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Research Article

Effects of trimetazidine on the Akt/eNOS signaling pathway and oxidative stress in an in vivo rat model of renal ischemia-reperfusion

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Pages 1436-1442 | Received 07 Mar 2014, Accepted 15 Jul 2014, Published online: 23 Sep 2014

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Houman Kamranian, Hadi Asoudeh, Roya Kamrani Sharif, Fereshteh Taheri, A. Wallace Hayes, Mina Gholami, Ahmad Alavi & Majid Motaghinejad. (2023) Neuroprotective potential of trimetazidine against tramadol-induced neurotoxicity: role of PI3K/Akt/mTOR signaling pathways. Toxicology Mechanisms and Methods 33:7, pages 607-623.
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Yan Yang, Qinqin Xu, Tao Li & Shiying Shao. (2021) Trimetazidine ameliorates hindlimb ischaemic damage in type 2 diabetic mice. Annals of Medicine 53:1, pages 1100-1108.
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Articles from other publishers (22)

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Xisheng Shan, Jiaxin Zhang, Xiang Wei, Wenhui Tao, Ke Peng, Huayue Liu, Yiqing Wang, Hong Liu, Xiaowen Meng & Fuhai Ji. (2022) Dexmedetomidine attenuates renal ischemia–reperfusion injury through activating PI3K / Akt‐eNOS signaling via α 2 adrenoreceptors in renal microvascular endothelial cells . The FASEB Journal 36:11.
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Marc Micó-Carnero, Mohamed Amine Zaouali, Carlos Rojano-Alfonso, Cristina Maroto-Serrat, Hassen Ben Abdennebi & Carmen Peralta. (2022) A Potential Route to Reduce Ischemia/Reperfusion Injury in Organ Preservation. Cells 11:17, pages 2763.
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Seçkin Engin, Elif Nur Barut, Yeşim Kaya Yaşar, Aysun Çelik Soysal, Tuğba Arıcı, Gökçen Kerimoğlu, Mine Kadıoğlu & Sena F. Sezen. (2022) Trimetazidine attenuates cyclophosphamide-induced cystitis by inhibiting TLR4-mediated NFκB signaling in mice. Life Sciences 301, pages 120590.
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Chérifa Slim, Hana Nassrallah, Mohamed Amine Zaouali, Fatma Amara, Hatem Majdoub, Didier Morin & Hassen Ben Abdennebi. (2022) Fucoidan alleviates the mitochondria and endoplasmic reticulum stresses in ischemic rat livers. Phytomedicine Plus 2:2, pages 100250.
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Rehab S. Abdelrahman, Ramy A. Abdelsalam & Marwa S. Zaghloul. (2022) Beneficial effect of trimetazidine on folic acid‐induced acute kidney injury in mice: Role of HIF‐1α/HO‐1. Journal of Biochemical and Molecular Toxicology 36:5.
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Juan P. Ortiz Fragola, Gabriel Cao, Mariano Tumarkin, Marisa Moriondo, Angélica Muller, Martin Sangiorgio, Francisco Azzato, Giuseppe Ambrosio & José Milei. (2022) Bretschneider Solution and Two Antianginal Drugs Protect Peripheral Tissue in an Animal Model of Hemorrhagic Shock. Journal of Cardiovascular Pharmacology 79:6, pages 896-903.
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Kunsheng Li, Pengyu Zhou, Shiliang Li, Shaoyi Zheng & Dongjin Wang. (2021) MicroRNA-29b reduces myocardial ischemia–reperfusion injury in rats via down-regulating PTEN and activating the Akt/eNOS signaling pathway. Journal of Thrombosis and Thrombolysis 53:1, pages 123-135.
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Kirti Gupta, Sneha Pandey, Newly Bagang, Kamalpreet Mehra & Gaaminepreet Singh. (2021) Trimetazidine an emerging paradigm in renal therapeutics: Preclinical and clinical insights. European Journal of Pharmacology 913, pages 174624.
