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Clinical Study

Antiapoptotic and Antioxidant Effects of GSPE in Preventing Cyclosporine A-Induced Cardiotoxicity

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Pages 460-466 | Received 24 Oct 2011, Accepted 09 Jan 2012, Published online: 02 Feb 2012

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Tsz Ki Wang, Shaoting Xu, Shuang Li & Yunjian Zhang. (2020) Proanthocyanidins Should Be a Candidate in the Treatment of Cancer, Cardiovascular Diseases and Lipid Metabolic Disorder. Molecules 25:24, pages 5971.
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Meng Wei, Fangming Guo, Dongsheng Rui, Haixia Wang, Gangling Feng, Shugang Li & Guanling Song. (2017) Alleviation of Arsenic-Induced Pulmonary Oxidative Damage by GSPE as Shown during In vivo and In vitro Experiments. Biological Trace Element Research 183:1, pages 80-91.
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Xin Wang, Dalin Jia, Juncheng Zhang & Wei Wang. (2017) Grape seed proanthocyanidins protect cardiomyocytes against hypoxia/reoxygenation injury by attenuating endoplasmic reticulum stress through PERK/eIF2α pathway. Molecular Medicine Reports 16:6, pages 9189-9196.
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Ying Liang, Jian Wang, Haiqing Gao, Quanzhen Wang, Jun Zhang & Jie Qiu. (2016) Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress. Molecular Medicine Reports.
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Adel El-Sayed El-Tarras, Hossam Fouad Attia, Mohammed Mohamed Soliman, Mohammed Abdelhamid El Awady & Adnan Abelghani Amin. (2016) Neuroprotective effect of grape seed extract against cadmium toxicity in male albino rats. International Journal of Immunopathology and Pharmacology 29:3, pages 398-407.
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Cengiz Kocak, Fatma Emel Kocak, Raziye Akcilar, Ozben Ozden Isiklar, Havva Kocak, Zeynep Bayat, Hasan Simsek, Figen Taser & Irfan Altuntas. (2016) Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats. Life Sciences 147, pages 15-23.
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Agnieszka Korolczuk, Kinga Caban, Magdalena Amarowicz, Grażyna Czechowska & Joanna Irla-Miduch. (2016) Oxidative Stress and Liver Morphology in Experimental Cyclosporine A-Induced Hepatotoxicity. BioMed Research International 2016, pages 1-9.
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Xiaxia Cai, Lei Bao, Jinwei Ren, Yong Li & Zhaofeng Zhang. (2016) Grape seed procyanidin B2 protects podocytes from high glucose-induced mitochondrial dysfunction and apoptosis via the AMPK-SIRT1-PGC-1α axis in vitro. Food & Function 7:2, pages 805-815.
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Sarah E. Edwards, Inês da Costa Rocha, Elizabeth M. Williamson & Michael Heinrich. 2015. Phytopharmacy. Phytopharmacy 186 188 .
Goksin Nilufer Yonguc, Yavuz Dodurga, Esat Adiguzel, Gulsah Gundogdu, Vural Kucukatay, Seda Ozbal, Ismail Yilmaz, Ulker Cankurt, Yusuf Yilmaz & Ilgaz Akdogan. (2015) Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats. Gene 555:2, pages 119-126.
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Tan Yang, Xiaomin Li, Wang Zhu, Cheng Chen, Zhihong Sun, Zhiliang Tan & Jinghe Kang. (2014) Alteration of Antioxidant Enzymes and Associated Genes Induced by Grape Seed Extracts in the Primary Muscle Cells of Goats In Vitro. PLoS ONE 9:9, pages e107670.
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Yejing Zhu, Jinyu Chi, Yue Liu, Yihua Sun, Yu Fu, Xiaohui Zhang, Xueliang Ding, Xinhua Yin & Dechao Zhao. (2012) Knockdown of dishevelled-1 attenuates cyclosporine A-induced apoptosis in H9c2 cardiomyoblast cells. Molecular and Cellular Biochemistry 374:1-2, pages 113-123.
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