Hu. (2023) Protective effect of Cistanche deserticola on gentamicin-induced nephrotoxicity in rats. Chinese Herbal Medicines 15:1, pages 102-109.
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Young-Eun Choi, Mi-Soon Kim, Yuna Ha, Yoon Cho, Jang Kyun Kim, Jae-Sung Rhee, Jae-Chun Ryu & Youn-Jung Kim. (2022) Association of expression of GADD family genes and apoptosis in human kidney proximal tubular (HK-2) cells exposed to nephrotoxic drugs. Molecular & Cellular Toxicology 18:4, pages 569-580.
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Bing‐feng Hu, Qian Gong, Shi‐qing Chen, Lin Yue, Wen‐xian Ma, Fang Wang, Xiao‐wen Feng, Jia‐nan Wang, Chao Li, Ming‐ming Liu, Xue‐fu Wang, Xiao‐ming Meng, Jun Li & Jia‐gen Wen. (2022) Protective effect of inhibiting necroptosis on gentamicin‐induced nephrotoxicity. The FASEB Journal 36:9.
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Esmaeel Babaeenezhad, Forouzan Hadipour Moradi, Sobhan Rahimi Monfared, Mohammad Davood Fattahi, Maryam Nasri, Abdolhakim Amini, Omid Dezfoulian & Hassan Ahmadvand. (2021) D-Limonene Alleviates Acute Kidney Injury Following Gentamicin Administration in Rats: Role of NF-κB Pathway, Mitochondrial Apoptosis, Oxidative Stress, and PCNA. Oxidative Medicine and Cellular Longevity 2021, pages 1-16.
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Aline D. Marinho, João A. M. Silveira, Adriano J. M. Chaves-Filho, Danielle S. Macedo, Luana D. Carmo, Nylane M. N. Alencar, Pedro H. S. Costa, Pedro L. Lopes, Francisco A. Nogueira-Junior, Natacha T. Q. Alves, Francisco A. F. Xavier-Junior, Janaina S. A. M. Evangelista, Tiago L. Sampaio, Alice M. C. Martins, Dyély C. O. Campos, Hermógenes D. Oliveira, Roberta J. B. Jorge & Helena S. A. Monteiro. (2020) Protective Effects Of A Lipid Transfer Protein Isolated from Morinda citrifolia Seeds in Gentamicin-Induced Nephrotoxicity in Rats. Revista Brasileira de Farmacognosia 30:4, pages 568-576.
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Dawit A. Ejigu & Solomon M. Abay. (2020) N-Acetyl Cysteine as an Adjunct in the Treatment of Tuberculosis. Tuberculosis Research and Treatment 2020, pages 1-11.
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Torkil Benterud, Sophia Manueldas, Svante Norgren, Rønnaug Solberg, Ola Didrik Saugstad & Lars O. Baumbusch. (2017) N-Acetylcysteine Amide (NACA) Reduces Cell Death after Oxidative Stress in a Porcine Embryonic Kidney Cell Line. Journal of Biomedical Science and Engineering 10:02, pages 31-36.
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Torkil Benterud, Martin B. Ystgaard, Sophia Manueldas, Leonid Pankratov, Clara Alfaro-Cervello, Geir Florholmen, Muhammad Shakil Ahmed, Leiv Sandvik, Svante Norgren, Magnar Bjørås, Lars O. Baumbusch, Ronnaug Solberg & Ola Didrik Saugstad. (2017) N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia. Neonatology 111:1, pages 12-21.
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Hassan Ahmadvand, Majid Tavafi, Vahideh Asadollahi, Leila Jafaripour, Forouzan Hadipour-Moradi, Reza Mohammadrezaei-Khoramabadi, Peyman Khosravi, Hadis Salehi & Ahmad Cheraghi. (2016) Protective Effect of Carvacrol on Renal Functional and Histopathological Changes in Gentamicin-Induced-Nephrotoxicity in Rats. Zahedan Journal of Research in Medical Sciences In Press:In Press.
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Xuezhong Gong, Yiru Duan, Junli Zheng, Yiquan Wang, Guohua Wang, Svante Norgren & Tom K. Hei. (2016) Nephroprotective Effects of N-Acetylcysteine Amide against Contrast-Induced Nephropathy through Upregulating Thioredoxin-1, Inhibiting ASK1/p38MAPK Pathway, and Suppressing Oxidative Stress and Apoptosis in Rats. Oxidative Medicine and Cellular Longevity 2016, pages 1-11.
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Eun Hui Bae, In Jin Kim, Soo Yeon Joo, Eun Young Kim, Joon Seok Choi, Chang Seong Kim, Seong Kwon Ma, JongUn Lee & Soo Wan Kim. (2013) Renoprotective effects of the direct renin inhibitor aliskiren on gentamicin-induced nephrotoxicity in rats. Journal of the Renin-Angiotensin-Aldosterone System 15:4, pages 348-361.
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Ko Eun Lee, Eun Young Kim, Chang Seong Kim, Joon Seok Choi, Eun Hui Bae, Seong Kwon Ma, Kyung Keun Kim, Jong Un Lee & Soo Wan Kim. (2013) Macrophage-stimulating protein attenuates gentamicin-induced inflammation and apoptosis in human renal proximal tubular epithelial cells. Biochemical and Biophysical Research Communications 434:3, pages 527-533.
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Xuezhong Gong, Qian Wang, Xiaochun Tang, Yuerong Wang, Dan Fu, Huayi Lu, Guohua Wang & Svante Norgren. (2013) Tetramethylpyrazine Prevents Contrast-Induced Nephropathy by Inhibiting p38 MAPK and FoxO1 Signaling Pathways. American Journal of Nephrology 37:3, pages 199-207.
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