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O. E. Antsiferova, M. P. Teleshchenko, Yu. M. Tsuverkalova, M. V. Pokrovsky, V. V. Gureev, M. A. Zatolokina & A. V. Gureeva. (2021) CORRECTION OF MORPHOFUNCTIONAL DISORDERS IN EXPERIMENTAL PREECLAMPSY BY COMBINED USE OF TRIMETAZIDINE AND PURIFIED MICRONIZED FLAVONOID FRACTION AS WELL AS THEIR COMBINATIONS WITH METHYLAMPSY. Pharmacy & Pharmacology 8:5, pages 304-315.
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María Herminia Hazelhoff, Romina Paula Bulacio & Adriana Monica Torres. (2021) Trimetazidine Protects from Mercury-Induced Kidney Injury. Pharmacology 106:5-6, pages 332-340.
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Hana Nasrallah, Imen Aissa, Chérifa Slim, Mohamed Ali Boujbiha, Mohamed Amine Zaouali, Mohamed Bejaoui, Victoria Wilke, Hichem Ben Jannet, Habib Mosbah & Hassen Ben Abdennebi. (2020) Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney. Life Sciences 255, pages 117833.
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Negin Amini, Alireza Sarkaki, Mahin Dianat, Seyyed Ali Mard, Akram Ahangarpour & Mohammad Badavi. (2019) Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation. Pharmacological Reports 71:6, pages 1059-1066.
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Amrit Pal Singh, Nirmal Singh, Devendra Pathak & Preet Mohinder Singh Bedi. (2018) Estradiol attenuates ischemia reperfusion-induced acute kidney injury through PPAR-γ stimulated eNOS activation in rats. Molecular and Cellular Biochemistry 453:1-2, pages 1-9.
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Yan-yan Wang, Yan-yan Li, Lin Li, Dong-li Yang, Kun Zhou & Yu-hong Li. (2018) Protective Effects of Shenfu Injection against Myocardial Ischemia–Reperfusion Injury <i>via</i> Activation of eNOS in Rats. Biological and Pharmaceutical Bulletin 41:9, pages 1406-1413.
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Jin Ha Park, Ji Hae Jun, Jae-Kwang Shim, Eun Jung Shin, Eunah Shin & Young-Lan Kwak. (2018) Effects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression. Oxidative Medicine and Cellular Longevity 2018, pages 1-10.
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Thais Rose dos Santos Hamilton, Adriano Felipe Perez Siqueira, Letícia Signori de Castro, Camilla Mota Mendes, Juliana de Carvalho Delgado, Patrícia Monken de Assis, Leonardo Pereira Mesquita, Paulo César Maiorka, Marcílio Nichi, Marcelo Demarchi Goissis, José Antonio Visintin & Mayra Elena Ortiz D. Ávila Assumpção. (2018) Effect of Heat Stress on Sperm DNA: Protamine Assessment in Ram Spermatozoa and Testicle. Oxidative Medicine and Cellular Longevity 2018, pages 1-14.
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D. I. Trukhan, A. L. Mazurov & E. L. Davydov. (2017) MYOCARDIAL CYTOPROTECTOR TRIMETAZIDINE MB-PREPARAT, INCREASES THE EFFECTIVENESS OF TREATMENT OF CHRONIC HEART FAILURE AND CORONARY HEART DISEASE. Medical Council:7, pages 75-83.
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Hui Li, Fu-Yuan Liu, Xiao-Lan Li, Xiao-Mei Li & Lei Zhu. (2016) Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy. Experimental and Therapeutic Medicine 12:2, pages 979-982.
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Yaling Feng, Lingqing Hu, Qian Xu, Hua Yuan, Linlin Ba, Yue He & Haisha Che. (2015) Cytoprotective Role of Alpha-1 Antitrypsin in Vascular Endothelial Cell Under Hypoxia/Reoxygenation Condition. Journal of Cardiovascular Pharmacology 66:1, pages 96-107.
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D. I Trukhan. (2014) Therapeutic possibilities of myocardial cytoprotector trimetazidine MR incoronary heart disease. CardioSomatics 5:3-4, pages 41-47.
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