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Pediatric Hematology and Oncology Volume 31, 2014 - Issue 2
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ORIGINAL ARTICLE Acute Lymphoblastic Leukemias

Association of -24CT, 1249GA, and 3972CT ABCC2 Gene Polymorphisms with Methotrexate Serum Levels and Toxic Side Effects in Children with Acute Lymphoblastic Leukemia

Mohamad Jafar Sharifi
,
Gholamreza BahoushDepartment of Pediatric Hematology-Oncology, Ali Asghar Children's Hospital, Iran University of Medical Sciences, Tehran, IR Iran
,
Farhad ZakerCorrespondence[email protected]
,
Shahla AnsariDepartment of Pediatric Hematology-Oncology, Ali Asghar Children's Hospital, Iran University of Medical Sciences, Tehran, IR Iran
,
Khadijeh Arjmandi RafsanjaniDepartment of Pediatric Hematology-Oncology, Ali Asghar Children's Hospital, Iran University of Medical Sciences, Tehran, IR Iran
&
Heidar Sharafi
Pages 169-177 | Received 03 Sep 2013, Accepted 26 Nov 2013, Published online: 19 Feb 2014

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Henrike Bruckmueller & Ingolf Cascorbi. (2021) ABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: what is our current understanding?. Expert Opinion on Drug Metabolism & Toxicology 17:4, pages 369-396.
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Rizal Husaini Razali, Mohd Nur Fakhruzzaman Noorizhab, Hisyam Jamari, Richard Johari James, Kok Hoi Teh, Hishamshah Mohd Ibrahim, Lay Kek Teh & Mohd Zaki Salleh. (2020) Association of ABCC2 with levels and toxicity of methotrexate in Malaysian Childhood Acute Lymphoblastic Leukemia (ALL). Pediatric Hematology and Oncology 37:3, pages 185-197.
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Abolfazl Kalantari, Farhad Zaker, Shahla Ansari, Heidar Sharafi & Mozhdeh Mohammadian. (2015) The effect of polymorphisms of gamma-glutamyl hydrolase (GGH) gene on methotrexate-induced toxicity in acute lymphoblastic leukemia. Toxin Reviews 34:3, pages 136-141.
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Evelien G. E. Hurkmans, Annouk C. A. M. Brand, Job A. J. Verdonschot, D. Maroeska W. M. te Loo & Marieke J. H. Coenen. (2022) Pharmacogenetics of chemotherapy treatment response and -toxicities in patients with osteosarcoma: a systematic review. BMC Cancer 22:1.
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Hedy Maagdenberg, Natanja Oosterom, Jolanda Zanen, Donato Gemmati, Rachael E. Windsor, Sandra G. Heil, Patricia Esperón, Shakila Jabeen, Guillermo J. Ruiz-Argüelles, Oliver Zolk, Susanne Hoerning, Charlotte Sleurs, Elixabet Lopéz-Lopéz, Mónica Moreno-Galván, Marry M. van den Heuvel-Eibrink, Anke H. Maitland-van der Zee & Bruce C. Carleton. (2021) Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis. Critical Reviews in Oncology/Hematology 161, pages 103312.
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Amit Kumar & Vikas Jaitak. (2019) Natural products as multidrug resistance modulators in cancer. European Journal of Medicinal Chemistry 176, pages 268-291.
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Ya-Hui Hu, Lin Zhou, Shan-Shan Wang, Xia Jing, Hong-Li Guo, Fang Sun, Yong Zhang, Feng Chen, Jing Xu & Xing Ji. (2019) Methotrexate Disposition in Pediatric Patients with Acute Lymphoblastic Leukemia: What Have We Learnt From the Genetic Variants of Drug Transporters. Current Pharmaceutical Design 25:6, pages 627-634.
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Guillermo Gervasini & Sonia Mota-Zamorano. (2019) Clinical Implications of Methotrexate Pharmacogenetics in Childhood Acute Lymphoblastic Leukaemia. Current Drug Metabolism 20:4, pages 313-330.
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Andrea Giletti & Patricia Esperon. (2018) Genetic markers in methotrexate treatments. The Pharmacogenomics Journal 18:6, pages 689-703.
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Rachel Conyers, Subalatha Devaraja & David Elliott. (2018) Systematic review of pharmacogenomics and adverse drug reactions in paediatric oncology patients. Pediatric Blood & Cancer 65:4, pages e26937.
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Xia Wen, Melanie S. Joy & Lauren M. Aleksunes. (2017) In Vitro Transport Activity and Trafficking of MRP2/ABCC2 Polymorphic Variants. Pharmaceutical Research 34:8, pages 1637-1647.
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Frédérique Rodieux, Verena Gotta, Marc Pfister & Johannes N. van den Anker. (2016) Causes and Consequences of Variability in Drug Transporter Activity in Pediatric Drug Therapy. The Journal of Clinical Pharmacology 56, pages S173-S192.
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Cheynne McLean, Aze Wilson & Richard B. Kim. (2016) Impact of Transporter Polymorphisms on Drug Development: Is It Clinically Significant?. The Journal of Clinical Pharmacology 56, pages S40-S58.
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Yun-Kai Zhang, Yi-Jun Wang, Pranav Gupta & Zhe-Sheng Chen. (2015) Multidrug Resistance Proteins (MRPs) and Cancer Therapy. The AAPS Journal 17:4, pages 802-812.
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Yang Chen & Zuojun Shen. (2015) Gene polymorphisms in the folate metabolism and their association with MTX-related adverse events in the treatment of ALL. Tumor Biology 36:7, pages 4913-4921.
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E Cecchin, G Perrone, S Nobili, J Polesel, E De Mattia, C Zanusso, P Petreni, S Lonardi, N Pella, M D'Andrea, D Errante, F Rizzolio, T Mazzei, I Landini, E Mini & G Toffoli. (2014) MTHFR-1298 A>C (rs1801131) is a predictor of survival in two cohorts of stage II/III colorectal cancer patients treated with adjuvant fluoropyrimidine chemotherapy with or without oxaliplatin. The Pharmacogenomics Journal 15:3, pages 219-225.
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A Gézsi, O Lautner-Csorba, D J Erdélyi, G Hullám, P Antal, Á F Semsei, N Kutszegi, M Hegyi, K Csordás, G Kovács & C Szalai. (2014) In interaction with gender a common CYP3A4 polymorphism may influence the survival rate of chemotherapy for childhood acute lymphoblastic leukemia. The Pharmacogenomics Journal 15:3, pages 241-247.
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Elixabet Lopez-Lopez, Angela Gutierrez-Camino, Nerea Bilbao-Aldaiturriaga, Maria Pombar-Gomez, Idoia Martin-Guerrero & Africa Garcia-Orad. (2014) Pharmacogenetics of childhood acute lymphoblastic leukemia. Pharmacogenomics 15:10, pages 1383-1398.
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